Roger D. Kornberg

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Roger D. Kornberg during the award ceremony at Stanford University

Roger David Kornberg (born April 24, 1947 in St. Louis , Missouri ) is an American biochemist and professor of structural biology at Stanford University Medical School. In 2006 he was awarded the Nobel Prize in Chemistry .

Life

Kornberg is the oldest of three children, the biochemist Sylvy and Arthur Kornberg , the Nobel Prize winner for medicine from 1959. 1967 he graduated from the Harvard University with a Bachelor of Science from, and then for his doctorate after Stanford to change where he 1972 at Harden M. McConnell with the work the diffusion of phospholipids in membranes doctorate was. Kornberg then went to Cambridge for a postdoc . In 1976 he became an assistant professor (about: German junior professor) at Harvard Medical School and returned to Stanford in 1978 for a professorship in structural biology.

In 2010 he was appointed head of the Russian Innovation Center near Skolkowo .

Scientific work

Roger D. Kornberg was awarded the Nobel Prize for Chemistry in 2006 for his work on the molecular basis of eukaryotic transcription , i.e. the complementary transcription of the genetic information of the cell nucleus onto the ribonucleic acids . His research focuses specifically on the enzyme RNA polymerase , which catalyzes the synthesis of ribonucleic acids . The structure and the exact mechanism of action of this enzyme complex was deciphered , among others, by the German professor Patrick Cramer during his time as a postdoctoral fellow in Kornberg's laboratory.

Kornberg encountered the problems of eukaryotic transcription while working with Francis Crick and Aaron Klug at Cambridge University in England in the early 1970s .

His colleague at Stanford University Medical School, Professor Andrew Z. Fire , received the 2006 Nobel Prize for Medicine for research into gene expression and suppression .

Awards

literature

  • Hinrich Boeger, David A. Bushnell, R. Avis, J. Griesenbeck, Y. Lorch, J. Seth Strattan, KD Westover and Roger D. Kornberg: Structural basis of eukaryotic gene transcriptions. In: FEBS Letters . Volume 579, 2005, pp. 899-903
  • Kenneth D. Westover, David A. Bushnell and Roger D. Kornberg: Structural basis of transcription. Separation of RNA from DNA by RNA polymerase II. In: Science. Volume 303, No. 5660, 2004, pp. 1014-1017.
  • Patrick Cramer; David A. Bushnell, Jianhua FuAverell L. Gnatt, Barbara Maier-Davis, Nancy E. Thompson, Richard R. Burgess, Aled M. Edwards, Peter R. David and Roger D. Kornberg: Architecture of RNA polymerase II and implications for the transcription mechanism. in: Science. Volume 288, 2000, pp. 640-649.
  • Seth A. Darst, Elizabeth W. Kubalek and Roger D. Kornberg: Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography. In: Nature . Volume 340, No. 6236, 1989, pp. 730-732.

Web links

Commons : Roger D. Kornberg  - Collection of pictures, videos and audio files

Individual evidence

  1. ↑ Biographies, publications and academic family tree of Roger D. Kornberg at academictree.org, accessed on February 24, 2018.
  2. ↑ Patrick Cramer, David A. Bushnell, Jianhua Fu, Averell L. Gnatt, Barbara Maier-Davis, Nancy E. Thompson, Richard R. Burgess, Aled M. Edwards, Peter R. David and Roger D. Kornberg: Architecture of RNA polymerase II and implications for the transcription mechanism. In: Science . Volume 288, 2000, pp. 640-649, PMID 10784442
  3. ↑ Directory of members: Roger D. Kornberg. Academia Europaea, accessed January 18, 2018 (English, with biographical and other information).
personal data
SURNAME Kornberg, Roger D.
ALTERNATIVE NAMES Kornberg, Roger David (full name)
BRIEF DESCRIPTION American biochemist and Nobel Prize winner in chemistry
DATE OF BIRTH April 24, 1947
PLACE OF BIRTH St. Louis , Missouri