William G. Kaelin

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William G. Kaelin

William George Kaelin (born November 23, 1957 in Jamaica , Queens , New York City ) is an American oncologist and professor at Harvard Medical School and researcher at the Dana-Farber Cancer Institute in Boston , Massachusetts . He was awarded the Nobel Prize in Medicine in 2019 .

Life

William G. Kaelin Jr. earned an MD from Duke University in Durham , North Carolina in 1982 . As an intern, he worked at the Johns Hopkins Hospital in Baltimore , Maryland , before joining the Dana-Farber Cancer Institute (DFCI) in Boston , Massachusetts as a clinical oncologist , where he also became a postdoctoral fellow with David M. Livingston . In 1992 he became an independent researcher at the DFCI, and since 1998 he has also conducted research for the Howard Hughes Medical Institute (HHMI). He is a professor of internal medicine at Harvard Medical School in Boston, Massachusetts.

Kaelin was married and has two children. His wife died of cancer in 2015.

Act

Kaelin isolated the first protein in the E2F family, E2F1 . It is a protein that promotes cell proliferation . Kaelin was also able to explain the genetic basis of Hippel-Lindau's disease (vHL). More recent work deals with the VHL tumor suppressor protein ( pVHL , von Hippel-Lindau protein or von Hippel-Lindau tumor suppressor), which is seen as the key to new forms of treatment for Hippel-Lindau's disease. It regulates the hypoxia-induced factor (HIF), which in turn regulates the vascular and thus the oxygen supply of tumors by means of Vascular Endothelial Growth Factor (VEGF). At his laboratory, he also studies various other tumor suppressor proteins (in addition to pVHL, among others, the homologue of p53 p73 and retinoblastoma protein pRB), their function and their possible uses against cancer.

Nobel Prize in Physiology / Medicine 2019: Cellular Adaptation to the Availability of Oxygen Using Hif

Awards (selection)

Fonts (selection)

  • with O. Iliopoulos u. a .: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein , Proc Natl Acad Sci USA, Volume 93, 1996, pp. 10595-10599.
  • with E. Maher, u. a .: von Hippel-Lindau Disease , Medicine, Volume 76, 1997, pp. 381-391.
  • with CE Stebbins u. a .: Structure of the VHL-ElonginC-elonginB complex: implications for VHL tumor suppressor function , Science, Volume 284, 1999, pp 455-461
  • with I. Mircea, K. Kondo u. a .: HIFa targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing , Science, Volume 292, 2001, pp. 464-468
  • Molecular basis of the VHL hereditary cancer syndrome , Nat. Rev. Cancer, Vol. 2, 2002, pp. 673-682, PMID 12209156
  • with K. Kondo u. a .: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein , Cancer Cell, Volume 1, 2002, pp. 237-246
  • with K. Kondo u. a .: Inhibition of HIF2alpha Is sufficient to suppress pVHL-defective tumor growth , PLoS Biol., Volume 1, 2003, pp. 439-444.
  • with WY Kim u. a .: The role of VHL gene mutation in human cancer , J. Clin. Oncol., Vol. 22, 2004, pp. 4991-5004.
  • with PJ Ratcliffe et al. a .: Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway , Mol. Cell, Volume 30, 2008, pp. 393-402
  • with YA Minamishima: Reactivation of hepatic EPO synthesis in mice after PHD loss , Science, Volume 329, 2010, p. 407.
  • The VHL Tumor Suppressor Gene: Insights into Oxygen Sensing and Cancer , Trans. Am. Clin. Climatol. Assoc., Volume 128, 2017, pp. 298-307. PMID 28790514
  • Common pitfalls in preclinical cancer target validation , Nat. Rev. Cancer, Volume 17, 2017, pp. 425-440
  • with M. Ivan: The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks , Mol. Cell, Volume 66, 2017, pp. 772-779
  • HIF2 Inhibitor Joins the Kidney Cancer Armamentarium , J. Clin. Oncol., Volume 36, 2018, pp. 908-910.
  • with J. Zhang u. a .: VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma , Science, Volume 361, 2018, pp. 290-295

literature

Web links

Individual evidence

  1. ↑ a b William G. Kaelin, Jr., T'79, MD'83 at medalum.duke.edu; Retrieved May 8, 2011
  2. ^ Dana-Farber mourns the death of breast surgeon Carolyn Kaelin, MD, MPH, FACS - Dana-Farber Cancer Institute - Boston, MA. In: dana-farber.org. August 3, 2015, accessed February 4, 2016 .
  3. ^ William G. Kaelin Honored with Gairdner International Award at hhmi.org; Retrieved May 8, 2011
  4. ^ William G. Kaelin Jr. - Gairdner Foundation. In: gairdner.org. Retrieved March 24, 2018 .
personal data
SURNAME Kaelin, William G.
ALTERNATIVE NAMES Kaelin, William George (full name)
BRIEF DESCRIPTION American oncologist
DATE OF BIRTH November 23, 1957
PLACE OF BIRTH Jamaica , New York City