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De
- De Abaitua, Matthew (born 1971), British writer
- De Adamich, Andrea (* 1941), Italian racing car driver
- De Agostini, Alberto Maria (1883–1960), Italian religious (Salesian Don Bosco) and missionary
- De Agostini, Fabio (* 1926), Italian screenwriter and film director
- De Agostini, Fabio (* 1933), Swiss playwright, film director and documentary filmmaker
- De Agostini, Luigi (* 1961), Italian football player
- De Aliprandini, Luca (* 1990), Italian ski racer
- De Amato, Nicolò (1701–1789), Italian Roman Catholic bishop
- De Ambris, Alceste (1874–1934), Italian journalist and syndicalist
- De Amicis, Anna Lucia (1733-1816), Italian opera singer (soprano)
- De Amicis, Edmondo (1846–1908), Italian writer
- De André, Cristiano (* 1962), Italian cantautore
- De André, Fabrizio (1940–1999), Italian songwriter
- De Andrea, Giovanni (1928–2012), Italian clergyman, Catholic curia bishop and diplomat
- De Andrea, Giuseppe (1930–2016), Italian clergyman, bishop of the Roman Curia, diplomat
- De Andrea, John (born 1941), American artist
- De Anesty, Dionisie , English noblewoman
- De Angelis, Alex (* 1984), San Marino motorcycle racer
- De Angelis, Elio (1958–1986), Italian racing driver
- De Angelis, Fabrizio (* 1940), Italian film director and producer
- De Angelis, Filippo (1792–1877), Italian cardinal and bishop
- De Angelis, Francesco (* 1959), Italian politician (Partito Democratico), MEP
- De Angelis, Francesco (* 1960), Italian sailor
- De Angelis, Guido (* 1944), Italian musician
- De Angelis, Jefferson (1859-1933) American actor and singer
- De Angelis, Matilda (* 1995), Italian actress and singer
- De Angelis, Maurizio (* 1947), Italian musician
- De Angelis, Michael (* 1967), Italian-Canadian ice hockey player
- De Angelis, Milo (* 1951), Italian poet
- De Angelis, Nicola (* 1939), Italian religious, retired Bishop of Peterborough
- De Angelis, Remo (born 1926), Italian stuntman and actor
- De Angelis, Richard (1932–2005), American actor and comedian
- De Angelis, Simone (* 1965), Italian historian
- De Angelis, Vertunnio , Italian film and dubbing director
- De Angulo, Jaime (1887–1950), American linguist, ethnologist and ethnomusicologist with Spanish-French roots
- De Antoni, Dino (1936–2019), Italian clergyman and Roman Catholic Archbishop of Gorizia
- De Antonio, Emile (1919–1989), American director and producer of documentaries
- De Arango, Bill (1921-2005), American jazz guitarist
- De Arellano, Margarita (* 1972), American opera singer (soprano)
- De Armond, David A. (1844–1909) American politician
- De Ávila, Santiago (* 1993), Uruguayan football player
- De Baca, Ezequiel Cabeza (1864–1917), American politician
- De Baca, Louis C. (1894–1969), American politician
- De Backer, Bert (* 1984), Belgian racing cyclist
- de Backer, Jean , Belgian water polo player
- De Backer, Philippe (* 1978), Belgian politician (Open VLD), MEP
- De Badlesmere, Bartholomew, 1st Baron Badlesmere († 1322), English nobleman, military man and rebel
- De Badlesmere, Elizabeth († 1356), English nobleman
- De Badlesmere, Giles, 2nd Baron Badlesmere (1314–1338), English nobleman
- De Bakker, Jos (* 1934), Belgian track cyclist
- de Balliol, Alexander , Anglo-Scottish nobleman, military man and politician
- De Balliol, Bernard , Anglo-Norman nobleman
- De Balliol, Bernard , Anglo-Norman nobleman
- De Balliol, Dervorguilla († 1290), Scottish noblewoman
- De Balliol, Eustace , Anglo-Norman nobleman
- De Balliol, Guy , Anglo-Norman nobleman
- de Balliol, Henry , Scottish nobleman and courtier
- De Balliol, Hugh , Anglo-Norman nobleman
- De Balliol, John , English magnate
- de 'Bardi, Giovanni (1534–1612), Italian soldier, composer and poet
- De Bartholomaeis, Vincenzo (1867–1953), Italian Romanist and Medievalist
- De Bassini, Achille (1819–1881), Italian opera singer (baritone)
- De Baz, Mar Narsai (1940–2010), Syrian clergyman, Metropolitan of the Assyrian Church of the East
- De Beauchamp, William, 9th Earl of Warwick , English magnate
- De Beaufort, India (* 1987), British actress
- De Beck, Erik (* 1951), Belgian athlete
- de Becker, Gavin (* 1954), American author and security specialist
- De Beer, Edward E. (1911–1994), Belgian civil engineer specializing in geotechnical engineering
- De Beer, Roman (* 1994), South African racing car driver
- De Beer, Willem (* 1988), South African athlete
- De Beer, Zach (1928–1999), South African politician, doctor, and businessman
- de Behr, Victor , Belgian water polo player
- De Benedetti, Carlo (* 1934), Italian entrepreneur
- De Benedetti, Leonardo (1898–1983), Italian physician and Auschwitz survivor
- De Benedictis, Giovanni (* 1968), Italian walker
- De Berkeley, Maurice, 2nd Baron Berkeley (1271-1326), English nobleman and rebel
- De Berkeley, Thomas, 1st Baron Berkeley (1245-1321), English nobleman
- De Berkeley, Thomas, 3rd Baron Berkeley († 1361), English nobleman
- De Bernardi, Isabella (born 1960), Italian actress
- De Bernardi, Mario (1893–1959), Italian fighter pilot in World War I, test pilot
- De Bernardi, Piero (1926-2010), Italian screenwriter
- De Bernardis, Paolo (* 1959), Italian astrophysicist and cosmologist
- De Bernardo Stempel, Patrizia (* 1953), Italian Celtologist and Indo-Europeanist
- De Bethune, Sabine (* 1958), Belgian lawyer and politician of the Christians Democratisch en Vlaams (CD&V)
- De Bette, Juan Francisco (1667–1725), Belgian nobleman in Spanish service
- De Bettin, Giorgio (* 1972), Italian ice hockey player, coach and official
- De Beukelaer, Emile (1867–1922), Belgian racing cyclist
- De Beul, Frans (1849–1919), Belgian animal and genre painter
- De Beule, Davy (* 1981), Belgian football player
- De Biasi, Gianni (* 1956), Italian football player and coach
- De Biasio, Melanie (* 1978), Belgian jazz and soul singer and flutist
- De Bie, Danny (* 1960), Belgian cyclocross rider
- De Bie, Ivon (1914–1989), Belgian jazz pianist and band leader
- De Bie, Jan (1892–1961), Belgian football goalkeeper
- De Bie, Jan (* 1937), Belgian clergyman, Roman Catholic bishop
- De Bie, Sean (* 1991), Belgian cyclist
- De Bilde, Gilles (* 1971), Belgian football player
- De Bisschop, Jules (1873–1954), Belgian rower
- De Blasi, Dante (1873-1956), Italian hygienist
- De Blasio, Bill (* 1961), American politician and Mayor of New York City
- De Bleeckere, Frank (* 1966), Belgian football referee
- De Block, Maggie (* 1962), Belgian politician and minister
- De Blois, George Des Brisay (1887–1964), Canadian politician, Lieutenant Governor of Prince Edward Island
- De Blois, Natalie (1921–2013), American architect
- De Blois, William († 1236), English clergyman, Bishop of Worcester
- De Bock, Jelle (* 1988), Belgian football player
- de Bœck, Égide (1875–1944), Belgian priest and editor of the first grammar and dictionary on Lingala
- De Boeck, Glen (* 1971), Belgian football player and coach
- De Boeck, Jeff (* 1918), Belgian jazz musician
- De Boer, Nicole (born 1970), Canadian actress
- De Boever, Jean François (1872–1949), Belgian symbolism painter, illustrator and art educator
- De Bohun, Henry, 1st Earl of Hereford († 1220), English nobleman, Lord High Constable of England, crusader
- De Bohun, Humphrey III. († 1181), Anglo-Norman nobleman, Lord High Constable of England
- De Bohun, Humphrey V. († 1265), English nobleman and rebel
- De Bohun, Margaret , English noblewoman
- De Bold, Adolfo J. (* 1942), Argentine-Canadian physiologist and pathologist
- De Bolebec, Isabel (1164-1245), English nobleman
- De Bolle, Catherine (* 1970), Belgian lawyer, director of Europol
- De Bolle, Christoff (* 1976), Belgian pop singer
- De Bolt, Rezin A. (1828-1891), American politician
- De Bonis, Donato (1930-2001), Italian Catholic bishop
- De Bonis, Francesco (* 1982), Italian racing cyclist
- De Bono, Emilio (1866–1944), Italian politician and marshal
- De Bonvoisin, Benoît (* 1939), Belgian businessman
- De Boor, Carl (* 1937), German-American mathematician
- De Borman, Anne (1881–1962), Belgian tennis player
- De Borman, Paul (1879–1948), Belgian tennis player
- De Bosdari, Alessandro (1867–1929), Italian diplomat, ambassador to Germany (1922–1926)
- De Bosio, Gianfranco (* 1924), Italian film director, theater director and screenwriter
- De Bosscher, Willy (* 1943), Belgian racing cyclist
- De Bounder de Melsbrœck, Théodore (1832–1909), Belgian diplomat
- De Bousies, Maxime (1865–1942), Belgian politician, lawyer and member of the International Olympic Committee
- De Brandt, Jan (* 1959), Belgian volleyball coach
- De Branges de Bourcia, Louis (* 1932), French mathematician
- De Breuker, Roger (1940-2018), Belgian racing cyclist
- De Briouze, Loretta , English noblewoman and hermit
- De Bruijn, Caroline (* 1962), Dutch actress
- De Brul, Tjörven (* 1973), Belgian football player and coach
- De Brulier, Nigel (1877–1948), British actor
- De Brum, Tony (1945-2017), Marshallic politician
- de Brus, Robert, Earl of Carrick , Anglo-Scottish magnate
- de Brus, Robert, Lord of Annandale , Anglo-Scottish nobleman
- de Brus, Robert, Lord of Annandale , Anglo-Scottish nobleman
- de Brus, Robert, Lord of Annandale († 1295), Anglo-Scottish magnate
- de Brus, William , Anglo-Scottish nobleman
- De Bruyckere, Berlinde (* 1964), Belgian artist
- De Bruyn, Elvire (1914–1989), Belgian cyclist
- De Bruyne, Fred (1930–1994), Belgian cyclist, author and journalist
- De Bruyne, Kevin (* 1991), Belgian football player
- De Bruyne, Kris (born 1950), Belgian singer
- De Buck, Sebbe (* 1995), Belgian snowboarder
- De Búrca, Déirdre (* 1963), Irish politician
- De Búrca, Méabh (* 1988), Irish football player
- De Burgh, Chris (born 1948), Irish singer
- de Burgh, Elizabeth (1289–1327), Queen of Scotland
- De Burgh, Elizabeth, 4th Countess of Ulster (1332-1363), Anglo-Irish nobleman
- De Burgh, Richard, 2nd Earl of Ulster († 1326), Hiberno-Norman nobleman, father-in-law of the Scottish King Richard I.
- De Burgh, William, 3rd Earl of Ulster (1312-1333), Irish nobleman and King's Deputy of Ireland
- De Buyst, Jasper (* 1993), Belgian racing cyclist
- De Cabooter, Arthur (1936–2012), Belgian racing cyclist
- De Caestecker, Iain (born 1987), Scottish actor
- De Caigny, Tine (* 1997), Belgian football player
- De Cal, Margherita (* 1950), Italian judoka
- De Caluwé, Edgard (1913–1985), Belgian cyclist
- De Camborne Lucy, Belinda (* 1976), British politician (Brexit Party)
- De Camilli, Pietro (* 1947), Italian-American biologist
- De Candia, Gianluca (* 1983), Italian Roman Catholic theologian
- De Canio, Luigi (* 1957), Italian football player and coach
- De Cantilupe, George (1251–1273), English nobleman
- De Cantilupe, Walter († 1266), English clergyman, Bishop of Worcester
- De Cantilupe, William († 1251), English nobleman
- De Cantilupe, William († 1254), English nobleman
- De Cardi, Beatrice (1914–2016), British Near Eastern archaeologist
- De Carlo, Andrea (* 1952), Italian writer
- De Carlo, Giancarlo (1919–2005), Italian architect and architecture professor
- De Carlo, Yvonne (1922–2007), Canadian actress
- De Carmine, Renato (1923-2010), Italian actor and voice actor
- De Caro, Lucio (* 1922), Italian screenwriter and film director
- De Caro, Marino Massimo (* 1973), Italian antiquarian, librarian, impostor and art forger
- De Caro, Raffaele (1883–1961), Italian politician
- De Carolis, Cinzia (* 1960), Italian actress and voice actress
- De Carolis, Giovanni (* 1984), Italian boxer
- De Carolis, Vincenzo , Italian film director and screenwriter
- De Carpentries, François , French director
- De Carvalho, Michel (* 1944), British luge rider and actor
- De Castella, Robert (* 1957), Australian long-distance runner
- De Castro, Carlos (1979-2015), Uruguayan football player
- de Castro, Milton (* 1954), Brazilian sprinter
- De Castro, Morris Fidanque (1902–1966), American politician
- De Castro, Paolo (* 1958), Italian politician (PD), Minister of Agriculture, MEP
- De Cataldo, Giancarlo (* 1956), Italian judge and author of detective novels
- De Cauter, Koen (* 1950), Belgian jazz musician (guitar, saxophone) and chanson singer
- De Ceglie, Paolo (* 1986), Italian football player
- De Censi, Ugo (1924–2018), Italian-Peruvian Salesian and founder of an aid organization
- De Cesare, Carlo (1824–1882), Italian economist and politician, member of the Camera dei deputati
- De Cesare, Michelina (1841–1868), Sicilian Brigantessa
- De Ceuninck, Armand (1858–1935), Belgian Lieutenant General, Minister of War
- de Changy, Alain (1922–1994), Belgian racing driver
- De Chatelain, Clara (1807–1876), English writer, composer and translator
- de Chaunac, Sébastien (* 1977), French tennis player
- de Chaworth, Maud , English noblewoman
- De Chiara, Franco (* 1948), Italian filmmaker and author
- De Chiara, Ghigo (1921–1995), Italian playwright, director, theater critic and screenwriter
- De Chiesa, Paolo (* 1956), Italian ski racer
- De Chirico, Giorgio (1888–1978), Italian painter and printmaker
- De Clare, Amicia , English noblewoman
- De Clare, Bogo (1248–1294), English clergyman
- De Clare, Gilbert, 4th Earl of Gloucester († 1230), English magnate
- De Clare, Gilbert, 6th Earl of Gloucester (1243–1295), English magnate
- De Clare, Gilbert, 7th Earl of Gloucester († 1314), English nobleman
- De Clare, Gilbert, Lord of Thomond , Anglo-Irish knight
- De Clare, Joan , Anglo-Scottish nobles
- De Clare, Margaret († 1333), Anglo-Irish nobleman
- De Clare, Maud , English noblewoman
- De Clare, Richard († 1338), English clergyman
- De Clare, Richard, 2nd Earl of Pembroke (1130–1176), English nobleman and military leader
- De Clare, Richard, 5th Earl of Gloucester (1222–1262), English magnate
- De Clare, Rohese (1252-1317), English nobleman
- De Clare, Thomas, Lord of Thomond († 1287), Lord of Thomond
- De Clare, William (1228–1258), English knight
- De Clerck, Stefaan (* 1951), Belgian politician
- De Clercq, Bart (* 1986), Belgian racing cyclist
- De Clercq, Eric (* 1967), Belgian racing cyclist
- De Clercq, Erik (* 1941), Belgian virologist and physician
- De Clercq, Hans (* 1969), Belgian cyclist
- De Clercq, Mario (* 1966), Belgian cyclist
- De Clercq, René (1945–2017), Belgian racing cyclist, world champion in cycling
- De Clercq, Willy (1927–2011), Belgian liberal politician, MEP
- De Cleyn, Bert (1917–1990), Belgian football player
- De Clifford, Maud , English nobleman
- De Clifford, Roger , English knight, rebel and civil servant
- De Clifford, Roger († 1282), English nobleman and military man
- De Clifford, Roger, 2nd Baron de Clifford († 1322), English nobleman and rebel
- De Clinton, John, 1st Baron Clinton († 1310), English nobleman
- De Clinton, John, 2nd Baron Clinton († 1335), English nobleman and politician
- De Clinton, John, 3rd Baron Clinton († 1398), English nobleman and politician
- De Cobham, Henry († 1339), English nobleman
- De Cock, André (1880–1964), Belgian philatelist
- De Cock, César (1823–1904), Belgian landscape painter in France
- De Cock, Niki (* 1985), Belgian soccer player
- De Cock, Olivier (* 1975), Belgian football player
- De Cock, Oscar (* 1881), Belgian rower
- De Cock, Xavier (1818-1896), Belgian animal painter
- De Coene, Jean-Henri (1798–1866), Belgian painter of genre scenes and landscapes and art educator
- De Concini, Corrado (* 1949), Italian mathematician
- De Coninck, Frank (* 1945), Belgian diplomat
- De Coninck, Monica (* 1956), Belgian politician and minister
- De Coninck, Wim (* 1959), Belgian football player, coach and official
- De Cordier, Thierry (* 1954), Belgian painter
- De Cosmos, Amor (1825-1897), Canadian politician and journalist
- De Coster, Charles (1827–1879), Belgian writer
- De Cottignon , French sailor
- de Courtenay, Thomas, 5th Earl of Devon (1414–1458), English nobleman and magnate
- De Creeft, José (1884–1982), American sculptor
- De Crem, Nicolas (* 1990), Belgian racing driver
- De Crem, Pieter (* 1962), Belgian minister and mayor
- De Crescenzo, Luciano (1928–2019), Italian writer and film director
- de Crespigny, Rafe (* 1936), Australian sinologist
- De Crignis, Alessio (* 1990), Italian ski jumper
- De Cristoforis, Giuseppe (1803–1837), Italian naturalist
- De Croo, Alexander (* 1975), liberal Flemish politician and entrepreneur
- De Croÿ, Réginald (1878–1961), Belgian diplomat
- De Cupis, Giovanni Domenico (1493–1553), Italian cardinal
- De Curtis, Ernesto (1875–1937), Italian composer
- De Decker, Armand (1948–2019), Belgian Senator and Mayor
- De Decker, Pieter (1812-1891), Belgian statesman
- De Deus, Felisberto (* 1999), East Timorese athlete
- De Deyville, John , English nobleman and rebel
- De Dijn, Rosine (* 1941), Belgian journalist and writer
- De Dominici, Bernardo (1683–1759), Italian painter and art historian
- De Dominici, Giampaolo (1680–1758), Italian actor, musician, singer and composer
- De Dominici, Raimondo (1645–1705), Italian painter
- De Dominicis, Gennaro (1919–1962), Italian film director and screenwriter
- De Donatis, Angelo (* 1954), Italian clergyman, vicar general of Rome
- De Donato, Luigi (* 1975), Italian opera singer (bass)
- De Dorigo, Marcello (* 1937), Italian cross-country skier
- De Droit, Johnny (1892-1986), American jazz cornetist
- De Dunstanville, Alan , English knight
- De Dunstanville, Walter , English knight
- De Dunstanville, Walter († 1241), English knight
- De Dunstanville, Walter († 1270), English knight
- de Estratlinges, John († 1293), knight from Savoy in England
- De Fabiani, Francesco (* 1993), Italian cross-country skier
- De Fabris, Giuseppe (1790–1860), Italian sculptor, President of the Roman Accademia di San Luca and General Director of the Vatican Museums
- De Facendis, Domenico (* 1884), Italian diplomat
- De Falco, Gregorio (* 1965), Italian naval officer and politician
- De Falco, Jonathan (* 1984), Belgian football player and porn actor
- De Falco, Lawrence Michael (1915–1979), American clergyman, Bishop of Amarillo
- De Falco, Michele , Italian opera composer
- De Falco, Vincenzo (* 1960), Italian lawyer and writer
- De Falco, Vittorio (* 1969), Italian pool player
- De Fauw, Dimitri (1981-2009), Belgian racing cyclist
- De Felice Giuffrida, Giuseppe (1859–1920), Italian politician and journalist
- De Felice, Emidio (1918–1993), Italian linguist, Romanist and name researcher
- De Felice, Lionello (1916–1989), Italian screenwriter and film director
- De Felice, Renzo (1929–1996), Italian historian
- De Felip, Andrea (* 1970), Italian diplomat
- De Felitta, Frank (1921-2016), American writer, director, screenwriter, film producer
- De Felitta, Raymond (* 1964), American actor, director, screenwriter and film producer
- De Feo, Francesco (* 1920), Italian documentary filmmaker and screenwriter
- De Ferrari, Giacinto (1804–1874), Italian religious, theologian and bishop of the Curia
- De Ferrariis, Antonio († 1517), Italian doctor and humanist
- De Ferrers, John, 1st Baron Ferrers of Chartley (1271-1312), English nobleman, Seneschal of Gascony
- De Ferrers, John, 4th Baron Ferrers of Chartley († 1367), English nobleman
- De Ferrers, Robert, 1st Baron Ferrers of Wemme , English nobleman
- De Ferrers, Robert, 2nd Baron Ferrers of Wemme , English nobleman
- De Ferrers, Robert, 3rd Baron Ferrers of Chartley (1309-1350), English nobleman
- De Ferrers, Robert, 6th Earl of Derby , English magnate and rebel
- De Ferrers, William, 4th Earl of Derby († 1247), English magnate
- De Ferrers, William, 5th Earl of Derby († 1254), English magnate
- De Ficoroni, Francesco (1664–1747), Italian archaeologist
- De Fiennes, Margaret (1268-1334), Anglo-French nobleman
- De Filip, Guido (1904–1968), Italian rower
- De Filippi, Bruno (1930-2010), Italian musician
- De Filippi, Filippo (1814–1867), Italian zoologist, museum director and explorer
- De Filippi, Maria (* 1961), Italian television presenter
- De Filippi, Primavera , author, artist, lawyer and researcher
- De Filippo, Eduardo (1900–1984), Italian actor and playwright and film director
- De Filippo, Marco (* 1990), Italian ice hockey goalkeeper
- De Filippo, Peppino (1903–1980), Italian actor
- De Fina, Oscar (1917–1988), Italian journalist and film director
- De Forest, Henry S. (1847-1917), American politician
- De Forest, John William (1826-1906), American writer
- De Forest, Lee (1873–1961), American engineer and inventor
- De Forest, Marian (1864–1935), American journalist, playwright, and suffragette
- De Forest, Robert E. (1845-1924) American politician
- De France, Cécile (* 1975), Belgian actress
- De Francesco, Alessandro (* 1981), Italian poet, theorist and sound artist
- De Franciscis, Alfonso (1915–1989), Italian Classical Archaeologist
- De Freitas, Geoffrey (1913–1982), British politician and diplomat
- De Gaál, Emery (* 1956), American Catholic theologian
- De Gaetano, Vincent (* 1952), Maltese lawyer and judge at the European Court of Human Rights
- De Gambarini, Elisabetta (1730–1765), English composer, mezzo-soprano, organist, harpsichordist, pianist, conductor and painter
- De Gasparis, Annibale (1819-1892), Italian astronomer
- De Gasperi, Alcide (1881–1954), Italian politician
- De Geer, Carl (1720–1778) Swedish industrialist, scientist and entomologist
- De Geer, Carl (1747–1805), Swedish baron and politician
- De Geer, Ebba Hult (1882–1969), Swedish geologist
- De Geer, Gerard Jakob (1858–1943), Swedish geologist and politician, member of the Riksdag
- De Geer, Louis (1818-1896), Swedish politician, writer and first Prime Minister of Sweden (Sveriges State Minister)
- De Geer, Louis (1854–1935), Swedish politician who was Prime Minister of Sweden for 121 days
- De Geer, Sten (1886–1933), Swedish geographer
- De Geest, Willy (* 1947), Belgian cyclist
- De Gemini, Franco (1928–2013), Italian composer and harmonica player
- De Gendt, Aimé (* 1994), Belgian cyclist
- De Gendt, Thomas (* 1986), Belgian racing cyclist
- De Geneville, Joan (1286-1356), English nobleman
- De Gennaro, Giovanni (* 1948), Italian police chief
- De Giorgi, Elsa (1914–1997), Italian actress, writer and film director
- De Giorgi, Emanuele (1973–1988), pupil
- De Giorgi, Salvatore (* 1930), Italian clergyman, Archbishop Emeritus of Palermo and Cardinal
- De Giosa, Nicola (1819–1885), Italian composer and conductor
- De Giovanni, Biagio (* 1931), Italian philosopher, university professor and politician, MEP
- De Giovanni, Maurizio (* 1958), Italian writer
- De Girolamo, Nunzia (* 1975), Italian politician with Forza Italia
- De Goldi, Kate (* 1959), New Zealand author
- De Gorter, Harry , agricultural economist
- De Gouveia, Francisco Fortunato (* 1951), South African clergyman and emeritus Roman Catholic Bishop of Oudtshoorn
- De Gouw, Jessica (* 1988), Australian actress
- De Graef, Garry (* 1974), Belgian football player
- De Graeve, Alois (1896–1970), Belgian track cyclist
- De Graff, John I. (1783–1848) American politician
- De Graffenreid, Reese C. (1859–1902), American politician
- De Grasse, Andre (* 1994), Canadian sprinter
- De Grasse, Joseph (1873-1940), Canadian actor and film director
- De Grasse, Robert (1900–1971), American cameraman
- De Grassi, Dario (1939–2013), Italian actor and voice actor
- De Grauwe, Paul (* 1946), Belgian economist and university professor
- De Gray, John († 1214), Bishop of Norwich and Legal Counsel of Ireland
- De Gray, Walter († 1255), English prelate and statesman
- De Grazia, Alfred (1919–2014), American political scientist
- De Greef, Arthur (1862–1940), Belgian pianist and composer
- De Greef, Arthur (* 1992), Belgian tennis player
- De Greef, Francis (* 1985), Belgian cyclist
- De Greef, Walter (* 1957), Belgian football player
- De Gregori, Francesco (* 1951), Italian Cantautore (songwriter)
- De Gregori, Luigi (1874–1947), Italian librarian
- De Gregorio, Emmanuele (1758–1839), Italian bishop and cardinal to the Curia
- De Gregorio, Leopoldo († 1785), Sicilian civil servant and politician in the Spanish service
- De Gregorio, Toni (1931-2006), Italian documentary and television director
- De Grève, Ferdinand (1910–1980), Belgian civil servant and resistance fighter
- De Grève, Marcel (1922–2002), Belgian Romance literary historian and foreign language teacher
- De Gray, Aubrey (* 1963), British biogerontologist and bioinformatician
- De Gray, Henry († 1219), English nobleman
- De Gray, Henry († 1308), English nobleman
- De Gray, John († 1272), English nobleman and rebel
- De Gray, Richard , English baron and rebel
- De Gray, Richard , English nobleman and military man
- De Gray, Thomas, 2nd Earl de Gray (1781-1859), British nobleman and politician
- De Grisantis, Vito (1941-2010), Italian clergyman, Roman Catholic bishop of Ugento-Santa Maria di Leuca
- De Groodt, Stéphane (* 1966), Belgian actor
- De Groot, Bob (* 1941), Belgian comic artist
- De Groot, Francis (1888–1969), Irish-Australian politician, leader of the Australian National Socialists
- De Groot, Jean (* 1948), American philosopher
- De Groote, Jacques (* 1932), Belgian financier and banker
- De Groux, Charles (1825–1870), Belgian painter and illustrator
- De Groux, Henry (1866–1930) Belgian Symbolism painter
- De Gruben, Hervé (1894–1967), Belgian diplomat
- De Gruchy, Bill (* 1930), Australian sprinter
- De Gubernatis, Angelo (1840–1913), Italian orientalist, literary historian and playwright
- De Gucht, Jean-Jacques (* 1983), Belgian politician (Open VLD)
- De Gucht, Karel (* 1954), Belgian politician, MEP and EU Commissioner
- De Haas, Eddie (* 1930), American jazz musician
- De Haes, Charles (* 1938), Belgian lawyer and economist
- De Haes, Frans (1895-1923), Belgian weightlifter
- De Haître, Vincent (* 1994), Canadian speed skater and track cyclist
- De Hart, John (1727–1795), American lawyer and politician
- De Haven, Edwin (1816–1865), American polar explorer and navigator
- De Haven, John J. (1845–1913), American lawyer and politician
- De Havering, John , English military man and civil servant
- De Havering, Richard , English clergyman and civil servant
- De Havilland, Olivia (1916-2020), British-American film actress
- De Havilland, Peter (1747–1821), British nobleman and politician
- De Havilland, Walter Augustus (1872–1968), British lawyer
- De Heer, Rolf (* 1951), Australian director, screenwriter and film producer
- De Hert, Albert (1921-2013), Belgian football player
- De Hetre, Katherine (1946–2007), American actress
- De Highden, Rod (* 1969), Australian long-distance runner
- De Houwer, Annick (* 1958), Belgian linguist
- De Hovre, Luc Alfons (1926–2009), Belgian religious, auxiliary bishop in Mechelen-Brussels, Belgium
- De Jager, John-Laffnie (* 1973), South African tennis player
- De Jersey, Peter (born 1965), British theater and film actor
- de Jesús Baéz, Mario (1924–2008), Dominican composer and music publisher
- De Jong, Dennis Harold (1931–2003), Zambian clergyman, Catholic bishop
- De Jong, Marinus (1891–1984), Dutch-Belgian composer and pianist
- de Jong, Randy (* 1993), Dutch chef
- De Jongh, Andrée (1916–2007), Belgian leader of an escape aid network of the Belgian Resistance
- De Jonghe, Kevin (* 1991), Belgian road cyclist
- De Jorio, Maurizio , Italian Eurobeat artist
- De Karske, Karl (1915–2010), American jazz and studio musician
- De Kay, James Ellsworth (1792-1851), American zoologist
- De Keersmaeker, Anne Teresa (* 1960), Belgian choreographer and solo dancer
- De Keersmaeker, Paul (* 1929), Belgian politician (CVP), MEP
- De Kerchove de Denterghem, André (1885–1945), Belgian liberal politician and ambassador
- De Kerchove de Denterghem, Charles (1911–1983), Belgian diplomat
- De Kerchove, Gilles (* 1956), Belgian politician
- De Kers, Robert (1906–1987), Belgian jazz musician (trumpet, also vibraphone, piano, vocals) and arranger
- De Kesel, Leo-Karel Jozef (1903-2001), Belgian Catholic bishop
- De Ketelaere, Charles (* 2001), Belgian football player
- De Ketele, Kenny (* 1985), Belgian racing cyclist
- De Keyser, Jan (* 1965), Belgian private banker
- De Keyser, Polydore (1832–1898), British lawyer and lord mayor of London
- De Keyser, Raoul (1930–2012), Belgian abstract artist
- De Keyser, Véronique (* 1945), Belgian psychologist, university professor and politician, MEP
- De Keyzer, Carl (* 1958), Belgian photographer
- de Klerk, Evette (* 1965), South African sprinter
- de Klerk, Faf (* 1991), South African rugby player
- De Knijff, Martin (* 1972), Swedish poker player
- De Kova, Frank (1910–1981), American actor
- De Koven, Reginald (1859–1920), American composer
- De Kremer, Raymundus Joannes (1887–1964), Belgian writer
- De Kresz, Norah (1882–1960), English pianist and music teacher
- De Kretser, David (born 1939), Australian medic, Governor of Victoria
- De la Bandera, Manuel , Mexican film director, actor, film producer and screenwriter
- De La Beckwith, Byron (1920–2001), American fanatic and murderer
- De la Bédoyère, Guy (* 1957), English historian and author
- De la Bédoyère, Michael (1900–1973), English journalist, editor and writer
- De la Bouillerie, Hubert C. (* 1951), American film editor and film director
- de la Fontaine, Alphonse (1825–1896), Luxembourgish forest engineer and zoologist
- De la Fontaine, Edmond (1823-1891), Luxembourg poet
- De la Fontaine, Gaspard Théodore Ignace (1787–1871), Luxembourg politician
- De la Fontaine, Léon (1819–1892), Luxembourg lawyer, politician and botanist
- De la Fuente, Joel (born 1969), American actor
- De La Fuente, Rocky (* 1954), Mexican-American businessman and politician
- De la Gardie, Axel Julius († 1710), Swedish military and statesman
- De la Gardie, Catharina Charlotta († 1697), wife of the Venetian generalissimo Otto Wilhelm Graf von Königsmarck
- De la Gardie, Ebba Margaretha (1704–1775), Swedish countess
- De la Gardie, Jakob (1583–1652), Swedish military leader
- De la Gardie, Johan (1582–1642), Swedish statesman
- De la Gardie, Magnus Gabriel (1622–1686), Swedish general and statesman
- De la Gardie, Magnus Julius (1668–1741), Swedish general and statesman, member of the Hats Party
- De la Gardie, Maria Sofia (1627–1694), Swedish countess, lady-in-waiting, banker and industrial entrepreneur
- De la Gardie, Pontus (1520–1585), Swedish military leader and governor of Livonia
- De la Garza, Alana (* 1976), American actress
- De la Garza, Kika (1927-2017), American politician
- De La Garza, Madison (* 2001), American actress
- De La Ghetto (* 1982), American reggaeton musician
- De la Hoese, Jean (1846–1917), Belgian portrait painter
- De la Hunty, Shirley Strickland (1925-2004), Australian track and field athlete and Olympic champion
- De La Matyr, Gilbert (1825-1892), American politician
- De La Montanya, James (1798–1849), American politician
- De la Mothe Borglum, John Gutzon (1867–1941), American sculptor
- De La Motte, Marguerite (1902–1950), American actress and dancer
- De la Noy, Kevin (* 1962), British film producer
- De la Pole, Edmund, 10th Baronet (1844–1912), British nobleman
- De la Pole, Frederick (1850-1926), British nobleman
- De la Pole, Hawise , Welsh nobles
- De la Pole, John, 1st Earl of Lincoln († 1487), English nobleman, Earl of Lincoln
- De la Pole, John, 6th Baronet (1757–1799), British nobleman and politician, Member of the House of Commons
- De la Pole, Owen († 1293), Lord of Powys (Wales)
- De la Renta, Óscar (1932-2014), Dominican fashion designer
- de la Riva-Agüero y Looz, Enrique (1857–1930), Peruvian politician and diplomat
- De la Rocha, Zack (* 1970), American singer
- De la Roche, Mazo (1879–1961), Canadian writer
- De la Rose, Jacob (* 1995), Swedish ice hockey player
- De La Rue, Warren (1815–1889), British chemist, inventor, and amateur astronomer
- De la Tour, Frances (born 1944), British actress
- De La Vallée Poussin, Charles-Jean (1866–1962), Belgian mathematician
- de la Varre, André (1904–1987), American film director and film producer
- de la Vega, Aurelio (* 1925), American composer
- De Lacy, Alice (1281-1348), English noblewoman
- De Lacy, Charles John (1856–1929), British painter, printmaker and illustrator, whose focus was pictures with marine motifs
- De Lacy, Edmund, 2nd Earl of Lincoln († 1258), English nobleman
- De Lacy, Henry, 3rd Earl of Lincoln († 1311), English magnate, diplomat and general
- De Lacy, Hugh (1910–1986), American politician
- De Lacy, John, 1st Earl of Lincoln († 1240), English magnate
- De Laet, Johan Alfried (1815-1891), Flemish writer
- De Laet, Ritchie (* 1988), Belgian football player
- De Lai, Gaetano (1853–1928), Italian cardinal to the curia
- De Lalaing, Charles Comte (1856–1919), Belgian lawyer and diplomat
- De Lancey, James (1703–1760), Governor of the English colony of New York
- De Lancie, John (born 1948), American actor
- De Lancie, Keegan (* 1984), American film and stage actor and comedian
- De Landa, Manuel (* 1952), Mexican writer, artist and philosopher
- De Lange, Tristan (* 1997), Namibian cyclist
- De Lano, Milton (1844–1922), American lawyer and politician
- De Large, Robert C. (1842–1874), American politician
- de Lastours, Élie (1874–1932), French tennis player
- De Lathouwer, Léon (1929–2008), Belgian racing cyclist
- De Latre, Jean († 1569), Franco-Flemish composer, singer and conductor of the Renaissance
- De Launay, Edoardo (1820–1892), Sardinian, later Italian diplomat
- De Laurentiis, Aurelio (* 1949), Italian film producer and football official
- De Laurentiis, Dino (1919–2010), Italian film producer
- De Laurentiis, Martha (* 1954), American film producer
- De Laurentiis, Raffaella (* 1954), Italian film producer
- De Laval, Erik (1888–1973), Swedish pentathlete
- De Laval, Georg (1883–1970), Swedish marksman and modern pentathlon
- De Laval, Gustav (1845–1913), Franco-Swedish engineer
- De Laval, Patrik (1886–1974), Swedish sports marksman and modern pentathlon
- De Léan, Catherine (* 1980), Canadian actress
- De Leath, Vaughn (1894–1943), American singer
- De Leeuw, Jan (* 1968), Belgian psychologist and author of books for young people
- De Leeuw, Lisa (* 1958), American porn actress
- De Leeuw, Nata (* 1991), Canadian ski jumper
- De Lellis, Camillo (* 1976), Italian mathematician
- De Leo, Antonello (* 1965), Italian film director
- De León, Carlos (1959-2020), Puerto Rican boxer
- De Leon, Daniel (1852-1914) American socialist
- De Leon, JoEllen Marie Sigua (* 1993), Filipino-American soccer player
- De León, Kevin (* 1966), American politician
- De León, Selvin (* 1980), Belizean-Guatemalan football player
- De Leonardis, Massimo (* 1949), Italian political scientist and military historian
- De L'Escaille de Lier, Bernard (1874–1957), Belgian ambassador
- De Leyburn, William, 1st Baron Leyburn († 1310), English nobleman and military man
- De Liguoro, Eugenio (1895–1952), Italian actor and film director
- De Liguoro, Rina (1892–1966), Italian pianist and actress with great success in silent films
- De Liguoro, Wladimiro (1893–1968), Italian actor and film director
- De Lillo, Antonietta (* 1960), Italian director
- De Lillo, Domenico (* 1937), Italian racing cyclist and sports official
- De Lima, Stephanie (* 1988), Canadian water diver
- De Lint, Charles (* 1951), Canadian fantasy author and musician
- De Lisi, Benedetto (1831–1875), Italian sculptor
- De Lisle, Heather (* 1976), American freelance television presenter
- De Lisle, Henry de Beauvoir (1864–1955), British general in the First World War
- de Lisle, John, 2nd Baron Lisle († 1355), English nobleman and military man
- De Lisle, Rik (* 1947), American radio host in Germany
- De Liva, Ottavio (1911–1965), Italian clergyman, Roman Catholic archbishop and diplomat of the Holy See
- De Loecker, Stefan (* 1967), Belgian manager
- De Lollis, Cesare (1863–1928), Italian literary critic, historian, Romanist, Italianist, Hispanist, Provençalist and Germanist
- De Lone, Erika (* 1972), American tennis player
- De Longis, Anthony (born 1950), American-Canadian actor, stunt performer and choreographer
- De Loof, Romain (* 1941), Belgian racing cyclist
- De Loore, Joris (* 1993), Belgian tennis player
- De Lorenzi, Carlo , Italian ski jumper
- De Lorenzi, Christian (* 1981), Italian biathlete
- De Lorenzo, Giovanni (1907–1973), Italian officer and politician
- De Lorenzo, Leonardo (1875–1962), American flautist, composer and university lecturer
- De Løvenørn, Poul Vendelbo (1686–1740), Danish army officer
- De Lovetot, John , English judge and civil servant
- De Luca, Alan (* 1960), Italian disc jockey, television presenter, comedian and actor
- De Luca, Antonino (1805-1883), Italian cardinal and bishop
- De Luca, Antonio (* 1956), Italian religious, Bishop of Teggiano-Policastro
- De Luca, Augusto (* 1955), Italian artist and photographer
- De Luca, Deborah (* 1980), Italian DJ and techno producer
- De Luca, Erri (* 1950), Italian writer and translator
- De Luca, Gianfranco (* 1949), Italian clergyman, Bishop of Termoli-Larino
- De Luca, Gianni (1927–1991), Italian comic artist
- De Luca, Giovanni Battista (1614–1683), Italian cardinal of the Roman Church
- De Luca, Giuseppe (1876–1950), Italian opera singer (baritone) and singing teacher
- De Luca, Giuseppe (* 1991), Italian football player
- De Luca, Joseph (1890–1935), Italian-American musician and composer
- De Luca, Lorella (1940-2014), Italian actress
- De Luca, Marco (* 1981), Italian walker
- De Luca, Michael (* 1965), American film producer
- De Luca, Michele (* 1956), Italian biochemist
- De Luca, Vincenzo (* 1949), Italian politician
- De Lucca, Yargo (1925–2008), Canadian painter, printmaker and sculptor
- De Lucchi, Michele (* 1951), Italian designer
- De Luce, Daniel (1911-2002), American journalist
- De Lucia, Alfonso (* 1983), Italian football goalkeeper
- De Lucia, Fernando (1860-1925), Italian opera singer (tenor)
- De Lucy, Thomas, 2nd Baron Lucy († 1365), English nobleman and military man
- de Luget, Guy (1884–1961), French foil fencer
- De Lugo, Ron (1930–2020), American politician
- De Luigi, Filippo (* 1938), Italian film and television maker
- De Luigi, Marco (* 1978), San Marino football player
- De Luxe, Funkstar (* 1973), Danish music producer
- De Maere, Luc Jozef Gerard (1956–2011), Belgian priest, diplomat of the Holy See
- De Maeyer, Jan (* 1949), Belgian composer and oboist
- De Maeyer, Leo (1927-2014), Belgian chemist
- De Magistris, Luigi (* 1926), Italian clergyman, emeritus pro-major penitentiary
- De Magistris, Luigi (* 1967), Italian prosecutor and politician, MEP
- De Man, Filip (* 1955), Flemish politician and journalist
- De Man, Mark (* 1983), Belgian football player
- De Man, Preben (* 1996), Belgian football player
- De Manincor, Luigi (1910–1986), Italian sailor and boat builder
- De Marchi, Alessandro (* 1962), Italian conductor and harpsichordist
- De Marchi, Alessandro (* 1986), Italian racing cyclist
- De Marchi, Emilio (* 1959), Italian actor
- De Marchi, Francesco (1504–1576), Italian courtier, architect, engineer and author
- De Marchi, Francesco (* 1986), Italian volleyball player
- De Marchi, Luigi (1927–2020), Italian film director, screenwriter and painter
- De Marchi, Matt (* 1981), Italian-American ice hockey player
- De Marchi, Pietro (* 1958), Italian-Swiss literary scholar and poet
- De Marchis, Marcella (1916–2009), Italian costume designer
- De Mari, Lorenzo († 1772), Doge of the Republic of Genoa
- De Mari, Silvana (* 1953), Italian writer
- De Maria, Astolfo (1891-1946) Italian painter
- De Maria, Enrico (* 1976), Swiss sailor
- De Maria, Giuseppe (* 1984), Italian racing cyclist
- De Maria, Nicola (* 1954), Italian painter
- De Maria, Pietro (* 1967), Italian pianist
- De Maria, Renato (* 1958), Italian director and screenwriter
- De Maria, Rino (* 1982), Italian songwriter
- De Maria, Walter (1935–2013), American artist
- De Marinis, Alberto (1868–1940), Italian Brigadier General, Military Attaché, Senator and Minister of State
- De Marney, Derrick (1906–1978), British actor and film producer
- De Martelaere, Patricia (1957–2009), Flemish writer and professor of philosophy
- De Martin Topranin, Virginia (* 1987), Italian cross-country skier
- De Martin, Francesca (1961–2009), German-Italian cabaret artist, playwright, theater director and actress
- De Martini, Susy (* 1952), Italian politician, MEP
- De Martino, Alberto (1929–2015), Italian film director and screenwriter
- De Martino, Francesco (1907–2002), Italian lawyer and politician, member of the Camera dei deputati
- De Martino, Giovanni (1870–1935), Italian sculptor
- De Martino, Pino (* 1928), Italian film producer
- De Masi, Domenico (* 1938), Italian sociologist
- De Masi, Fabio (* 1980), German politician (Die Linke), MEP
- De Masi, Francesco (1930–2005), Italian composer and conductor
- De Mattei, Roberto (* 1948), Italian historian
- De Matteis, Maria (1898–1988), Italian costume designer
- De Matteis, Paolo (1662–1728), Italian painter, draftsman, silversmith
- De Mattia, Massimo (* 1959), Italian jazz musician and composer
- De Mattias, Maria (1805–1866), founder of an Italian order, saint
- De Mauro, Mauro (1921–1970), Italian journalist, Mafia victim
- De Mauro, Tullio (1932–2017), Italian linguist and politician
- De Mayer, Jérôme (1875-1958), Belgian archer
- De 'Medici, Lorenzo (* 1951), Italian writer and comes from the Medici family
- de Mello, Duília (* 1963), Brazilian astronomer, astrophysicist and university professor
- De Mello, Margo (* 1964), American anthropologist
- De Meo, Francesco (* 1963), German chairman of the Helios clinics
- De Meo, Gustavo (1920–2010), Italian politician, member of the Camera dei deputati
- De Merode, Amaury (1902–1980), Belgian nobleman and President of the FIA
- De Merode, Werner (1914–1995), Belgian diplomat
- De Metz, Georgi Georgijewitsch (1861–1947), Russian physicist, methodologist and university rector
- De Meuland, Roger († 1295), English clergyman, Bishop of Coventry and Lichfield
- De Meulder, Christophe (* 1988), Belgian poker player
- De Meulder, Matthias (* 1988), Belgian poker player
- de Meuron, Andrea (* 1973), Swiss politician
- De Mey, Michèle Anne (* 1959), Belgian dancer and choreographer
- De Meyer, Patrick , Belgian music producer
- De Micheli, Giulio (1899–1940), Italian composer
- De Micheli, Paola (* 1973), Italian politician
- De Michelis, Cesare G. (* 1944), Italian literary scholar, university professor and professor of Russian literature and author
- De Michelis, Gianni (1940–2019), Italian politician, member of the Camera dei deputati, MEP
- De Middeleir, Robert (1938-2016), Belgian racing cyclist
- De Mille, James (1833–1880), Canadian literary scholar and writer
- De Mille, William C. (1878–1955), American playwright and director
- De Minaur, Alex (* 1999), Australian tennis player
- De Mistura, Staffan (* 1947), Italian-Swedish diplomat, UN envoy for Syria
- De Mita, Ciriaco (* 1928), Italian politician (UdC), member of the Camera dei deputati, MEP
- De Mitri, Leonardo (1914–1956), Italian film director
- De Mola, Tina (1923–2012), Italian actress and singer
- De Montagu, Simon, 1st Baron Montagu († 1316), English nobleman
- De Monte, Isabella (* 1971), Italian politician
- De Montebello, Philippe (* 1936), American art historian
- De Montfort, Guy , English nobleman and rebel
- De Monti, Filippo († 1680), Italian priest, bishop of Ascoli Piceno and Teramo
- De Morgan, Augustus (1806–1871), English mathematician
- De Mornay, Rebecca (* 1959), American actress and film producer
- De Morpurgo, Umberto (1896–1961), Italian tennis player
- De Mortimer, Anne (1390–1411), daughter of Roger Mortimer, 4th Earl of March, and Eleanor de Holland
- De Mott, John (1790-1870), American politician
- De Motte, Mark L. (1832-1908), American politician
- De Mowbray, Isabel († 1452), English noblewoman
- De Mowbray, William , English nobleman and rebel
- De Mul, Tom (* 1986), Belgian football player
- De Mulder, Frans (1937-2001), Belgian racing cyclist
- De Mulder, Jan , Belgian badminton player
- De Munchensi, Warin , English nobleman, rebel and soldier
- De Mura, Francesco (1696–1782), Italian painter
- De Muschamp, Geoffrey († 1208), English clergyman, Bishop of Coventry
- De Muth, Peter J. (1892-1993), American politician
- De Muynck, Johan (* 1948), Belgian racing cyclist
- De Napoli, Fernando (* 1964), Italian football player
- De Nardis, Luciano (1865–1964), Italian poet and painter of Futurism
- De Nardo, Marcello (* 1963), Swiss actor, singer, dancer and director
- De Neef, Roger (1906-2001), Belgian cyclist
- De Neef, Steven (* 1971), Belgian track and road cyclist
- De Negri, Enrico (1902–1990), Italian philosopher, Romanist and Italianist
- De Negri, Mario (1901–1978), Italian sprinter and hurdler
- De Negri, Pierpaolo (* 1986), Italian racing cyclist
- De Neve, Guido (* 1963), Belgian violinist
- De Neville, Geoffrey , English nobleman, Seneschal of Gascony and King's Chamberlain of the Household
- De Neville, Hugh , English nobleman and chief forest judge
- De Neville, John , English nobleman and chief forest judge
- De Neville, Ralph , English prelate and statesman
- De Nicola, Enrico (1877–1959), Italian lawyer and politician
- De Nicola, Giacomo (1879–1926), Italian art historian
- De Nicola, Giuseppe (1876–1958), Italian Roman Catholic clergyman and auxiliary bishop in Naples
- De Nicolao, Andrea (* 1991), Italian basketball player
- De Nicolò, Mariano (1932–2020), Italian clergyman, Roman Catholic bishop of Rimini
- De Nicolò, Paolo (* 1937), Italian Catholic clergyman, retired Curia Bishop
- De Nicolò, Pier Giacomo (* 1929), Italian clergyman, Catholic bishop, emeritus Apostolic Nuncio in Switzerland and Liechtenstein
- De Niese, Danielle (* 1979), Australian opera singer (soprano)
- De Nil, Ines (* 1947), German photographer, painter and documentary filmmaker
- De Niro, Drena (* 1967), American actress
- De Niro, Robert (* 1943), American actor and producer
- De Niro, Robert Sr. (1922–1993) American painter
- De Nittis, Francesco (1933–2014), Italian clergyman, Roman Catholic archbishop and diplomat to the Holy See
- De Nittis, Giuseppe (1846–1884), Italian impressionist painter
- De Nobili, Lila (1916–2002), Italian fashion illustrator, set designer and costume designer
- De Nutte, Sarah (* 1992), Luxembourg table tennis player
- de Oliveira, Claire (* 1961), French translator and literary scholar
- de Oliveira, Gabriel (* 1998), German-Brazilian basketball player
- De Olivera, Lucas (* 1996), Uruguayan football player
- De Olivera, Rodrigo (* 1994), Uruguayan football player
- De Padt, Guido (* 1954), Belgian politician
- De Paduwa, Walter , Belgian radio presenter and music producer
- De Paepe, César (1841–1890), Belgian socialist
- De Palma, Brett (* 1949), American painter
- De Palma, Brian (* 1940), American film director
- De Palma, Fred (* 1989), Italian rapper
- De Palma, Joseph Anthony (1913–2005), American clergyman, Bishop of De Aar
- de Palma, Luigi Michele (* 1958), Italian clergyman and church historian
- De Palma, Piero (1925-2013), Italian opera singer (tenor)
- De Paoli, Ambrose Battista (1934–2007), Roman Catholic Archbishop, Diplomat, Nuncio
- De Paoli, Daniele (* 1973), Italian racing cyclist
- De 'Paoli, Domenico (1894–1984), Italian musicologist, music critic and composer
- De Paoli, Virginio (1938–2009), Italian football player and coach
- De Paolis, Luciano (* 1941), Italian bobsledder
- De Paolis, Riccardo (1854-1892), Italian mathematician
- De Paolis, Velasio (1935–2017), Italian religious, cardinal to the Curia
- De Pape, Lorne (* 1955), New Zealand curler
- De Paris, Sidney (1905–1967), American jazz trumpeter
- De Paris, Wilbur (1900–1973), American jazz trombonist, composer and band leader of Dixieland jazz
- De Pascale, Ernesto (1958–2011), Italian music journalist and rock musician
- De Passe, Suzanne (* 1946), American screenwriter, company manager and film and television producer
- De Pastel, Karen (* 1949), US-American-Austrian university professor, pianist, organist, violinist, conductor and composer
- De Paul, Gene (1919–1988), American composer and songwriter
- de Paul, Lynsey (1948–2014), British singer and songwriter
- De Paul, Vincent (* 1968), American actor and model
- De Pauw, Ayrton (* 1998), Belgian cyclist
- De Pauw, Jean-Baptiste (1852–1924), Belgian organist, composer and music teacher
- De Pauw, Josse (* 1952), Belgian actor, writer and director
- De Pauw, Moreno (* 1991), Belgian racing cyclist
- De Pauw, René (1887–1946), Belgian painter, draftsman, caricaturist and illustrator
- De Pedrina, Franco (* 1941), Italian rower
- De Pena, Carlos (* 1992), Uruguayan football player
- De Percy, Margaret († 1375), English nobleman
- De Percy, Richard , English nobleman and rebel
- De Petra, Giulio (1841-1925), Italian Classical Archaeologist
- De Petter, Steven (* 1985), Belgian football player
- De Peyster, John Watts (1821–1907) American author, general, historian
- De Peyster, John Watts, Jr. (1841–1873), American Union Army officer during the American Civil War
- De Phillippi, Connor (* 1992), American racing driver
- De Piccoli, Franco (* 1937), Italian boxer
- De Pierro, Adriano (* 1991), Italian-Swiss football player
- De Pietro, Michele (1884–1967), Italian politician
- De Pinedo, Francesco (1890–1933), Italian aviation pioneer and pilot in the Italian Air Force
- De Piscopo, Tullio (* 1946), Italian percussionist and pop singer
- De Pisis, Filippo (1896–1956), Italian painter
- De Plessis, Hugh († 1292), English nobleman
- De Plus, Laurens (* 1995), Belgian racing cyclist
- De Poerck, Guy (1910–1996), Belgian Romanist
- De Poix, Vincent P. (1916-2015), American Vice Admiral
- De Poli, Paolo (1905–1996), Italian designer
- De Poli, Valentina (* 1968), Italian journalist
- de Pontoise, John († 1304), English clergyman, Bishop of Winchester
- De Poortere, Ingmar (* 1984), Belgian track and road cyclist
- De Potter, Louis (1786-1859), Belgian politician
- de Potton, Richard († 1270), Scottish clergyman
- De Pourbaix-Lundin, Marietta (* 1951), Swedish politician (Moderata samlingspartiet)
- De Pretto, Olinto (1857–1921), Italian engineer and agronomist
- De Priest, Oscar Stanton (1871–1951), American politician
- De Primo, Giuseppe , Sicilian Mafioso of the Black Hand Gang in New York
- De Puydt, Paul Émile (1810–1891), Belgian botanist, economist and writer
- De Quincey, Thomas (1785-1859) British writer, essayist and journalist
- De Quincy, Robert († 1257), English nobleman
- De Quincy, Saer, 1st Earl of Winchester († 1219), English magnate
- De Rachewiltz, Boris (1926–1997), Italian Egyptologist
- de Ramsay, Peter , Scottish clergyman
- De Razzo, Elizabeth (born 1980), American actress
- De Renzi, Mario (1897–1967), Italian architect
- De Reuck, Colleen (* 1964), American long-distance runner of South African origin
- De Ridder, Daniela (* 1962), German politician (SPD), social and communication scientist
- De Ridder, Louis (1902–1981), Belgian ice hockey player, bobsledder and speed skater
- De Ridder, Paul (* 1948), Belgian historian and politician
- De Rijck, Luc (1965–1991), Belgian football player
- De Rinaldo, Nicola (* 1942), Italian documentary filmmaker, film director and screenwriter
- De Robeck, John (1862–1928), British admiral
- De Robertis, Carolina (* 1975), Uruguayan-American writer
- De Robertis, Deborah (* 1984), Luxembourgish performance artist
- De Robertis, Domenico (1921–2011), Italian Romanist and Italianist
- De Robertis, Francesco (1902–1959), Italian film director and screenwriter
- De Robertis, Giuseppe (1888–1963), Italian Romanist and Italianist
- De Rochemont, Richard (1903–1982), American film producer and documentary filmmaker
- De Roeck, Jonas (* 1979), Belgian football player
- De Rola, Stash (born 1942), British actor, singer, writer and record producer
- De Roo, Antoon (1936–1971), Belgian ornithologist
- De Roo, Peter (1839–1926), Belgian Catholic priest and historian
- De Roo, Remi Joseph (* 1924), Canadian clergyman, Roman Catholic Bishop of Victoria
- De Roover, Marcel (1890–1971), Belgian industrialist and banker
- De Roover, Raymond (1904–1972), Belgian-American economic and mentality historian
- De Roover, Sepp (* 1984), Belgian football player
- De Ros, John, 1st Baron Ros , English nobleman, courtier and admiral
- De Ros, Robert († 1285), English nobleman
- De Ros, William , English nobleman
- De Ros, William, 6th Baron de Ros († 1414), English nobleman and Lord Treasurer
- De Rosa, Ernesto (1918–1980), Italian author and film director
- De Rosa, Mario (* 1920), Italian filmmaker
- De Rosa, Michele (* 1940), Italian clergyman, emeritus Roman Catholic bishop of Cerreto Sannita-Telese-Sant'Agata de 'Goti
- De Rosa, Pacecco († 1656), Italian painter of Neapolitan baroque painting
- De Rosa, Raffaele (* 1973), Swiss economist and politician (CVP)
- De Rosa, Raffaele (* 1987), Italian motorcycle racer
- De Rosario, Dwayne (* 1978), Canadian football player
- De Rosis, Franco (1913–1994), Italian composer and filmmaker
- De Rossa, Proinsias (* 1940), Irish politician and MEP for Ireland
- De Rossi, Barbara (* 1960), Italian actress
- De Rossi, Bastiano , Italian author
- De Rossi, Daniele (* 1983), Italian football player
- De Rossi, Giannetto (* 1942), Italian make-up artist, special effects artist and film director
- De Rossi, Giovanni Battista (1822-1894), Italian archaeologist and epigraphist
- De Rossi, Mino (* 1931), Italian racing cyclist
- de 'Rossi, Vincenzo (1525–1587), Italian sculptor
- De Rosso, Antonio (1941–2009), Senior Metropolitan of the Orthodox Church in Italy
- De Rosso, Guido (* 1940), Italian racing cyclist
- De Rouen, René L. (1874–1942), American politician
- De Rudder, Pieter (1822–1898), Belgian farm worker
- De Ruggiero, Gaetano (1816–1896), Italian cardinal and prelate of the Catholic Church
- De Ruyck, Lauren (* 1995), Belgian singer and actress
- De Ruysscher, Jeannine , Belgian triathlete
- De Ryck, Isidore (1926–2009), Belgian racing cyclist
- De Rycke, Charlie (* 1987), Belgian squash player
- De Rycke, Leo , Belgian basketball official
- de Sá, Mateus (* 1995), Brazilian athlete
- De Sabata, Victor (1892–1967), Italian conductor and composer
- De Sadeleer, Louis (1852–1924), Belgian politician and diplomat
- De Saint-Hubert, Aline Mayrisch (1874–1947), Luxembourg women's rights activist, author and philanthropist
- De Salvo, Donna , chief curator and assistant director of the Whitney Museum of American Art
- De Sanctis, Cesare (1824–1916), Italian composer, church musician and music teacher
- De Sanctis, Francesco , Italian architect
- De Sanctis, Francesco (1817–1883), Italian literary historian and critic and politician, member of the Camera dei deputati
- De Sanctis, Gaetano (1870–1957), Italian historian, senator for life
- De Sanctis, Gino (1912-2001), Italian screenwriter
- De Sanctis, Giovanni (* 1949), Italian astronomer
- De Sanctis, Giuseppe (1858–1924), Italian portrait and history painter and art teacher
- De Sanctis, Morgan (* 1977), Italian football goalkeeper
- De Sandre, Giovanni (* 1935), Italian computer scientist
- De Santi, Guido (1923–1998), Italian racing cyclist
- De Santis, Andrea (* 1964), Italian philosopher
- De Santis, Dina (* 1943), Italian former actress
- De Santis, Giuseppe (1917–1997), Italian film director
- De Santis, Lucio (1922-2006), Italian actor
- De Santis, Mario (1904–1985), Italian Roman Catholic clergyman and auxiliary bishop in Troia, Bovino and Foggia
- De Santis, Orchidea (born 1948), Italian actress
- De Santis, Pasqualino (1927–1996), Italian cameraman
- De Santis, Sandro (* 1952), Italian director
- De Santis, Sante (1965–2016), Italian chef, cookbook author and television chef
- De Sart, Julien (* 1994), Belgian football player
- De Saussure, William F. (1792–1870), American lawyer and politician
- De Sauzé, Émile B. (1878–1964), American Romance scholar and foreign language teacher of French origin
- De Scalzi, Erminio (* 1940), Italian Roman Catholic clergyman, auxiliary bishop emeritus in Milan
- De Schepper, Werner (* 1965), Swiss journalist
- De Schrijver, Karel (1908–1992), Belgian composer and professor
- De Schrooder, Benny (* 1980), Belgian racing cyclist
- De Schryver, August (1898–1991), Belgian politician
- De Schweinitz, Edmund Alexander (1825–1887), American bishop of the Moravian Church
- De Sciglio, Mattia (* 1992), Italian football player
- De Segonzac, Jean , American director, cameraman and screenwriter
- De Sena, Joe (* 1969), American extreme athlete, entrepreneur and author
- De Serres-Rainville, Camille (* 1995), Canadian short tracker
- De Seta, Vittorio (1923–2011), Italian screenwriter and film director
- De Sève, Alfred (1858–1927), Canadian violinist, music teacher and composer
- De Seversky, Alexander Procofieff (1894–1974), American aeronautical engineer of Russian origin
- De Shalit, Amos (1926–1969), Israeli physicist and university professor
- De Sica, Christian (* 1951), Italian actor and film director
- De Sica, Manuel (1949-2014), Italian composer
- De Sica, Vittorio (1901–1974), Italian actor and film director of neorealism
- De Siervo, Ugo (* 1942), Italian constitutional judge
- De Signoribus, Eugenio (* 1947), Italian writer
- De Silva, Daniel (born 1997), Australian soccer player
- De Silva, Upeshka , American poker player
- De Silva, Walter Maria (* 1951), Italian automobile designer
- De Silvestri, Lorenzo (* 1988), Italian football player
- De Silvestri, Pietro (1803–1875), Italian cardinal of the Roman Church
- De Simone, Annalisa (* 1983), Italian writer
- De Simone, Antonio (* 1962), Italian mathematician
- De Simone, Camillo (1737–1818), Italian clergyman, cardinal of the Roman Church
- De Simone, Carlo (* 1932), Italian etrusologist
- De Simone, Claudio (* 1984), German-Italian actor
- De Simone, Domenico (1768–1837), Italian cardinal of the Roman Church
- De Simone, Fabrizio (* 1971), Italian racing driver
- De Simone, Lara (* 1993), German writer
- De Simone, Roberto (* 1933), Italian composer, theater man, author, opera director, musicologist, mythologist and ethnologist
- De Simone, Titti (* 1970), Italian politician, member of the Camera dei deputati
- De Simoni, Luciana (* 1957), Italian medalist
- De Sisti, Giancarlo (* 1943), Italian football player and coach
- De Sisti, Vittorio (1940–2006), Italian sound engineer and director
- De Smedt, Emil-Jozef (1909–1995), Belgian clergyman, Bishop of Bruges
- De Smedt, Julien (* 1975), Belgian-Danish architect
- De Smet, Joseph-Jean (1794–1877), Belgian clergyman and historian
- De Smet, Pierre-Jean (1801–1873), Jesuit missionary in the Northwest US and Canada
- De Somer, Pieter (1917–1985), Flemish medic and biologist
- De Sordi, Nílton (1931–2013), Brazilian soccer player
- de Soules, John , Scottish knight and politician
- de Soulis, Nicholas , Scottish nobleman
- de Sousa Ferreira, Herlison Caion (* 1990), Brazilian soccer player
- De Sousa Moreira, Clayton (* 1988), Luxembourg soccer player
- de Sousa, Christophe (* 1992), Luxembourg soccer player
- de Sousa, José Oliveira (* 1974), Portuguese dart player
- De Sousa, Melissa (* 1967), American actress
- De Sousa, Raphael (* 1993), Luxembourg soccer player
- De Souza, Brian (* 1994), Uruguayan soccer player
- De Souza, Briana (* 1991), Canadian-Guyanese soccer player
- De Souza, Jordan (* 1988), Canadian conductor
- De Souza, Kayla (* 1990), Canadian-Guyanese soccer player
- De Souza, Sebastian (* 1993), British actor
- De Souza, Steven E. (* 1947), American screenwriter, producer and director
- De St John, John († 1302), English nobleman, military man and diplomat
- De St John, Robert († 1267), English nobleman
- De St John, Roger († 1265), English nobleman and rebel
- De Staercke, Andre (1913–2003), Belgian diplomat
- De Ste Croix, Geoffrey (1910-2000), British ancient historian
- De Stefani, Carlo (1851-1924), Italian geologist and paleontologist
- De Stefani, Eduardo Luigi (1869–1921), Italian classical philologist
- De Stefani, Fausto (* 1952), Italian extreme mountaineer
- De Stefano, Gildo , Italian jazz writer, journalist and music critic
- De Stoop, Chris (* 1958), Belgian journalist
- de Stuteville, Joan († 1276), English nobleman
- De Sutter, Justine (* 1995), Belgian tennis player
- De Sutter, Petra (* 1963), Belgian politician (Groen) and professor of gynecology
- De Sutter, Tom (* 1985), Belgian football player
- De Toledo, Zoe (* 1987), British rower
- De Tolfa, Scipione († 1595), Italian Roman Catholic clergyman
- De Toni, Manuel (* 1979), Italian ice hockey player
- De Tornaco, Charles (1927–1953), Belgian racing driver
- De Tornaco, Raymond (1886–1960), Belgian racing driver
- De Tornaco, Victor (1805–1875), Luxembourg politician
- De Torres, Cosimo (1584–1642), Italian cardinal and archbishop
- De Torres, Ludovico (1551–1609), Italian cardinal and archbishop
- De Toth, André (1913–2002), American director
- De Toth, Nicolas (* 1960), American film editor
- De Treaux, Tamara (1959–1990), American actress
- de Treville, Richard (1801–1875), American politician
- De Troyer, Kristin (* 1963), Belgian Old Testament scholar and university professor
- De Turberville, Gilbert , English nobleman
- De Turberville, Hugh († 1293), English knight and military man; Seneschal of Gascony
- De Turberville, Payn , English nobleman
- De Turberville, Richard , English nobleman
- De Turberville, Richard , English nobleman
- De Turberville, Thomas († 1295), English knight and spy
- De Umfraville, Gilbert († 1175), Anglo-Scottish nobleman
- De Umfraville, Gilbert , Anglo-Scottish nobleman
- de Umfraville, Gilbert, 9th Earl of Angus († 1381), English nobleman, titular Earl of Angus
- De Umfraville, Odinel , Anglo-Scottish nobleman
- De Umfraville, Odinel († 1182), Anglo-Scottish nobleman
- De Umfraville, Robert , Anglo-Scottish nobleman
- De Valence, Joan , English noblewoman
- De Vanna, Lisa (* 1984), Australian soccer player
- De Vargas, Valentin (1935-2013), American actor
- De Varona, Donna (* 1947), American swimmer
- De Vautort, Ralph , English nobleman
- De Vautort, Roger , English nobleman
- De Vautort, Roger († 1206), English nobleman
- De Vaux, John († 1287), English nobleman and civil servant
- De Vecchi, Arturo (1898–1988), Italian saber fencer
- De Vecchi, Cesare Maria (1884–1959), Italian politician, companion of Mussolini and officer
- De Vecchi, Renzo (1894–1967), Italian football player and coach
- De Veen, Robert (1886–1939), Belgian football player and coach
- De Venecia, Jose Jr. (* 1936), Filipino politician, journalist and entrepreneur
- De Verdon, Isabel (1317-1349), English nobleman
- De Verdon, John († 1274), English nobleman
- De Verdon, Nicholas († 1231), Anglo-Irish nobleman
- De Verdon, Theobald, 1st Baron Verdon († 1309), Anglo-Irish nobleman
- De Verdon, Theobald, 2nd Baron Verdon (1278–1316), English nobleman
- De Vere, Aubrey († 1462), English knight
- De Vere, Aubrey II († 1141), English nobleman
- de Vere, Aubrey, 1st Earl of Oxford († 1194), English nobleman
- De Vere, Cecil (1845–1875), English chess player
- De Vère, Clémentine (1888–1973), British actress and illusionist
- De Vère, Élise , French actress with English roots
- De Vere, John, 7th Earl of Oxford , English magnate and military man
- De Vere, Margaret († 1398), English nobleman
- de Vere, Robert, 5th Earl of Oxford , English nobleman
- de Vere, Robert, 6th Earl of Oxford , English nobleman
- De Vere, Thomas, 8th Earl of Oxford , English magnate
- De Vere, William († 1198), Anglo-Norman clergyman, Bishop of Hereford
- De Vescy of Kildare, William († 1314), Anglo-Irish nobleman and politician
- De Vescy, Isabel , Anglo-French nobles
- De Vescy, John (1244–1289) English nobleman, military man, and diplomat
- De Vescy, William, 1st Baron Vescy (1245–1297), English nobleman
- De Vestel, Robert (1925–1997), production designer and art director
- De Vet, Charles V. (1911-1997) American science fiction writer
- De Vettori, Matteo (* 1993), Italian ski racer
- De Vezze, Daniele (* 1980), Italian football player
- De Ville, James (1777-1846), English phrenologist
- De Ville, Nicholas (* 1944), British graphic artist
- De Villiers, Hendrik (* 1981), South African triathlete
- De Villiers, Marq (* 1940), South African-Canadian journalist and writer
- de Villiers, Nannie (* 1976), South African tennis player
- De Vinck, Antoine (1924–1992), Belgian ceramist
- De Vinna, Clyde (1890–1953), American cinematographer
- De Vinne, Theodore Low (1828–1914), American entrepreneur, printer, typographer, and bibliophile
- De Vis, Charles Walter (1829–1915), British-Australian clergyman, zoologist and museum director
- De Visscher, Charles (1884–1973), Belgian lawyer and expert in the field of international law
- De Vita, Massimo (* 1941), Italian comic artist
- De Viti De Marco, Antonio (1858–1943), Italian economist and politician
- De Vito, Francesco (* 1970), Italian actor
- De Vito, Maria Pia (* 1960), Italian jazz singer
- De Vits, Mia (* 1950), Belgian politician, MEP
- De Vivo, Giovanni (1940-2015), Italian Roman Catholic clergyman and Bishop of Pescia
- De Vlaeminck, Erik (1945–2015), Belgian racing cyclist
- De Vlaeminck, Roger (* 1947), Belgian racing cyclist
- De Vocht, Godfried (1908–1985), Belgian racing cyclist
- De Vocht, Liesbet (* 1979), Belgian racing cyclist
- De Vocht, Wim (* 1982), Belgian racing cyclist
- De Voegt, Koen (* 1980), Belgian politician (Pirate Party) and co-chair of Pirate Parties International
- De Voest, Rik (* 1980), South African tennis player
- De Vol, Frank (1911–1999), American composer, band leader and arranger
- De Voogdt, Titus (* 1979), Belgian actor and visual artist
- De Vorzon, Barry (* 1934), American composer, songwriter, singer and music producer
- De Vos, Louis (1929–1964), Belgian-Canadian cyclist
- De Vos, Luc (* 1946), Belgian officer and historian
- De Vree, Paul (1909–1982), Belgian author, painter and printmaker
- De Vreese, Laurens (* 1988), Belgian road cyclist
- De Vries, Marion (1865–1939), American lawyer and politician
- de Vries, Ruan (* 1986), South African hurdler
- De Vylder, Lindsay (* 1995), Belgian cyclist
- De Waal, Kit (* 1960), British social worker and writer
- De Waard, Steven (born 1991), Australian tennis player
- De Waele, Bert (* 1975), Belgian racing cyclist
- De Waele, Ellen (* 1973), Belgian film producer
- De Waele, Maurice (1896–1952), Belgian racing cyclist
- De Walderstein, Nerina (1925–2011), Italian resistance fighter against National Socialism
- De War, Kostio (1896–1986), French actress and fashion designer, founder of the Kostio de War fashion house
- De Weert, Anna (1867–1950), Belgian painter
- De Weert, Kevin (* 1982), Belgian racing cyclist
- De Welles, Adam, 1st Baron Welles († 1311), English nobleman, military man and diplomat
- De Wever Van der Heyden, Anuna (* 2001), Belgian climate activist
- De Wever, Bart (* 1970), Belgian politician
- De Wilde, Brandon (1942–1972), American actor
- De Wilde, Etienne (* 1958), Belgian racing cyclist
- De Wilde, Filip (* 1964), Belgian football goalkeeper and goalkeeping coach
- De Wilde, François-Odon (1908–1976), Belgian religious, Roman Catholic bishop of Isiro-Niangara
- De Wilde, Sjef (* 1981), Belgian racing cyclist
- De Wildeman, Émile Auguste Joseph (1866–1947), Belgian botanist
- De Winne, Frank (* 1961), Belgian spaceman
- De Winne, Jan (* 1962), Belgian flautist and flute maker
- De Witt, Alexander (1798–1879), American politician
- De Witt, Charles G. (1789–1839), American lawyer and politician
- De Witt, David M. (1837–1912), American lawyer and politician
- De Witt, Francis B. (1849–1929), American politician
- De Witt, Jacob H. (1784–1867), American politician
- De Witt, Simeon (1756–1834), American cartographer
- De Witte, Adrien (1850–1935), Belgian painter, draftsman and etcher
- De Witte, André (* 1944), Belgian clergyman and Roman Catholic bishop of Ruy Barbosa
- De Witte, Gaston-François (1897–1980), Belgian herpetologist
- De Wolf, Alfons (* 1956), Belgian racing cyclist
- De Wolf, Dirk (* 1961), Belgian cyclist
- De Wolf, James (1764–1837), American politician
- De Wolf, Karel (1952–2011), Belgian composer, conductor and musician
- De Wolf, Michel (* 1958), Belgian football player and coach
- De Wolf, Nazaire (1917–1983), Belgian composer and band leader
- De Wolf, Ortwin (* 1997), Belgian football player
- De Wolfe, Billy (1907–1974), American actor
- De Wolfe, Elsie (1865–1950), American interior designer
- De Wolfe, Roland (* 1979), British poker player
- De Wolff, Francis (1913–1984), British actor
- De Wulf, Frank (* 1968), Belgian DJ, musician and label owner
- De Wulf, Roger (1929-2016), Belgian politician
- De Wykerslooth De Rooyesteyn, Jacques (1896–1988), Belgian modern pentathlon
- De Young, Bailey (* 1989), American actress and dancer
- De Zan, Manuel (* 1989), Italian grass skier
- De Zarn, Tim (born 1952), American actor
- De Zayas, Alfred (* 1947), American international lawyer and historian
- de Zeeuw, Maxime (* 1987), Belgian basketball player
- De Zerbi, Roberto (* 1979), Italian football player and coach
- De Zigno, Achille (1813-1892), Italian botanist, geologist and paleontologist
- De Zoete, Beryl (1879–1962), English ballet dancer, orientalist, and dance critic and researcher
- De Zolt Ponte, Roberto (* 1970), Italian cross-country skier
- De Zolt, Maurilio (* 1950), Italian cross-country skier
- De Zordo, Agostino , Italian ski jumper
- De Zordo, Bruno (* 1941), Italian ski jumper
- De Zordo, Dino (* 1937), Italian ski jumper
- De Zordo, Nevio (1943-2014), Italian bobsleigh athlete
- De Zulueta, Tana (* 1951), Italian journalist and politician, member of the Camera dei deputati
- De Zutter, Cedric (* 1992), Belgian tennis player
- De Zutter, Kristof (* 1982), Belgian racing cyclist
- De, Sambhu Nath (1915-1985), Indian microbiologist
- De, Shobhaa (* 1948), Indian author