Phillip Allen Sharp

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Phillip Allen Sharp
Phillip Sharp with George W. Bush, at the National Medal of Science awards in 2006.
Born (1944-06-06) June 6, 1944 (age 79)
Falmouth, Kentucky
NationalityAmerican
Alma materUnion College
University of Illinois at Urbana-Champaign
SpouseAnn Holcombe
AwardsNobel Prize in Physiology or Medicine (1993), National Medal of Science (2006)
Scientific career
FieldsBiologist
InstitutionsCaltech
Cold Spring Harbor Laboratory
MIT
Doctoral studentsAndrew Fire

Phillip Allen Sharp (born June 6, 1944) is an American geneticist and molecular biologist who co-discovered gene splicing. He shared the 1993 Nobel Prize in Physiology or Medicine with Richard J. Roberts for "the discovery that genes in eukaryotes are not contiguous strings but contain introns, and that the splicing of messenger RNA to delete those introns can occur in different ways, yielding different proteins from the same DNA sequence".

Sharp was born in Falmouth, Kentucky. He studied at Union College and majored in chemistry and mathematics. He completed his Ph.D. in chemistry at the University of Illinois at Urbana-Champaign in 1969. After completing his Ph.D., he worked at the California Institute of Technology until 1971, where he studied plasmids and, later, gene expression in human cells at the Cold Spring Harbor Laboratory under James Dewey Watson.

In 1974, he was offered a position at MIT by biologist Salvador Luria. He was director of MIT's Center for Cancer Research (now the Koch Institute for Integrative Cancer Research) from 1985 to 1991; head of the Biology department from 1991 to 1999; and director of the McGovern Institute for Brain Research from 2000 to 2004. He is currently a professor of Biology and has been an Institute Professor since 1999; he is also a member of the Koch Institute. Sharp co-founded Biogen (now part of Biogen Idec), Alnylam Pharmaceuticals, and Magen Biosciences, and serves on the boards of all three companies.[1] He is an editorial advisor to Xconomy, and is a member of the Board of Scientific Governors at The Scripps Research Institute.

In 1988 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Thomas R. Cech.

Sharp married Ann Holcombe in 1964. They have three daughters.

Selected publications

  • Cheng C., Yaffe M.B., Sharp P.A. (1 Jul 2006). "A Positive Feedback Loop Couples Ras Activation and CD44 Alternative Splicing". Genes Dev. 20 (13): 1715–20. doi:10.1101/gad.1430906. PMID 16818603.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Miskevich F., Doench J.G., Townsend M.T., Sharp P.A., Constantine-Paton M. (15 Apr 2006). "RNA Interference of Xenopus NMDAR NR1 in vitro and in vivo". J Neurosci Methods. 152 (1–2): 65–73. doi:10.1016/j.jneumeth.2005.08.010. PMID 16182372.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Hong J.H., Hwang E.S., McManus M.T., Amsterdam A., Tian Y., Kalmukova R., Mueller E., Benjamin T., Spiegelman B.M., Sharp P.A., Hopkins N., Yaffe M.B. (12 Aug 2005). "TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation". Science. 309 (5737): 1074–8. doi:10.1126/science.1110955. PMID 16099986.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Johnson D.M., Yamaji S., Tennant J., Srai S.K., Sharp P.A. (28 Mar 2005). "Regulation of Divalent Metal Transporter Expression in Human Intestinal Epithelial Cells Following Exposure to Non-haem Iron". FEBS Lett. 579 (9): 1923–9. doi:10.1016/j.febslet.2005.02.035. PMID 15792797.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Neilson J.R., Sharp P.A. (Apr 2005). "Herpesviruses Throw a Curve Ball: New Insights into microRNA Biogenesis and Evolution". Nat Methods. 2 (4): 252–4. doi:10.1038/nmeth0405-252. PMID 15782215.
  • Lee K.B., Sharp P.A. (7 Dec 2004). "Transcription-dependent Polyubiquitination of RNA Polymerase II Requires Lysine 63 of Ubiquitin". Biochemistry. 43 (48): 15223–9. doi:10.1021/bi048719x. PMID 15568815.
  • Mansfield J.H., Harfe B.D., Nissen R., Obenauer J., Srineel J., Chaudhuri A., Farzan-Kashani R., Zuker M., Pasquinelli A.E., Ruvkun G., Sharp P.A., Tabin C.J., McManus M.T. (Oct 2004). "MicroRNA-responsive 'Sensor' Transgenes Uncover Hox-like and Other Developmentally Regulated Patterns of Vertebrate MicroRNA Expression". Nat Genet. 36 (10): 1079–83. doi:10.1038/ng1421. PMID 15361871.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  • Fairbrother W.G., Holste D., Burge C.B., Sharp P.A. (Sep 2004). "Single Nucleotide Polymorphism-based Validation of Exonic Splicing Enhancers". PLoS Biol. 2 (9): E268. doi:10.1371/journal.pbio.0020268. PMID 15340491.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)

See also

Reference and external links

  1. ^ Biogen Idec, Inc. (2008). “Proxy statement for annual meeting of stockholders to be held on June 19, 2008 at 9:00 A.M., local time″, 7.

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