From Wikipedia, the free encyclopedia
Chloralose
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Names
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IUPAC name
(5ξ)-1,2-O-[2,2,2-Trichloroethylidene]-α-xylo-hexofuranose
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Identifiers
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85418
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ChEMBL
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ChemSpider
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ECHA InfoCard
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100.036.363
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EC Number
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KEGG
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MeSH
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Chloralose
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- 7057995
- 40467114 (2R,3aR,5R,6R)-6-hydroxy-2-methyl-furo-5-yl
- 27525 (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
- 16211632 (1R)-dioxol, (2R,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
- 186624 (1R)-dioxol, (3aR,5R,6S,6aR)-6-hydroxy-furo-5-yl
- 2723807 (2R,3aR,5R,6S,6aR)-6-hydroxy-2-methyl-furo-5-yl
- 85991
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RTECS number
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UNII
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InChI=1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 YKey: OJYGBLRPYBAHRT-IPQSZEQASA-N YInChI=1/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1 Key: OJYGBLRPYBAHRT-IPQSZEQABF
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C([C@H]([C@@H]1[C@@H]([C@@H]2[C@H](O1)O[C@@H](O2)C(Cl)(Cl)Cl)O)O)O
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Properties
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C8H11Cl3O6
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Molar mass
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309.52 g·mol−1
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Melting point
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176 to 182 °C (349 to 360 °F; 449 to 455 K)
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Hazards
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Occupational safety and health (OHS/OSH):
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Main hazards
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Harmful if swallowed
Harmful if inhaled
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Related compounds
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Related compounds
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Chloral hydrate
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Chloralose is an avicide, and a rodenticide used to kill mice in temperatures below 15 °C. It is also widely used in neuroscience and veterinary medicine as an anesthetic and sedative.[1] Its anesthetic action is due to positive allosteric agonism of the GABAA receptor, and as such is capable of affecting humans. Symptoms of exposure would be similar to the presentation of a benzodiazepine overdose and may be fatal (by means of respiratory arrest and subsequent hypoxia) but mechanical ventilation reduces the risk of death after exposure to near zero if medical assistance is obtained promptly.
Chemically, it is a chlorinated acetal derivative of glucose.
It is listed in Annex I of Directive 67/548/EEC with the classification Harmful (Xn)
References
- ^ Silverman J, Muir WW (Jun 1993). "A review of laboratory animal anesthesia with chloral hydrate and chloralose". Lab Anim Sci. 43 (3): 210–6. PMID 8355479.
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Barbiturates | |
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Benzodiazepines | |
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Carbamates | |
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Flavonoids | |
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Imidazoles | |
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Kava constituents | |
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Monoureides | |
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Neuroactive steroids | |
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Nonbenzodiazepines | |
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Phenols | |
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Piperidinediones | |
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Pyrazolopyridines | |
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Quinazolinones | |
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Volatiles/gases | |
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Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Alogabat
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- Darigabat
- DEABL
- Deuterated etifoxine
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- KRM-II-81
- Lanthanum
- Lavender oil
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Niacinamide
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
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