Aspirin and Daniela Hantuchová: Difference between pages

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{{Infobox Tennis player
{{drugbox |
|playername = Daniela Hantuchová
| IUPAC_name = 2-ethanoylhydroxybenzoic acid
|image = [[Image:Daniela Hantuchová - Bank of the West Classic.jpg|250px]] Hantuchová at the 2007 [[Bank of the West Classic]]
| image = Aspirin-skeletal.svg
|nickname = Danka (in Slovak)</br> Dani (in English)
| image2 = Aspirin-B-3D-balls.png
| width = 150
|country = {{SVK}}
|residence = [[Monte Carlo, Monaco]]
| width2 = 150
|datebirth = {{birth date and age|1983|4|23}}
| CAS_number = 50-78-2
|placebirth = [[Poprad]], [[Slovakia]], (then [[Czechoslovak Socialist Republic|CSSR]])
| ChemSpiderID = 2157
|height = {{height|m=1.81}}
| ATC_prefix = A01
|weight = {{convert|62|kg|lb st|abbr=on|lk=on}}<ref>[http://www.sonyericssonwtatour.com/2/players/playerprofiles/Playerbio.asp?PlayerID=80394 Official WTA profile of Hantuchova]</ref>
| ATC_suffix = AD05
|turnedpro = [[May]] 1999
| ATC_supplemental = {{ATC|B01|AC06}}, {{ATC|N02|BA01}}
|plays = Right; Two-handed backhand
| PubChem = 2244
| careerprizemoney = $5,883,537
| DrugBank = APRD00264
| singlesrecord = 339–208
| C=9 | H=8 | O=4
| singlestitles = 3 [[Women's Tennis Association|WTA]], 3 [[International Tennis Federation|ITF]]
| molecular_weight = 180.160 g/mol
| highestsinglesranking = No. 5 ([[January 27]], [[2003]])
| smiles = CC(=O)Oc1ccccc1C(=O)O
| AustralianOpenresult = SF (2008)
| synonyms = 2-acetyloxybenzoic acid<br />2-(acetyloxy)benzoic acid<br />acetylsalicylate<br />acetylsalicylic acid<br />O-acetylsalicylic acid
| FrenchOpenresult = 4R (2002, 2006)
| density = 1.40
| Wimbledonresult = QF (2002)
| melting_point = 135
| USOpenresult = QF (2002)
| boiling_point = 140
| doublesrecord = 188–131
| boiling_notes = (decomposes)
| doublestitles = 8 [[Women's Tennis Association|WTA]], 1 [[International Tennis Federation|ITF]]
| solubility = 10
| highestdoublesranking = No. 5 ([[August 26]], [[2002]])
| bioavailability = Rapidly and completely absorbed
| updated = [[September 29]], [[2008]]
| protein_bound = 99.6%
| metabolism = [[Liver|Hepatic]]
| elimination_half-life = 300–650&nbsp;mg dose: 3.1–3.2hrs<br />1 g dose: 5 hours<br />2 g dose: 9 hours
| excretion = [[Kidney|Renal]]
| pregnancy_AU = C
| pregnancy_US = C
| legal_AU = unscheduled
| legal_CA =
| legal_UK = GSL
| legal_US = OTC
| legal_status =
| routes_of_administration = Most commonly oral, also rectal. [[Lysine acetylsalicylate]] may be given [[intravenous therapy|IV]] or [[intramuscular injection|IM]]
}}
}}
'''Daniela Hantuchová''' ({{pronounced|ˈdanɪjɛla ˈɦantuxɔvaː}}, roughly ''HAHN-too-koh-vah''; born [[April 23]], [[1983]] in [[Poprad]], [[Czechoslovakia]], now [[Slovakia]]) is a [[Slovaks|Slovak]] professional [[tennis]] player.
'''Aspirin''', or '''acetylsalicylic acid (ASA)''' ({{IPAEng|əˌsɛtɨlsælɨˌsɪlɨk ˈæsɨd}}), is a [[salicylate]] [[medication|drug]], often used as an [[analgesic]] to relieve minor aches and pains, as an [[antipyretic]] to reduce [[fever]], and as an [[anti-inflammatory]] medication.


She is currently working with a number of coaches who work out of the Sanchez-Casal Academy, primarily Angel Gimenez and occasionally with Eduardo Nicolas. Her [[Women's Tennis Association|WTA]] Tour mentor in the "Partners for Success" program was [[Martina Navratilova]], who was her doubles partner for a brief period in early 2005. As of [[August 4]], [[2008]], Hantuchova is ranked World No. 13 in singles.<ref>[http://www.sonyericssonwtatour.com/2/rankings/singles_numeric.asp [[Women's Tennis Association|WTA]] Tour Singles Rankings]</ref>
In countries where Aspirin is a registered [[trademark]] owned by [[Bayer]], the generic term is "ASA."


==Personal life==
Aspirin also has an [[Antiplatelet drug|antiplatelet]] or "anti-clotting" effect and is used in long-term, low doses to prevent [[myocardial infarction|heart attacks]], [[stroke]]s and [[thrombus|blood clot]] formation in people at high risk for developing blood clots.<ref>{{Cite journal| issn = 00284793| volume = 309| issue = 7| pages = 396–403| last = Lewis| first = H D
Hantuchová's tour debut and early results were auspicious. Her performance temporarily crumbled, as a result of her parents splitting up in 2003.<ref name="ESPN">[http://sports.espn.go.com/sports/tennis/aus08/news/story?id=3209689 Hantuchova, Ivanovic persevere despite growing pains at ESPN]</ref> For example, despite being seeded ninth at [[2003 Wimbledon Championships|Wimbledon]] that year, she lost to the 81st ranked player in the world, failing to convert match points and weeping on court. She lost weight and was suspected to be [[Anorexia|anorexic]] then.<ref name="ESPN"/>
| coauthors = J W Davis, D G Archibald, W E Steinke, T C Smitherman, J E Doherty, H W Schnaper, M M LeWinter, E Linares, J M Pouget, S C Sabharwal, E Chesler, H DeMots| title = Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina. Results of a Veterans Administration Cooperative Study| journal = The New England journal of medicine| date = 1983-08-18}}</ref> It has also been established that low doses of aspirin may be given immediately after a heart attack to reduce the risk of another heart attack or of the death of cardiac tissue.<ref name="anticoag">{{cite journal | last = Julian | first = D G | coauthors = D A Chamberlain, S J Pocock | title = A comparison of aspirin and anticoagulation following thrombolysis for myocardial infarction (the AFTER study): a multicentre unblinded randomised clinical trial | journal = BMJ| volume = 313 | issue = 7070 | pages = 1429–1431 | publisher = British Medical Journal | date = 1996-09-24| url = http://www.bmj.com/cgi/content/full/313/7070/1429 | accessdate = 2007-10-04 | pmid = 8973228}}</ref><ref>{{Cite journal| volume = 92| issue = 10| pages = 2841–2847| last = Krumholz| first = Harlan M.| coauthors = Martha J. Radford, Edward F. Ellerbeck, John Hennen, Thomas P. Meehan, Marcia Petrillo, Yun Wang, Timothy F. Kresowik, Stephen F. Jencks| title = Aspirin in the Treatment of Acute Myocardial Infarction in Elderly Medicare Beneficiaries : Patterns of Use and Outcomes| journal = Circulation| accessdate = 2008-05-15| date = 1995-11-15| url = http://circ.ahajournals.org/cgi/content/abstract/92/10/2841| pmid = 7586250}}</ref>


Hantuchová speaks six languages and was trained as a classical [[pianist]].<ref name="ESPN"/> She is thought to be a perfectionist and places a lot of pressure on herself during her training.<ref name="ESPN"/> She qualified for university in Slovakia but deferred it to pursue tennis.{{Fact|date=June 2008}} Her comeback among the world's best was in March 2007 when she won the 2007 [[Tier I]] [[Pacific Life Open]] in [[Indian Wells]] for the second time.<ref name="ESPN"/>
The main [[adverse drug reaction|undesirable side effects]] of aspirin are [[gastrointestinal]]—[[gastric ulcer|ulcers]] and stomach bleeding—and [[tinnitus]], especially in higher doses. In children under 19 years of age, aspirin is no longer used to control [[Influenza|flu]]-like symptoms or the symptoms of [[chickenpox]], due to the risk of [[Reye's syndrome]].<ref name="BMJ2002-Macdonald">{{cite journal | author=Macdonald S | title=Aspirin use to be banned in under 16 year olds | journal=BMJ | volume=325 | issue=7371 | pages=988 | year=2002 | pmid= 12411346 |pmc=1169585 | doi=10.1136/bmj.325.7371.988/c}}</ref>


==Career==
Aspirin was the first-discovered member of the class of drugs known as [[non-steroidal anti-inflammatory drugs]] (NSAIDs), not all of which are salicylates, although they all have similar effects and most have some [[Non-steroidal anti-inflammatory drugs#Mode of action|mechanism of action]] which involves non-selective inhibition of the enzyme [[cyclooxygenase]]. Today, aspirin is one of the most widely used medications in the world, with an estimated 40,000 [[metric tons]] of it being consumed each year.<ref name='cox3article'> {{cite journal|title=Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?|journal=Proc Natl Acad Sci U S a|date=2002-10-15|first=|last=|coauthors=Warner TD, Mitchell JA.|volume=99|issue=21|pages=13371–3|pmid=12374850 |url=http://www.pnas.org/cgi/content/extract/99/21/13371|accessdate=2008-05-08|doi=10.1073/pnas.222543099|author=Warner, T. D. }}</ref>
===Overall===
Hantuchová has won three WTA singles tournaments in her career, the first in 2002 at the Tier I [[Pacific Life Open]], defeating [[Martina Hingis]] 6–3 6–4 in the final, and in 2007 at the same tournament, defeating Hingis again in the fourth round and [[Svetlana Kuznetsova]] in the final 6–3 6–4 ending a 5-year title drought. Her most recent title came at the [[Generali Ladies Linz]] in [[Austria]], where she defeated [[Patty Schnyder]] 6–4, 6–2 in the final.


She has reached six other finals in her career &mdash; [[Filderstadt]] 2002 losing to [[Kim Clijsters]], [[Eastbourne]] 2004 losing to [[Svetlana Kuznetsova]], [[Los Angeles]] 2005 where she lost to Clijsters again, the 2006 [[Zurich Open]] losing to [[Maria Sharapova]], in [[Commonwealth Bank Tennis Classic|Bali]] 2007 losing to [[Lindsay Davenport]] and [[Fortis Championships Luxembourg|Luxembourg]] 2007 to [[Ana Ivanovic]].
== History ==
{{Main|History of aspirin}}


She has also achieved reasonable results in the Grand Slam events. Her most notable career-bests are three quarterfinals at Wimbledon, US Open in 2002 and the Australian Open in 2003. Also earlier this year she scored a semi-final at the Australian Open defeating Maria Kirirlenko and Agnieszka Radwańska before losing to Ana Ivanović of Serbia. This was seen as a controversial match, where Ivanović was heard to be squeaking her trainers on the court before Hantuchová's serve, a claim Ivanović disputes. The score ended as 0-6 6-3 6-4 - after Hantuchová won the first eight games at 6-0 2-0.
Medicines containing derivatives of [[salicylic acid]], structurally similar to aspirin, have been in medical use since ancient times. [[Salicylate]]-rich [[willow]] bark extract became recognized for its specific effects on fever, pain and inflammation in the mid-eighteenth century. By the nineteenth century pharmacists were experimenting with and prescribing a variety of chemicals related to [[salicylic acid]], the active component of willow extract.


===Playing style===
A French chemist, [[Charles Frederic Gerhardt]], was the first to prepare acetylsalicylic acid (named aspirin in 1899) in 1853. In the course of his work on the synthesis and properties of various [[acid anhydride]]s, he mixed [[acetyl chloride]] with a [[sodium]] salt of salicylic acid (sodium salicylate). A vigorous reaction ensued, and the resulting melt soon solidified.<ref name=gerhardt>{{de icon}} {{cite journal |author=Gerhardt C |title=Untersuchungen über die wasserfreien organischen Säuren |journal=Annalen der Chemie und Pharmacie|volume=87 |issue= |pages=149–179 |year=1853 |doi=10.1002/jlac.18530870107}}</ref> Since no structural theory existed at that time, Gerhardt called the compound he obtained "salicylic-acetic anhydride" (''wasserfreie Salicylsäure-Essigsäure''). This preparation of aspirin ("salicylic-acetic anhydride") was one of the many reactions Gerhardt conducted for his paper on anhydrides, and he did not pursue it further.
Hantuchová's game is built around natural timing. She is able to produce "effortless" power from her flowing groundstrokes and possesses a superb down-the-line forehand and backhand. She possesses a heavy serve and has a particularly effective "kick" second serve. Her favourite and most effective construction of a winning point is her flat serve out wide on the Ad-court, followed by a backhand winner down the line.
Her volleys are very well-produced and often have the deftest of touch. Due to these attributes she is known as an "All-arounder".
A weakness of Hantuchová since she emerged from the juniors was her lack of explosive movement around the court. In recent years, however, this aspect of her tennis has been vastly improved.


===Doubles===
[[Image:BayerHeroin.png|thumb|right|180px|Advertisement for Aspirin, Heroin, Lycetol, Salophen]]
Hantuchová's biggest successes have so far come in [[mixed doubles]]. In this event, she won the 2001 [[Wimbledon championships]] with Leos Friedl, the 2002 [[Australian Open]] with [[Kevin Ullyett]], the 2005 [[French Open]] with [[Fabrice Santoro]], and 2005 [[U.S. Open (tennis)|U.S. Open]] with [[Mahesh Bhupathi]]. She was runner-up in the 2002 [[Wimbledon championships|Wimbledon]] with Ullyett, and she reached the semi-finals at the [[French Open]] in 2004 with [[Todd Woodbridge]]. At the 2005 U.S. Open she completed a career mixed doubles Grand Slam with [[Mahesh Bhupathi]] when they beat Katarina Srebotnik and Nenad Zimonjic in the final in straight sets 6–4, 6–2. This makes her only the 5th women in tennis history (after Hart, [[Margaret Court|Court]], [[Billie Jean King|King]] and [[Martina Navratilova|Navratilova]]) to complete a career [[Grand Slam (tennis)|Grand Slam]] in mixed doubles. In [[Perth, Western Australia]] also in 2005, Hantuchová won the [[Hopman Cup]] with [[Dominik Hrbatý]].
Six years later, in 1859, von Gilm obtained analytically pure acetylsalicylic acid (which he called "acetylierte Salicylsäure", ''acetylated salicylic acid'') by a reaction of salicylic acid and acetyl chloride.<ref name=gilm>{{de icon}} {{cite journal |author=von Gilm H |title=Acetylderivate der Phloretin- und Salicylsäure |journal=Annalen der Chemie und Pharmacie|volume=112 |issue=2 |pages=180–185 |year=1859 |doi=10.1002/jlac.18591120207}}</ref> In 1869 Schröder, Prinzhorn and Kraut repeated both Gerhardt's (from sodium salicylate) and von Gilm's (from salicylic acid) syntheses and concluded that both reactions gave the same compound—acetylsalicylic acid. They were first to assign to it the correct structure with the acetyl group connected to the phenolic oxygen.<ref>{{de icon}} {{cite journal |author= Schröder, Prinzhorn, Kraut K |title=Uber Salicylverbindungen |journal=Annalen der Chemie und Pharmacie|volume=150 |issue=1 |pages=1–20 |year=1869 |doi=10.1002/jlac.18691500102}}</ref>


Hantuchová's other achievements include winning eight women's doubles titles (as of July 2007). From 2005 to early 2007 she played doubles with [[Ai Sugiyama]], with some fans affectionately referring to the team as "Hantuyama". They have won 3 titles together in Rome, Doha, and Birmingham, England, as well as reaching the final at the French Open in 2006 (Hantuchova's first Grand Slam doubles final was in 2002 with [[Arantxa Sanchez Vicario]] at the Australian Open). "Hantuyama" won the title of "Fans favorite doubles team 2005" at the Stars for Stars in Miami.
In 1897, scientists at the drug and dye firm [[Bayer]] began investigating acetylsalicylic acid as a less-irritating replacement for standard common salicylate medicines. By 1899, Bayer had dubbed this drug ''Aspirin'' and was selling it around the world.<ref>{{cite book | last = Jeffreys | first = Diarmuid | title = Aspirin: The Remarkable Story of a Wonder Drug | publisher = Bloomsbury USA | date = August 11, 2005 | pages = 73 | isbn = 1582346003 }}</ref>The name Aspirin is derived from A = Acetyl and "Spirsäure" = an old (German) name for salicylic acid.<ref>Ueber Aspirin. Pflügers Archiv : European journal of physiology, Volume: 84, Issue: 11-12 (March 1, 1901), pp: 527-546.</ref> Aspirin's popularity grew over the first half of the twentieth century, spurred by its effectiveness in the wake of [[Spanish flu pandemic]] of 1918, and aspirin's profitability led to fierce competition and the proliferation of aspirin brands and products, especially after the American patent held by Bayer expired in 1917.<ref>Jeffreys, ''Aspirin'', pp. 136-142 and 151-152</ref><ref>http://www.history.com/this-day-in-history.do?action=VideoArticle&id=52415</ref>


In early 2007, the partnership between Sugiyama and herself ended after Tokyo though the pair continued playing at Dubai and Doha because Hantuchová (eager to play doubles with [[Martina Hingis]]) wanted to give Sugiyama time to find a new partner. They only played once (reaching the Semi-Finals of Miami) due to Hingis's subsequent injury which kept her out until Wimbledon. Thereafter she partnered [[Nadia Petrova]] and Ana Ivanovic in the bigger tournaments before reuniting with Hingis on the summer hardcourts in America and reaching the third round of the US Open in their first attempt together at a grand slam. In the absence of Hingis in Bali she played doubles with [[Lindsay Davenport]]. Over the start of the 2008 season she has played with Davenport, [[Ana Ivanovic]], [[Martina Hingis]] and re joined [[Ai Sugiyama]] for the 2008 [[Pacific Life Open]]
As part of war reparations following Germany's surrender after [[World War I]], Aspirin lost its status as a registered trademark in [[France]], [[United Kingdom]] and the [[United States]] where it became a generic name.<ref>http://www.ul.ie/~childsp/CinA/Issue59/TOC43_Aspirin.htm</ref> Aspirin remains a registered trademark of Bayer in Germany and in over 80 other countries.<ref>http://www.aspirin.com/faq_en.html</ref>


===2002===
Aspirin's popularity declined after the market releases of [[paracetamol]] (acetaminophen) in 1956 and [[ibuprofen]] in 1969.<ref>Jeffreys, ''Aspirin'', pp. 212-217</ref> In the 1960s and 1970s, John Vane and others discovered the basic mechanism of aspirin's effects, while clinical trials and other studies from the 1960s to the 1980s established aspirin's efficacy as an anti-clotting agent that reduces the risk of clotting diseases.<ref>Jeffreys, ''Aspirin'', pp. 226-231</ref> Aspirin sales revived considerably in the last decades of the twentieth century, and remain strong in the twenty-first, thanks to widespread use as a preventive treatment for [[heart attack]]s and [[stroke]]s.<ref>Jeffreys, ''Aspirin'', pp. 267-269</ref>


2002 was Hantuchová's breakout season, in which she won her first tournament at the prestigious [[Indian Wells Masters|Indian Wells]] event, defeating [[Justine Henin]] (her first victory over a top 10 player) in the fourth round 6–3 6–3 and [[Martina Hingis]] in the final 6–3 6–4. Later on that year, Hantuchova also reached the final in Filderstadt, losing to [[Kim Clijsters]] 4–6 6–3 6–4, the only set Hantuchova took from Clijsters in their nine meetings.
== Therapeutic uses ==
Aspirin is one of the most frequently used drugs in the treatment of mild to moderate pain, including that of [[migraine]]s and [[fever]].<ref>{{cite journal |author=Aukerman G, Knutson D, Miser WF |title=Management of the acute migraine headache |journal=Am Fam Phys |volume=66 |issue=11 |pages=2123–30 |year=2002
|pmid=12484694 |url=http://www.aafp.org/afp/20021201/2123.html}}</ref><ref>{{Cite journal| volume = 286| issue = 6372| last = Addy| first = D P| title = Cold comfort for hot children| journal = British Medical Journal (Clinical research ed.)| date = 1983-04-09}}</ref> It is often combined with other [[non-steroidal anti-inflammatory drug]]s and [[opioid analgesic]]s in the treatment of moderate to severe pain.<ref name="R Barkin">{{cite journal | last = Barkin | first = Robert | title = Acetaminophen, Aspirin, or Ibuprofen in Combination Analgesic Products | journal = American Journal of Therapeutics | volume = 8 | issue = 6 | pages = 433–42 | date = November/December 2001 | url = http://www.americantherapeutics.com/pt/re/ajt/abstract.00045391-200111000-00008.htm;jsessionid=LbQGQ3kCysg2DRjQQ5FhndrgfbXyp1vcpSqhhSP7prKz48H611H5!1379360954!181195629!8091!-1| accessdate = 2008-05-02 | doi = 10.1097/00045391-200111000-00008}}</ref>


Elsewhere in the year, she made the semifinals in Linz, New Haven, Montreal, and Eastbourne. Hantuchová also made her first two Slam quarterfinals, defeating [[Jelena Dokić]] 6–4 7–5 in the fourth round at Wimbledon, losing to eventual champion [[Serena Williams]] in the quarterfinals, and defeated [[Justine Henin]] again in the fourth round at the US Open 6–1 3–6 7–6(4), losing to eventual champion Serena Williams again in the quarterfinals.
In high doses, aspirin and other salicylates are used in the treatment of [[rheumatic fever]], [[arthritis|rheumatic arthritis]], and other inflammatory joint conditions. In lower doses, aspirin also has properties as an inhibitor of [[platelet]] aggregation, and has been shown to decrease the incidence of transient ischemic attacks and unstable [[Angina pectoris|angina]] in men, and can be used prophylactically. It is also used in the treatment of [[pericarditis]], [[coronary artery disease]], and acute [[myocardial infarction]].<ref> {{cite journal|title=Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes|journal=Circulation|date=1995 November 15|first=HM|last=Krumholz|coauthors=Radford MJ, Ellerbeck EF, Hennen J, Meehan TP, Petrillo M, Wang Y, Kresowik TF, Jencks SF.|volume=92|issue=10|pages=2841–7|pmid=7586250 |url=http://circ.ahajournals.org/cgi/content/full/92/10/284|accessdate=2008-05-02 }}</ref><ref name="Lancet1988-ISIS2">{{cite journal | author=ISIS-2 Collaborative group | title=Randomized trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2 | journal=Lancet | year=1988 | pages=349–60 | issue=2 | pmid= 2899772}}</ref> Low doses of aspirin are also recommended for the prevention of [[stroke]], and myocardial infarction in patients with either diagnosed coronary artery disease or who have an elevated risk of [[cardiovascular disease]].


Hantuchová went 6-10 against top 10 players; 6–2 in singles Fed Cup play, helping lead Slovakia to their first Fed Cup victory against Spain in the final; 10-6 on indoor carpet, 6–2 on grass, 11-7 on clay, and 29-10 on hardcourts.
===Experimental uses===
[[Image:Acetylsalicylicacid-crystals.jpg|thumb|right|300px|Aspirin in its pure state]]
Aspirin has been theorized to reduce [[cataract]] formation in diabetic patients, but one study showed it was ineffective for this purpose.<ref name="chew">{{cite journal |author=Chew EY, Williams GA, Burton TC, Barton FB, Remaley NA, Ferris FL |title=Aspirin effects on the development of cataracts in patients with diabetes mellitus. Early treatment diabetic retinopathy study report 16 |journal=Arch Ophthalmol |volume=110 |issue=3 |pages=339–42 |year=1992 |pmid=1543449 |doi=}}</ref> The role of aspirin in reducing the incidence of many forms of [[cancer]] has also been widely studied. In several studies, aspirin use did not reduce the incidence of [[prostate|prostate cancer]].<ref>{{cite journal | author=Bosetti, ''et al.'' | title=Aspirin and the risk of prostate cancer | journal=Eur J Cancer Prev | year=2006 | pages=43–5 | volume=15 | issue=1 | pmid= 16374228 | doi=10.1097/01.cej.0000180665.04335.de}}</ref><ref>{{cite journal | author=Menezes, ''et al.'' | title=Regular use of aspirin and prostate cancer risk (United States) | journal=Cancer Causes & Control | year=2006 | pages=251–6 | volume=17 | issue=3 | pmid= 16489532 |doi=10.1007/s10552-005-0450-z}}</ref> Its effects on the incidence of pancreatic cancer are mixed; one study published in 2004 found a statistically significant increase in the risk of pancreatic cancer among women,<ref>{{cite journal | author=Schernhammer, ''et al.'' | title=A Prospective Study of Aspirin Use and the Risk of Pancreatic Cancer in Women | journal=J Natl Cancer Inst | year=2004 | pages=22–28 | volume=96 | issue=1 | pmid= 14709735 | url=http://jnci.oxfordjournals.org/cgi/content/full/96/1/22 | doi=10.1093/jnci/djh001}}</ref> while a meta-analysis of several studies, published in 2006, found no evidence that aspirin or other NSAIDs are associated with an increased risk for the disease.<ref>{{cite journal |author=Larsson SC, Giovannucci E, Bergkvist L, Wolk A |title=Aspirin and nonsteroidal anti-inflammatory drug use and risk of pancreatic cancer: a meta-analysis |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue=12 |pages=2561–4 |year=2006 |month=December |pmid=17164387 |doi=10.1158/1055-9965.EPI-06-0574 |url=http://cebp.aacrjournals.org/cgi/content/full/15/12/2561}}</ref> The drug may be effective in reduction of risk of various cancers, including those of the [[colon cancer|colon]],<ref name="thun">{{cite journal |author=Thun MJ, Namboodiri MM, Heath CW |title=Aspirin use and reduced risk of fatal colon cancer |journal=[[New England Journal of Medicine|N Engl J Med]] |volume=325 |issue=23 |pages=1593–6 |year=1991 |pmid=1669840 |doi=}}</ref><ref>{{cite journal | author=Baron, ''et al.'' | title=A randomized trial of aspirin to prevent colorectal adenomas | journal=N Engl J Med | year=2003 | pages=891–9 | volume=348 | issue=10 | pmid=12621133 | doi=10.1056/NEJMoa021735}}</ref><ref>{{cite journal | author=Chan, ''et al.'' | title=A Prospective Study of Aspirin Use and the Risk for Colorectal Adenoma | journal=Ann Intern Med | year=2004 | pages=157–66 | volume=140 | issue=3 | pmid= 14757613}}</ref><ref>{{cite journal | author=Chan, ''et al.'' | title=Long-term Use of Aspirin and Nonsteroidal Anti-inflammatory Drugs and Risk of Colorectal Cancer | journal=JAMA | year=2005 | pages=914–23 | volume=294 | issue=8 | pmid= 16118381 | doi=10.1001/jama.294.8.914}}</ref> [[lung cancer|lung]],<ref>{{cite journal | author=Akhmedkhanov, ''et al.'' | title=Aspirin and lung cancer in women | journal=Br J cancer | year=2002 | pages=1337–8 | volume=87 | issue=11 | pmid= 12085255 | doi=10.1038/sj.bjc.6600370}}</ref><ref>{{cite journal |author=Moysich KB, Menezes RJ, Ronsani A, ''et al'' |title=Regular aspirin use and lung cancer risk |journal=BMC Cancer |volume=2 |issue= |pages=31 |year=2002 |pmid=12453317 |doi=}} [http://www.biomedcentral.com/1471-2407/2/31 Free full text]</ref> and possibly the upper GI tract, though some evidence of its effectiveness in preventing cancer of the upper GI tract has been inconclusive.<ref name='Asprin upper GI cancer'> {{cite journal|title=Regular aspirin use and esophageal cancer risk|journal=Int J Cancer|date=2006-07-01|first=|last=|coauthors=Jayaprakash V, Menezes RJ, Javle MM, McCann SE, Baker JA, Reid ME, Natarajan N, Moysich KB.|volume=119|issue=1|pages=202–7|pmid=16450404 |doi=10.1002/ijc.21814|author=Jayaprakash, Vijayvel }}</ref><ref>{{cite journal | author=Bosetti, ''et al.'' | title=Aspirin use and cancers of the upper aerodigestive tract | journal=Br J Cancer | year=2003 | pages=672–74 | volume=88 | issue=5 | pmid= 12618872 | doi=10.1038/sj.bjc.6600820}}</ref><ref name='Asprin upper GI cancer'/> Its preventative effect against adenocarcinomas may be explained by its inhibition of [[Cyclooxygenase|COX-2]] enzymes expressed in them.<ref>{{cite journal | author=Wolff, ''et al.'' | title=Expression of cyclooxygenase-2 in human lung carcinoma | journal=Cancer Research | year=1998 | pages=4997–5001 | volume=58 | issue=22 | url=http://cancerres.aacrjournals.org/cgi/content/abstract/58/22/4997 | pmid=9823297}}</ref> An older study{{Fact|date=August 2008}} claimed that aspirin may reduce the neurotoxicity of [[THC]], the active drug in [[cannabis]]. However, this theory has been discredited, as newer studies{{Fact|date=August 2008}} indicate THC to be [[neuroprotective]] rather than [[neurotoxic]].


===Veterinary uses===
===2003===
Aspirin has been used to treat pain and arthritis in veterinary medicine, primarily in [[cat]]s and [[dog]]s, although it is often not recommended for this purpose, as there are newer medications available with fewer side effects in these animals. Dogs, for example, are particularly susceptible to the gastrointestinal side effects associated with salicylates.<ref>{{cite web | last = Crosby | first = Janet Tobiassen | title = Veterinary Questions and Answers | publisher = About.com | year = 2006 | url = http://vetmedicine.about.com/cs/altvetmedgeneral/a/dogcataspirin.htm | accessdate = 2007-09-05}}</ref> [[Horse]]s have also been given aspirin for pain relief, although it is not commonly used due to its relatively short-lived analgesic effects. Horses are also fairly sensitive to the gastrointestinal side effects. Nevertheless, it has shown promise in its use as an [[anticoagulant]], mostly in cases of [[laminitis]].<ref name="CambridgeH">{{cite journal |author=Cambridge H, Lees P, Hooke RE, Russell CS |title=Antithrombotic actions of aspirin in the horse |journal=Equine Vet J |volume=23 |issue=2 |pages=123–7 |year=1991 |pmid=1904347 |doi=}}</ref> Aspirin should only be used in animals under the direct supervision of a [[veterinarian]].


Hantuchová started 2003 solidly, reaching the quarterfinals at her first three events in Sydney, losing to [[Lindsay Davenport]] 6–4 3–6 7–6(3), [[Venus Williams]] 6–4 6–3 at the Australian Open (her third Slam quarterfinal in a row), and [[Elena Dementieva]] in Paris 7–5 6–3. Hantuchová reached her first semifinal of the year at her fourth event in Antwerp, losing to Williams again, 6–1 6–4. By then, Hantuchova's ranking was at an all-time high, cracking the top five at No. 5.
== Mechanism of action ==
{{main|Mechanism of action of aspirin}}
[[Image:COX-2 inhibited by Aspirin.png|thumb|Structure of COX-2 inactivated by Aspirin. In the active site of each of the two monomers, Serine 530 has been acetylated. Also visible is the salicylic acid which has transferred the acyl group, and the heme cofactor.]]


Defending a title for the first time in her career, Hantuchova made it to the fourth round in Indian Wells, losing to [[Amanda Coetzer]] 6–4 6–4. Despite a first round loss to [[Alicia Molik]] in Miami, Hantuchova rebounded in the Tier I Charleston event, making her fifth quarterfinal in seven events, losing to [[Ashley Harkleroad]] 6–2 6–1. She made her sixth quarterfinal at her next event in [[Amelia Island]], losing to eventual champion Dementieva 6–0 6–1.
In 1971, British [[pharmacologist]] [[John Robert Vane]], then employed by the [[Royal College of Surgeons]] in London, showed that aspirin suppressed the production of [[prostaglandin]]s and [[thromboxane]]s.<ref>{{cite journal | title = Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs | author = John Robert Vane| journal = Nature - New Biology| year = 1971| volume = 231| issue = 25| pages = 232–5| pmid= 5284360}}</ref><ref>{{cite journal |author=Vane JR, Botting RM |month=June |year=2003 |title=The mechanism of action of aspirin |journal=Thromb Res |volume=110 |issue=5-6 |pages=255–8 |pmid=14592543 |doi=10.1016/S0049-3848(03)00379-7 |url=http://www.eao.chups.jussieu.fr/polys/certifopt/saule_coxib/theme/1vane2003.pdf}}</ref> For this discovery, he was awarded both a [[Nobel Prize]] in [[Nobel Prize in Physiology or Medicine|Physiology or Medicine]] in 1982 and a [[knighthood]].


Hantuchová went undefeated in first round Fed Cup play against Germany, winning both of her matches. Following Fed Cup, she again made it to the quarterfinals for the seventh time of the year at the Tier I Berlin tournament, losing to Kim Clijsters 6–0 6–3.
Aspirin's ability to suppress the production of prostaglandins and thromboxanes is due to its irreversible inactivation of the [[cyclooxygenase]] (COX) enzyme. Cyclooxygenase is required for prostaglandin and thromboxane synthesis. Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a [[serine]] residue in the active site of the COX enzyme. This makes aspirin different from other NSAIDs (such as [[diclofenac]] and [[ibuprofen]]), which are reversible inhibitors.


[[Image:Hantuchova in 2003.jpg|left|thumb|Hantuchová in 2003]]
Low-dose, long-term aspirin use irreversibly blocks the formation of [[thromboxane A2|thromboxane A<sub>2</sub>]] in [[platelet]]s, producing an inhibitory effect on [[platelet|platelet aggregation]]. This anticoagulant property makes aspirin useful for reducing the incidence of heart attacks.<ref> {{cite web|url=http://www.americanheart.org/presenter.jhtml?identifier=4456 |title=Aspirin in Heart Attack and Stroke Prevention |accessdate=2008-05-08 |publisher=American Heart Association }}</ref> 40&nbsp;mg of aspirin a day is able to inhibit a large proportion of maximum thromboxane A<sub>2</sub> release provoked acutely, with the prostaglandin I2 synthesis being little affected; however, higher doses of aspirin are required to attain further inhibition.<ref>{{cite journal | last = Tohgi| first = H| coauthors = S Konno, K Tamura, B Kimura and K Kawano | year = 1992 | title = Effects of low-to-high doses of aspirin on platelet aggregability and metabolites of thromboxane A2 and prostacyclin | journal = Stroke| volume = Vol 23 | pages = 1400–1403 |pmid=1412574}}</ref>


At the French Open, Hantuchová lost in the second round in a marathon match to Harkleroad again 7–6(2) 4–6 9–7 making 101 unforced errors, leading to long-time coach Nigel Sears criticising her attitude publicly.<ref>theage.com.au [http://www.theage.com.au/articles/2003/06/29/1056825268466.html A towering talent]</ref> Following the match, her extremely thin physique was noticed for the first time publicly and some wondered about Hantuchova's health.
Prostaglandins are local [[hormone]]s produced in the body and have diverse effects in the body, including the transmission of pain information to the brain, modulation of the [[hypothalamus|hypothalamic]] thermostat, and inflammation. Thromboxanes are responsible for the aggregation of [[platelet]]s that form [[clot|blood clots]]. Heart attacks are primarily caused by blood clots, and low doses of aspirin are seen as an effective medical intervention for acute [[myocardial infarction]]. The major side-effect of this is that because the ability of blood to clot is reduced, excessive bleeding may result from the use of aspirin.


Kicking off the grass season in Eastbourne, Hantuchová lost in the quarterfinals to [[Conchita Martinez]], but more famously she lost in the second round of Wimbledon to [[Shinobu Asagoe]] 0–6 6–4 12-10, with Hantuchova breaking down crying during the latter stages of the match in the midst of making 57 unforced errors. Later people theorised that the media frenzy regarding her weight plus her breakdown during the match, along with personal problems of her parents' divorce and feeling the pressure of success at just 19 years old was the reasoning behind the subsequent fall of Hantuchova from the top of women's tennis.
There are at least two different types of cyclooxygenase: COX-1 and COX-2. Aspirin irreversibly inhibits COX-1 and modifies the enzymatic activity of COX-2. Normally COX-2 produces prostanoids, most of which are pro-inflammatory. Aspirin-modified COX-2 produces lipoxins, most of which are anti-inflammatory. Newer NSAID drugs called [[COX-2 selective inhibitor]]s have been developed that inhibit only COX-2, with the intent to reduce the incidence of gastrointestinal side-effects.<ref name="cox3article" />


Following Wimbledon Hantuchová went 6–8 for the rest of the year, 0–4 against top 10 players, 28-23 overall going 4–3 on indoor carpet, 10-6 on clay, 2–2 on grass, 12-12 on hardcourts; and fell to No. 17 in the world. Further signs of the pressure and problems she was facing during this period was that in July she made herself unavailable for Slovakia in the Fed Cup in order to concentrate on her singles career and in November she parted company with Sears.<ref>news.bbc.co.uk - [http://news.bbc.co.uk/sport1/hi/tennis/3245989.stm ''Hantuchova splits with coach'']</ref>
However, several of the new [[COX-2 selective inhibitor]]s, such as [[Vioxx]], have been recently withdrawn, after evidence emerged that COX-2 inhibitors increase the risk of heart attack. It is proposed that endothelial cells lining the microvasculature in the body express COX-2, and, by selectively inhibiting COX-2, prostaglandins (specifically PGI2; prostacyclin) are downregulated with respect to thromboxane levels, as COX-1 in platelets is unaffected. Thus, the protective anti-coagulative effect of PGI2 is decreased, increasing the risk of thrombus and associated heart attacks and other circulatory problems. Since platelets have no DNA, they are unable to synthesize new COX once aspirin has irreversibly inhibited the enzyme, an important difference with reversible inhibitors.


===2004===
Furthermore, aspirin has been shown to have at least three additional modes of action. It uncouples [[oxidative phosphorylation]] in cartilaginous (and hepatic) mitochondria, by diffusing from the inner membrane space as a proton carrier back into the mitochondrial matrix, where it ionizes once again to release protons.<ref name="SomasundaramS">{{cite journal|last=Somasundaram, S. et al.|year=2000|title=Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat|journal=Aliment Pharmacol Ther|volume=14|pages=639–650|url=http://www.blackwell-synergy.com/doi/pdf/10.1046/j.1365-2036.2000.00723.x|accessdate=2008-05-28|doi=10.1046/j.1365-2036.2000.00723.x|doi_brokendate=2008-06-24}}</ref> In short, aspirin buffers and transports the protons. When high doses of aspirin are given, aspirin may actually cause fever due to the heat released from the electron transport chain, as opposed to the antipyretic action of aspirin seen with lower doses. Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduced leukocyte adhesion, which is an important step in immune response to infection; however, there is currently insufficient evidence to show that aspirin helps to fight infection.<ref> Mark J. Paul-Clark, Thong van Cao, Niloufar Moradi-Bidhendi, Dianne Cooper, and Derek W. Gilroy 15-epi-lipoxin A4–mediated Induction of Nitric Oxide Explains How Aspirin Inhibits Acute Inflammation
J. Exp. Med. 200: 69-78; published online before print as 10.1084/jem.20040566</ref> More recent data also suggests that salicylic acid and its derivatives modulate signaling through [[NF-κB]].<ref>{{cite journal | last = McCarty| first = MF| coauthors = KI Block | year = 2006 | title = Preadministration of high-dose salicylates, suppressors of NF-kappaB activation, may increase the chemosensitivity of many cancers: an example of proapoptotic signal modulation therapy | journal = Integr Cancer Ther.| volume = Vol 5 |issue = 3 | pages = 252–268 | pmid= 16880431 |doi=10.1177/1534735406291499}}</ref> NF-κB is a [[transcription factor]] complex that plays a central role in many biological processes, including inflammation.


[[Image:Daniela Hantuchova in US Open 2004.jpg|thumb|Hantuchová in US Open 2004]]
==Chemistry==
Aspirin is an [[acetyl]] derivative of salicylic acid that is a white, crystalline, weakly acidic substance, with [[melting point]] 135°C. Acetylsalicylic acid decomposes rapidly in solutions of [[ammonium acetate]] or of the [[acetates]], [[carbonates]], [[citrates]] or [[hydroxides]] of the [[alkali metals]]. Acetylsalicylic acid is stable in dry air, but gradually [[hydrolyses]] in contact with moisture to acetic and salicylic [[acids]]. In solution with alkalis, the hydrolysis proceeds rapidly and the clear solutions formed may consist entirely of acetate and salicylate.<ref>
Reynolds EF (ed) (1982). Aspirin and similar analgesic and anti-inflammatory agents. Martindale, The Extra Pharmacopoeia 28 Ed, 234-82.</ref>


2004 proved to be largely a continuation of Hantuchová's poor second half of '03 with all the same struggles (she briefly hired Harold Soloman, who had previously coached her friend [[Jennifer Capriati]] as well as [[Anna Kournikova]] before re-hiring Sears in March <ref>rediff.com - [http://www.rediff.com/sports/2004/mar/10tennis.htm ''Hantuchova rehires Sears'']</ref>), she reached just three quarterfinals, her first of which at the first Tier I event in Tokyo was not until halfway through the season. At Tokyo, however, she garnered her thus far only victory over [[Maria Sharapova]] in the second round, falling to Davenport 6–2 6–2 in the quarters. The tournament that saved her from a completely disastrous 2004 was Eastbourne, in which she defeated [[Ai Sugiyama]] in the quarterfinals 6–1 7–6(7) and [[Amelie Mauresmo]] in the semifinals 4–6 6–4 6–4 before losing to [[Svetlana Kuznetsova]] in the third final of her career, 2–6 7–6(2) 6–4. However, Hantuchová was serving for the championship, up 6–2 6–5, but got broken.
=== Synthesis ===
The synthesis of aspirin is classified as an [[esterification]] reaction, where the alcohol group from the [[salicylic acid]] reacts with an acid derivative ([[acetic anhydride]]), yielding aspirin and [[acetic acid]] as a byproduct. Small amounts of [[sulfuric acid]] (and occasionally [[phosphoric acid]]) are used as a catalyst. This method is commonly employed in undergraduate teaching labs.<ref>{{cite book |title=Experimental Organic Chemistry |last=Palleros |first=Daniel R. |year=2000 |publisher=John Wiley & Sons|location=New York|isbn=0-471-28250-2 |pages=494}}</ref>


Hantuchová was ranked No. 54 as she entered Eastbourne, but found herself ranked No. 38 as she went into Wimbledon, losing to eventual champion Sharapova in the third round 6–3 6–1. Hantuchova would make one more quarterfinal at New Haven, losing to [[Lisa Raymond]] 6–4 6–3. At the US Open one week later, Hantuchova lost 7–6 in the third to [[Patty Schnyder]] in the third round despite having match points in the third set.
:[[Image:Aspirin synthesis.png|490px]]


Hantuchová finished the year ranked No. 31, with a 24-24 win-loss ratio going 3–3 on indoor carpet, 6–3 on grass, 2–5 on clay, and 13-13 on hardcourts. She finished 1–4 against top 10 players overall, the sole victory over Mauresmo.
Formulations containing high concentrations of aspirin often smell like [[vinegar]].<ref> {{cite web|url=http://www.newton.dep.anl.gov/askasci/chem00/chem00314.htm |title=Aspirin Aging |accessdate=2008-05-08 |last=Barrans |first=Richard |publisher=Newton BBS }}</ref> This is because aspirin can decompose in moist conditions, yielding salicylic acid and [[acetic acid]].<ref>{{cite journal
| last = Carstensen
| first = J.T.
| coauthors = F Attarchi and XP Hou
| title = Decomposition of aspirin in the solid state in the presence of limited amounts of moisture
| journal = Journal of Pharmaceutical Sciences
| volume = 77
| issue = 4
| pages = 318–21
| month = Jul | year = 1985 |pmid=4032246
| doi = 10.1002/jps.2600770407 }}</ref>


===2005===
The acid dissociation constant ([[Acid dissociation constant|pK<sub>a</sub>]]) for acetylsalicylic acid is 3.5 at 25&nbsp;°C.<ref name="asaaciddissconst">{{cite web | title = Acetylsalicylic acid | publisher = Jinno Laboratory, School of Materials Science, Toyohashi University of Technology | date = [[March 1]] [[1996]] | url = http://chrom.tutms.tut.ac.jp/JINNO/DRUGDATA/07acetylsalicylic_acid.html | accessdate = 2007-09-07}}</ref>


Hantuchová reached the third round of the Australian Open, losing to Dementieva in a tight three-setter, 7–5 5–7 6–4. Following that, she made her first quarterfinal of the year in Tokyo for the second straight year, losing to Kuznetsova 7–6(4) 7–6(4). At her next event she reached the semifinals in Doha, losing to Sharapova 6–2 6–4. Then she made another quarterfinal at her next tournament in Dubai, losing to Serena Williams 6–4 6-3; at Dubai also, in the first round, she garnered her 10th top 10 victory over No. 8 [[Alicia Molik]] 7–6(8) 6–2.
===Polymorphism===


Hantuchová made the third round at the French and Wimbledon, losing to Clijsters 6–4 6–2 in Paris and eventual champion Venus Williams 7–5 6–3 in England.
[[Polymorphism (materials science)|Polymorphism]], or the ability of a substance to form more than one [[crystal structure]], is important in the development of pharmaceutical ingredients. Many drugs are receiving regulatory approval for only a single crystal form or polymorph. For a long time, only one crystal structure for aspirin was known, although there had been indications that aspirin might have a second crystalline form since the 1960s. The elusive second polymorph was first discovered by Vishweshwar and coworkers in 2005,<ref>{{cite journal | author= Peddy Vishweshwar, Jennifer A. McMahon, Mark Oliveira, Matthew L. Peterson, and Michael J. Zaworotko| title = The Predictably Elusive Form II of Aspirin | journal = [[J. Am. Chem. Soc.]] | year = 2005 | volume = 127 | issue = 48 | pages = 16802–16803 | doi = 10.1021/ja056455b}}</ref> and fine structural details were given by Bond et al.<ref>{{cite journal | author= Andrew D. Bond, Roland Boese, Gautam R. Desiraju | title = On the Polymorphism of Aspirin: Crystalline Aspirin as Intergrowths of Two "Polymorphic" Domains | journal = [[Angewandte Chemie International Edition]] | year = 2007 | volume = 46 | issue = 4 | pages = 618–622 | doi = 10.1002/anie.200603373}}</ref> A new crystal type was found after attempted co-crystallization of aspirin and [[levetiracetam]] from hot [[acetonitrile]]. The form II is only stable at 100 [[Kelvin|K]] and reverts back to form I at ambient temperature. In the (unambiguous) form I, two salicylic molecules form centrosymmetric [[dimer]]s through the [[acetyl]] groups with the (acidic) [[methyl]] proton to [[carbonyl]] [[hydrogen bond]]s, and in the newly claimed form II, each salicylic molecule forms the same hydrogen bonds with two neighboring molecules instead of one. With respect to the hydrogen bonds formed by the [[carboxylic acid]] groups both polymorphs form identical dimer structures.


Hantuchová had a successful US Open series run, where she reached the semifinals in Cincinnati, getting upset by No. 74 Akiko Morigami 6–4 6–4. After Cincinnati, in Stanford, Hantuchova lost to Clijsters in the quarterfinals 6–3 6–1. And after a second round loss in San Diego to Sugiyama, Hantuchova reached her fourth final in Los Angeles, getting a walkover in the quarterfinals over Sharapova, and got revenge against Dementieva in the semifinals, defeating her 6–3 6–4 (Hantuchova stands 2–0 against Dementieva in semifinals). In the final, for the seventh time in their head-to-head, Clijsters defeated Hantuchova 6–4 6–1. For the third time at the event, Hantuchova made the quarterfinals in New Haven, losing to Davenport 6–2 7–6(5).
==Pharmacokinetics==


Hantuchová would lose to eventual quarterfinalist Venus Williams in the third round at the US Open.
[[Salicylic acid]] is a weak acid, and very little of it is ionized in the [[stomach]] after oral administration. Acetylsalicylic acid is poorly soluble in the [[pH|acidic]] conditions of the stomach, which can delay absorption of high doses for 8 to 24 hours. In addition to the increased pH of the [[small intestine]], aspirin is rapidly absorbed there due to the increased surface area, which in turn allows more of the salicylate to dissolve. Due to the issue of solubility, however, aspirin is absorbed much more slowly during overdose, and [[blood plasma|plasma]] concentrations can continue to rise for up to 24 hours after ingestion.<ref name='RK Ferguson'> {{cite journal|title=Death following self-poisoning with aspirin|journal=Journal of the American Medical Association|date=1970-08-17|first=RK|last=Ferguson|coauthors=Boutros, AR|volume=|issue=|pages=|pmid=5468267 }}</ref><ref name='FL Kaufman'> {{cite journal|title=Darvon poisoning with delayed salicylism: a case report|journal=Pediatrics|date=1970-04|first=FL|last=Kaufman|coauthors=Dubansky, AS|volume=49|issue=4|pages=610–1|pmid=5013423 }}</ref><ref name='G Levy'> {{cite journal|title=Salicylate accumulation kinetics in man|journal=New England Journal of Medicine|date=1972-09-31|first=G|last=Levy|coauthors=Tsuchiya, T|volume=287|issue=9|pages=430–2|pmid=5044917 |url= }}</ref>


In Luxembourg, Hantuchova made her eighth quarterfinal of the season, losing to [[Nathalie Dechy]] 6–1 6–4. In Filderstadt the following week, Hantuchová made the semifinals, her third of the year, defeating No. 10 Patty Schnyder in the second round and [[Flavia Pennetta]] in the quarterfinals; she lost to Davenport in the semifinals. And at the final Tier I event of the year, Hantuchova pushed Davenport to three sets and had match points in the second set in Zurich before losing 3–6 7–5 6–2. And in her final event of the year, in Linz, Hantuchova made her 10th quarterfinal, losing to Schnyder 6–2 6–1.
About 50&ndash;80% of salicylate in the blood is bound by [[protein]] while the rest remains in the active, ionized state; protein binding is concentration-dependent. Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1&ndash;0.2 l/kg. Acidosis increases the volume of distribution because of enhancement of tissue penetration of salicylates.<ref name='G Levy'/>


Hantuchová finished 2005 with a 3-10 record against the top 10, 37-25 overall record with 2–1 on indoor carpet, 3–4 on clay, 2–3 on grass, 30-17 on hardcourts, reaching 10 quarterfinals, three semifinals, and one final.
As much as 80% of therapeutic doses of salicylic acid is [[metabolism|metabolized]] in the [[liver]]. Conjugation with [[glycine]] forms [[salicyluric acid]] and with [[glucuronic acid]] forms salicyl acyl and phenolic glucuronide. These metabolic pathways have only a limited capacity. Small amounts of salicylic acid are also hydroxylated to gentisic acid. With large salicylate doses, the kinetics switch from first order to zero order, as [[metabolic pathway]]s become saturated and [[kidneys|renal]] excretion becomes increasingly important.<ref name="G Levy"/>


===2006===
Salicylates are excreted mainly by the [[kidneys]] as salicyluric acid (75%), free salicylic acid (10%), salicylic phenol (10%) and acyl (5%) glucuronides, and gentisic acid (< 1%). When small doses (less than 250 mg in an adult) are ingested, all pathways proceed by first order kinetics, with an elimination half-life of about 2 to 4.5 hours.<ref name='O Hartwig'>{{cite journal|title=Pharmacokinetic considerations of common analgesics and antipyretics|journal=American Journal of Medicine|date=1983-11-14|first=Otto H|last=Hartwig|coauthors=|volume=75|issue=5A|pages=30–7|pmid=6606362 |pmc=1725844 |doi=10.1016/0002-9343(83)90230-9}}</ref><ref name='AK Done'> {{cite journal|title=Salicylate intoxication. Significance of measurements of salicylate in blood in cases of acute ingestion|journal=Pediatrics|date=1960-11|first=AK|last=Done|coauthors=|volume=|issue=|pages=800–7|pmid=13723722 |url= }}</ref> When higher doses of salicylate are ingested (more than 4 g), the half-life becomes much longer (15-30 hours)<ref name="Chyka2007"/> because the biotransformation pathways concerned with the formation of salicyluric acid and salicyl phenolic glucuronide become saturated.<ref>{{cite journal |author=Prescott LF, Balali-Mood M, Critchley JA, Johnstone AF, Proudfoot AT |title=Diuresis or urinary alkalinisation for salicylate poisoning? |journal=Br Med J (Clin Res Ed) |volume=285 |issue=6352 |pages=1383–6 |year=1982 |month=November |pmid=6291695 |pmc=1500395 |doi= }}</ref> Renal excretion of salicylic acid becomes increasingly important as the metabolic pathways become saturated, because it is extremely sensitive to changes in [[urine|urinary]] pH. There is a 10 to 20 fold increase in renal clearance when urine pH is increased from 5 to 8. The use of urinary alkalinization exploits this particular aspect of salicylate elimination.<ref name="EmergMed2002-Dargan"/>
[[Image:Daniela Hantuchova Zurich Open 2006.jpg|thumb|left|Daniela Hantuchová at the [[Zurich Open]] 2006]]
In 2006 Hantuchová reached the quarterfinals of Sydney with a win over top 10 player [[Patty Schnyder]] and got to the semifinals of Auckland. She continued this form at the Australian Open with her third round 6–1, 7–6 (5) victory over defending champion and seven-time Grand Slam winner [[Serena Williams]], who had entered the tournament with a lack of match practice and questions over her fitness. This victory (the first and only over Serena in her career) ensured Daniela progressed to the fourth round of a Grand Slam tournament for the first time in three years. She lost to 4th-seeded [[Maria Sharapova]] in straight sets in the fourth round.


Thereafter she was unable to find a consistent level of form. She reached the fourth-round at the Australian Open, but prior to the clay court season she parted company for a second time (and permanently) with Sears.<ref>news.bbc.co.uk - [http://news.bbc.co.uk/sport1/hi/tennis/4941978.stm ''Hantuchova parts with coach again'']</ref> He was replaced by Angel Giminez. After the split with Sears she played her first Fed Cup matches for Slovakia in almost 3 years (Slovakia had slipped from being winners in 2003 to languishing in the Europe/Africa zone having being relegated every year in Hantuchova's absence). It was a successful return with Hantuchova winning her both singles and doubles matches against [[Luxembourg]], her singles match against [[The Netherlands]] and the decisive singles rubber in the tie against [[Great Britain]]. With the help of Hantuchova's 4–0 record over the 6-day period Slovakia booked a place in the World Group II play-off against [[Thailand]].
==Contraindications and resistance==
<!--Note that Contraindications is spelled correctly! It does not need to be changed.-->
Aspirin should be avoided by those known to be allergic to [[ibuprofen]] or [[naproxen]],<ref name="drugs.com"/><ref name="personalmd" /> or to have [[salicylate intolerance]]<ref name="pmid16247191">{{cite journal
| author = Raithel M, Baenkler HW, Naegel A, ''et al''
| title = Significance of salicylate intolerance in diseases of the lower gastrointestinal tract
| journal = J. Physiol. Pharmacol.
| volume = 56 Suppl 5
| issue =
| pages = 89–102
| year = 2005
| month = September
| pmid = 16247191
| doi =
| url = http://www.jpp.krakow.pl/journal/archive/0905_s5/pdf/89_0905_s5_article.pdf
| issn =
|format=PDF}}</ref><ref name="pmid8566739">{{cite journal
| author = Senna GE, Andri G, Dama AR, Mezzelani P, Andri L
| title = Tolerability of imidazole salycilate in aspirin-sensitive patients
| journal = Allergy Proc
| volume = 16
| issue = 5
| pages = 251–4
| year = 1995
| pmid = 8566739
| doi =
| url = http://openurl.ingenta.com/content/nlm?genre=article&issn=1088-5412&volume=16&issue=5&spage=251&aulast=Senna
| issn =
}}</ref> or a more generalized [[drug intolerance]] to NSAIDs, and caution should be exercised in those with [[asthma]] or [[NSAID]]-precipitated [[bronchospasm]]. Due to its effect on the stomach lining, manufacturers recommend that patients with [[kidney disease]], [[peptic ulcer]]s, mild [[diabetes]], [[gout]] or [[gastritis]] talk to their doctors before using aspirin.<ref name="drugs.com"/><ref name="mercksource">{{Citation| title = PDR® Guide to Over the Counter (OTC) Drugs|url=http://www.mercksource.com/pp/us/cns/cns_hl_pdr.jspzQzpgzEzzSzppdocszSzuszSzcnszSzcontentzSzpdrotczSzotc_fullzSzdrugszSzfgotc036zPzhtm| accessdate = 2008-04-28 }}.</ref> Even if none of these conditions are present, there is still an increased risk of [[gastrointestinal hemorrhage|stomach bleeding]] when aspirin is taken with [[alcoholic beverage|alcohol]] or [[warfarin]].<ref name="drugs.com"/><ref name="personalmd" /> Patients with [[hemophilia]] or other bleeding tendencies should not take aspirin or other salicylates.<ref name="drugs.com"/><ref name="mercksource" /> Aspirin is known to cause [[hemolytic anemia]] in people who have the genetic disease [[glucose-6-phosphate dehydrogenase deficiency]] (G6PD), particularly in large doses and depending on the severity of the disease.<ref>{{Citation| title = G6PD (Glucose-6-Phosphate Dehydrogenase) Deficiency|url=http://www.healthsystem.virginia.edu/uvahealth/adult_blood/glucose.cfm |accessdate = 2008-05-07|publisher=University of Virginia}}</ref><ref>{{Citation| title = G6PD (Glucose-6-Phosphate Dehydrogenase) Deficiency|url=http://www.utmbhealthcare.org/Health/Content.asp?PageID=P00091 |accessdate = 2008-05-07 |publisher=University of Texas Medical Branch}}</ref> Aspirin should not be given to children or adolescents to control cold or influenza symptoms as this has been linked with [[Reye's syndrome]].<ref name="BMJ2002-Macdonald"/> Use of aspirin during [[Dengue Fever]] is not recommended due to increased bleeding tendency.<ref>{{Citation |title= Dengue and Dengue Hemorrhagic Fever: Information for Health Care Practitioners|url = http://www.cdc.gov/NCIDOD/dvbid/dengue/dengue-hcp.htm| accessdate = 2008-04-28}}</ref>


Despite disappointing results in the warm-up tournaments she equalled her Australian Open performance by getting to the fourth round of both the French Open and Wimbledon before extending her 2006 Fed Cup record to 6–0 by winning both her singles matches in Slovakia's 5–0 rout of Thailand, which ensured their promotion to the World Group II. Her fourth-round streak at Grand Slams ended when she was beaten by a resurgent Serena Williams at the second round of the US Open, which was the culmination of a very disappointing American hard court season (her record was 7–6 including the US Open, failing to get past the last 16 of any of the tournaments she entered).
For some people, aspirin does not have as strong an effect on platelets as for others, an effect known as [[aspirin resistance]] or insensitivity. One study has suggested that women are more likely to be resistant than men<ref>{{cite news | title=Aspirin may be less effective heart treatment for women than men | date=2007-04-26. | publisher= | url =http://www.ns.umich.edu/htdocs/releases/story.php?id=5825 | work =University of Michigan | pages = | accessdate = 2007-09-09 | language = }}</ref><ref>{{cite journal |author=Dorsch MP, Lee JS, Lynch DR, Dunn SP, Rodgers JE, Schwartz T, Colby E, Montague D, Smyth SS |title=Aspirin Resistance in Patients with Stable Coronary Artery Disease with and without a History of Myocardial Infarction |journal=Ann Pharmacother |volume= 41|issue=May |pages= 737|year=2007 |month=24 Apr |pmid=17456544 |doi=10.1345/aph.1H621}}</ref> and a different, aggregate study of 2,930 patients found 28% to be resistant.<ref>{{cite news| title=Increased risk of heart attack or stroke for patients who are resistant to aspirin | date=2008-01-17 | url=http://www.eurekalert.org/pub_releases/2008-01/bmj-iro011608.php | accessdate=2008-01-20}}</ref>


Daniela showed what she is capable of producing the week before Stuttgart beating an in-form Tatiana Golovin in straight sets before losing out to Dinara Safina. The following week she reached the quarterfinals of Stuttgart with an easy victory over the now top 10 player Safina in the 2nd round, the same player to whom she had lost convincingly the previous week. This was both her first victory over a top 10 player and appearance in a quarter final since January. In October 2006, Hantuchova reached the final of the Zurich Open. In the first round, she upset 6th seed [[Patty Schnyder]]. In the second round, she defeated her doubles parter [[Ai Sugiyama]]. Daniela was then scheduled to play World No.1 [[Amelie Mauresmo]] in the quarter finals. However, Mauresmo withdrew due to a right shoulder injury. In the semi finals, Daniela upset World No.4 [[Svetlana Kuznetsova]] 6–4 6–2 to reach the final of the Tier I event. In the final, Daniela lost in a tight 3 setter to 2nd seed [[Maria Sharapova]]. Sharapova winning 6–1 4–6 6–3. The results in this tournament were the culmination of Hantuchová's up turn of form which kept her in the world's top 20 as she had arrived in Zurich outside the top group for the first time in over 11 months. The injury she suffered to her right rib,<ref>tvnz.co.nz – [http://tvnz.co.nz/view/page/411317/866503 ''Hantuchova through to final''] Accessed 28 June 2007</ref> after Mary Pierce hit a shot at her in doubles, caused her her most serious injury of her career and also forced her to retire in her match against Vesnina the following week in Linz.
== Adverse effects ==
===Gastrointestinal side effects===
Aspirin use has been shown to increase the risk of [[gastrointestinal bleeding]].<ref name="H Toft">{{cite journal |author=Sørensen HT, Mellemkjaer L, Blot WJ, ''et al'' |title=Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin |journal=Am. J. Gastroenterol. |volume=95 |issue=9 |pages=2218–24 |year=2000 |month=Sept |pmid=11007221 |doi=10.1111/j.1572-0241.2000.02248.x |url=http://www.blackwell-synergy.com/openurl?genre=article&sid=nlm:pubmed&issn=0002-9270&date=2000&volume=95&issue=9&spage=2218}}</ref> Although some enteric coated formulations of aspirin are advertised as being "gentle to the stomach", in one study enteric coating did not seem to reduce this risk.<ref name="H Toft" /> Combining aspirin with other [[NSAID]]s has also been shown to further increase this risk.<ref name="H Toft" /> Using aspirin in combination with [[clopidogrel]] or [[warfarin]] also increases the risk of upper GI bleeding.<ref>{{cite journal |author=Delaney JA, Opatrny L, Brophy JM & Suissa S |month=August |year=2007 |title=Drug drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding |journal=CMAJ |volume=177 |issue=4 |pages=347–51 |pmid=17698822 |doi=10.1503/cmaj.070186 |pmc=1942107}}</ref>


Hantuchová finished the year ranked 17th in the world with a 34-25 record. She went 24-17 on hard courts, 5–4 on clay, 3–2 on grass and 2–2 on carpet. She was 4–6 against top 10 players beating Schnyder (twice), Safina and Kuznetsova, with losses to Sharapova (twice), Clijsters, Henin-Hardenne, Dementieva and Nadia Petrova.
===Central effects===
Large doses of salicylate, a metabolite of aspirin, have been proposed to cause [[tinnitus]], based on the experiments in rats, via the action on arachidonic acid and NMDA receptors cascade.<ref name="Gutton">{{cite journal |author=Guitton MJ, Caston J, Ruel J, Johnson RM, Pujol R, Puel JL |title=Salicylate induces tinnitus through activation of cochlear NMDA receptors |journal=J. Neurosci. |volume=23 |issue=9 |pages=3944–52 |year=2003 |month=May |pmid=12736364 |doi= |url=http://www.jneurosci.org/cgi/content/full/23/9/3944}}</ref>


===Pediatrics===
===2007===
[[Image:Daniela Hantuchova - Fortis Championships 2007 by Jean & Nathalie.jpg|thumb|250px|Daniela Hantuchová at the 2007 Fortis Championships in Luxembourg]]
{{see also|Reye's syndrome}}
Hantuchová's first tournament of the year was at the Tier IV [[ASB Classic]] in [[Auckland, New Zealand]], where she lost in the second round to [[Virginie Razzano]] 6–1, 7–5. Hantuchova then lost to [[Nicole Vaidišová]] in the first round of the Tier II [[Medibank International|New South Wales Open/Medibank International]] in [[Sydney]] and reached her second consecutive [[Australian Open]] fourth round, where she lost to World No. 5 [[Kim Clijsters]] 6–1, 7–5.
Reye's syndrome can occur when children or pediatric patients are given aspirin for a fever or other illnesses or infections. In one study, 213 patients under the age of 18 were reported for Reye's syndrome from the nationwide Reye's syndrome surveillance system. Out of 213 patients 211 had known that had another antecedent illness: 89% reported being ill (severe vomiting, mental strain, respiratory illness, vericella or gastrointestinal illness) two weeks before onset of Reye's syndrome. Salicylate levels, the active acid in aspirin, were present in 162 of the 213 patients. <ref>{{cite journal |author=Rogers MF, Schonberger LB, Hurwitz ES & Rowley DL |month=February |year=1985 |title=National Reye syndrome surveillance, 1982 |journal=Pediatrics |volume=75 |issue=2 |pages=260–4 |pmid=3969325}}</ref>


Hantuchová was then upset in the first round of the [[Tier I]] [[Toray Pan Pacific Open]] in [[Tokyo]] by [[Roberta Vinci]] 6–4, 6–4. Three weeks later at the Tier II [[Dubai Tennis Championships]], Hantuchová defeated [[Maria Kirilenko]] in the second round 2–6, 6–4, 7–6(4) before losing her quarterfinal match against [[Amelie Mauresmo]] 6–3, 3–6, 6–4. The following week at the Tier II [[Qatar Total Open]] in [[Doha]], Hantuchová trailed World No. 6 [[Martina Hingis]] in their quarterfinal match 4–1 in the second set before coming back to win 1–6, 6–4, 6–4. She then lost her semifinal match against World No. 5 [[Svetlana Kuznetsova]] 6–4, 6–2.
Reye's syndrome is due to fatty deterioration of liver cells. In another study, 12 livers were obtained from children who had died from Reye's syndrome, and another liver from a child who died of accidental causes was used as a control. The autopsy stated in seven of the 12 livers, micro vesicular fatty change was present.<ref>{{cite journal |author=Rogan WJ, Yang GC & Kimbrough RD |month=March |year=1985 |title=Aflatoxin and Reye’s syndrome: a study of livers from deceased cases |journal=ArchEnviron Health |volume=40 |issue=2 |pages=91–5 |pmid=4004347}}</ref>


In her seventh tournament of the year, Hantuchová won six matches, the last four of which were upsets of higher seeded players, to win the Tier I [[Pacific Life Open]] in [[Indian Wells, California]]. She upset Hingis in the fourth round 6–4, 6–3, [[Shahar Peer]] in the quarterfinals 6–2, 5–7, 7–6(5), [[Li Na (tennis)|Li Na]] in the semifinals 7–5, 4–6, 6–1, and Kuznetsova in the final in straight sets.
===Other effects===
Aspirin can cause prolonged bleeding after operations for up to 10 days. In one study, thirty patients were observed after their various surgeries. Twenty of the thirty patients had to have an additional unplanned operation because of postoperative bleeding.<ref>{{cite journal |author=Scher, K.S. |month=January |year=1996 |title=Unplanned reoperation for bleeding |journal=Am Surg |volume=62 |issue=1 |pages=52–55 |pmid=8540646}}</ref> This diffuse bleeding was associated with aspirin alone or in combination with another NSAID in 19 out of the 20 who had to have another operation due to bleeding after their operation. The average recovery time for the second operation was 11 days.


Hantuchová, however, struggled in her next four events. She was upset in the third round of the Tier I [[Sony Ericsson Open]] in [[Key Biscayne, Florida]] by [[Vera Zvonareva]] 6–2, 6–4. On [[clay court|clay]] at the [[Bausch & Lomb Championships]] in [[Amelia Island, Florida]], Hantuchova lost to [[Sybille Bammer]] in the quarterfinals 2–6, 6–2, 6–2. Two weeks later, Hantuchova lost both of her [[Fed Cup]] matches against the [[Czech Republic]] in [[Bratislava]] on clay, losing to Vaidišová 6–2, 6–7(1), 6–3 and [[Lucie Šafářová]] 7–6(1), 4–6, 6–3. Losing her fourth consecutive match, Hantuchová was upset in the first round of the Tier I [[Qatar Telecom German Open]] in [[Berlin]] by [[Zuzana Ondrášková]] 6–1, 6–3.
Aspirin can induce [[angioedema]] in some people. In one study, angioedema appeared 1-6 hours after ingesting aspirin in some of the patients participating in the study. However, when the aspirin was taken alone it did not cause angioedema in these patients; the aspirin was either taken in combination with another NSAID-induced drug when angioedema appeared.<ref>{{cite journal |author=Berges-Gimeno MP & Stevenson DD |month=June |year=2004 |title=Nonsteroidal anti-inflammatory drug-induced reactions and desensitization |journal=J Asthma |volume=41 |issue=4 |pages=375–84 |pmid=15281324 |doi=10.1081/JAS-120037650}}</ref>


Hantuchová then reached her first career clay court semifinal at the [[Internazionali BNL d'Italia]] in [[Rome]]. She upset seventh-seeded [[Anna Chakvetadze]] in the third round 6–3, 6–3 before losing to second-seeded Kuznetsova in the semifinals 6–4, 6–2. At the [[French Open]], Hantuchova was upset in the third round by [[Anabel Medina Garrigues]] 4–6, 7–6(2), 7–5.
== Interactions ==
Aspirin is known to [[Drug interaction|interact]] with other drugs. For example, [[acetazolamide]] and [[ammonium chloride]] have been known to enhance the intoxicating effect of salicyclates, and [[alcohol]] also enhances the gastrointestinal bleeding associated with these types of drugs as well.<ref name='drugs.com'> {{cite web|url=http://www.drugs.com/aspirin.html |title=Aspirin information from Drugs.com |accessdate=2008-05-08 |publisher=Drugs.com }}</ref><ref name='personalmd'> {{cite web|url=http://www.personalmd.com/drgdb/3.htm |title=Oral Aspirin information |accessdate=2008-05-08 |publisher=First DataBank }}</ref> Aspirin is known to displace a number of drugs from protein binding sites in the blood, including the [[anti-diabetic drug]]s [[tolbutamide]] and [[chlorpropamide]], the [[immunosuppressant]] [[methotrexate]], [[phenytoin]], [[probenecid]], [[valproic acid]] (as well as interfering with [[beta oxidation]], an important part of valproate metabolism) and any [[NSAID|nonsteroidal anti-inflammatory drug]]. Corticosteroids may also reduce the concentration of aspirin. The pharmacological activity of [[spironolactone]] may be reduced by taking aspirin, and aspirin is known to compete with [[Penicillin|Penicillin G]] for renal tubular secretion.<ref name="interactions">Katzung (1998), p. 584.</ref> Aspirin may also inhibit the absorption of [[vitamin C]].<ref>{{cite journal |author=Loh HS, Watters K & Wilson CW |year=1973 |title=The Effects of Aspirin on the Metabolic Availability of Ascorbic Acid in Human Beings |journal=J Clin Pharmacol |volume=13 |issue=11 |pages=480–6 |pmid=4490672 |url=http://jcp.sagepub.com/cgi/content/abstract/13/11/480}}</ref><ref>{{cite journal |author=Basu TK |month= |year=1982 |title=Vitamin C-aspirin interactions |journal=Int J Vitam Nutr Res Suppl |volume=23 |issue= |pages=83–90 |pmid=6811490}}</ref><ref>{{cite journal |author=Ioannides C, Stone AN, Breacker PJ & Basu TK |month=December |year=1982 |title=Impairment of absorption of ascorbic acid following ingestion of aspirin in guinea pigs |journal=Biochem Pharmacol |volume=31 |issue=24 |pages=4035–8 |pmid=6818974 |doi=10.1016/0006-2952(82)90652-9}}</ref>


After defeating [[Eleni Daniilidou]] in the third round of the Tier III [[grass court]] [[2007 DFS Classic|DFS Classic]] in [[Birmingham, United Kingdom]], Hantuchová was guaranteed a return to the top 10 for the first time since August 2003. She then lost to [[Marion Bartoli]] in the quarterfinals 5–7, 6–4, 7–5. The following week at the Tier III [[Ordina Open]] in [['s-Hertogenbosch]], the [[Netherlands]], Hantuchová defeated World No. 6 [[Ana Ivanovic]] in the quartefinals 6–3, 6–1 before losing to Chakvetadze in the semifinals 6–7(6), 6–3, 6–2. This result caused Hantuchová to drop out of the top 10.
== Dosage ==
[[Image:Regular strength enteric coated aspirin tablets.jpg|thumb|Coated 325&nbsp;mg aspirin tablets]]
For adults doses are generally taken four times a day for fever or arthritis,<ref name=BNF>{{cite book | title=[[British National Formulary]] | edition=45 | month=March | year=2003 | publisher= [[British Medical Journal]] and [[Royal Pharmaceutical Society of Great Britain]]}}</ref> with doses near the maximal daily dose used historically for the treatment of rheumatic fever.<ref>[http://www.medscape.com/druginfo/monograph?cid=med&drugid=3881&drugname=Aspirin+EC+Oral&monotype=monograph Aspirin monograph: dosages, etc]</ref> For the prevention of myocardial infarction in someone with documented or suspected coronary artery disease, much lower doses are taken once daily.<ref name=BNF />


Hantuchová was the tenth-seeded player at [[The Championships, Wimbledon|Wimbledon]] and did not lose a set in her first two matches. She then defeated [[Slovenia]]n [[Katarina Srebotnik]] in the third round 2–6, 6–3, 6–4 before losing to World No. 8 [[Serena Williams]] in the fourth round 6–2, 6–7(2), 6–2.
For those under 12 years of age, the dose previously varied with the age, but aspirin is no longer routinely used in children due to the association with [[Reye's syndrome]]; [[paracetamol]] (known as acetaminophen in North America) or other NSAIDs, such as [[ibuprofen]], are now used instead. [[Kawasaki disease]] remains one of the few indications for aspirin use in children, with aspirin taken at dosages based on body weight, initially four times a day for up to two weeks and then at a lower dose once daily for a further six to eight weeks.<ref>{{cite book | title=[[British National Formulary for Children]] | year=2006 | publisher= [[British Medical Journal]] and [[Royal Pharmaceutical Society of Great Britain]]}}</ref>


Immediately after Wimbledon, Hantuchová helped [[Slovakia]] win its Fed Cup World Group II play-off against [[Serbia]]. On an indoor [[hard court]] in [[Košice]], she beat [[Ana Timotić]] 6–1, 6–2 and [[Vojislava Lukić]] 6–0, 6–2.
== Overdose ==
{{Splitsection|salicylate intoxication|date=August 2008}}
Aspirin overdose can be acute or chronic. In acute poisoning, a single large dose is taken; in chronic poisoning, supratherapeutic doses are taken over a period of time. Acute overdose has a [[mortality rate]] of 2%. Chronic overdose is more commonly lethal with a mortality rate of 25%; chronic overdose may be especially severe in children.<ref name="Pediatrics1982-gaudreault">{{cite journal | author=Gaudreault P, Temple AR, Lovejoy FH Jr. | title=The relative severity of acute versus chronic salicylate poisoning in children: a clinical comparison | journal=Pediatrics | year=1982 | pages=566–9 | volume=70 | issue=4 | pmid= 7122154}}</ref>


Hantuchová played five tournaments during the [[North America]]n summer hard court season. She began the [[US Open Series]] by losing to Chakvetadze 6–7(6), 6–3, 6–2 in the semifinals of the Tier II [[Bank of the West Classic]] in [[Stanford, California]]. This result put her back in the top 10. At the Tier I [[Acura Classic]] in [[San Diego]], she lost to World No. 16 [[Venus Williams]] in the second round 6–0, 6–3. The following week at the Tier II [[JPMorgan Chase Open]] in [[Los Angeles]], Hantuchova retired from her third round match with [[Elena Dementieva]] while trailing 6–3, 4–1. Hantuchová once again fell out of the top 10 after losing in the second round of the Tier II [[Pilot Pen Tennis]] tournament in [[New Haven, Connecticut]] to eventual runner-up [[Agnes Szavay]] 7–5, 6–3. At the [[2007 U.S. Open (tennis)|US Open]], Hantuchova was the ninth-seeded player but lost to [[Ukraine|Ukraine's]] [[Julia Vakulenko]] in the first round 6–4, 3–6, 6–1. It was Hantuchova's earliest loss at this tournament since her debut in 2001 and her earliest loss at a [[Grand Slam (tennis)|Grand Slam]] tournament since the [[2004 French Open]].
=== Symptoms ===
Aspirin overdose has potentially serious consequences, sometimes leading to significant [[morbidity]] and [[death]]. Patients with mild [[intoxication]] frequently have [[nausea]] and [[vomiting]], abdominal pain, lethargy, [[tinnitus]], and [[dizziness]]. More significant symptoms occur in more severe poisonings and include [[hyperthermia]], [[tachypnea]], [[respiratory alkalosis]], [[metabolic acidosis]], [[hyperkalemia]], [[hypoglycemia]], [[hallucinations]], [[Mental confusion|confusion]], [[seizure]], [[cerebral edema]], and [[coma]]. The most common cause of death following an aspirin overdose is cardiopulmonary arrest usually due to [[pulmonary edema]].<ref name="ActaAnaesthesiol1987-Thisted">{{cite journal | author=Thisted B, Krantz T, Stroom J, Sorensen MB. | title=Acute salicylate self-poisoning in 177 consecutive patients treated in ICU | journal=Acta Anaesthesiol Scand | year=1987 | pages=312–6 | volume=31 | issue=4 | pmid= 3591255}}</ref>


Hantuchová then played four consecutive tournaments. She reached her second final of the year at the Tier III [[Commonwealth Bank Tennis Classic]] in [[Bali]], losing to [[Lindsay Davenport]] in three sets. At the Tier III [[Sunfeast Open]] in [[Kolkata, India]], Hantuchova lost in the semifinals to [[Maria Kirilenko]] 4–6, 6–2, 6–1 but reentered the top 10. Traveling back to [[Europe]], Hantuchová played in the Tier II [[Fortis Championships Luxembourg]]. She defeated [[Patty Schnyder]] in the quarterfinals and Bartoli in the semifinals to advance to her third final of the year for the first time in her career. Hantuchová then lost to World No. 6 Ivanovic in the final 3–6, 6–4, 6–4 after leading the match 6–3, 3–0. At the [[Porsche Tennis Grand Prix]] in [[Stuttgart]], Hantuchová defeated Safarova in the first round but lost in the second round to Dementieva 6–4, 6–4. This loss, however, did not prevent Hantuchová from rising to World No. 9, her highest ranking in over four years.
=== Toxicity ===
The acutely [[toxic]] dose of aspirin is generally considered greater than 150&nbsp;mg per kg of body mass.<ref name="Chyka2007">{{cite journal |author=Chyka PA, Erdman AR, Christianson G, Wax PM, Booze LL, Manoguerra AS, Caravati EM, Nelson LS, Olson KR, Cobaugh DJ, Scharman EJ, Woolf AD, Troutman WG; Americal Association of Poison Control Centers; Healthcare Systems Bureau, Health Resources and Services Administration, Department of Health and Human Services. |title=Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management |journal=Clin Toxicol (Phila) |volume=45 |issue=2 |pages=95–131 |year=2007 |pmid=17364628 |doi=10.1080/15563650600907140 |url=}}</ref> Moderate toxicity occurs at doses up to 300&nbsp;mg/kg, severe toxicity occurs between 300 to 500&nbsp;mg/kg, and a potentially lethal dose is greater than 500&nbsp;mg/kg.<ref name="ArchInternMed1981-Temple">{{cite journal | author=Temple AR. | title=Acute and chronic effects of aspirin toxicity and their treatment | journal=Arch Intern Med | year=1981 | pages=364–9 | volume=141 | issue=3 Spec No | pmid= 7469627 | doi=10.1001/archinte.141.3.364}}</ref> This is the equivalent of many dozens of the common 325&nbsp;mg tablets, depending on body weight. Chronic toxicity may occur following doses of 100 mg/kg per day for two or more days.<ref name="ArchInternMed1981-Temple"/>


At the Tier I [[Zurich Open]], Hantuchova defeated [[Dinara Safina]] in the first round 7–6(2), 7–6(4) before losing to [[Agnieszka Radwańska]] 6–3, 6–3. One week later, Hantuchová won her third career title at the Tier II [[Generali Ladies Linz]]. In the semifinals, she defeated Vaidisova for the first time in her career 2–6, 6–2, 7–6(3). Hantuchová then defeated Schnyder in the straight-sets final. This title enabled Hantuchova to qualify for the year-ending [[WTA Tour Championships|Sony Ericcson Championships]] in [[Madrid]]. But Hantuchová did not advance past the round robin stage in [[2007 WTA Tour Championships|Madrid]]. She lost to [[Maria Sharapova]] 6–4, 7–5 and Ivanovic 6–2, 7–6(9) before beating Kuznetsova 7–6(7), 6–0 to finish third in her group.
=== Treatment ===
All overdose patients should be conveyed to a hospital for assessment immediately. Initial treatment of an acute overdose includes gastric decontamination. This is achieved by administering [[activated charcoal]], which [[adsorbs]] the aspirin in the [[gastrointestinal tract]]. [[gastric lavage|Stomach pumps]] are no longer routinely used in the treatment of poisonings but are sometimes considered if the patient has ingested a potentially lethal amount less than 1 hour previously.<ref name=”jtoxclintox2004-vale”>{{cite journal | author=Vale JA, Kulig K; American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. | title=Position paper: gastric lavage | journal=J Toxicol Clin Toxicol | year=2004 | pages=933–43 | volume=42 | issue=7 | pmid= 15641639 | doi=10.1081/CLT-200045006}}</ref> Inducing [[emesis]] with [[syrup of ipecac]] is not recommended.<ref name="Chyka2007"/> Repeated doses of charcoal have been proposed to be beneficial in aspirin overdose;<ref name="BMJ1985-hillman">{{cite journal | author=Hillman RJ, Prescott LF. | title=Treatment of salicylate poisoning with repeated oral charcoal | journal=Br Med J (Clin Res Ed) | year=1985 | pages=1472 | volume=291 | issue=6507 | pmid= 3933714}}</ref> although, one study found that repeat dose charcoal might not be of significant value.<ref name="ArchInternMed1990-Kirshenbaum">{{cite journal | author=Kirshenbaum LA, Mathews SC, Sitar DS, Tenenbein M. | title=Does multiple-dose charcoal therapy enhance salicylate excretion? | journal=Arch Intern Med | year=1990 | pages=1281–3 | volume=150 | issue=6 | pmid= 2191636 |id= | doi=10.1001/archinte.150.6.1281}}</ref> However, most clinical toxicologists will administer additional charcoal if serum salicylate levels are increasing.


Hantuchová's win-loss record for 2007 was 52-28. She was 6-11 versus top 10 players, with two victories against Hingis, two against Kuznetsova, one against Ivanovic, and one against Chakvetadze. The losses were to Clijsters, Mauresmo, Chakvetadze (twice), Kuznetsova (twice), Vaidišová, Serena Williams, Ivanović (twice), and Sharapova. Hantuchová finished the year at World No. 9, her first top-10 finish since 2002.
Patients are monitored until their peak salicylate blood level has been determined.<ref name="EmergMed2002-Dargan">{{cite journal | author=Dargan PI, Wallace CI, Jones AL. | title=An evidenced based flowchart to guide the management of acute salicylate (aspirin) overdose | journal=Emerg Med J | year=2002 | pages=206–9 | volume=19 | issue=3 | pmid= 11971828 |doi=10.1136/emj.19.3.206|pmc=1725844}}</ref> Blood levels are usually assessed four hours after ingestion and then every two hours after that to determine the maximum level. Maximum levels can be used as a guide to toxic effects expected.<ref name="drugs1986-Meredith">{{cite journal | author=Meredith TJ, Vale JA. | title=Non-narcotic analgesics. Problems of overdosage | journal=Drugs | year=1986 | pages=117–205 | volume=32 | issue=Suppl 4 | pmid= 3552583 | doi=10.2165/00003495-198600324-00013}}</ref>


===2008===
There is no antidote to salicylate poisoning. Monitoring of biochemical parameters such as electrolytes, liver and kidney function, [[urinalysis]], and [[complete blood count]] is undertaken along with frequent checking of [[salicylate]] and [[blood sugar]] levels. [[Arterial blood gas]] assessments are performed to test for [[alkalosis|respiratory alkalosis]] and [[metabolic acidosis]]. Patients are monitored and often treated according to their individual symptoms, patients may be given [[intravenous]] [[potassium chloride]] to counteract [[hypokalemia]], [[glucose]] to restore [[blood sugar]] levels, [[benzodiazepines]] for any seizure activity, fluids for [[dehydration]], and importantly [[sodium bicarbonate]] to restore the blood's sensitive [[pH]] balance. Sodium bicarbonate also has the effect of increasing the pH of urine, which in turn increases the elimination of salicylate. Additionally, [[hemodialysis]] can be implemented to enhance the removal of salicylate from the blood. Hemodialysis is usually used in severely poisoned patients; for example, patients with significantly high salicylate blood levels, significant neurotoxicity (agitation, coma, convulsions), renal failure, pulmonary edema, or cardiovascular instability are hemodialyzed.<ref name="EmergMed2002-Dargan"/> Hemodialysis also has the advantage of restoring [[electrolyte]] and [[acid-base]] abnormalities while removing salicylate;<ref name="EmergMed2002-Dargan"/> hemodialysis is often life-saving in severely ill patients.
[[Image:Hantuchova - Australian Open Tennis by **sasho.jpg|thumb|250px|left|Daniela Hantuchová]]
Hantuchová first started her 2008 campaign by entering the [[Medibank International]] as the sixth-seeded player. In her first round match Hantuchová faced Russian [[Dinara Safina]] in an epic three set match, which she won 5-7 6-4 6-4. As well as the media for the match Hantuchova received lots of media for wearing the [[Nike, Inc.|Nike]] Women's Maria Aussie Dress in the colour of "Tweed", which was deemed to be the signature [[Australian Open]] dress for [[Maria Sharapova]]; Sharapova eventually wore the dress in white in Melbourne. Hantuchová was then swept aside easily by twelfth-ranked Czech [[Nicole Vaidisova]] in the round of 16.


At the [[2008 Australian Open|Australian Open]], Hantuchová reached her first [[Grand Slam (tennis)|Grand Slam]] semifinal.<ref>[http://www.australianopen.com/en_AU/news/articles/2008-01-23/200801231201065332875.html Hantuchova praises mental strength]</ref> She won her first three matches without losing a set but was tested in the fourth round by [[Maria Kirilenko]] before Hantuchová won 1–6, 6–4, 6–4. Her quarterfinal match was against the [[Poland|Polish]] teenager [[Agnieszka Radwańska]], who had defeated second-seeded [[Svetlana Kuznetsova]] and [[Nadia Petrova]] in earlier rounds. Hantuchova defeated Radwanska 6–2, 6–2. Hantuchová then lost to [[Ana Ivanovic]] in a semifinal 0–6, 6–3, 6–4 despite Hantuchová leading the match 6–0, 2–0. She subsequently claimed that Ivanovic had been putting her off by squeaking her trainers on the court before serving, a claim Ivanovic disputes.<ref>[http://news.bbc.co.uk/sport1/hi/tennis/7206368.stm Hantuchova blasts Ivanovic tactic]</ref> Hantuchova then climbed from world number 9 to 8 in the [[WTA]] rankings.
=== Epidemiology ===
In the later part of the 20th century the number of salicylate poisonings has declined mainly due to the popularity of other over-the-counter analgesics such as [[paracetamol]] (acetaminophen). Fifty-two deaths involving single-ingredient aspirin were reported in the [[United States]] in 2000. However, in all but three cases, the reason for the ingestion of lethal doses was intentional, predominantly suicides.<ref name="AmJEmergMed2001-Litovitz">{{cite journal | author=Litovitz TL, Klein-Schwartz W, White S, Cobaugh DJ, Youniss J, Omslaer JC, Drab A, Benson BE | title=2000 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System | journal=Am J Emerg Med | year=2001 | pages=337–95 | volume=19 | issue=5 | pmid= 11555795 |doi=10.1053/ajem.2001.25272 }}</ref>


Hantuchová then played at the [[Open Gaz de France]] in [[Paris]]. As the second seed, she received a first round bye and reached quarterfinals by beating Slovenian [[Katarina Srebotnik]] in three sets 6-4 1-6 6-3. However, in the subsequent quarterfinal match, she was defeated by seventh seed [[Agnes Szavay]] of [[Hungary]] 7-6(4) 6-1 after being up a break in the first set at 4-2. She then went on to participate at the [[Proximus Diamond Games]] in [[Antwerp]], [[Belgium]] as the third seed, where again she reached the quarterfinals after beating [[wildcard]] Yanina Wickmayer of Belgium in an easy straight set victory 6-4 6-3. she then retired against [[Timea Bacsinszky]] after leveling the match at 2-6 6-4, but had a large blister on her right hand, which meant she had to retire in the fifth game of the third set at 1-4.
==See also==
{{portal|Pharmacy and Pharmacology|Tabletten.JPG}}


Hantuchová was then scheduled to play at the [[Qatar Total Open]], the first [[Tier I]] event of the year and a Tier II event, the [[Barclays Dubai Tennis Championships]], but withdrew due to fatigue.
*[[Aspergum]]

*[[Copper aspirinate]]
At the [[Tier I]] [[2008 Pacific Life Open|Pacific Life Open]] in [[Indian Wells, California]], Hantuchová was the defending champion and fifth seed. She lost to fourth-seeded [[Maria Sharapova]] in the quarterfinals 7–6(2), 6–1. In doubles, Hantuchová and [[Ai Sugiyama]] were the eighth seeds and lost in the semifinals to the eventual champions [[Dinara Safina]] and [[Elena Vesnina]].
*[[Non-steroidal anti-inflammatory drug]]

*[[History of aspirin]]
At the Tier I [[Sony Ericsson Open]] in [[Key Biscayne, Florida]], Hantuchová failed to reach the fourth round in this event for the ninth consecutive year. She lost to former doubles partner Sugiyama in the third round 6–4, 6–7(8), 7–5 despite leading 3-0 in the third set. In doubles, Hantuchová partnered with [[Lindsay Davenport]] to reach the quarterfinals where they lost to Sugiyama and [[Katarina Srebotnik]], who went on to win the event.
*[[Salicylic acid]]

The following week at the Tier II [[Bausch & Lomb Championships]] in [[Amelia Island, Florida]], Hantuchová was the third seed and received a bye in the first round but lost in the second round to [[Karolina Sprem]] 6–3, 1–6, 6–3.

Hantuchová spent the month of May recovering from a stress fracture in her right foot, which resulted in her withdrawal from the Tier I [[Internazionali BNL d'Italia]] in [[Rome]],<ref>[http://afp.google.com/article/ALeqM5iYHxV4j3hF2_IF3lD12oW5cGDoEg Sharapova, Hantuchová pull out of German Open]</ref> the Tier III [[Istanbul Cup]],<ref>[http://www.dhantuchova.com/news.php?id=579 Daniela withdraws from Istanbul]</ref> the [[French Open]],<ref>[http://www.iht.com/articles/ap/2008/05/23/sports/EU-SPT-TEN-French-Open-Withdrawals.php Sebastien Grosjean and Daniela Hantuchova withdraw from French Open with injuries]</ref> <ref>[http://www.dhantuchova.com/news.php?id=581 Daniela withdraws from the French Open]</ref> and the Tier III [[Ordina Open]] in [['s-Hertogenbosch]], [[The Netherlands]]. She recovered in time for [[Wimbledon 2008|Wimbledon]] but lost in the second round to unseeded [[Alisa Kleybanova]] 6–3, 4–6, 6–1.

At the [[Bank of the West Classic]] in [[Stanford, California]], Hantuchová lost in the second round to Sugiyama 6–3, 6–1. The following week at the [[East West Bank Classic]] in [[Los Angeles]], Hantuchova was the sixth seed but lost in the second round to [[Olga Govortsova]] of [[Belarus]] 6–2, 6–4.

Hantuchová competed in the 2008 Olympics in Beijing and was drawn against Ai Sugiyama, whom she won in straight sets, 6-2, 7-5. In round two she lost 6-1, 6-3 to [[Caroline Wozniacki]] of [[Denmark]].

She then participated in the [[2008 US Open]], where she was upset in the first-round by a resurgent [[Anna-Lena Groenefeld]]. She then competed in [[Bali]], where she lost in the semifinals to [[Tamira Paszek]], as well as competing in the [[Toray Pan Pacific Open]], where she lost in the first round to [[Francesca Schiavone]] in straight sets. Then next at the [[China Open]], she won her first round easily beat against [[Gisela Dulko]] 6-3, 6-1, then just beat [[Tamarine Tanasugarn]] in a strange three set match with the score 6-1, 0-6, 7-5, she then went on to meet top seed, [[Jelena Jankovic]] in the quarterfinals where she was beaten in straight sets, 7-5, 6-1, after serving for the first set at 5-4.

Seeded number eight at the Tennis.com [[Zürich Open]], Hantuchova lost to [[Maria Kirilenko]] 7-5 6-3.

Her next scheduled tounament is the [[Fortis Championships Luxembourg|Fortis Championships]], which means she will not be able to defend her title at the [[Generali Ladies Linz|Linz]].

==Records against other players==
===Record against top 10 players===

The following is Hantuchová's win-loss singles record against players included in the top 10 of the [[Women's Tennis Association]] rankings as of [[September 27]], [[2008]].

*[[Svetlana Kuznetsova]] 4-6
*[[Dinara Safina]] 3-2
*[[Elena Dementieva]] 3-9
*[[Anna Chakvetadze]] 2-3
*[[Jelena Janković]] 1-2
*[[Agnieszka Radwańska]] 1-1
*[[Ana Ivanović]] 1-3
*[[Serena Williams]] 1-6
*[[Maria Sharapova]] 1-7
*[[Venus Williams]] 0-9

===Record against other players (active and retired)===

The following is Hantuchova's win-loss singles record against other selected players according to the [[Women's Tennis Association]] as of [[June 9]], [[2008]].

*[[Patty Schnyder]] 9-8
*[[Jelena Dokic]] 3-1
*[[Marion Bartoli]] 3-1
*[[Martina Hingis]] 3-2
*[[Conchita Martinez]] 3-3
*[[Justine Henin]] 2-3
*[[Amelie Mauresmo]] 2-3
*[[Martina Navratilova]] 1-0
*[[Nadia Petrova]] 1-3
*[[Mary Pierce]] 0-1
*[[Monica Seles]] 0-1
*[[Jennifer Capriati]] 0-2
*[[Anastasia Myskina]] 0-2
*[[Lindsay Davenport]] 0-7
*[[Kim Clijsters]] 0-9
*[[Caroline Wozniacki]] 0-1

==Endorsements==
===Product endorsement and equipment===
Hantuchova endorses [[Nike, Inc.|Nike]] sportswear and has her own line with them for her tournament wear, such as [[Maria Sharapova]] and [[Serena Williams]].

Hantuchova also has had endorsement by three racquet makers. She was first endorsed by [[Babolat]] from being a junior until late 2003, then [[Yonex]] until the 2007 Toray Pan Pacific Open in [[Tokyo]] when she then used the [[Prince Sports|Prince]] Ozone Seven Racquets from the 2007 [[Barclays Dubai Tennis Championships]].

===Video games===
Hantuchova has been in many sports/tennis related video games with such players as [[Maria Sharapova]], [[Lindsay Davenport]], [[Venus Williams]] and [[Anna Kournikova]]. Some of the titles are [[Top Spin]] (both [[Xbox]] and [[Play Station 2]] versions), [[Smash Court Tennis Pro Tournament 2]] and [[Virtua Tennis 3]]. Hantuchova is currently ranked third behind Serena Williams and [[Ana Ivanovic]] in a poll for new downloadable players for [[Top Spin 3]].

==Grand Slam mixed doubles finals (5)==
===Wins (4)===
{|
|-
|width="75"|'''Year
|width="175"|'''Championship
|width="175"|'''Partner
|width="175"|'''Opponent in Final
|width="100"|'''Score in Final
|-bgcolor="#CCFFCC"
| 2001 ||[[The Championships, Wimbledon|Wimbledon]] || {{flagicon|CZE}} [[Leos Friedl]] ||{{flagicon|USA}} [[Mike Bryan]]<br> {{flagicon|RSA}} [[Liezel Huber]] || 4–6 6–3 6–2
|-bgcolor="#CCCCFF"
| 2002 ||[[Australian Open]] ||{{flagicon|ZIM}} [[Kevin Ullyett]]||{{flagicon|ARG}} [[Gastón Etlis]]<br>{{flagicon|ARG}} [[Paola Suarez]]||6–3 6–2
|-bgcolor="#EBC2AF"
| 2005 ||[[French Open]] ||{{flagicon|FRA}} [[Fabrice Santoro]]||{{flagicon|IND}} [[Leander Paes]] <br> {{flagicon|USA}} [[Martina Navratilova]]||3–6 6–3 6–2
|-bgcolor="#FFFFCC"
| 2005 ||[[U.S. Open (tennis)|US Open]]||{{flagicon|IND}} [[Mahesh Bhupathi]] ||{{flagicon|SCG}} [[Nenad Zimonjic]] <br> {{flagicon|Slovenia}} [[Katarina Srebotnik]]||6–4 6–2
|}

===Runner-up (1)===
{|
|-
|width="75"|'''Year
|width="175"|'''Championship
|width="175"|'''Partner
|width="175"|'''Opponent in Final
|width="100"|'''Score in Final
|-bgcolor="#CCFFCC"
| 2002 ||[[The Championships, Wimbledon|Wimbledon]] || {{flagicon|ZIM}} [[Kevin Ullyett]] ||{{flagicon|RUS}} [[Elena Likhovtseva]]<br>{{flagicon|IND}} [[Mahesh Bhupathi]] || 2–6 6–1 1–6
|}

==Grand Slam doubles finals (2)==
===Runner-up (2)===
{|
|-
|width="75"|'''Year
|width="175"|'''Championship
|width="175"|'''Partner
|width="175"|'''Opponent in Final
|width="100"|'''Score in Final
|-bgcolor="#CCCCFF"
| 2002 ||[[Australian Open]] ||{{flagicon|ESP}} [[Arantxa Sanchez Vicario]]||{{flagicon|RUS}} [[Anna Kournikova]]<br>{{flagicon|SUI}} [[Martina Hingis]] || 6–2, 6–7, 6–1
|-bgcolor="#EBC2AF"
| 2006 ||[[French Open]] ||{{flagicon|JPN}} [[Ai Sugiyama]]||{{flagicon|USA}} [[Lisa Raymond]]<br>{{flagicon|AUS}} [[Samantha Stosur]] || 6–3, 6–2
|}

==WTA tour finals==
===Singles wins (3)===

{| width=68%
| valign=top width=33% align=left |
{| class="wikitable"
|- bgcolor="#eeeeee"
|'''Legend'''
|- bgcolor="#FFFF99"
| Grand Slam (0)
|- bgcolor="#FF6666"
| WTA Championships (0)
|- bgcolor="#ffcccc"
| Tier I (2)
|- bgcolor="#ccccff"
| Tier II (1)
|- bgcolor="#CCFFCC"
| Tier III (0)
|- bgcolor="#66CCFF"
| Tier IV (0)
|}
| valign=top width=33% align=left |
{| class="wikitable"
|- bgcolor="#eeeeee"
|'''Titles by Surface'''
|-
| Hard (3)
|-
| Grass (0)
|-
| Clay (0)
|-
| Carpet (0)
|}
|}

{| class="sortable wikitable"
|- bgcolor="#eeeeee"
|'''No.'''
|'''Date'''
|'''Tournament'''
|'''Surface'''
|'''Opponent in Final'''
|'''Score in Final'''
|- bgcolor="#ffcccc"
| 1.
| [[16 March]], [[2002]]
| [[Pacific Life Open]], [[Indian Wells, California]], [[U.S.]]
| Hard
| {{flagicon|SUI}} [[Martina Hingis]]
| 6–3, 6–4
|- bgcolor="#ffcccc"
| 2.
| [[17 March]], [[2007]]
| Pacific Life Open, Indian Wells, California, U.S.
| Hard
| {{flagicon|RUS}} [[Svetlana Kuznetsova]]
| 6–3, 6–4
|- bgcolor="#ccccff"
| 3.
| [[28 October]], [[2007]]
| [[Generali Ladies Linz]], [[Linz]], [[Austria]]
| Hard (i)
|{{flagicon|SUI}} [[Patty Schnyder]]
| 6–4, 6–2
|- bgcolor="#ccccff"
|}

===Singles runner-ups (6)===

{| class="sortable wikitable"
|- bgcolor="#eeeeee"
|'''No.'''
|'''Date'''
|'''Tournament'''
|'''Surface'''
|'''Opponent in Final'''
|'''Score in Final'''
|- bgcolor="#ccccff"
| 1.
| [[13 October]], [[2002]]
| [[Porsche Tennis Grand Prix]], [[Filderstadt]], [[Germany]]
| Hard (i)
| {{flagicon|BEL}} [[Kim Clijsters]]
| 4–6, 6–3, 6–4
|- bgcolor="#ccccff"
| 2.
| [[19 June]], [[2004]]
| [[The Hastings Direct International Championships]], [[Eastbourne]], [[United Kingdom]]
| Grass
| {{flagicon|RUS}} [[Svetlana Kuznetsova]]
| 2–6, 7–6(2), 6–4
|- bgcolor="#ccccff"
| 3.
| [[14 August]], [[2005]]
| [[JPMorgan Chase Open]], [[Los Angeles]]
| Hard
| {{flagicon|BEL}} Kim Clijsters
| 6–4, 6–1
|- bgcolor="#ffcccc"
| 4.
| [[22 October]], [[2006]]
| [[Zürich Open]], [[Zürich, Switzerland]]
| Hard (i)
| {{flagicon|RUS}} [[Maria Sharapova]]
| 6–1, 4–6, 6–3
|- bgcolor="#CCFFCC"
| 5.
| [[16 September]], [[2007]]
| [[Commonwealth Bank Tennis Classic]], [[Bali, Indonesia]]
| Hard
| {{flagicon|USA}} [[Lindsay Davenport]]
| 6–4, 3–6, 6–2
|- bgcolor="#ccccff"
| 6.
| [[30 September]], [[2007]]
| [[Fortis Championships Luxembourg]], [[Luxembourg City]], [[Luxembourg]]
| Hard (i)
| {{flagicon|SRB}} [[Ana Ivanovic]]
| 3–6, 6–4, 6–4
|}

===Doubles wins (8) ===

{| width=68%
| valign=top width=33% align=left |
{| class="wikitable"
|- bgcolor="#eeeeee"
|'''Legend'''
|- bgcolor="#FFFF99"
| Grand Slam (0)
|- bgcolor="#FF6666"
| WTA Championships (0)
|- bgcolor="#ffcccc"
| Tier I (1)
|- bgcolor="#ccccff"
| Tier II (5)
|- bgcolor="#CCFFCC"
| Tier III (2)
|- bgcolor="#66CCFF"
| Tier IV (0)
|}
| valign=top width=33% align=left |
{| class="wikitable"
|- bgcolor="#eeeeee"
|'''Titles by Surface'''
|-
| Hard (5)
|-
| Grass (1)
|-
| Clay (2)
|-
| Carpet (0)
|}
|}

{| class="sortable wikitable"
|- bgcolor="#eeeeee"
|'''No.'''
|'''Date'''
|'''Tournament'''
|'''Surface'''
|'''Partner'''
|'''Opponents in Final'''
|'''Score in Final'''
|- bgcolor="#CCFFCC"
| 1.
| [[October 29]] [[2000]]
| [[WTA Bratislava]], [[Bratislava]], [[Slovak Republic]]
| Hard (i)
| {{flagicon|SVK}} [[Karina Habsudova]]
| {{flagicon|HUN}} [[Petra Mandula]]<br> {{flagicon|Austria}} [[Patricia Wartusch]]
| w/o
|-bgcolor="#ccccff"
| 2.
| [[October 28]] [[2001]]
| [[Fortis Championships Luxembourg]], [[Luxembourg]], [[Luxembourg]]
| Hard (i)
| {{flagicon|RUS}} [[Elena Bovina]]
| {{flagicon|GER}} [[Bianka Lamade]]<br>{{flagicon|SUI}} [[Patty Schnyder]]
| 6–3, 6–3
|-bgcolor="#ccccff"
| 3.
| [[April 14]] [[2002]]
| [[Bausch & Lomb Championships]], [[Amelia Island, Florida]], [[U.S.]]
| Clay
| {{flagicon|ESP}} [[Arantxa Sanchez Vicario]]
| {{flagicon|ARG}} [[Maria Emilia Salerni]] <br> {{flagicon|SWE}} [[Åsa Svensson]]
| 6–4, 6–2
|-bgcolor="#ccccff"
| 4.
| [[August 24]] [[2002]]
| [[Pilot Pen Tennis]], [[New Haven, Connecticut]], U.S.
| Hard
| {{flagicon|ESP}} Arantxa Sanchez Vicario
| {{flagicon|ITA}} [[Tathiana Garbin]] <br>{{flagicon|SVK}} [[Janette Husarova]]
| 6–3, 1–6, 7–5
|-bgcolor="#CCFFCC"
| 5.
| [[June 12]] [[2005]]
| [[DFS Classic]], [[Birmingham]], [[United Kingdom]]
| Grass
| {{flagicon|JPN}} [[Ai Sugiyama]]
| {{flagicon|GRE}} [[Eleni Daniilidou]]<br> {{flagicon|USA}} [[Jennifer Russell]]
| 6–2, 6–3
|-bgcolor="#ccccff"
| 6.
| [[October 9]] [[2005]]
| [[Porsche Tennis Grand Prix]], [[Filderstadt]], [[Germany]]
| Hard (i)
| {{flagicon|RUS}} [[Anastasia Myskina]]
| {{flagicon|CZE}} [[Květa Peschke]]<br>{{flagicon|ITA}} [[Francesca Schiavone]]
| 6–0, 3–6, 7–5
|-bgcolor="#ccccff"
| 7.
| [[March 4]] [[2006]]
| [[Qatar Total Open]], [[Doha]]
| Hard
| {{flagicon|JPN}} Ai Sugiyama
| {{flagicon|CHN}} [[Li Ting (tennis)|Ting Li]]<br>{{flagicon|CHN}} [[Tian Tian Sun]]
| 6–4, 6–4
|- bgcolor="#ffcccc"
| 8.
| [[May 21]] [[2006]]
| [[Internazionali BNL d'Italia]], [[Rome]]
| Clay
| {{flagicon|JPN}} Ai Sugiyama
| {{flagicon|CZE}} Květa Peschke<br>{{flagicon|ITA}} Francesca Schiavone
| 3–6, 6–3, 6–1
|}

==ITF titles (4)==
===Singles (3)===

{| class="wikitable"
|- bgcolor="#eeeeee"
|'''No.'''
|'''Date'''
|'''Tournament'''
|'''Surface'''
|'''Opponent in the final'''
|'''Score'''
|-
| 1.
| [[May 23]] [[1999]]
| [[Jackson, Mississippi|Jackson]], [[United States|U.S.]]
| Clay
| {{flagicon|VEN}} [[Milagros Sequera]]
| 6–2, 6–1
|-
| 2.
| [[September 12]] [[1999]]
| [[Fano]], [[Italy]]
| Clay
| {{flagicon|ITA}} [[Flora Perfetti]]
| 6–4, 6–7, 6–2
|-
| 3.
| [[August 20]] [[2000]]
| [[Bronx]], [[United States|U.S.]]
| Hard
| {{flagicon|CHN}} [[Jing-Qian Yi]]
| 6–4, 6–4
|}

===Doubles (1)===

{| class="wikitable"
|- bgcolor="#eeeeee"
|'''No.'''
|'''Date'''
|'''Tournament'''
|'''Surface'''
|'''Partner'''
|'''Opponent in the final'''
|'''Score'''
|-
| 1.
| [[July 11]] [[1999]]
| [[Civitanova]], [[Italy]]
| Clay
| {{flagicon|DEN}} [[Eva Dyrberg]]
| {{flagicon|ESP}} [[Rosa Maria Andres Rodriguez]]<br>{{flagicon|ESP}} [[Conchita Martinez Granados]]
| 7–6, 4–6, 6–3
|}

==Singles performance timeline==
{{Performance timeline legend}}
''To prevent confusion and double counting, information in this table is updated only once a tournament or the player's participation in the tournament has concluded. This table is current through [[The Championships, Wimbledon|Wimbledon]] in [[London]], which ended on [[July 6]], [[2008]].''
{| class="wikitable"
|- bgcolor="#efefef"
! Tournament !! 1998 !! 1999 !! 2000 !! 2001 !! 2002 !! 2003 !! 2004 !! 2005 !! 2006 !! 2007 !! 2008 !! Career SR !! Career W/L
|-
| colspan="14" | '''Grand Slam Tournaments'''
|-
|style="background:#EFEFEF;"|[[Australian Open]]
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|LQ<sup>1</sup>
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:yellow;"|SF
|align="center" style="background:#EFEFEF;"|'''0 / 9'''
|align="center" style="background:#EFEFEF;"|21-9
|-
|style="background:#EFEFEF;"|[[French Open (tennis)|French Open]]
|align="center"|A
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|3R
|align="center"|A
|align="center" style="background:#EFEFEF;"|'''0 / 7'''
|align="center" style="background:#EFEFEF;"|12-7
|-
|style="background:#EFEFEF;"|[[The Championships, Wimbledon|Wimbledon]]
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|LQ<sup>1</sup>
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R<sup>2</sup>
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#EFEFEF;"|'''0 / 9'''
|align="center" style="background:#EFEFEF;"|17-9
|-
|style="background:#EFEFEF;"|[[U.S. Open (tennis)|U.S. Open]]
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|LQ<sup>1</sup>
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#EFEFEF;"|'''0 / 9'''
|align="center" style="background:#EFEFEF;"|12-9
|-
|style="background:#EFEFEF;"|Grand Slam SR
|align="center" style="background:#EFEFEF;"|0 / 0
|align="center" style="background:#EFEFEF;"|0 / 0
|align="center" style="background:#EFEFEF;"|0 / 3
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 4
|align="center" style="background:#EFEFEF;"|0 / 3
|align="center" style="background:#EFEFEF;"|0 / 34
|align="center" style="background:#EFEFEF;"|N/A
|- bgcolor="#efefef"
|Grand Slam Win-Loss
|align="center"|0–0
|align="center"|0–0
|align="center"|3–3
|align="center"|2–4
|align="center"|13-4
|align="center"|8–4
|align="center"|4–4
|align="center"|8–4
|align="center"|10-4
|align="center"|8–4
|align="center"|6–3
|align="center"|N/A
|align="center"|62-34
|-
| colspan="14" | '''Year-End Championship'''
|-
|style="background:#EFEFEF;"|[[WTA Tour Championships]]
|align="center"|A
|align="center"|A
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|1R
|align="center"|A
|align="center"|A
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|RR
|align="center"|
|align="center" style="background:#EFEFEF;"|'''0 / 2'''
|align="center" style="background:#EFEFEF;"|1–3
|-
| colspan="14" | '''Olympic Games'''
|-
|style="background:#EFEFEF;"|[[Tennis at the Summer Olympics|Summer Olympics]]
|align="center"|NH
|align="center"|NH
|align="center"|A
|align="center"|NH
|align="center"|NH
|align="center"|NH
|align="center" style="background:#afeeee;"|2R
|align="center"|NH
|align="center"|NH
|align="center"|NH
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#EFEFEF;"|'''0 / 1
|align="center" style="background:#EFEFEF;"|1–1
|-
| colspan="14" | '''Current WTA Tier I Tournaments'''<sup>3</sup>
|-
|style="background:#EFEFEF;"|[[Qatar Total Open|Doha]]<sup>4</sup>
|align="center" colspan="10" style="color:#cccccc;"| Not Tier I or Was Not Held
|align="center"|A
|align="center" style="background:#EFEFEF;"|'''0 / 0'''
|align="center" style="background:#EFEFEF;"|0–0
|-
|style="background:#EFEFEF;"|[[Indian Wells Masters|Indian Wells]]
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" style="background:#afeeee;"|1R<sup>5</sup>
|align="center" style="background:#00ff00;"|'''W'''
|align="center" style="background:#afeeee;"|4R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R
|align="center" |A
|align="center" style="background:#00ff00;"|'''W'''
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#EFEFEF;"|'''2 / 7'''
|align="center" style="background:#EFEFEF;"|20-5
|-
|style="background:#EFEFEF;"|[[Miami Masters|Miami]]
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#EFEFEF;"|'''0 / 9'''
|align="center" style="background:#EFEFEF;"|4–9
|-
|style="background:#EFEFEF;"|[[Family Circle Cup|Charleston]]
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" |A
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#ffebcd;"|QF
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" style="background:#EFEFEF;"|'''0 / 2'''
|align="center" style="background:#EFEFEF;"|3–2
|-
|style="background:#EFEFEF;"|[[Qatar Telecom German Open|Berlin]]
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" style="background:#afeeee;"|LQ<sup>1</sup>
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|1R
|align="center" |A
|align="center" style="background:#EFEFEF;"|'''0 / 7'''
|align="center" style="background:#EFEFEF;"|7–7
|-
|style="background:#EFEFEF;"|[[Rome Masters|Rome]]
|align="center"|A
|align="center"|A
|align="center"|A
|align="center" style="background:#afeeee;"|3R<sup>5</sup>
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:yellow;"|SF
|align="center"|A
|align="center" style="background:#EFEFEF;"|'''0 / 7'''
|align="center" style="background:#EFEFEF;"|9–7
|-
|style="background:#EFEFEF;"|[[Canada Masters|Montreal/Toronto]]
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:yellow;"|SF
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|3R
|align="center" |A
|align="center" |A
|align="center" style="background:#EFEFEF;"|'''0 / 6'''
|align="center" style="background:#EFEFEF;"|8–6
|-
|style="background:#EFEFEF;"|[[Toray Pan Pacific Open|Tokyo]]
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#EFEFEF;"|'''0 / 5'''
|align="center" style="background:#EFEFEF;"|5–5
|-
|style="background:#EFEFEF;"|[[Kremlin Cup|Moscow]]
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" style="background:#afeeee;"|1R
|align="center" |A
|align="center" |A
|align="center" |A
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#EFEFEF;"|'''0 / 1'''
|align="center" style="background:#EFEFEF;"|0–1
|-
| colspan="14" | '''Former WTA Tier I Tournaments'''<sup>3</sup>
|-
|style="background:#EFEFEF;"|[[Zurich Open|Zurich]]<sup>4</sup>
|align="center"|A
|align="center"|A
|align="center" |A
|align="center" style="background:#ffebcd;"|QF<sup>6</sup>
|align="center" style="background:#ffebcd;"|QF
|align="center" style="background:#afeeee;"|1R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#D8BFD8;"|F
|align="center" style="background:#afeeee;"|2R
|align="center" |-
|align="center" style="background:#EFEFEF;"|'''0 / 7'''
|align="center" style="background:#EFEFEF;"|13-7
|-
|style="background:#EFEFEF;"|[[Acura Classic|San Diego]]<sup>4</sup>
|align="center" colspan="6" style="color:#cccccc;"| Not Tier I or Was Not Held
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|2R
|align="center" style="background:#afeeee;"|3R
|align="center" style="background:#afeeee;"|3R
|align="center" |-
|align="center" style="background:#EFEFEF;"|'''0 / 4'''
|align="center" style="background:#EFEFEF;"|5–4
|-
| colspan="14" | '''Career Statistics'''
|- bgcolor="#efefef"
|Runner-up
|align="center"|0
|align="center"|1
|align="center"|0
|align="center"|0
|align="center"|1
|align="center"|0
|align="center"|1
|align="center"|1
|align="center"|1
|align="center"|2
|align="center"|0
|align="center"|N/A
|align="center"|7
|- bgcolor="#efefef"
|'''Tournaments Won'''
|align="center"|'''0'''
|align="center"|'''1'''
|align="center"|'''1'''
|align="center"|'''0'''
|align="center"|'''1'''
|align="center"|'''0'''
|align="center"|'''0'''
|align="center"|'''0'''
|align="center"|'''0'''
|align="center"|'''2'''
|align="center"|'''0'''
|align="center"|'''N/A
|align="center"|'''5'''
|- bgcolor="#efefef"
|Overall Win-Loss
|align="center"|3–1
|align="center"|21-5
|align="center"|27-16
|align="center"|38-20
|align="center"|56-25
|align="center"|28-23
|align="center"|24-24
|align="center"|37-25
|align="center"|34-25
|align="center"|52-28
|align="center"|13-7
|align="center"|N/A
|align="center"|333-199<sup>7</sup>
|- bgcolor="#efefef"
|Year End Ranking
|align="center" |None
|align="center" |197
|align="center" |108
|align="center" |38
|align="center" style="background:#EEE8AA;"|8
|align="center" |19
|align="center" |31
|align="center" |19
|align="center" |18
|align="center" style="background:#EEE8AA;"|9
|align="center" |
|align="center"|N/A
|align="center"|N/A
|}

*- = tournament either not held or was not a [[Tier I]] event when it was held.

*SR = the ratio of the number of singles tournaments won to the number of those tournaments played.

*<sup>1</sup> She lost in the second round of the qualifying tournament.

* <sup>2</sup> Her second round match was a walkover in her favor, which does not count as a win on her official record.

* <sup>3</sup> This table includes tournaments that were classified on the WTA Tour as Tier I at the time they were held, regardless of whether those tournaments are still being held or are still classified as Tier I.

* <sup>4</sup> [[Qatar Total Open|Doha]] became a Tier I event in 2008, replacing [[Acura Classic|San Diego]] and [[Zurich Open|Zurich]].

* <sup>5</sup> Won two qualifying matches to reach the main draw.

* <sup>6</sup> Won three qualifying matches to reach the main draw.

* <sup>7</sup> Her win-loss record includes all matches listed on the [http://www.sonyericssonwtatour.com WTA website], including challenger and [http://www.fedcup.com/teams/player.asp?player=20011505 Fed Cup] matches.

== Notable matches ==

'''2002 [[Pacific Life Open]] final:''' defeated heavily-favored former champion and world number 4 [[Martina Hingis]] in straight sets, with the score 6-3 6-4. This was Hantuchova's first career title and first title at the Pacific Life Open.

'''2002 [[Fed Cup]] final:''' defeated Spanish former Wimbledon champion [[Conchita Martinez]] 6-7 7-5 6-4 in the first singles rubber and a 6-2 6-1 victory over Magui Serna, which was the match that gave Slovakia it's one and only Fed Cup title.

'''2003 [[Wimbledon Championships]] second round:''' defeated by [[Shinobu Asagoe]] 0–6 6–4 12-10, with Hantuchova leading comfortably in the first set and leading in the second, only to be broken and lose the set. Again, after leading Hantuchova started to lose while breaking down crying during the latter stages of the match in the midst of making 57 unforced errors. This was seen to be the start of Hantuchova's fall from the top of women's tennis.

'''2004 [[International Women's Open]] final:''' defeated by [[Svetlana Kuznetsova]] 2-6 7-6 6-4 after serving for the match at 6-2 6-5 and having a match point at 40-30 and following on to lose the set and eventually the match. Hantuchova also reached the final by recording a 4-6 6-4 6-4 win over top-seed [[Amelie Mauresmo]] in the semi-final.

'''2006 [[Zurich Open]] final:''' defeated by [[Maria Sharapova]] in three entertaining sets 6-1 4-6 6-3. This was Hantuchova's fifth career final and first three set match with Sharapova. Many went on to say that was Hantuchova's start of her comeback.

'''2007 [[Pacific Life Open]] final:''' defeated world number 4 Svetlana Kuznetsova in straight sets, with the score 6-3 6-4 again. This was Hantuchova's second career title and second title at the Pacific Life Open.

'''2007 [[Wimbledon Championships]] fourth round:''' defeated by [[Serena Williams]] 6-2 6-7 6-2, a match which was seen as a controversial match, when after being broken by Williams when serving for the second set at 2-6 5-3, Williams cramped in her left calf after losing a point and needed a medical time-out. After waiting to resume play Hantuchova gave Williams sympathy. Play resumed and Hantuchova took the set in a tiebreak 7-6(2), and went on to lose the match with a third set score of 6-2. After the match Williams was criticised by many thst the cramp was merely a tactic and gamesmanship against Hantuchova.

'''2007 [[Generali Ladies Linz]] final:''' defeated [[Patty Schnyder]] to take her third career title and second of the year. Winning this match also secured her place in the [[Sony Ericsson Championships]]. She won it 6-4 6-2.

'''2008 [[Australian Open]] semi-final:''' defeated by [[Ana Ivanovic]] in three sets 0-6 6-3 6-4 after leading 6-0 2-0. This was seen as a controversial match, where Ivanovic was heard to be squeaking her trainers on the court before Hantuchova's serve, a claim Ivanovic disputes.

==Achievements==
===Team achievements===
*2000 Eurotel Doubles Champion
*2002 [[Fed Cup]] Champion (Slovakia)
*2004 [[Hopman Cup]] Finalist (with [[Karol Kučera]])
*2004 Athens Olympic Games
*2005 Hopman Cup Champion (with [[Dominik Hrbatý]])

===Special achievements===
*2001 [[WTA Awards|WTA Newcomer of the Year]] Award
*2002 [[WTA Awards|WTA Most Improved Player of the Year]] Award
*2003 [[Laureus]] World Sports Academy Award nominee for World Newcomer of the Year Award

== See also ==
* [[Slovakia Fed Cup team]]


== References ==
== References ==
{{reflist|2}}
{{reflist|2}}


==External links==
== External links ==
{{commons|Aspirin}}
{{commons|Daniela Hantuchova}}
* [http://dhantuchova.com Daniela Hantuchova official web site]
*[http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD00264 DrugBank Aspirin Entry]
* {{wta|id=80394|name=Daniela Hantuchova}}
*[http://www.nextbio.com/b/home/home.nb?q=aspirin NextBio Aspirin Entry]
*[http://bmj.bmjjournals.com/cgi/content/full/321/7276/1591 Reappraisal]
*[http://almaz.com/nobel/medicine/aspirin.html An aspirin a day keeps the doctor away]
*[http://www.wellcome.ac.uk/en/bia/gallery.html?image=24 Colour-enhanced scanning electron micrograph of aspirin crystals]
* [http://chemed.chem.purdue.edu/genchem/topicreview/bp/1biochem/research7.html Aspirin research in the 1990s]
*[http://www.med.mcgill.ca/mjm/issues/v02n02/aspirin.html The History of Aspirin]
*[http://www.jhu.edu/~jhumag/0297web/health.html Aspirin and heart disease]
*[http://www.howstuffworks.com/aspirin How Aspirin works]
*[http://www.bluerhinos.co.uk/molview/indv.php?id=5 Molview from bluerhinos.co.uk] See Aspirin in 3D
*[http://biotechnology-innovation.com.au/innovations/pharmaceuticals/aspro.html History of Aspro]
*[http://www.creatingtechnology.org/biomed/aspirin.htm The science behind aspirin]
* [http://pubs.acs.org/subscribe/journals/mdd/v03/i08/html/10health.html Take two: Aspirin], New uses and new dangers are still being discovered as aspirin enters its second century. Shauna Roberts, American Chemical Society
* {{cite encyclopedia | last = Ling | first = Greg | title = Aspirin | encyclopedia = How Products are Made | volume = 1 | pages = | publisher = Thomson Gale | location = | year = 2005 | isbn = | url = http://www.madehow.com/Volume-1/Aspirin.html}}
*[http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE5258 A Gene Expression Omnibus entry of a genome-wide transcriptional expression data for bioactive small molecules (Aspirin among them)]


{{start box}}
<br>
{{Antithrombotics}}
{{s-ach|aw}}
{{succession box |
{{Anti-inflammatory and antirheumatic products}}
| before = [[Daja Bedanova]]|
{{NSAIDs}}
| after = [[Svetlana Kuznetsova]]|
{{analgesics}}
| title = [[WTA Awards|WTA Newcomer of the Year]]|
| years = 2001}}
{{succession box |
| before = [[Justine Henin-Hardenne]]|
| after = [[Nadia Petrova]]|
| title = [[WTA Awards|WTA Most Improved Player of the Year]]|
| years = 2002}}
{{end box}}


<!-- Metadata: see [[Wikipedia:Persondata]] -->
[[Category:Aspirin|*]]

[[Category:Non-steroidal anti-inflammatory drugs]]
{{Persondata
[[Category:Antiplatelet drugs]]
|NAME = Hantuchova, Daniela
[[Category:Acetates]]
|ALTERNATIVE NAMES =
[[Category:Benzoic acids]]
|SHORT DESCRIPTION = Professional [[tennis]] player
[[Category:Bayer brands]]
|DATE OF BIRTH = [[23 April]] [[1983]]
[[Category:Equine medications]]
|PLACE OF BIRTH = [[Poprad]], [[Slovakia]], (then [[Czechoslovak Socialist Republic|CSSR]])
|DATE OF DEATH =
|PLACE OF DEATH =
}}
{{DEFAULTSORT:Hantuchova, Daniela}}
[[Category:1983 births]]
[[Category:Living people]]
[[Category:Slovak tennis players]]
[[Category:Olympic tennis players of Slovakia]]
[[Category:Tennis players at the 2004 Summer Olympics]]
[[Category:Tennis players at the 2008 Summer Olympics]]
[[Category:Australian Open champions]]
[[Category:French Open champions]]
[[Category:Wimbledon champions]]
[[Category:US Open champions]]


{{Link FA|he}}
{{Link FA|simple}}
{{Link FA|nl}}


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Revision as of 18:50, 13 October 2008

Daniela Hantuchová
Hantuchová at the 2007 Bank of the West Classic
Country (sports) Slovakia
ResidenceMonte Carlo, Monaco
Height1.81 m (5 ft 11+12 in)
Turned proMay 1999
PlaysRight; Two-handed backhand
Prize money$5,883,537
Singles
Career record339–208
Career titles3 WTA, 3 ITF
Highest rankingNo. 5 (January 27, 2003)
Grand Slam singles results
Australian OpenSF (2008)
French Open4R (2002, 2006)
WimbledonQF (2002)
US OpenQF (2002)
Doubles
Career record188–131
Career titles8 WTA, 1 ITF
Highest rankingNo. 5 (August 26, 2002)
Last updated on: September 29, 2008.

Daniela Hantuchová (IPA: [ˈdanɪjɛla ˈɦantuxɔvaː], roughly HAHN-too-koh-vah; born April 23, 1983 in Poprad, Czechoslovakia, now Slovakia) is a Slovak professional tennis player.

She is currently working with a number of coaches who work out of the Sanchez-Casal Academy, primarily Angel Gimenez and occasionally with Eduardo Nicolas. Her WTA Tour mentor in the "Partners for Success" program was Martina Navratilova, who was her doubles partner for a brief period in early 2005. As of August 4, 2008, Hantuchova is ranked World No. 13 in singles.[2]

Personal life

Hantuchová's tour debut and early results were auspicious. Her performance temporarily crumbled, as a result of her parents splitting up in 2003.[3] For example, despite being seeded ninth at Wimbledon that year, she lost to the 81st ranked player in the world, failing to convert match points and weeping on court. She lost weight and was suspected to be anorexic then.[3]

Hantuchová speaks six languages and was trained as a classical pianist.[3] She is thought to be a perfectionist and places a lot of pressure on herself during her training.[3] She qualified for university in Slovakia but deferred it to pursue tennis.[citation needed] Her comeback among the world's best was in March 2007 when she won the 2007 Tier I Pacific Life Open in Indian Wells for the second time.[3]

Career

Overall

Hantuchová has won three WTA singles tournaments in her career, the first in 2002 at the Tier I Pacific Life Open, defeating Martina Hingis 6–3 6–4 in the final, and in 2007 at the same tournament, defeating Hingis again in the fourth round and Svetlana Kuznetsova in the final 6–3 6–4 ending a 5-year title drought. Her most recent title came at the Generali Ladies Linz in Austria, where she defeated Patty Schnyder 6–4, 6–2 in the final.

She has reached six other finals in her career — Filderstadt 2002 losing to Kim Clijsters, Eastbourne 2004 losing to Svetlana Kuznetsova, Los Angeles 2005 where she lost to Clijsters again, the 2006 Zurich Open losing to Maria Sharapova, in Bali 2007 losing to Lindsay Davenport and Luxembourg 2007 to Ana Ivanovic.

She has also achieved reasonable results in the Grand Slam events. Her most notable career-bests are three quarterfinals at Wimbledon, US Open in 2002 and the Australian Open in 2003. Also earlier this year she scored a semi-final at the Australian Open defeating Maria Kirirlenko and Agnieszka Radwańska before losing to Ana Ivanović of Serbia. This was seen as a controversial match, where Ivanović was heard to be squeaking her trainers on the court before Hantuchová's serve, a claim Ivanović disputes. The score ended as 0-6 6-3 6-4 - after Hantuchová won the first eight games at 6-0 2-0.

Playing style

Hantuchová's game is built around natural timing. She is able to produce "effortless" power from her flowing groundstrokes and possesses a superb down-the-line forehand and backhand. She possesses a heavy serve and has a particularly effective "kick" second serve. Her favourite and most effective construction of a winning point is her flat serve out wide on the Ad-court, followed by a backhand winner down the line. Her volleys are very well-produced and often have the deftest of touch. Due to these attributes she is known as an "All-arounder". A weakness of Hantuchová since she emerged from the juniors was her lack of explosive movement around the court. In recent years, however, this aspect of her tennis has been vastly improved.

Doubles

Hantuchová's biggest successes have so far come in mixed doubles. In this event, she won the 2001 Wimbledon championships with Leos Friedl, the 2002 Australian Open with Kevin Ullyett, the 2005 French Open with Fabrice Santoro, and 2005 U.S. Open with Mahesh Bhupathi. She was runner-up in the 2002 Wimbledon with Ullyett, and she reached the semi-finals at the French Open in 2004 with Todd Woodbridge. At the 2005 U.S. Open she completed a career mixed doubles Grand Slam with Mahesh Bhupathi when they beat Katarina Srebotnik and Nenad Zimonjic in the final in straight sets 6–4, 6–2. This makes her only the 5th women in tennis history (after Hart, Court, King and Navratilova) to complete a career Grand Slam in mixed doubles. In Perth, Western Australia also in 2005, Hantuchová won the Hopman Cup with Dominik Hrbatý.

Hantuchová's other achievements include winning eight women's doubles titles (as of July 2007). From 2005 to early 2007 she played doubles with Ai Sugiyama, with some fans affectionately referring to the team as "Hantuyama". They have won 3 titles together in Rome, Doha, and Birmingham, England, as well as reaching the final at the French Open in 2006 (Hantuchova's first Grand Slam doubles final was in 2002 with Arantxa Sanchez Vicario at the Australian Open). "Hantuyama" won the title of "Fans favorite doubles team 2005" at the Stars for Stars in Miami.

In early 2007, the partnership between Sugiyama and herself ended after Tokyo though the pair continued playing at Dubai and Doha because Hantuchová (eager to play doubles with Martina Hingis) wanted to give Sugiyama time to find a new partner. They only played once (reaching the Semi-Finals of Miami) due to Hingis's subsequent injury which kept her out until Wimbledon. Thereafter she partnered Nadia Petrova and Ana Ivanovic in the bigger tournaments before reuniting with Hingis on the summer hardcourts in America and reaching the third round of the US Open in their first attempt together at a grand slam. In the absence of Hingis in Bali she played doubles with Lindsay Davenport. Over the start of the 2008 season she has played with Davenport, Ana Ivanovic, Martina Hingis and re joined Ai Sugiyama for the 2008 Pacific Life Open

2002

2002 was Hantuchová's breakout season, in which she won her first tournament at the prestigious Indian Wells event, defeating Justine Henin (her first victory over a top 10 player) in the fourth round 6–3 6–3 and Martina Hingis in the final 6–3 6–4. Later on that year, Hantuchova also reached the final in Filderstadt, losing to Kim Clijsters 4–6 6–3 6–4, the only set Hantuchova took from Clijsters in their nine meetings.

Elsewhere in the year, she made the semifinals in Linz, New Haven, Montreal, and Eastbourne. Hantuchová also made her first two Slam quarterfinals, defeating Jelena Dokić 6–4 7–5 in the fourth round at Wimbledon, losing to eventual champion Serena Williams in the quarterfinals, and defeated Justine Henin again in the fourth round at the US Open 6–1 3–6 7–6(4), losing to eventual champion Serena Williams again in the quarterfinals.

Hantuchová went 6-10 against top 10 players; 6–2 in singles Fed Cup play, helping lead Slovakia to their first Fed Cup victory against Spain in the final; 10-6 on indoor carpet, 6–2 on grass, 11-7 on clay, and 29-10 on hardcourts.

2003

Hantuchová started 2003 solidly, reaching the quarterfinals at her first three events in Sydney, losing to Lindsay Davenport 6–4 3–6 7–6(3), Venus Williams 6–4 6–3 at the Australian Open (her third Slam quarterfinal in a row), and Elena Dementieva in Paris 7–5 6–3. Hantuchová reached her first semifinal of the year at her fourth event in Antwerp, losing to Williams again, 6–1 6–4. By then, Hantuchova's ranking was at an all-time high, cracking the top five at No. 5.

Defending a title for the first time in her career, Hantuchova made it to the fourth round in Indian Wells, losing to Amanda Coetzer 6–4 6–4. Despite a first round loss to Alicia Molik in Miami, Hantuchova rebounded in the Tier I Charleston event, making her fifth quarterfinal in seven events, losing to Ashley Harkleroad 6–2 6–1. She made her sixth quarterfinal at her next event in Amelia Island, losing to eventual champion Dementieva 6–0 6–1.

Hantuchová went undefeated in first round Fed Cup play against Germany, winning both of her matches. Following Fed Cup, she again made it to the quarterfinals for the seventh time of the year at the Tier I Berlin tournament, losing to Kim Clijsters 6–0 6–3.

File:Hantuchova in 2003.jpg
Hantuchová in 2003

At the French Open, Hantuchová lost in the second round in a marathon match to Harkleroad again 7–6(2) 4–6 9–7 making 101 unforced errors, leading to long-time coach Nigel Sears criticising her attitude publicly.[4] Following the match, her extremely thin physique was noticed for the first time publicly and some wondered about Hantuchova's health.

Kicking off the grass season in Eastbourne, Hantuchová lost in the quarterfinals to Conchita Martinez, but more famously she lost in the second round of Wimbledon to Shinobu Asagoe 0–6 6–4 12-10, with Hantuchova breaking down crying during the latter stages of the match in the midst of making 57 unforced errors. Later people theorised that the media frenzy regarding her weight plus her breakdown during the match, along with personal problems of her parents' divorce and feeling the pressure of success at just 19 years old was the reasoning behind the subsequent fall of Hantuchova from the top of women's tennis.

Following Wimbledon Hantuchová went 6–8 for the rest of the year, 0–4 against top 10 players, 28-23 overall going 4–3 on indoor carpet, 10-6 on clay, 2–2 on grass, 12-12 on hardcourts; and fell to No. 17 in the world. Further signs of the pressure and problems she was facing during this period was that in July she made herself unavailable for Slovakia in the Fed Cup in order to concentrate on her singles career and in November she parted company with Sears.[5]

2004

File:Daniela Hantuchova in US Open 2004.jpg
Hantuchová in US Open 2004

2004 proved to be largely a continuation of Hantuchová's poor second half of '03 with all the same struggles (she briefly hired Harold Soloman, who had previously coached her friend Jennifer Capriati as well as Anna Kournikova before re-hiring Sears in March [6]), she reached just three quarterfinals, her first of which at the first Tier I event in Tokyo was not until halfway through the season. At Tokyo, however, she garnered her thus far only victory over Maria Sharapova in the second round, falling to Davenport 6–2 6–2 in the quarters. The tournament that saved her from a completely disastrous 2004 was Eastbourne, in which she defeated Ai Sugiyama in the quarterfinals 6–1 7–6(7) and Amelie Mauresmo in the semifinals 4–6 6–4 6–4 before losing to Svetlana Kuznetsova in the third final of her career, 2–6 7–6(2) 6–4. However, Hantuchová was serving for the championship, up 6–2 6–5, but got broken.

Hantuchová was ranked No. 54 as she entered Eastbourne, but found herself ranked No. 38 as she went into Wimbledon, losing to eventual champion Sharapova in the third round 6–3 6–1. Hantuchova would make one more quarterfinal at New Haven, losing to Lisa Raymond 6–4 6–3. At the US Open one week later, Hantuchova lost 7–6 in the third to Patty Schnyder in the third round despite having match points in the third set.

Hantuchová finished the year ranked No. 31, with a 24-24 win-loss ratio going 3–3 on indoor carpet, 6–3 on grass, 2–5 on clay, and 13-13 on hardcourts. She finished 1–4 against top 10 players overall, the sole victory over Mauresmo.

2005

Hantuchová reached the third round of the Australian Open, losing to Dementieva in a tight three-setter, 7–5 5–7 6–4. Following that, she made her first quarterfinal of the year in Tokyo for the second straight year, losing to Kuznetsova 7–6(4) 7–6(4). At her next event she reached the semifinals in Doha, losing to Sharapova 6–2 6–4. Then she made another quarterfinal at her next tournament in Dubai, losing to Serena Williams 6–4 6-3; at Dubai also, in the first round, she garnered her 10th top 10 victory over No. 8 Alicia Molik 7–6(8) 6–2.

Hantuchová made the third round at the French and Wimbledon, losing to Clijsters 6–4 6–2 in Paris and eventual champion Venus Williams 7–5 6–3 in England.

Hantuchová had a successful US Open series run, where she reached the semifinals in Cincinnati, getting upset by No. 74 Akiko Morigami 6–4 6–4. After Cincinnati, in Stanford, Hantuchova lost to Clijsters in the quarterfinals 6–3 6–1. And after a second round loss in San Diego to Sugiyama, Hantuchova reached her fourth final in Los Angeles, getting a walkover in the quarterfinals over Sharapova, and got revenge against Dementieva in the semifinals, defeating her 6–3 6–4 (Hantuchova stands 2–0 against Dementieva in semifinals). In the final, for the seventh time in their head-to-head, Clijsters defeated Hantuchova 6–4 6–1. For the third time at the event, Hantuchova made the quarterfinals in New Haven, losing to Davenport 6–2 7–6(5).

Hantuchová would lose to eventual quarterfinalist Venus Williams in the third round at the US Open.

In Luxembourg, Hantuchova made her eighth quarterfinal of the season, losing to Nathalie Dechy 6–1 6–4. In Filderstadt the following week, Hantuchová made the semifinals, her third of the year, defeating No. 10 Patty Schnyder in the second round and Flavia Pennetta in the quarterfinals; she lost to Davenport in the semifinals. And at the final Tier I event of the year, Hantuchova pushed Davenport to three sets and had match points in the second set in Zurich before losing 3–6 7–5 6–2. And in her final event of the year, in Linz, Hantuchova made her 10th quarterfinal, losing to Schnyder 6–2 6–1.

Hantuchová finished 2005 with a 3-10 record against the top 10, 37-25 overall record with 2–1 on indoor carpet, 3–4 on clay, 2–3 on grass, 30-17 on hardcourts, reaching 10 quarterfinals, three semifinals, and one final.

2006

Daniela Hantuchová at the Zurich Open 2006

In 2006 Hantuchová reached the quarterfinals of Sydney with a win over top 10 player Patty Schnyder and got to the semifinals of Auckland. She continued this form at the Australian Open with her third round 6–1, 7–6 (5) victory over defending champion and seven-time Grand Slam winner Serena Williams, who had entered the tournament with a lack of match practice and questions over her fitness. This victory (the first and only over Serena in her career) ensured Daniela progressed to the fourth round of a Grand Slam tournament for the first time in three years. She lost to 4th-seeded Maria Sharapova in straight sets in the fourth round.

Thereafter she was unable to find a consistent level of form. She reached the fourth-round at the Australian Open, but prior to the clay court season she parted company for a second time (and permanently) with Sears.[7] He was replaced by Angel Giminez. After the split with Sears she played her first Fed Cup matches for Slovakia in almost 3 years (Slovakia had slipped from being winners in 2003 to languishing in the Europe/Africa zone having being relegated every year in Hantuchova's absence). It was a successful return with Hantuchova winning her both singles and doubles matches against Luxembourg, her singles match against The Netherlands and the decisive singles rubber in the tie against Great Britain. With the help of Hantuchova's 4–0 record over the 6-day period Slovakia booked a place in the World Group II play-off against Thailand.

Despite disappointing results in the warm-up tournaments she equalled her Australian Open performance by getting to the fourth round of both the French Open and Wimbledon before extending her 2006 Fed Cup record to 6–0 by winning both her singles matches in Slovakia's 5–0 rout of Thailand, which ensured their promotion to the World Group II. Her fourth-round streak at Grand Slams ended when she was beaten by a resurgent Serena Williams at the second round of the US Open, which was the culmination of a very disappointing American hard court season (her record was 7–6 including the US Open, failing to get past the last 16 of any of the tournaments she entered).

Daniela showed what she is capable of producing the week before Stuttgart beating an in-form Tatiana Golovin in straight sets before losing out to Dinara Safina. The following week she reached the quarterfinals of Stuttgart with an easy victory over the now top 10 player Safina in the 2nd round, the same player to whom she had lost convincingly the previous week. This was both her first victory over a top 10 player and appearance in a quarter final since January. In October 2006, Hantuchova reached the final of the Zurich Open. In the first round, she upset 6th seed Patty Schnyder. In the second round, she defeated her doubles parter Ai Sugiyama. Daniela was then scheduled to play World No.1 Amelie Mauresmo in the quarter finals. However, Mauresmo withdrew due to a right shoulder injury. In the semi finals, Daniela upset World No.4 Svetlana Kuznetsova 6–4 6–2 to reach the final of the Tier I event. In the final, Daniela lost in a tight 3 setter to 2nd seed Maria Sharapova. Sharapova winning 6–1 4–6 6–3. The results in this tournament were the culmination of Hantuchová's up turn of form which kept her in the world's top 20 as she had arrived in Zurich outside the top group for the first time in over 11 months. The injury she suffered to her right rib,[8] after Mary Pierce hit a shot at her in doubles, caused her her most serious injury of her career and also forced her to retire in her match against Vesnina the following week in Linz.

Hantuchová finished the year ranked 17th in the world with a 34-25 record. She went 24-17 on hard courts, 5–4 on clay, 3–2 on grass and 2–2 on carpet. She was 4–6 against top 10 players beating Schnyder (twice), Safina and Kuznetsova, with losses to Sharapova (twice), Clijsters, Henin-Hardenne, Dementieva and Nadia Petrova.

2007

Daniela Hantuchová at the 2007 Fortis Championships in Luxembourg

Hantuchová's first tournament of the year was at the Tier IV ASB Classic in Auckland, New Zealand, where she lost in the second round to Virginie Razzano 6–1, 7–5. Hantuchova then lost to Nicole Vaidišová in the first round of the Tier II New South Wales Open/Medibank International in Sydney and reached her second consecutive Australian Open fourth round, where she lost to World No. 5 Kim Clijsters 6–1, 7–5.

Hantuchová was then upset in the first round of the Tier I Toray Pan Pacific Open in Tokyo by Roberta Vinci 6–4, 6–4. Three weeks later at the Tier II Dubai Tennis Championships, Hantuchová defeated Maria Kirilenko in the second round 2–6, 6–4, 7–6(4) before losing her quarterfinal match against Amelie Mauresmo 6–3, 3–6, 6–4. The following week at the Tier II Qatar Total Open in Doha, Hantuchová trailed World No. 6 Martina Hingis in their quarterfinal match 4–1 in the second set before coming back to win 1–6, 6–4, 6–4. She then lost her semifinal match against World No. 5 Svetlana Kuznetsova 6–4, 6–2.

In her seventh tournament of the year, Hantuchová won six matches, the last four of which were upsets of higher seeded players, to win the Tier I Pacific Life Open in Indian Wells, California. She upset Hingis in the fourth round 6–4, 6–3, Shahar Peer in the quarterfinals 6–2, 5–7, 7–6(5), Li Na in the semifinals 7–5, 4–6, 6–1, and Kuznetsova in the final in straight sets.

Hantuchová, however, struggled in her next four events. She was upset in the third round of the Tier I Sony Ericsson Open in Key Biscayne, Florida by Vera Zvonareva 6–2, 6–4. On clay at the Bausch & Lomb Championships in Amelia Island, Florida, Hantuchova lost to Sybille Bammer in the quarterfinals 2–6, 6–2, 6–2. Two weeks later, Hantuchova lost both of her Fed Cup matches against the Czech Republic in Bratislava on clay, losing to Vaidišová 6–2, 6–7(1), 6–3 and Lucie Šafářová 7–6(1), 4–6, 6–3. Losing her fourth consecutive match, Hantuchová was upset in the first round of the Tier I Qatar Telecom German Open in Berlin by Zuzana Ondrášková 6–1, 6–3.

Hantuchová then reached her first career clay court semifinal at the Internazionali BNL d'Italia in Rome. She upset seventh-seeded Anna Chakvetadze in the third round 6–3, 6–3 before losing to second-seeded Kuznetsova in the semifinals 6–4, 6–2. At the French Open, Hantuchova was upset in the third round by Anabel Medina Garrigues 4–6, 7–6(2), 7–5.

After defeating Eleni Daniilidou in the third round of the Tier III grass court DFS Classic in Birmingham, United Kingdom, Hantuchová was guaranteed a return to the top 10 for the first time since August 2003. She then lost to Marion Bartoli in the quarterfinals 5–7, 6–4, 7–5. The following week at the Tier III Ordina Open in 's-Hertogenbosch, the Netherlands, Hantuchová defeated World No. 6 Ana Ivanovic in the quartefinals 6–3, 6–1 before losing to Chakvetadze in the semifinals 6–7(6), 6–3, 6–2. This result caused Hantuchová to drop out of the top 10.

Hantuchová was the tenth-seeded player at Wimbledon and did not lose a set in her first two matches. She then defeated Slovenian Katarina Srebotnik in the third round 2–6, 6–3, 6–4 before losing to World No. 8 Serena Williams in the fourth round 6–2, 6–7(2), 6–2.

Immediately after Wimbledon, Hantuchová helped Slovakia win its Fed Cup World Group II play-off against Serbia. On an indoor hard court in Košice, she beat Ana Timotić 6–1, 6–2 and Vojislava Lukić 6–0, 6–2.

Hantuchová played five tournaments during the North American summer hard court season. She began the US Open Series by losing to Chakvetadze 6–7(6), 6–3, 6–2 in the semifinals of the Tier II Bank of the West Classic in Stanford, California. This result put her back in the top 10. At the Tier I Acura Classic in San Diego, she lost to World No. 16 Venus Williams in the second round 6–0, 6–3. The following week at the Tier II JPMorgan Chase Open in Los Angeles, Hantuchova retired from her third round match with Elena Dementieva while trailing 6–3, 4–1. Hantuchová once again fell out of the top 10 after losing in the second round of the Tier II Pilot Pen Tennis tournament in New Haven, Connecticut to eventual runner-up Agnes Szavay 7–5, 6–3. At the US Open, Hantuchova was the ninth-seeded player but lost to Ukraine's Julia Vakulenko in the first round 6–4, 3–6, 6–1. It was Hantuchova's earliest loss at this tournament since her debut in 2001 and her earliest loss at a Grand Slam tournament since the 2004 French Open.

Hantuchová then played four consecutive tournaments. She reached her second final of the year at the Tier III Commonwealth Bank Tennis Classic in Bali, losing to Lindsay Davenport in three sets. At the Tier III Sunfeast Open in Kolkata, India, Hantuchova lost in the semifinals to Maria Kirilenko 4–6, 6–2, 6–1 but reentered the top 10. Traveling back to Europe, Hantuchová played in the Tier II Fortis Championships Luxembourg. She defeated Patty Schnyder in the quarterfinals and Bartoli in the semifinals to advance to her third final of the year for the first time in her career. Hantuchová then lost to World No. 6 Ivanovic in the final 3–6, 6–4, 6–4 after leading the match 6–3, 3–0. At the Porsche Tennis Grand Prix in Stuttgart, Hantuchová defeated Safarova in the first round but lost in the second round to Dementieva 6–4, 6–4. This loss, however, did not prevent Hantuchová from rising to World No. 9, her highest ranking in over four years.

At the Tier I Zurich Open, Hantuchova defeated Dinara Safina in the first round 7–6(2), 7–6(4) before losing to Agnieszka Radwańska 6–3, 6–3. One week later, Hantuchová won her third career title at the Tier II Generali Ladies Linz. In the semifinals, she defeated Vaidisova for the first time in her career 2–6, 6–2, 7–6(3). Hantuchová then defeated Schnyder in the straight-sets final. This title enabled Hantuchova to qualify for the year-ending Sony Ericcson Championships in Madrid. But Hantuchová did not advance past the round robin stage in Madrid. She lost to Maria Sharapova 6–4, 7–5 and Ivanovic 6–2, 7–6(9) before beating Kuznetsova 7–6(7), 6–0 to finish third in her group.

Hantuchová's win-loss record for 2007 was 52-28. She was 6-11 versus top 10 players, with two victories against Hingis, two against Kuznetsova, one against Ivanovic, and one against Chakvetadze. The losses were to Clijsters, Mauresmo, Chakvetadze (twice), Kuznetsova (twice), Vaidišová, Serena Williams, Ivanović (twice), and Sharapova. Hantuchová finished the year at World No. 9, her first top-10 finish since 2002.

2008

Daniela Hantuchová

Hantuchová first started her 2008 campaign by entering the Medibank International as the sixth-seeded player. In her first round match Hantuchová faced Russian Dinara Safina in an epic three set match, which she won 5-7 6-4 6-4. As well as the media for the match Hantuchova received lots of media for wearing the Nike Women's Maria Aussie Dress in the colour of "Tweed", which was deemed to be the signature Australian Open dress for Maria Sharapova; Sharapova eventually wore the dress in white in Melbourne. Hantuchová was then swept aside easily by twelfth-ranked Czech Nicole Vaidisova in the round of 16.

At the Australian Open, Hantuchová reached her first Grand Slam semifinal.[9] She won her first three matches without losing a set but was tested in the fourth round by Maria Kirilenko before Hantuchová won 1–6, 6–4, 6–4. Her quarterfinal match was against the Polish teenager Agnieszka Radwańska, who had defeated second-seeded Svetlana Kuznetsova and Nadia Petrova in earlier rounds. Hantuchova defeated Radwanska 6–2, 6–2. Hantuchová then lost to Ana Ivanovic in a semifinal 0–6, 6–3, 6–4 despite Hantuchová leading the match 6–0, 2–0. She subsequently claimed that Ivanovic had been putting her off by squeaking her trainers on the court before serving, a claim Ivanovic disputes.[10] Hantuchova then climbed from world number 9 to 8 in the WTA rankings.

Hantuchová then played at the Open Gaz de France in Paris. As the second seed, she received a first round bye and reached quarterfinals by beating Slovenian Katarina Srebotnik in three sets 6-4 1-6 6-3. However, in the subsequent quarterfinal match, she was defeated by seventh seed Agnes Szavay of Hungary 7-6(4) 6-1 after being up a break in the first set at 4-2. She then went on to participate at the Proximus Diamond Games in Antwerp, Belgium as the third seed, where again she reached the quarterfinals after beating wildcard Yanina Wickmayer of Belgium in an easy straight set victory 6-4 6-3. she then retired against Timea Bacsinszky after leveling the match at 2-6 6-4, but had a large blister on her right hand, which meant she had to retire in the fifth game of the third set at 1-4.

Hantuchová was then scheduled to play at the Qatar Total Open, the first Tier I event of the year and a Tier II event, the Barclays Dubai Tennis Championships, but withdrew due to fatigue.

At the Tier I Pacific Life Open in Indian Wells, California, Hantuchová was the defending champion and fifth seed. She lost to fourth-seeded Maria Sharapova in the quarterfinals 7–6(2), 6–1. In doubles, Hantuchová and Ai Sugiyama were the eighth seeds and lost in the semifinals to the eventual champions Dinara Safina and Elena Vesnina.

At the Tier I Sony Ericsson Open in Key Biscayne, Florida, Hantuchová failed to reach the fourth round in this event for the ninth consecutive year. She lost to former doubles partner Sugiyama in the third round 6–4, 6–7(8), 7–5 despite leading 3-0 in the third set. In doubles, Hantuchová partnered with Lindsay Davenport to reach the quarterfinals where they lost to Sugiyama and Katarina Srebotnik, who went on to win the event.

The following week at the Tier II Bausch & Lomb Championships in Amelia Island, Florida, Hantuchová was the third seed and received a bye in the first round but lost in the second round to Karolina Sprem 6–3, 1–6, 6–3.

Hantuchová spent the month of May recovering from a stress fracture in her right foot, which resulted in her withdrawal from the Tier I Internazionali BNL d'Italia in Rome,[11] the Tier III Istanbul Cup,[12] the French Open,[13] [14] and the Tier III Ordina Open in 's-Hertogenbosch, The Netherlands. She recovered in time for Wimbledon but lost in the second round to unseeded Alisa Kleybanova 6–3, 4–6, 6–1.

At the Bank of the West Classic in Stanford, California, Hantuchová lost in the second round to Sugiyama 6–3, 6–1. The following week at the East West Bank Classic in Los Angeles, Hantuchova was the sixth seed but lost in the second round to Olga Govortsova of Belarus 6–2, 6–4.

Hantuchová competed in the 2008 Olympics in Beijing and was drawn against Ai Sugiyama, whom she won in straight sets, 6-2, 7-5. In round two she lost 6-1, 6-3 to Caroline Wozniacki of Denmark.

She then participated in the 2008 US Open, where she was upset in the first-round by a resurgent Anna-Lena Groenefeld. She then competed in Bali, where she lost in the semifinals to Tamira Paszek, as well as competing in the Toray Pan Pacific Open, where she lost in the first round to Francesca Schiavone in straight sets. Then next at the China Open, she won her first round easily beat against Gisela Dulko 6-3, 6-1, then just beat Tamarine Tanasugarn in a strange three set match with the score 6-1, 0-6, 7-5, she then went on to meet top seed, Jelena Jankovic in the quarterfinals where she was beaten in straight sets, 7-5, 6-1, after serving for the first set at 5-4.

Seeded number eight at the Tennis.com Zürich Open, Hantuchova lost to Maria Kirilenko 7-5 6-3.

Her next scheduled tounament is the Fortis Championships, which means she will not be able to defend her title at the Linz.

Records against other players

Record against top 10 players

The following is Hantuchová's win-loss singles record against players included in the top 10 of the Women's Tennis Association rankings as of September 27, 2008.

Record against other players (active and retired)

The following is Hantuchova's win-loss singles record against other selected players according to the Women's Tennis Association as of June 9, 2008.

Endorsements

Product endorsement and equipment

Hantuchova endorses Nike sportswear and has her own line with them for her tournament wear, such as Maria Sharapova and Serena Williams.

Hantuchova also has had endorsement by three racquet makers. She was first endorsed by Babolat from being a junior until late 2003, then Yonex until the 2007 Toray Pan Pacific Open in Tokyo when she then used the Prince Ozone Seven Racquets from the 2007 Barclays Dubai Tennis Championships.

Video games

Hantuchova has been in many sports/tennis related video games with such players as Maria Sharapova, Lindsay Davenport, Venus Williams and Anna Kournikova. Some of the titles are Top Spin (both Xbox and Play Station 2 versions), Smash Court Tennis Pro Tournament 2 and Virtua Tennis 3. Hantuchova is currently ranked third behind Serena Williams and Ana Ivanovic in a poll for new downloadable players for Top Spin 3.

Grand Slam mixed doubles finals (5)

Wins (4)

Year Championship Partner Opponent in Final Score in Final
2001 Wimbledon Czech Republic Leos Friedl United States Mike Bryan
South Africa Liezel Huber
4–6 6–3 6–2
2002 Australian Open Zimbabwe Kevin Ullyett Argentina Gastón Etlis
Argentina Paola Suarez
6–3 6–2
2005 French Open France Fabrice Santoro India Leander Paes
United States Martina Navratilova
3–6 6–3 6–2
2005 US Open India Mahesh Bhupathi Serbia and Montenegro Nenad Zimonjic
Slovenia Katarina Srebotnik
6–4 6–2

Runner-up (1)

Year Championship Partner Opponent in Final Score in Final
2002 Wimbledon Zimbabwe Kevin Ullyett Russia Elena Likhovtseva
India Mahesh Bhupathi
2–6 6–1 1–6

Grand Slam doubles finals (2)

Runner-up (2)

Year Championship Partner Opponent in Final Score in Final
2002 Australian Open Spain Arantxa Sanchez Vicario Russia Anna Kournikova
Switzerland Martina Hingis
6–2, 6–7, 6–1
2006 French Open Japan Ai Sugiyama United States Lisa Raymond
Australia Samantha Stosur
6–3, 6–2

WTA tour finals

Singles wins (3)

Legend
Grand Slam (0)
WTA Championships (0)
Tier I (2)
Tier II (1)
Tier III (0)
Tier IV (0)
Titles by Surface
Hard (3)
Grass (0)
Clay (0)
Carpet (0)
No. Date Tournament Surface Opponent in Final Score in Final
1. 16 March, 2002 Pacific Life Open, Indian Wells, California, U.S. Hard Switzerland Martina Hingis 6–3, 6–4
2. 17 March, 2007 Pacific Life Open, Indian Wells, California, U.S. Hard Russia Svetlana Kuznetsova 6–3, 6–4
3. 28 October, 2007 Generali Ladies Linz, Linz, Austria Hard (i) Switzerland Patty Schnyder 6–4, 6–2

Singles runner-ups (6)

No. Date Tournament Surface Opponent in Final Score in Final
1. 13 October, 2002 Porsche Tennis Grand Prix, Filderstadt, Germany Hard (i) Belgium Kim Clijsters 4–6, 6–3, 6–4
2. 19 June, 2004 The Hastings Direct International Championships, Eastbourne, United Kingdom Grass Russia Svetlana Kuznetsova 2–6, 7–6(2), 6–4
3. 14 August, 2005 JPMorgan Chase Open, Los Angeles Hard Belgium Kim Clijsters 6–4, 6–1
4. 22 October, 2006 Zürich Open, Zürich, Switzerland Hard (i) Russia Maria Sharapova 6–1, 4–6, 6–3
5. 16 September, 2007 Commonwealth Bank Tennis Classic, Bali, Indonesia Hard United States Lindsay Davenport 6–4, 3–6, 6–2
6. 30 September, 2007 Fortis Championships Luxembourg, Luxembourg City, Luxembourg Hard (i) Serbia Ana Ivanovic 3–6, 6–4, 6–4

Doubles wins (8)

Legend
Grand Slam (0)
WTA Championships (0)
Tier I (1)
Tier II (5)
Tier III (2)
Tier IV (0)
Titles by Surface
Hard (5)
Grass (1)
Clay (2)
Carpet (0)
No. Date Tournament Surface Partner Opponents in Final Score in Final
1. October 29 2000 WTA Bratislava, Bratislava, Slovak Republic Hard (i) Slovakia Karina Habsudova Hungary Petra Mandula
Austria Patricia Wartusch
w/o
2. October 28 2001 Fortis Championships Luxembourg, Luxembourg, Luxembourg Hard (i) Russia Elena Bovina Germany Bianka Lamade
Switzerland Patty Schnyder
6–3, 6–3
3. April 14 2002 Bausch & Lomb Championships, Amelia Island, Florida, U.S. Clay Spain Arantxa Sanchez Vicario Argentina Maria Emilia Salerni
Sweden Åsa Svensson
6–4, 6–2
4. August 24 2002 Pilot Pen Tennis, New Haven, Connecticut, U.S. Hard Spain Arantxa Sanchez Vicario Italy Tathiana Garbin
Slovakia Janette Husarova
6–3, 1–6, 7–5
5. June 12 2005 DFS Classic, Birmingham, United Kingdom Grass Japan Ai Sugiyama Greece Eleni Daniilidou
United States Jennifer Russell
6–2, 6–3
6. October 9 2005 Porsche Tennis Grand Prix, Filderstadt, Germany Hard (i) Russia Anastasia Myskina Czech Republic Květa Peschke
Italy Francesca Schiavone
6–0, 3–6, 7–5
7. March 4 2006 Qatar Total Open, Doha Hard Japan Ai Sugiyama China Ting Li
China Tian Tian Sun
6–4, 6–4
8. May 21 2006 Internazionali BNL d'Italia, Rome Clay Japan Ai Sugiyama Czech Republic Květa Peschke
Italy Francesca Schiavone
3–6, 6–3, 6–1

ITF titles (4)

Singles (3)

No. Date Tournament Surface Opponent in the final Score
1. May 23 1999 Jackson, U.S. Clay Venezuela Milagros Sequera 6–2, 6–1
2. September 12 1999 Fano, Italy Clay Italy Flora Perfetti 6–4, 6–7, 6–2
3. August 20 2000 Bronx, U.S. Hard China Jing-Qian Yi 6–4, 6–4

Doubles (1)

No. Date Tournament Surface Partner Opponent in the final Score
1. July 11 1999 Civitanova, Italy Clay Denmark Eva Dyrberg Spain Rosa Maria Andres Rodriguez
Spain Conchita Martinez Granados
7–6, 4–6, 6–3

Singles performance timeline

Template:Performance timeline legend To prevent confusion and double counting, information in this table is updated only once a tournament or the player's participation in the tournament has concluded. This table is current through Wimbledon in London, which ended on July 6, 2008.

Tournament 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 Career SR Career W/L
Grand Slam Tournaments
Australian Open A A LQ1 1R 3R QF 2R 3R 4R 4R SF 0 / 9 21-9
French Open A A A 2R 4R 2R 1R 3R 4R 3R A 0 / 7 12-7
Wimbledon A A LQ1 2R QF 2R 3R2 3R 4R 4R 2R 0 / 9 17-9
U.S. Open A A LQ1 1R QF 3R 3R 3R 2R 1R 1R 0 / 9 12-9
Grand Slam SR 0 / 0 0 / 0 0 / 3 0 / 4 0 / 4 0 / 4 0 / 4 0 / 4 0 / 4 0 / 4 0 / 3 0 / 34 N/A
Grand Slam Win-Loss 0–0 0–0 3–3 2–4 13-4 8–4 4–4 8–4 10-4 8–4 6–3 N/A 62-34
Year-End Championship
WTA Tour Championships A A A A 1R A A A A RR 0 / 2 1–3
Olympic Games
Summer Olympics NH NH A NH NH NH 2R NH NH NH 2R 0 / 1 1–1
Current WTA Tier I Tournaments3
Doha4 Not Tier I or Was Not Held A 0 / 0 0–0
Indian Wells A A A 1R5 W 4R 2R 3R A W QF 2 / 7 20-5
Miami A A 1R 1R 2R 2R 3R 2R 3R 3R 3R 0 / 9 4–9
Charleston A A A A 2R QF A A A A A 0 / 2 3–2
Berlin A A A LQ1 QF QF 1R 1R 3R 1R A 0 / 7 7–7
Rome A A A 3R5 1R 3R 1R 1R 1R SF A 0 / 7 9–7
Montreal/Toronto A A A 2R SF 3R 2R 1R 3R A A 0 / 6 8–6
Tokyo A A A A A A QF QF 2R 1R 1R 0 / 5 5–5
Moscow A A A A A A 1R A A A 2R 0 / 1 0–1
Former WTA Tier I Tournaments3
Zurich4 A A A QF6 QF 1R 2R 2R F 2R - 0 / 7 13-7
San Diego4 Not Tier I or Was Not Held 2R 2R 3R 3R - 0 / 4 5–4
Career Statistics
Runner-up 0 1 0 0 1 0 1 1 1 2 0 N/A 7
Tournaments Won 0 1 1 0 1 0 0 0 0 2 0 N/A 5
Overall Win-Loss 3–1 21-5 27-16 38-20 56-25 28-23 24-24 37-25 34-25 52-28 13-7 N/A 333-1997
Year End Ranking None 197 108 38 8 19 31 19 18 9 N/A N/A
  • - = tournament either not held or was not a Tier I event when it was held.
  • SR = the ratio of the number of singles tournaments won to the number of those tournaments played.
  • 1 She lost in the second round of the qualifying tournament.
  • 2 Her second round match was a walkover in her favor, which does not count as a win on her official record.
  • 3 This table includes tournaments that were classified on the WTA Tour as Tier I at the time they were held, regardless of whether those tournaments are still being held or are still classified as Tier I.
  • 5 Won two qualifying matches to reach the main draw.
  • 6 Won three qualifying matches to reach the main draw.
  • 7 Her win-loss record includes all matches listed on the WTA website, including challenger and Fed Cup matches.

Notable matches

2002 Pacific Life Open final: defeated heavily-favored former champion and world number 4 Martina Hingis in straight sets, with the score 6-3 6-4. This was Hantuchova's first career title and first title at the Pacific Life Open.

2002 Fed Cup final: defeated Spanish former Wimbledon champion Conchita Martinez 6-7 7-5 6-4 in the first singles rubber and a 6-2 6-1 victory over Magui Serna, which was the match that gave Slovakia it's one and only Fed Cup title.

2003 Wimbledon Championships second round: defeated by Shinobu Asagoe 0–6 6–4 12-10, with Hantuchova leading comfortably in the first set and leading in the second, only to be broken and lose the set. Again, after leading Hantuchova started to lose while breaking down crying during the latter stages of the match in the midst of making 57 unforced errors. This was seen to be the start of Hantuchova's fall from the top of women's tennis.

2004 International Women's Open final: defeated by Svetlana Kuznetsova 2-6 7-6 6-4 after serving for the match at 6-2 6-5 and having a match point at 40-30 and following on to lose the set and eventually the match. Hantuchova also reached the final by recording a 4-6 6-4 6-4 win over top-seed Amelie Mauresmo in the semi-final.

2006 Zurich Open final: defeated by Maria Sharapova in three entertaining sets 6-1 4-6 6-3. This was Hantuchova's fifth career final and first three set match with Sharapova. Many went on to say that was Hantuchova's start of her comeback.

2007 Pacific Life Open final: defeated world number 4 Svetlana Kuznetsova in straight sets, with the score 6-3 6-4 again. This was Hantuchova's second career title and second title at the Pacific Life Open.

2007 Wimbledon Championships fourth round: defeated by Serena Williams 6-2 6-7 6-2, a match which was seen as a controversial match, when after being broken by Williams when serving for the second set at 2-6 5-3, Williams cramped in her left calf after losing a point and needed a medical time-out. After waiting to resume play Hantuchova gave Williams sympathy. Play resumed and Hantuchova took the set in a tiebreak 7-6(2), and went on to lose the match with a third set score of 6-2. After the match Williams was criticised by many thst the cramp was merely a tactic and gamesmanship against Hantuchova.

2007 Generali Ladies Linz final: defeated Patty Schnyder to take her third career title and second of the year. Winning this match also secured her place in the Sony Ericsson Championships. She won it 6-4 6-2.

2008 Australian Open semi-final: defeated by Ana Ivanovic in three sets 0-6 6-3 6-4 after leading 6-0 2-0. This was seen as a controversial match, where Ivanovic was heard to be squeaking her trainers on the court before Hantuchova's serve, a claim Ivanovic disputes.

Achievements

Team achievements

Special achievements

See also

References

External links

Awards
Preceded by WTA Newcomer of the Year
2001
Succeeded by
Preceded by WTA Most Improved Player of the Year
2002
Succeeded by


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