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You
- Du Bartas, Guillaume (1544–1590), French Baroque writer
- Du Bellay, Martin (1703–1775), French Roman Catholic clergyman, abbot and bishop
- Du Berry, Belle (1966-2020), French singer, songwriter and actress
- Du Bois de Beauchesne, Alcide Hyacinthe (1804–1873), French historian and writer
- du Bois, Charles (1656–1740), English merchant and botanist
- Du Bois, Charles (1874–1963), Swiss dermatologist
- Du Bois, Félicien (* 1983), Swiss ice hockey player
- Du Bois, François , French composer, marimba player, professor and writer
- Du Bois, Georg (1874–1947), Swiss manager of the German metallurgical and chemical industry
- Du Bois, Kerwin (* 1977), Trinidadian singer, songwriter and producer of soca and calypso music
- Du Bois, Léon (1859–1935), Belgian composer and organist
- Du Bois, Paul (1859–1938), Belgian sculptor and medalist
- Du Bois, Raoul Pene (1914–1985), American scene and costume designer
- Du Bois, Victoire , French actress
- Du Bois, WEB (1868–1963), American civil rights activist, sociologist, philosopher, journalist, pacifist
- Du Bois-Reymond Marcus, Eveline (1901–1990), German-Brazilian zoologist and illustrator
- du Bois-Reymond, Emil (1818–1896), German physiologist and theoretical physician
- Du Bois-Reymond, Paul (1831–1889), German mathematician
- Du Boisgobey, Fortuné (1821-1891), French writer
- Du Bos, Charles (1882–1939), French writer and literary critic
- Du Bourg, Anne (1521–1559), martyr
- Du Brey, Claire (1892–1993), American actress
- Du Buc de Rivéry, Aimée , French noblewoman, alleged harem slave and mother of Mahmud II.
- Du Bus de Gisignies, Bernard Amé Léonard (1808–1874), Belgian ornithologist, paleontologist and artist
- Du Bus de Warnaffe, Charles (1894–1965), Belgian politician
- Du Camp, Maxime (1822-1894), French writer, journalist and photography pioneer
- Du Cane, Charles (1825–1889), British politician, Member of the House of Commons, Governor of Tasmania
- Du Cane, John Philip (1865–1947), British officer and Governor of Malta
- Du Cange, Charles du Fresne (1610–1688), French lawyer and lexicographer
- du Cann, Edward (1924-2017) British politician, Member of the House of Commons
- Du Cann, John (1946-2011), British guitarist, singer and songwriter
- Du Casse, Jean Baptiste (1646–1715), French flibustier and admiral
- Du Casse, Pierre Emanuel Albert (1813-1893), French military writer
- Du Chaillu, Paul Belloni (1835–1903), French anthropologist and Africa explorer
- Du Chao (* 1982), Chinese ice hockey player
- Du Chayla, Alexandre (1885–1947), French nobleman
- Du Closel, Amaury (* 1956), French composer and orchestra leader
- Du Couret, Louis (1812–1867), French adventurer
- Du Fail, Noël († 1591), French Renaissance writer
- Du Faur de Pibrac, Guy (1529–1584), French lawyer and judge, diplomat and poet
- Du Fay, Charles (1698–1739) French scientist and superintendent of the royal gardens in France
- du Féaux, Emmy , German-Baltic writer and journalist
- Du Ferrier, Arnaud († 1585), French lawyer and diplomat
- Du Four, Vital († 1327), cardinal
- Du Fu (712–770), poet of the Tang Dynasty
- Du Guangting (850–933), Daoist and court scholar at the end of the Tang Dynasty
- Du Halde, Jean-Baptiste (1674–1743), French Jesuit and geographer, author of the "Description de la Chine"
- du Hamel, Alaert , Dutch architect, sculptor, printmaker and draftsman
- You Hamel, Alexius , Saxon lieutenant general
- Du Hamel, Franz († 1705), Prussian general of the cavalry and later generalissimo of the Republic of Venice
- Du Hamel, Jean-Baptiste (1624–1706), French philosopher and theologian
- Du Hamel, Joseph (1768–1840), Russian senator and governor of Livonia
- Du Jardin, Aldephonse Alexandre Félix (1796–1870), Belgian diplomat
- Du Jarric, Pierre (1566–1617), French Jesuit, philosopher, theologian and historian
- Du Jarrys Freiherr von La Roche, Luitpold (1837-1884), royal Bavarian government official
- Du Lau d'Allemans, Jean Marie (1738–1792), last Archbishop of Arles
- Du Locle, Camille (1832–1903), French librettist
- Du Mage, Pierre († 1751), French organist and composer
- Du Marsais, César Chesneau (1676–1756), French philosopher and grammarian
- du Mée, Elly (1914–2002), Dutch sprinter
- Du Méril, Édélestand (1801–1871), French Romance studies and literary scholar
- Du Mesnil, Emmanuel Mangel (1815–1890), French photographer, diplomat
- Du Monchaux, Pierre-Antoine-Joseph (1733–1766), French doctor and writer
- Du Mont, Mirja (* 1976), German model
- Du Mont, Sky (* 1947), German actor and author
- du Mont, Wolf-Walther (* 1945), German chemist, professor of inorganic chemistry
- Du Moulin, Peter (1681–1756), Prussian general of the infantry
- Du Moulin-Eckart, Karl Leon (1900–1991), German SA leader
- Du Moulin-Eckart, Richard (1864–1938), German historian
- Du Mu (803-852), Chinese poet
- Du Noyer, Anne Marguerite Petit (1663–1719), French journalist
- du Page, Julie (* 1973), French actress and a model
- Du Pan, Barthélemy (1712–1763), Swiss portrait painter
- Du Parcq, Herbert, Baron du Parcq (1880–1949), British jurist, Lord Justice
- Du Parquet, Emmanuel (1869–1933), French officer and diplomat
- Du Paty de Clam, Armand (1853–1916), French professional soldier
- Du Petit-Thouars, Louis Marie Aubert (1758–1831), French traveler and botanist
- Du Pierry, Louise , French astronomer
- Du Pineau, Gabriel-Joseph (1694–1756), French cleric, Romanist, dialectologist and lexicographer
- Du Pisani, André (* 1949), Namibian political scientist
- Du Plat Taylor, Francis Maurice Gustavus (1878–1954), British marine engineer
- Du Plat Taylor, Joan (1906-1983), British underwater archaeologist
- Du Plat Taylor, John Lowther (1829–1904), British officer and founder of the Army Post Office Corps
- Du Plat Taylor, St. John Louis Hyde (1865–1936), British Lieutenant Colonel
- Du Plat, Anton Heinrich (1738–1791), lieutenant general and cartographer from Hanover
- Du Plat, Charles Taylor (1823–1900), British major general
- du Plat, Claude (1809–1864), Danish major general and city commander
- du Plat, Georg Josua (1722–1795), lieutenant general and cartographer from Hanover
- Du Plat, Johann Heinrich Christian (1769–1852), royal Danish major general and cartographer
- Du Plat, Johann Wilhelm (1735–1806), lieutenant general and cartographer from Hanover
- du Plat, Peter Joseph (1761-1824), royal Hanoverian lieutenant general
- Du Plessis d'Argentré, Charles (1673–1740), French bishop
- Du Plessis d'Argentré, Jean-Baptiste (1720–1805), French bishop
- Du Plessis, David (1905–1987), South African Pentecostal preacher
- Du Plessis, Johannes (1868–1935), South African theologian and missionary
- Du Pont de Nemours, Pierre Samuel (1739–1817), French economist
- Du Pont, Alfred I. (1864–1935), American industrialist, investor, and philanthropist
- Du Pont, Alfred V. (1798–1856), French-American chemist and entrepreneur
- du Pont, Eleuthère Irénée (1771–1834), French chemist
- du Pont, Henry A. (1838–1926), American politician (Republican Party)
- Du Pont, John Eleuthère (1938-2010), American ornithologist, conchologist and wrestler trainer; convicted murderer
- Du Pont, Pierre S. IV. (* 1935), American politician
- du Pont, T. Coleman (1863–1930) American businessman and politician
- du Porter, Gavin (* 1949), English pop and pop singer and songwriter
- Du Pré, Antoine (* 1961), French author
- Du Pré, Guillaume , French carver
- du Preez, Charlene (* 1987), South African track cyclist
- Du Preez, Johan (* 1936), Zimbabwean sprinter
- du Prel, Alexander (* 1970), German cameraman
- Du Prel, Carl (1839–1899), German philosopher, spiritualist and occult writer
- Du Prez, John (* 1946), British film music composer
- Du Puy, François (1450–1521), French lawyer, canon, clergyman, monk and humanist of the late Middle Ages
- Du Puy, Jean Baptiste Édouard († 1822), violinist, singer, conductor and composer
- Du Resnel du Bellay, Jean-François (1692–1761), French oratorian, Commendatar abbot, journalist, translator and member of the Académie des Inscriptions et Belles-Lettres and the Académie française
- Du Rieux, Louis , German poet and world traveler
- Du Roi, Georg August Wilhelm (1787-1853), German instance judge
- Du Roi, Johann Philipp (1741–1785), German doctor and botanist
- Du Roi, Julius Georg Paul (1754–1825), German lawyer and Braunschweig councilor
- Du Roveray, Raoul († 1961), English badminton player
- Du Ryer, Pierre († 1658), French pre-classical playwright and translator, member of the Académie française
- Du Sommerard, Alexandre (1779–1842), French archaeologist and art collector
- Du Temple, Raymond († 1404), French builder
- Du Terrail, Jacques († 1535), French bishop
- Du Terrail, Philippe († 1532), French bishop
- Du Tertre, Jean-Baptiste (1610–1687), Dominican missionary and botanist
- Du Titre, Madame (1748–1827), Berlin Huguenot
- Du Toit, Alexander (1878–1948), South African geologist
- du Toit, David S. (* 1961), South African Reformed theologian
- Du Vinage, Amelie (1877–1968), German physician
- Du Welz, Fabrice (* 1972), Belgian director and screenwriter
- You, Bin (* 1972), Chinese journalist, photographer and documentary filmmaker
- You, Daobin (* 1964), Chinese dissident
- You, Jing (* 1984), Chinese badminton player
- You, John (* 1954), Filipino clergyman, Roman Catholic Archbishop of Palo
- Du, Li (* 1982), Chinese sports shooter
- You, Peng (* 1994), Chinese badminton player
- You, Pengyu (* 1988), Chinese badminton player
- Du, Ruiqing (1943–2019), Chinese translator, educator and academic administrator
- You, Selena , Miss Intercontinental of the USA
- You, Yuesheng (1887–1951), leader of the Green Gang, a triad in Shanghai
- Du, Yun (* 1977), Chinese composer, multi-instrumentalist and performance artist