Chloralose: Difference between revisions
IUPAC name bugfix, C-5 stereo is not unknown |
m image name fix / more precise (chem.) name |
||
| Line 5: | Line 5: | ||
| ImageFile = Chloralose structure.svg |
| ImageFile = Chloralose structure.svg |
||
| ImageFile_Ref = {{Chemboximage|correct|CAS}} |
| ImageFile_Ref = {{Chemboximage|correct|CAS}} |
||
| ImageName = |
| ImageName = Structural formula of α-chloralose |
||
| IUPACName = 1,2-''O''-[2,2,2-Trichloroethylidene]-α-''gluco''-hexofuranose |
| IUPACName = 1,2-''O''-[2,2,2-Trichloroethylidene]-α-''gluco''-hexofuranose |
||
| SystematicName = <!-- 1-[6-Hydroxy-2-(trichloromethyl)-tetrahydro-2''H''-furo[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol --> |
| SystematicName = <!-- 1-[6-Hydroxy-2-(trichloromethyl)-tetrahydro-2''H''-furo[2,3-d][1,3]dioxol-5-yl]ethane-1,2-diol --> |
||
Revision as of 13:11, 20 August 2019
| |
| Names | |
|---|---|
| IUPAC name
1,2-O-[2,2,2-Trichloroethylidene]-α-gluco-hexofuranose
| |
| Identifiers | |
3D model (JSmol)
|
|
| 85418 | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.036.363 |
| EC Number |
|
| KEGG | |
| MeSH | Chloralose |
PubChem CID
|
|
| RTECS number |
|
| UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
| Properties | |
| C8H11Cl3O6 | |
| Molar mass | 309.52 g·mol−1 |
| Melting point | 176 to 182 °C (349 to 360 °F; 449 to 455 K) |
| Hazards | |
| Occupational safety and health (OHS/OSH): | |
Main hazards
|
Harmful if swallowed Harmful if inhaled |
| Related compounds | |
Related compounds
|
Chloral hydrate |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
| |
Chloralose (also known as α-chloralose) is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.[1]
Chemically, it is a chlorinated acetal derivative of glucose.
It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)
Chloralose exerts barbiturate-like actions on synaptic transmission in the brain, including potent effects at inhibitory γ-aminobutyric acid type A (GABAA) receptors.[2][3] A structural isomer of chloralose, β-chloralose (also called parachloralose in older literature), is inactive as a GABAA modulator and also as a general anesthetic.[4]
References
- ^ Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.
- ^ R. A. Nicoll & J. M. Wojtowicz (1980). "The effects of pentobarbital and related compounds on frog motoneurons". Brain Research. 191 (1): 225–237. PMID 6247012.
- ^ K. M. Garrett & J. Gan (1998). "Enhancement of gamma-aminobutyric acidA receptor activity by alpha-chloralose". The Journal of Pharmacology and Experimental Therapeutics. 285 (2): 680–686. PMID 9580613.
- ^ M. D. Krasowski & N. L. Harrison (2000). "The actions of ether, alcohol and alkane general anaesthetics on GABAA and glycine receptors and the effects of TM2 and TM3 mutations". British Journal of Pharmacology. 129 (4): 731–743. doi:10.1038/sj.bjp.0703087. PMC 1571881. PMID 10683198.
 | This sedative-related article is a stub. You can help Wikipedia by expanding it. |