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- Le Baigue, Jim , British jazz and improvisation musician (drums)
- Le Banner, Jérôme (* 1972), French martial artist
- Le Barbenchon, Louis (1911–1980), French film architect
- Le Bas, Damian (1963-2017), British artist
- Le Bas, Jacques-Philippe (1707–1783), French engraver
- Le Bas, Philippe (1794–1860), French classical philologist, educator of Napoléon III.
- Le Bas, Philippe-François-Joseph (1764–1794), French revolutionary and politician
- Le Bauld de Nans, Claude Étienne († 1792), French actor, director and French teacher
- Le Bauld de Nans, Claudius Franz (1767–1844), Prussian general
- Le Bé, Guillaume (1525–1598), die cutter, type designer, type caster and publisher in the Renaissance
- Le Beau, Luise Adolpha (1850–1927), German pianist and composer
- Le Beau, Wilhelm August (1820–1896), Colonel from Baden, later Royal Prussian Major General and first in Baden, and finally in the Prussian War Ministry
- Le Beauf, Sabrina (* 1958), American actress
- Le Bègue de Villaines, Pierre († 1406), captain, adviser and chamberlain to the French kings Charles V and Charles VI.
- Le Bègue, René (1857–1914), French photographer
- Le Bègue, René (1914–1946), French racing driver
- Le Bel, Jean († 1370), Belgian chronicler
- Le Bel, Joseph (1847–1930) French chemist
- Le Bellec, Gaël (* 1988), French racing cyclist, duathlete and triathlete
- Le Berre, Alexandre (1925–1975), French football player
- Le Berre, Fred (* 1964), French comic book author
- Le Besco, Isild (* 1982), French film actress, screenwriter and film director
- Le Bidois, Georges , French Romance philologist, literary scholar and linguist
- Le Bidois, Robert (1897–1971), French Romance studies scholar, linguist and diplomat
- Le Bihan, Clarisse (* 1994), French soccer player
- Le Bihan, Denis (* 1957), French neuroscientist, radiologist and biophysicist
- Le Bihan, Samuel (* 1965), French actor
- Le Blanc Souville, Eugen von (1801–1886), Prussian major general
- Le Blanc, Max (1865–1943), German electrochemist
- Le Blanc, Thomas (* 1951), German author and editor
- Le Blanc, Vincent , French explorer and writer
- Le Blon, Jakob Christoph (1667–1741), German painter, engraver and inventor
- Le Blond, Francis Celeste (1821–1902), American politician
- Le Blond, Guillaume (1704–1781) French mathematician, encyclopedist, and military theorist
- Le Blond, Jean-Baptiste Alexandre (1679–1719), French-Russian Baroque architect
- Le Blond, Louis-Vincent-Joseph, Comte de Saint-Hilaire (1766–1809), French army leader
- Le Boeuf, Pascal (* 1986), American jazz musician (piano, composition)
- Le Boeuf, Remy (* 1986), American jazz musician (alto saxophone)
- Le Bohec, Yann (* 1943), French ancient historian
- Le Bon de Beauvoir, Sylvie (* 1941), French writer and philosophy professor
- Le Bon, Cate (born 1983), Welsh musician and producer
- Le Bon, Charlotte (* 1986), Canadian actress, television presenter and model
- Le Bon, Gustave (1841-1931), French social psychologist
- Le Bon, Johan (* 1990), French road cyclist
- Le Bon, Joseph (1765–1795), French politician and revolutionary
- Le Bon, Laurent (* 1969), French art historian, museum curator and museum director
- Le Bon, Simon (* 1958), British singer and member of the Duran Duran group
- Le Borg, Reginald (1902–1989), Austrian-American film director
- Le Borgn ', Pierre-Yves (* 1964), French politician, member of the National Assembly
- Le Borne, Fernand (1862–1929), French composer of Belgian origin
- Le Boucher, Maurice (1882–1964), French composer, organist and music teacher
- Le Boucher, Raoul (1883-1907), French wrestler
- Le Boulanger, Yoann (* 1975), French racing cyclist
- Le Boulch, Dimitri (* 1989), French road cyclist
- Le Boulch, Isabelle (* 1964), French soccer player
- Le Boulc'h, Laurent (* 1960), French clergyman, Bishop of Coutances
- Le Bourdais, Isabel (1909–2003), Canadian journalist and miscarriage of justice
- Le Bourdon, Raymond (1861–1937), French lawyer and Minister of State of Monaco
- Le Bourgeois, Armand François M. (1911–2005), French clergyman, Bishop of Autun
- Le Bras, Martine (* 1945), French table tennis player
- Le Braz, Anatole (1859-1926), Breton author
- Le Bret, Jean (1872–1947), French sailor
- Le Breton, Alain-Sébastien (1888–1964), French clergyman, Roman Catholic bishop
- Le Breton, André (1708–1779), French bookseller, printer, publisher
- Le Breton, Auguste (1913–1999), French author, lexicographer and Romance philologist
- Le Breton, David (* 1953), French anthropologist and sociologist
- Le Breton, David Francis Battye (born 1931), British diplomat
- Le Breton, Julie (* 1975), Canadian actress
- Le Breton, Louis (1818–1866) French physician and painter
- Le Breton, Louis (1823-1896) French architect
- Le Breton, Roger (* 1914), French lawyer
- Le Breton, Tomás Alberto (1868–1959), Argentine diplomat
- Le Bris, Benoît (* 1976), French football player
- Le Bris, Jean Marie (1817–1872), French aviation pioneer
- Le Bris, Régis (* 1975), French football player
- Le Brix, Joseph (1899–1931), French aviation pioneer
- Le Brun, Agnès (* 1961), French politician (UMP), MEP
- Le Brun, Charles (1619–1690) French painter and ornamental artist
- Le Brun, Christopher (* 1951), British visual artist
- Le Brun, Jeannine (1915–1977), German photographer
- Le Bussy, Alain (1947-2010) Belgian science fiction writer
- Le Cadre, Pierre-Marie-David (1875–1952), French priest, Vicar Apostolic of the Marquesas Islands
- Le Caisne, Garance , French journalist and author
- Le Calm, Renée (1918–2019), French actress
- Le Cam, Lucien (1924-2000), French mathematician
- Le Camus, Antoine (1722–1772), French medic, author and journalist
- Le Camus, Émile (1839–1906), French Roman Catholic clergyman, theologian, and Bishop of La Rochelle
- Le Camus, Pierre Alexandre (1774–1824), politician and statesman
- Le Camus, Sébastien († 1677), French composer, lutenist and viol player
- Le Carpentier, Adolphe Claire (1809–1869), French music teacher and composer
- Le Carré, John (born 1931), British writer
- Le Cat, Claude-Nicolas (1700–1768) French surgeon and physiologist
- Le Cène, Michel-Charles († 1743), French-Dutch music publisher and printer
- Le Cerf de La Viéville, Jean-Laurent (1674–1707), French writer and musicologist
- Lê Chân Tông (1630–1649), Vietnamese emperor of the restored Lê dynasty
- Le Chanois, Jean-Paul (1909–1985), French screenwriter and film director
- Le Chapelier, Isaac René Guy (1754–1794), politician during the French Revolution
- Le Chatelier, Henry (1850–1936) French chemist, metallurgist, and physicist
- Le Chatelier, Louis (1815–1873), French engineer
- Le Chenadec, Gilbert (* 1938), French football player
- Le Chevalier, Jean-Baptiste (1752–1836), French archaeologist and astronomer
- Lê Chiêu Tông (1506–1526), Vietnamese emperor of the Lễ dynasty
- Le Clark, Maya (* 2011), American actress
- Le Cléac'h, Armel (* 1977), French ocean sailor
- Le Cléac'h, Hervé-Maria (1915–2012), French clergyman, Roman Catholic bishop of Taiohae o Tefenuaenata, French Polynesia
- Le Clerc, François († 1563), privateer captain
- Le Clerc, Jean († 1621), French geographer, engraver, printer and publisher
- Le Clerc, Jean (1586–1633) French painter
- Le Clerc, Jean V († 1637), French engraver, printer and publisher
- Le Clerc, Louis August (1688–1771) French sculptor
- Le Clerc, Michel (1622–1691), French playwright, translator and member of the Académie française
- Le Clerc, Sébastien (1637–1714), French etcher and engraver
- Le Clercq, Jasper (* 1970), Dutch jazz violinist
- Le Clézio, Jean-Marie Gustave (* 1940), French-Mauritian writer
- Le Coffre, Benoît (1671–1722), Danish painter of French descent
- Le Compte, Herman (1929–2008), Belgian physician, gerontologist and gerontologist
- Le Compte, Karl M. (1887–1972), American politician
- Le Conte, John Eatton (1784–1860), American naturalist
- Le Conte, John Lawrence (1825-1883), American entomologist
- Le Conté, Joska (* 1987), Dutch skeleton pilot
- Le Coq de Kerland, Charles (1887–1978), French lawyer
- Le Coq, Albert von (1860–1930), German archaeologist and Central Asia researcher
- Le Coq, André Auguste (1827–1894), Prussian businessman and insurance director
- Le Coq, Bernard (born 1950), French actor
- Le Coq, Gustav von (1799–1880), Prussian diplomat
- Le Coq, Jacques (1676–1766), Electoral Saxon Privy Councilor of War, secret cabinet secretary and diplomat; Member of the Reformed Congregation in Dresden
- Le Coq, Jean Louis Albert (1800–1875), Prussian and later English merchant, winery owner and wine and beer merchant
- Le Coq, Johann Ludwig von (1719–1789), Saxon lieutenant general
- Le Coq, Karl Christian Erdmann von (1767-1830), Saxon lieutenant general
- Le Coq, Karl Ludwig von († 1829), Prussian major general and cartographer
- Le Coq, Ludwig Daniel (1756–1816), German senior judge, councilor of war and secret legation councilor
- Le Coq, Paul Ludwig (1773–1824), Prussian civil servant in the foreign service and police chief
- Le Coq, Pierre (* 1989), French windsurfer
- Le Corbusier (1887–1965), Swiss-French architect, architectural theorist, town planner, painter, draftsman, sculptor and furniture designer
- Le Cordier, Jacques (1904–2003), French clergyman and Roman Catholic bishop of Saint-Denis
- Le Corre, Jean-François (* 1965), French film producer
- Le Corre, Pascal (* 1959), French pianist and music teacher
- Le Corre, Pierre (* 1990), French duathlete, triathlete, U23 world champion (2013) and two-time national triathlon champion (2014, 2015)
- Le Couppey, Félix (1811–1887), French music teacher, pianist and composer
- Le Cour Grandmaison, Olivier (* 1960), French university professor of political science and political philosophy
- Le Courayer, Pierre François (1681–1776), French Augustinian canon and theologian, professor at Oxford in exile in England
- Le Crom, Ronan (* 1974), French football goalkeeper
- Lê Đắc Trọng, Phaolô (1918–2009), Catholic auxiliary bishop in Hanoi
- Le Déroff, Jean-Yves (* 1957), French sailor
- Le Despenser, Edward, 1st Baron le Despenser (1336-1375), English nobleman and military man
- Le Despenser, Isabel, 5th Baroness Burghersh (1400–1439), English nobleman
- Le Despenser, Richard, 4th Baron Burghersh , English nobleman
- Le Dissez, Viviane (* 1959), French politician, member of the National Assembly
- Le Divellec, Emmanuel (* 1966), French organist
- Le Dœuff, Michèle (* 1948), French philosopher
- Le Douarin, Nicole (* 1930), French developmental biologist
- Le Dran, Henry François (1685–1770), chief surgeon at the Charité in Paris and royal field surgeon
- Le Drian, Jean-Yves (* 1947), French politician, member of the National Assembly
- Le Drogo, Ferdinand (1903–1976), French racing cyclist
- Le Du, Théodore (1893–1966), French racing car driver
- Lê Duẩn (1907–1986), Vietnamese politician
- Lê Đức Anh (1920–2019), Vietnamese general and politician
- Le Duey, Anthony (* 1973), French triathlete
- Le Ewer, Robert († 1322), English military man and rebel
- Le Faguays, Pierre (1892–1962), French Art Deco sculptor
- Le Fanu, Joseph Sheridan (1814–1873), Irish writer
- Le Fauconnier, Henri (1881–1946), French Cubist painter
- le Febvre, Isaak († 1702), Huguenot
- Le Fée, Enzo (* 2000), French football player
- Le Feubure, Carl (1847–1911), Bavarian painter
- Le Feuvre, Danielle (* 1978), English badminton player (Jersey)
- Le Fèvre de Saint-Remy, Jean († 1468), French chronicler
- le Fèvre, André (1898–1977), Dutch football player
- Le Fevre, Benjamin (1838–1922), American politician
- Le Fevre, Frank J. (1874–1941), American politician
- Le Fèvre, Hermann Adolf (1708–1745), German lawyer and Council Secretary of the Hanseatic City of Lübeck
- Le Fevre, Jay (1893–1970) American politician
- Le Fèvre, Tanneguy (1615–1672), French humanist
- Le Fevre, Ulrik (* 1946), Danish football player and players agent
- Le Flem, Paul (1881–1984), French composer
- Le Fleming, Orlando (* 1976), British cricketer and jazz musician
- Le Flô, Adolphe (1804-1887), French general and politician
- Le Floc'h, Ezec (* 1970), French circus performer and playwright
- Le Floch, Henri (1862–1950), French Roman Catholic clergyman and theologian
- Le Floch, Xavier (* 1973), French triathlete
- Le Floch-Prigent, Loïk (* 1943), French manager
- Le Foll, Stéphane (* 1960), French politician (PS), MEP
- Le Fontenay, Odette (1885–1965), French opera singer and vocal teacher
- Le Forestier, Maxime (* 1949), French chansonnier
- Le Fort, Carl Peter Johann von (1794–1862), merchant and district administrator in Mecklenburgisch-Schwerin, monastery captain in Dobbertin
- Le Fort, François (1656–1699), first Russian admiral
- Le Fort, Gertrud von (1876–1971), German writer
- Le Fort, Pierre (1676–1754), Geneva military in Russian service
- Le Fort, René (1869–1951), French surgeon
- Le Fur, Louis (1870–1943), French legal scholar
- Le Gac, Jean (* 1936), French painter and photographer
- Le Gac, Olivier (* 1993), French cyclist
- Le Gal, Patrick (* 1953), French clergyman, Roman Catholic bishop
- Le Gall, Frank (* 1959), French comic artist
- Le Gall, Jean-François (* 1959), French mathematician
- Le Gall, Joël (1913–1991), French ancient historian and archaeologist
- Le Gall, Robert (* 1946), French priest, Archbishop of Toulouse
- Le Gallienne, Dorian (1915–1963), Australian composer
- Le Gallienne, Eva (1899–1991), American actress, director, theater director and producer
- Le Gentil, Georges (1875–1953), French Hispanist and Lusitanist
- Le Gentil, Guillaume (1725–1792), French astronomer
- Le Gentil, Pierre (1906–1989), French Romanist, Medievalist and Hispanicist
- Lê Gia Tông (1661–1675), Vietnamese emperor of the restored Lê dynasty
- Le Glay, Edward (1814–1894), French historian, Romanist, and Medievalist
- Le Glay, Marcel (1920–1992), French classical archaeologist and epigraphist
- Le Goff, Anton (* 1964), German actress and cabaret artist
- Le Goff, Jacques (1924-2014), French historian
- Le Goff, Nicolas (* 1992), French volleyball player
- Le Goff, Paul (1883–1915), French sculptor
- Le Goffic, Charles (1863–1932) French poet, writer and historian
- Le Goullon, François (1757–1839), French cook and author
- Le Graët, Noël (* 1941), French entrepreneur, politician and football official
- Le Grand, Fedde (* 1977), Dutch house DJ and music producer
- Le Gras, Jacques (1560–1600), French lawyer and poet
- Le Gras, Philippe (1752-1824), French jurist
- Le Gray, Gustave (1820-1884), photographer
- Le Grevès, René († 1946), French cyclist
- Le Grice, Malcolm (* 1940), British avant-garde film artist and film theorist
- Le Grip, Constance (* 1960), French politician (UMP), MEP
- Le Groing de La Romagère, Mathias (1756–1841), French bishop
- Le Groing de la Romagère, Pierre-Joseph (1752–1794), French priest, victim of the reign of terror during the French Revolution
- Le Gros Clark, Wilfrid (1895–1971) British anatomist, primatologist and paleoanthropologist
- Le Gros, Pierre the Younger (1666–1719), French sculptor in Rome
- Le Guay de Prémontval, Pierre (1716–1764), French mathematician and philosopher
- Le Guay, Philippe (* 1956), French director, screenwriter and actor
- Le Guen, Paul (* 1964), French football player and coach
- Le Guennant, Auguste (1881–1972), French organist, composer and music teacher
- Le Guerranic, Ernest (1831–1915), French architect
- Le Guin, Ursula K. (1929–2018), American writer
- Le Hardy de Beaulieu, Philippe (1887–1942), Belgian fencer
- Le Hénaff, René (1901–2005), French film editor and film director
- Le Hérissé, Auguste (1876–1953), French administrator of Dahomey
- Lê Hiền Đức (* 1932), Vietnamese civil rights activist against corruption
- Lê Hiến Tông (1461–1504), Vietnamese emperor of the Lễ dynasty
- Le Hir, Yves (1919–2005), French Romance scholar, literary scholar and stylist
- Le Hoc, Louis-Grégoire (1743-1810), French diplomat
- Le Hon, Charles (1792–1868), Belgian politician
- Le Hong, Trang (* 1987), German-Vietnamese actress
- Le Houérou, Annie (* 1960), French politician, member of the National Assembly
- Le Houérou, Philippe (* 1957), French economist
- Le Hunte, George (1852-1925) British colonial administrator, governor of South Australia and Trinidad and Tobago
- Le Huray, Judith (* 1954), German author for children and young people
- Lê Hữu Từ, Thaddée Anselme (1897–1967), Vietnamese clergyman, Catholic bishop
- Lê Huyền Tông (1654–1671), Vietnamese emperor of the restored Lê dynasty
- Lê Huỳnh Châu (* 1987), Vietnamese Taekwondoin
- Lê Hy Tông (1663–1716), Vietnamese emperor of the restored Lê dynasty
- Le Hyaric, Patrick (* 1957), French politician, MEP and journalist
- Le Jan, Yves (* 1952), French mathematician
- Le Jeune, Claude († 1600), Franco-Flemish composer of the Renaissance
- Le Jeune, Philippe (* 1960), Belgian show jumper, individual world champion
- Le Jingyi (* 1975), Chinese swimmer and Olympic champion
- Le Jolis, Auguste François (1823–1904), French cryptogam and algae expert
- Lê Khả Phiêu (1931–2020), Vietnamese politician
- Lê Kính Tông (1588–1619), ruler of Vietnam
- Le Lamer, René (* 1948), French football player and coach
- Le Lann, Éric (* 1957), French jazz trumpeter and composer
- Le Lann, Lola (* 1996), French actress
- Le Lavasseur, Jacques , French sailor
- Le Lay, David (* 1979), French racing cyclist
- Le Lay, Patrick (1942-2020), French media manager
- Le Lievre, John (born 1956), English squash player
- Le Lionnais, François (1901–1984), French writer, science journalist and publisher
- Lê Lợi (1385–1433), Vietnamese emperor, first emperor of the Lễ dynasty
- Le Long, Isaac (1683–1762), German historian, bibliographer and translator of Huguenot descent
- Le Lorrain, Robert (1666–1743), French baroque sculptor
- Le Louchier, Agnes († 1717), French dancer and mistress of the Bavarian Elector Maximilian Emanuel
- Le Ly Hayslip (* 1949), Vietnamese-American writer and philanthropist
- Le Magueresse, Jean-Luc (* 1961), French football player
- Le Maingre, Geoffroi , Bishop of Laon, Pair de France
- Le Maingre, Jean I († 1367), Marshal of France
- Le Maire de Warzée d'Hermalle, William (1878–1966), Belgian tennis player
- Le Maire, Bruno (* 1969), French politician (LREM), Minister for the Economy and Finance
- Le Maire, Charles (1897–1985), American costume designer
- Le Maire, Gunther (* 1940), German painter
- Le Maire, Isaac († 1624), Dutch entrepreneur
- Le Maire, Jacob (1585–1616), Dutch navigator and explorer
- Le Maistre, Albin (1839–1929), German administrative lawyer in Saxony; first police chief in Dresden
- Le Maistre, Antoine (1608–1658), French lawyer, author, Jansenist and hermit
- Le Maistre, Mattheus († 1577), Franco-Flemish composer and conductor of the Renaissance
- Le Maistre, Rudolf Friedrich (1835–1903), German ambassador
- Le Mar, Gabriel (* 1966), German music producer and DJ
- Le Marchant, Spencer (1931–1986) British politician, Member of the House of Commons
- Le Mare, Mike (* 1938), American sound engineer
- Le Mascrier, Jean-Baptiste (1697–1760), French clergyman and author
- Le Masson, Innocent (1627–1703), French monk, Prior of the Grande Chartreuse and Minister General of the Carthusian Order
- Le Mat, Paul (* 1945), American actor
- Le May, Alan (1899–1964), American author
- Le May, Reginald (1885–1972), British art historian
- Le Mener, Jean-Yves (* 1952), French cameraman and entrepreneur
- Le Mercier de La Rivière, Pierre-Paul (1719–1801), French economist
- Le Mercier, François-Joseph (1604–1690), French Jesuit, missionary in Quebec and superior general of the missions in New France and the West Indies
- Le Mercier, Jean († 1397), adviser to the French kings Charles V and Charles VI.
- Le Messurier, Nicolas , sound engineer
- Le Mesurier, James (1971–2019), British officer and NGO founder
- Le Mével, Christophe (* 1980), French racing cyclist
- Lê Minh Khuê (* 1949), Vietnamese writer
- Le Minor, Léon (* 1920), French microbiologist
- Le Moal, Jean (1909–2007) French painter, theater decorator, and sculptor
- Le Moignan, Martine (* 1962), English squash player
- Le Moigne, Sarah (* 1968), English badminton player
- Le Moine, Anna (* 1973), Swedish curler
- Le Moine, Stephanus (1624–1689), French Reformed theologian
- Le Mole, Mario (* 1967), German singer in the band Mind Odyssey
- Le Monnier, Anton von (1819–1873), Austrian police officer
- Le Monnier, Louis Guillaume (1717–1799), French physician, botanist, mycologist and encyclopaedist
- Le Montagner, Benjamin (* 1988), French road cyclist
- Le Moyne de Bienville, Jean-Baptiste († 1767), French colonist and governor of Louisiana
- Le Moyne d'Iberville, Pierre , founder of the Louisiana colony
- Le Moyne, John V. (1828-1918) American politician
- Le Moyne, Pierre (1602–1671) French Jesuit, preacher and writer
- Le Muet, Pierre (1591–1669), architect of the French king in Paris
- Le Nain de Tillemont, Louis-Sébastien (1637–1698), French historian
- Le Nain, Antoine († 1648), French painter
- Le Nain, Louis († 1648), French painter
- Le Nain, Mathieu (1607–1677), French painter
- Le Net, Marie (* 2000), French cyclist
- Lê Ngọc Nguyên Nhung (* 1984), Vietnamese badminton player
- Lê Nhân Tông (1441–1459), Vietnamese emperor, second emperor of the Lễ dynasty
- Le Noble, Franz von (1707–1772), Prussian colonel
- Le Normand, Robin (* 1996), French football player
- Le Nôtre, André (1613–1700), French garden designer
- Le Ny, Anne (born 1962), French actress
- Le Page, Sally , British evolutionary biologist and science communicator
- Le Paige, Constantin (1852-1929), Belgian mathematician
- Le Paige, Louis Adrien (1712–1803), French lawyer and publicist
- Le Pailleur, Jacques († 1654), French poet and mathematician
- Le Parc, Julio (* 1928), Argentine kinetic artist
- Le Pautre, Antoine (1621–1691), French architect
- Le Péchoux, Erwann (* 1982), French foil fencer
- Le Pecq de la Clôture, Louis (1736–1804), French physician and professor of surgery
- Le Peletier de Saint-Fargeau, Louis-Michel (1760–1793), politician during the French Revolution
- Le Peletier, Amédée Louis Michel (1770–1845), French entomologist
- Le Pen, Jean-Marie (* 1928), French politician, chairman of the Front National, MEP, right-wing extremist and Holocaust denier
- Le Pen, Marine (* 1968), French lawyer and politician, MEP
- Le Pensec, Louis (* 1937), French politician (PS), member of the National Assembly
- Le Père, Gratien (1769–1826), chief engineer of the then forerunner of the French École Nationale des Ponts et Chaussées
- Le Père, Jacques-Marie (1763–1841), French engineer
- Le Person, Paul (1931–2005), French actor
- Le Petit, Alfred (1841–1909) French painter and caricaturist
- Le Petit, Claude (1638–1662), French libertine and satirical writer
- Lê Phong Thuân, Emmanuel (1930–2010), Vietnamese clergyman, Bishop of Cần Thơ
- Le Pichon, Xavier (* 1937), French geologist
- Le Picq, Charles (1744–1806), French ballet dancer and choreographer
- Le Play, Julian (* 1991), Austrian singer, songwriter and radio host
- Le Play, Pierre Guilleaume Fréderic (1806–1882), French engineer, economist, sociologist and social reformer
- Le Plongeon, Alice Dixon (1851-1910) British photographer
- Le Plongeon, Augustus (1825–1908) British photographer and amateur archaeologist
- Le Poer, Richard (* 1987), British polo player
- Le Poer, Roger , Lord Chancellor and Keeper of the Seal of England
- Le Pogam, Pierre-Ange (* 1954), French film producer
- Le Pors, Anicet (born 1931), French politician (PCF), senator
- Le Pottier, Justine (* 1983), French actress and screenwriter
- Le Poulain, Corinne (1948-2015), French actress
- Le Preux, Jean , printer
- Le Prévost, Auguste (1787–1859), French archaeologist and historian
- Le Prince, Louis , French chemist, inventor and film pioneer
- Le Puits, Yann (* 1951), French writer
- Lê Quan Ninh (* 1961), French percussionist
- Lê Quang Liêm (* 1991), Vietnamese chess grandmaster
- Lê Quang, Vincent (* 1975), French jazz musician (saxophone, composition)
- Le Quellec, Vincent (* 1975), French cyclist
- Le Quéré, Corinne , Canadian climate scientist
- Le Querrec, Guy (* 1941), French photographer and filmmaker
- Le Queux, William (1864–1927), English journalist, writer, and diplomat of French descent
- Le Quien, Michel (1661–1733), French Dominican, librarian, dogmatist, church historian
- Le Quieu, Antoine (1601–1676), French Roman Catholic clergyman, Dominican and founder of an order
- Le Rachinel, Fernand (* 1942), French politician, MEP
- Le Ray, Alain (1910–2007), French general and resistance fighter
- Le Renard, Michel , French badminton player
- Le Riche, Nicolas (* 1972), French ballet dancer
- Le Rider, Georges (1928–2014), French classical scholar, numismatist and librarian
- Le Rider, Jacques (* 1954), French Germanist and cultural scientist
- Le Romain, Jean-Baptiste-Pierre , French engineer and contributor to the Encyclopédie
- Le Rond, Henri (1864–1949), French general and head of the Inter-Allied Government and Plebiscite Commission in Upper Silesia
- Le Rossignol, Robert (1884–1976), English engineer
- Le Rouge, Georges Louis , cartographer, architect, draftsman and engraver
- Le Rouge, Guillaume , Franco-Flemish composer and singer of the early Renaissance
- Le Roux de Lincy, Antoine (1806–1869), French librarian, Romanist and Medievalist
- Le Roux, Bruno (* 1965), French politician
- Le Roux, Gaspard († 1707), French harpsichordist and Baroque composer
- Le Roux, Isabel (* 1987), South African athlete
- Le Roux, Jean-Marie (1863–1949), French mathematician
- Le Roux, Madrie (* 1995), South African tennis player
- Le Roux, PK (1904–1985), South African politician
- Le Roux, Philibert-Joseph , French lexicographer
- Le Roux, Shaun (* 1986), South African squash player
- Le Roux, Yvon (* 1960), French football player and coach
- Le Rouzic, Zacharie (1864–1939), French prehistorian and photographer
- Le Roy Ladurie, Emmanuel (* 1929), French historian and writer
- Le Roy, Adrian († 1598), French lutenist, music publisher and composer
- Le Roy, Charles (1726–1779) French physician and encyclopaedist
- Le Roy, Charles-Georges (1723–1789), French man of letters, encyclopedist and naturalist
- Le Roy, Claude (* 1948), French football player and coach
- Le Roy, Édouard (1870–1954), French philosopher and mathematician
- Le Roy, Fulgence Werner (1924–2017), Belgian religious, Roman Catholic Bishop of Pietersburg
- Le Roy, Guillaume († 1493), printer v. a. in Lyon
- Le Roy, Henri L. (1926–2015), Swiss agricultural scientist, biometrician and population geneticist
- Le Roy, Jean-Baptiste (1720–1800), French polymath, director of the Académie royale des sciences and one of the main contributors to the Encyclopédie
- Le Roy, Jean-Pierre (* 1953), Swiss actor
- Le Roy, Julien (1686–1759), French watchmaker
- Le Roy, Maximilien (* 1985), French comic artist
- Le Roy, Philibert († 1646), French builder
- Le Roy, Pierre (1717–1785), French watchmaker, inventor
- Le Roy, Xavier (* 1963), French dancer, choreographer and performance artist
- Le Royer, Philippe (1816–1897), French politician, member of the National Assembly
- Le Rue, Paul-Henri de (* 1984), French snowboarder
- Le Rue, Xavier de (* 1979), French snowboarder
- Le Sage, Bill (1927-2001), British jazz pianist
- Le Sage, Éric (* 1964), French pianist
- Le Saux, Graeme (* 1968), English football player
- Le Saux, Yannick (* 1965), French football player
- Le Saux, Yorick (* 1968), French cameraman
- Le Saux, Yves (* 1960), French clergyman, Bishop of Le Mans
- Le Scrope, Richard (1350–1405), English prince of the church
- Le Secq, Henri (1818–1882) French painter, etcher, art collector, and photographer
- Le Sénéchal, Louis (1910–1977), French politician, member of the National Assembly
- Le Sénéchal, Raymond , French jazz pianist and vibraphonist
- Le Seur, Paul (1877–1963), German theologian
- Le Seur, Rosa (1846–1920), German theater actress and singer (soprano)
- Le Seur, Thomas (1703–1770), French mathematician and physicist
- Le Shuuk (* 1987), German DJ
- Le Sidaner, Henri (1862–1939), French painter
- Le Soldat, Judith (1947–2008), Swiss psychoanalyst, researcher, lecturer and author
- Le Sommer, Eugénie (* 1989), French soccer player
- Le Souëf, Dudley (1856–1923), Australian zoologist, zoo director, and wildlife photographer
- Le Soufaché, Joseph-Michel (1804–1887), French architect of historicism
- Le Sourd, Philippe , French cameraman
- Le Squer, Christian (* 1962), French chef
- Le Strat, Alexis (1898–1970), French politician (SFIO), member of the National Assembly
- Le Sueur, Blaise Nicolas (1714–1783) French painter
- Le Sueur, Eustache (1616–1655) French painter
- Le Sueur, Meridel (1900–1996), American author and suffragette
- Le Sueur, Terry (born 1942), British politician, Chief Minister of Jersey
- Le Suire, Günther von (1846–1906), Bavarian major general and chamberlain
- Le Suire, Hermann von (1861–1933), German landscape painter
- Le Suire, Karl von (1898–1954), German general of the mountain troops in World War II
- Le Suire, Wilhelm von (1787-1852), Bavarian Lieutenant General, Bavarian and Greek Minister of War
- Le Tallec, Anthony (* 1984), French football player
- Le Tallec, Damien (* 1990), French football player
- Le Tanneux von Saint Paul, Hans Friedrich (1897–1961), German administrative officer
- Le Tanneux von Saint Paul, Moritz (1813–1892), Prussian district administrator in the Heiligenbeil district (1854–1869)
- Le Tellier, Auguste (1783–1844), member of the Chamber of Peers
- Le Tellier, Charles Maurice (1642–1710), Archbishop of Reims
- Le Tellier, Hervé (* 1957), French writer
- Le Tellier, Louis-Charles-César (1695–1771), French general, Marshal of France
- Le Tellier, Michel (1643–1719), French Jesuit, Provincial of the Jesuit Order and confessor of Louis XIV.
- Le Tendre, Serge (* 1946), French comic book writer and copywriter
- Le Tensorer, Jean-Marie (* 1947), French archaeologist
- Le Testu, Guillaume († 1573), French cartographer
- Lê Thái Tông (1423–1442), Vietnamese emperor, second emperor of the Lễ dynasty
- Lê Thần Tông (1607–1662), ruler of Vietnam
- Lê Thành Khôi (* 1923), Vietnamese-French educational scientist and university professor
- Lê Thánh Tông (1442–1497), Vietnamese emperor, fifth emperor of the Lễ dynasty
- Lê Thế Tông (1567–1599), ruler of Vietnam
- Le Theule, Joël (1930–1980), French politician, member of the National Assembly
- Le Thomas, Pia (1920–2009), French Cistercian, abbess and founder of a monastery
- Le Tissier, Darren (* 1968), British badminton player
- Le Tissier, Matthew (born 1968), British football player
- Le Tissier, Tony (born 1932), British historian
- Le Tocq, Paul (born 1981), Welsh badminton player
- Le Tonnelier de Breteuil, Achille (1781–1864), French politician and diplomat
- Le Tonnelier de Breteuil, Louis Nicolas (1648–1728), French diplomat and royal advisor
- Le Tourneur, Étienne-François (1751–1817), French politician
- Le Toux, Sébastien (* 1984), French football player
- Lê Trang Tông (1514–1548), Vietnamese emperor of the Lễ dynasty
- Le Troquer, André (1884–1963), French politician (SFIO), member of the National Assembly
- Le Trosne, Guillaume-François (1728–1780), French lawyer and economist
- Lê Tú Chinh (* 1997), Vietnamese athlete
- Lê Tương Dực (1495–1516), Vietnamese emperor of the Lễ dynasty
- Le Tyrant, Albert (* 1946), French archer
- Lê Uy Mục (1488–1509), Vietnamese emperor of the Lễ dynasty
- Le Va, Barry (born 1941), American artist
- Lê Văn Hông, François-Xavier (* 1940), Vietnamese clergyman, emeritus Roman Catholic Archbishop of Huê
- Lê Văn Hưu (1230–1322), Vietnamese scholar and historian during the Trần dynasty
- Lê Văn Tân (* 1984), Vietnamese-Ghanaian soccer player
- Le Van Thiem (1918–1991), Vietnamese mathematician
- Le Vau, Louis (1612–1670), French builder in Paris
- Le Vell, Michael (born 1964), English actor
- Le Veneur de Tillières, Alexis (1746–1833), French division general and politician
- Le Ver, Firmin († 1444), French Carthusian monk, philologist, Romanist and lexicographer
- Le Verrier, Max (1891–1973), French sculptor
- Le Verrier, Urbain (1811–1877) French mathematician and astronomer
- Le Vert, Jean-Marie (* 1959), French clergyman, Roman Catholic auxiliary bishop in Bordeaux
- Le Vigan, Robert (1900–1972), French film actor
- le Viseur, Hilde (1910–1999), German hurdler
- Le Vot, François (* 1970), French aerobatic pilot
- Le Waitte, Antoine (1600–1677), Roman Catholic clergyman, Cistercian, abbot of two monasteries, theologian and author
- Le, Aaron (* 1982), German-Vietnamese actor, voice actor and police officer
- Le, Chi (* 1987), German actress
- Lê, Công Vinh (* 1985), Vietnamese soccer player
- Le, Cung (* 1972), Vietnamese actor and martial artist
- Lê, Dinh Q. (* 1968), Vietnamese photographer and installation artist
- Lê, Đức Thọ (1911–1990), Vietnamese politician
- Lé, Francesca (* 1970), American porn actress
- Lê, Hà Anh (* 1991), Vietnamese badminton player
- Le, Hiep Thi († 2017), Vietnamese-American actress
- Le, Hong Phong (1902–1942), Vietnamese Communist Party cadre
- Le, Iwan (1895–1978), Ukrainian-Soviet writer
- Lê, Linda (* 1963), Vietnamese-French writer
- Lê, Lương Minh (* 1952), Vietnamese politician and diplomat
- Le, Maosheng (* 1978), Chinese weightlifter
- Le, Nam (born 1980), American poker player
- Lê, Nguyên (* 1959), French jazz guitarist and composer
- Le, Nhi (* 1995), German journalist, speaker, presenter and author
- Le, Quy Don (1726–1784), Vietnamese intellectual and Mandarin
- Lê, Sáng (1920–2010), Vietnamese martial artist
- Lê, Tấn Tài (* 1984), Vietnamese soccer player
- Lê, Thị Mộng Tuyền (* 1990), Vietnamese athlete
- Le, Thiet Hung (1908–1986), Vietnamese general and diplomat
- Lê, Thu Huyền (* 1994), Vietnamese badminton player
- Le, Tuan (born 1978), American poker player
- Lê, Văn Tỵ (1904–1964), South Vietnamese general
- Le-Mentzel, Van Bo (* 1977), German architect of Laotian origin
- Le-Roy, Anastasia (* 1987), Jamaican sprinter
- Le1f (* 1989), American rapper