Chloralose: Difference between revisions

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'''Chloralose''' is an [[avicide]], and a [[rodenticide]] used to kill mice in temperatures below 15&nbsp;°C. It is also widely used in neuroscience and veterinary medicine as an [[anesthetic]] and [[sedative]].<ref>{{cite journal |author=Silverman J, Muir WW |title=A review of laboratory animal anesthesia with chloral hydrate and chloralose |journal=Lab Anim Sci. |volume=43 |issue=3 |pages=210–6 |date=Jun 1993 |pmid=8355479 }}</ref> Its anesthetic action is due to [[allosteric modulator|positive allosteric agonism]] of the [[GABAA receptor|GABA<sub>A</sub> receptor]].
'''Chloralose''' is an [[avicide]], and a [[rodenticide]] used to kill mice in temperatures below 15&nbsp;°C. It is also widely used in neuroscience and veterinary medicine as an [[anesthetic]] and [[sedative]].<ref>{{cite journal |author=Silverman J, Muir WW |title=A review of laboratory animal anesthesia with chloral hydrate and chloralose |journal=Lab Anim Sci. |volume=43 |issue=3 |pages=210–6 |date=Jun 1993 |pmid=8355479 }}</ref> Its anesthetic action is due to [[allosteric modulator|positive allosteric agonism]] of the [[GABAA receptor|GABA<sub>A</sub> receptor]], and as such is capable of affecting humans.


Chemically, it is a [[chlorine|chlorinated]] [[acetal]] derivative of [[glucose]].
Chemically, it is a [[chlorine|chlorinated]] [[acetal]] derivative of [[glucose]].

Revision as of 07:12, 23 November 2016

Chloralose
Stetreo structural formula of chloralose
Names
IUPAC name
(5ξ)-1,2-O-[2,2,2-Trichloroethylidene]-α-xylo-hexofuranose
Identifiers
3D model (JSmol)
85418
ChEMBL
ChemSpider
ECHA InfoCard 100.036.363 Edit this at Wikidata
EC Number
  • 240-016-7
KEGG
MeSH Chloralose
  • 7057995
  • 40467114 (2R,3aR,5R,6R)-6-hydroxy-2-methyl-furo-5-yl
  • 27525 (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
  • 16211632 (1R)-dioxol, (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
  • 186624 (1R)-dioxol, (3aR,5R,6S,6aR)-6-hydroxy-furo-5-yl
  • 2723807 (2R,3aR,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
  • 85991
RTECS number
  • FM9450000
UNII
  • InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 checkY
    Key: OJYGBLRPYBAHRT-IPQSZEQASA-N checkY
  • InChI=1/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1
    Key: OJYGBLRPYBAHRT-IPQSZEQABF
  • C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O
Properties
C8H11Cl3O6
Molar mass 309.52 g·mol−1
Melting point 176 to 182 °C (349 to 360 °F; 449 to 455 K)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Harmful if swallowed

Harmful if inhaled

Related compounds
Related compounds
 Chloral hydrate
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.[1] Its anesthetic action is due to positive allosteric agonism of the GABAA receptor, and as such is capable of affecting humans.

Chemically, it is a chlorinated acetal derivative of glucose.

It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)

References

  1. ^ Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.



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