The 1978/79 season was the 36th regular championship round in Mexico since the introduction of the Primera División in the 1943/44 season.
The relegated from the previous season , Atlas Guadalajara , was replaced by the promoted CD Zacatepec. Also had to say goodbye, after ten years of membership in the first division, the CF Laguna , whose license was sold to the newly added team of Club Deportivo Coyotes Neza.
As already practiced in the previous season, the competition was divided into 4 groups of 5 teams each. Regardless of this, each team in the league continued to play against each other twice (in one home and one away game). At the end of the league round, the two best-placed teams in each group qualified for the final round, which was held in two groups of four teams each. Each team had to play a total of six games (one home and one away game against the other teams in the same group) and in the end the two group winners contested the final pairings.
Relegated to the second division was the lowest point team of CD Veracruz at the end of the season.
