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Up
Upa
- Upadhyay, Hema (1972–2015), Indian artist who worked with photography and installation
- Upadhyaya, Shailendra Kumar (1929-2011), Nepalese politician
- Upadhyaya, Vijay (* 1966), Indian choir director, conductor and composer
- Upadit Pachariyangkun (1920–2012), Thai politician and diplomat
- Upali , Buddhist monk
- Upamecano, Dayot (* 1998), French football player
- Upatnieks, Juris (* 1936), Latvian-American physicist
- Upayuvaraja I (1597–1622), King of the Lan Xang Empire in today's Laos
Upc
- Upchurch (* 1991), American country rapper
- Upchurch, Greg (* 1971), American drummer
- Upchurch, Paul (* 1967), British paleontologist
- Upchurch, Phil (born 1941), American jazz guitarist
- Upchurch, Rick (born 1952), American football player
Upd
- Updale, Eleanor (* 1953), English author
- Updegraff, Allan Eugene (1883–1965), American writer, poet, and journalist
- Updegraff, Jonathan T. (1822-1882), American politician (Republican Party)
- Updegraff, Thomas (1834-1910), American politician
- Updike, John (1932-2009), American writer
- Updike, Ralph E. (1894–1953), American politician
Upe
- Upenieks, Gundars (* 1971), Latvian biathlete
- Upenieks, Kārlis (1914–1945), Latvian football player and coach
- Uperi , king of Dilmun (around 710 BC)
Upf
- Upfield, Arthur W. (1890–1964), British-Australian crime novelist
Uph
- Uphagen, Johann (1731–1802), German shipowner, merchant and bibliophile collector
- Upham, Charles Hazlitt (1908–1994), New Zealand soldier, two-time Victoria Cross bearer
- Upham, Charles Wentworth (1802–1875), American politician
- Upham, George B. (1768–1848), American politician
- Upham, Jabez (1764-1811), American politician
- Upham, Misty (1982-2014), American actress
- Upham, Nathaniel (1774–1829), American politician
- Upham, Warren (1850–1934), American geologist, botanist, and historian
- Upham, William (1792-1853), American politician
- Upham, William H. (1841-1924), American politician
- Uphaus-Wehmeier, Annette (* 1955), German communication scientist and university professor
- Uphoff, Benjamin (* 1993), German soccer player
- Uphoff, Carl Emil (1885–1971), German painter
- Uphoff, Fritz (1890–1966), German painter
- Uphoff, Nicole (* 1967), German dressage rider
- Uphoff, Norman T. (* 1940), American social scientist
- Uphoff, Tinka (* 1983), German marathon and ultramarathon runner
- Uphoff, Tjorben (* 1994), German soccer player
- Uphues, Jan (* 1987), German football official
- Uphues, Joseph (1850–1911), German sculptor
- Uphues, Karl Goswin (1841–1916), German philosopher
Upi
- Upilio, Christoph († 1645), city physician in Bad Neustadt an der Saale
- Upilio, Wilhelm († 1594), doctor and professor of medicine
- Upington, Thomas (1844–1898), Cape Colony politician and Prime Minister
- Upīts, Andrejs (1877–1970), Latvian writer
Upj
- Upjohn, Gerald, Baron Upjohn (1903–1971), British lawyer and brigadier general
- Upjohn, Richard (1802-1878), American architect
Upl
- Upledger, John E. (1932–2012), American Alternative Medicine Physician
- Uplegger, Susann (* 1971), German actress
Rpm
- Upmann, Hermann (1902–1944), German NSDAP functionary
- Upmann, Hermann Dietrich (1816–1894), German banker, merchant and cigar maker in Cuba and Germany
- Upmann, Julius (1838–1900), German chemist and explosives expert
- Upmann, Oliver (* 1988), German judoka
- Upmeier, Ursula (* 1927), German lyricist
- Upmeier, Werner (* 1944), German entrepreneur
- Upmeyer, Bernd (* 1973), German architect and urbanist
- Upmeyer, Joachim (1914–1987), German politician (CDU)
- Upmeyer, Walter (1876–1961), German musician, musicologist and music collector
Upn
- Upnmoor, Bernd (* 1940), German filmmaker, actor and cameraman
Upp
- Uppalavannā , follower of Buddha
- Uppenborn, Friedrich (1859–1907), German electrical engineer
- Uppenborn, Wilhelm (1904–1988), German certified farmer, author and Prussian country stable master
- Uppenbrink, Martin (1934–2008), German university professor, President of the Federal Agency for Nature Conservation
- Uppendahl, Herbert (1944–1989), German political scientist
- Uppenkamp, Felix (1881–1960), German Catholic priest and provost
- Uppenkamp, Reinhard (* 1950), German manager
- Uppenkamp, Theo (1923–2002), German soccer player
- Upper, Dmitri Sergejewitsch (* 1978), Kazakh ice hockey player
- Upperton, Helen (* 1979), Canadian bobsleigh pilot
Upr
- Üpraus, Oskar (1898–1968), Estonian national soccer player
- Uprichard, Norman (1928-2011), Northern Irish football goalkeeper
Oops
- Upshall, Scottie (born 1983), Canadian ice hockey player
- Upshaw, Courtney (born 1989), American football player
- Upshaw, Dawn (* 1960), American opera singer (soprano)
- Upshaw, Gene (1945-2008), American football player and official
- Upshaw, Grace (* 1975), American athlete
- Upshaw, Reggie (born 1995), American basketball player
- Upshaw, William D. (1866–1952), American politician
- Upshur, Abel P. (1790–1844), American lawyer, politician (Whig Party) and Secretary of State
- Upson, Charles (1821–1885), American politician
- Upson, Christopher C. (1829–1902), American politician
- Upson, Matthew (* 1979), English soccer player
- Upson, Walter Lyman (1877–1974), American electrical engineer
- Upson, William H. (1823–1910), American lawyer and politician
Upt
- Uptmoor, Franz (1897–1978), German Roman Catholic pastor
- Uptmoor, Luzie (1899–1984), German painter
- Upton, Charles H. (1812–1877), American politician
- Upton, David (* 1988), Australian ice hockey player
- Upton, Eben (* 1978), British computer scientist
- Upton, Francis Robbins (1852–1921), American physicist and mathematician
- Upton, Fred (* 1953), American politician
- Upton, Jason (* 1973), American Christian pop musician
- Upton, Jim (1940-2017), Scottish football player
- Upton, Kate (* 1992), American model and actress
- Upton, Mary (born 1946), Irish politician
- Upton, Pat (1944-1999), Irish politician
- Upton, Robert W. (1884–1972), American politician
- Uptown, Trisha (* 1979), American porn actress
Upw
- Upward, Edward (1903-2009), British writer