List of sons and daughters of the City of Pittsburgh
This list of sons and daughters of the City of Pittsburgh includes, without claiming to be exhaustive , personalities born in Pittsburgh , Pennsylvania . It is irrelevant whether you subsequently worked in Pittsburgh.
A.
- Al Aarons (1932-2015), jazz musician
- F. Murray Abraham (born 1939), actor
- Kyle Abraham (* 1977), contemporary dancer and choreographer
- Valentine Abt (1873–1942), mandolinist, composer and music teacher
- Richard Henry Ackerman (1903–1992), Roman Catholic religious bishop of Covington
- JC Adams (* 1970), author, journalist, blogger and film director
- Jonathan Adams (born 1967), actor
- Gregory Ain (1908–1988), architect
- Eric Alexander (* 1988), football player
- Don Aliquo (* 1960), jazz saxophonist, university teacher and band leader
- Hervey Allen (1889-1949), writer (Antonio Adverso)
- Jacob A. Ambler (1829–1906), politician
- Eric Andersen (* 1943), singer and songwriter
- Kurt Angle (* 1968), freestyle wrestler, Olympic champion and wrestler for the WWE and TNA
- Walter Conrad Arensberg (1878–1954), literary scholar, cryptanalyst and art collector
- Frances H. Arnold (* 1956), biochemist and chemical engineer
- Steve Ash (* 1957), jazz musician
- James Mitchell Ashley (1824–1896), politician and governor of the Montana Territory
- Alfred Atherton (1921-2002), diplomat
- Sharif Atkins (* 1975), film actor and film producer
- Tom Atkins (born 1935), actor
B.
- Bob Babbitt (1937–2012), bass player and studio musician
- Donald A. Bailey (1945-2020), politician
- Donald Baird (1926-2011), paleontologist
- Charles Montague Bakewell (1867–1957), politician
- George A. Banker (1874–1917), cyclist
- Andrew Jackson Barchfeld (1863-1922), politician
- Chris Barker (* 1980), bassist, singer and songwriter
- John Gilbert Barrett (born 1952), martial artist, stuntman and actor
- Matt Bartkowski (* 1988), ice hockey player
- William Warren Bartley (1934–1990), philosopher
- Jayce Bartok (born 1974), actor
- Mickey Bass (* 1943), jazz musician
- Harry Bates (1900–1981), editor and writer of science fiction
- William Baziotes (1912–1963), painter and representative of Abstract Expressionism
- Robert W. Bazley (1925–2012), General of the US Air Force and Commander in Chief of the US Air Forces in the Pacific
- Thomas Andrew Becker (1832–1899), Bishop of Savannah
- Don Beddoe (1903-1991), actor
- James M. Beggs (1926–2020), head of the US space agency NASA
- Sandra Bem (1944–2014), psychologist and pioneer in gender studies
- George Benson (* 1943), jazz guitarist and singer
- Julie Benz (* 1972), actress
- Gretchen J. Berg (* 1971), screenwriter and producer
- Matthias Berking (* 1971), Professor of Clinical Psychology and Psychotherapy
- Pandro S. Berman (1905-1996), film producer
- David Berlin (* 1943), composer and music teacher
- Malcolm C. Bert (1902–1973), production designer and art director
- Carl Betz (1921–1978), actor
- Lawrence Sigmund Bittaker (1940-2019), serial killer
- Samuel Watson Black (1816–1862), politician and governor of the Nebraska Territory
- Shane Black (* 1961), film director, screenwriter and actor
- DeJuan Blair (born 1989), basketball player
- Paul Blair (1942–2011), journalist, radio presenter and publisher
- Allen Blairman (* 1940), modern jazz drummer
- Art Blakey (1919–1990), jazz drummer
- Mel Bochner (* 1940), concept artist, draftsman, painter and art theorist
- Patrick Body (* 1982), American football and arena football player
- Robert Bork (1927–2012), lawyer and United States Solicitor General
- Herbert W. Boyer (* 1936), biochemist and one of the founders of the first biotechnology company, Genentech
- Henry Marie Brackenridge (1786–1871), politician
- Charles Bradley (1902-1979), psychiatrist
- John I. Brauman (* 1937), chemist
- Joseph Carl Breil (1870–1926), composer, tenor and director
- Lewis H. Brereton (1890-1967), military person
- Matilda Moldenhauer Brooks (1888–1981), biologist
- Harry Joe Brown (1890–1972), film producer and director
- James W. Brown (1844-1909), politician
- Ray Brown (1926-2002), jazz bassist
- Ailsa Mellon Bruce (1901–1969), collector, philanthropist and patron
- Bob Buczkowski (1964-2018), American football player
- Erik Buell (* 1950), engineer and inventor of the motorcycle brands BUELL and ErikBuellRacing
- Kenneth Burke (1897–1993), writer, philosopher, literary and communication theorist
- Edward James Burns (born 1957), Roman Catholic clergyman, Bishop of Dallas
- Augusten Burroughs (* 1965), writer and journalist
- Jack Butler (1927-2013), American football player, sports scout
- Eben Byers (1880–1932), businessman, athlete and member of high society
C.
- Carole Caldwell Graebner (1943-2008), tennis player
- Daryl "Flea" Campbell (1924–2011), jazz musician
- Howard E. Campbell (1890–1971), politician
- Louis Cancelmi (* 20th century), actor
- Twink Caplan (born 1947), actress and comedian
- Dave Carey (1926–2019), orchestral, jazz and studio musician
- Coleman Francis Carroll (1905–1977), Archbishop of Miami
- Howard Joseph Carroll (1902–1960), Bishop of Altoona-Johnstown
- William Carroll (1788–1844), politician and governor of Tennessee
- John Renshaw Carson (1886-1940), communications engineer
- Mary Cassatt (1844-1926), painter
- Ted Cassidy (1932–1979), actor
- Eddie Chambers (born 1982), boxer
- Paul Chambers (1935-1969), jazz bassist
- Samuel Charters (1929–2015), blues musician and researcher
- Éric de Chassey (* 1965), art historian
- Stephen Chbosky (* 1970), novelist, screenwriter and director
- Norman Christ (* 1943), physicist
- Barry Church (born 1988), football player
- Kenny Clarke (1914–1985), jazz drummer and innovator of the bebop drum style
- Bernard Leonard Cohen (1924–2012), nuclear physicist
- Vinnie Colaiuta (* 1956), drummer
- Bill Cole (* 1937), jazz musician, ethnomusicologist and university professor
- Mary Colter (1869-1958), architect
- Henry Steele Commager (1902-1998), historian
- Miguel Condé (* 1939), Mexican figurative painter and engraver
- Billy Conn (1917-1993), boxer
- William Graham Connare (1911–1995), Bishop of Greensburg
- David Conrad (born 1967), actor
- Frank Conrad (1874–1941), radio pioneer
- Robert Conway (born 1974), wrestler
- Bob Cooper (1925-1993), jazz musician
- Chuck Cooper (1926-1984), basketball player
- Robert J. Corbett (1905–1971), politician
- William Corbett (1902–1971), politician
- Robert Costanza (* 1950), professor of ecological economics
- Dolores Costello (1903–1979), film actress
- Maurice Costello (1877–1950), actor and silent film director
- John Covert (1882–1960), painter
- William J. Coyne (1936-2013), politician
- Ray Crawford (1924-1997), jazz guitarist
- Adrian Cronauer (1938–2018), radio DJ and lawyer
- Mark Cuban (born 1958), self-made billionaire, owner of the Dallas Mavericks and co-founder of 2929 Entertainment
D.
- Julianne Dalcanton (* 1968), astronomer
- Jennifer Darling (born 1946), actress and voice actress
- Sidney Darlington (1906-1997), electrical engineer
- Cornelius Darragh (1809-1854), lawyer and politician
- Robyn Dawes (1936-2010), psychologist
- Marpessa Dawn (1934–2008), actress
- Daya (* 1998), singer
- James Deahl (* 1945), writer and poet
- John DeChancie (born 1946), fantasy author
- Mark Deklin (* 1967), actor and battle choreographer
- James Demmel (* 1955), Mathematician '
- Peter J. De Muth (1892–1993), politician
- Harmar Denny (1794-1852), politician
- Michelle DiBucci (* 20th century), composer
- John Dick (1794–1872), Pennsylvania politician in the US House of Representatives
- Barry Dierks (1899-1960), architect
- Frank Dileo (1947–2011), music manager and actor
- Annie Dillard (* 1945), poet, essayist, university lecturer and Pulitzer Prize winner
- Francesca Di Lorenzo (* 1997), tennis player
- Dwayne Dolphin (* 1963), jazz musician
- Aaron Donald (born 1991), American football player
- Kim Donovan (* 20th century), actress and voice actress
- J. Robert Dorfman (* 1937), physicist
- Paul Doucette (* 1972), musician
- Haldane Douglas (* 1892), artist, art director and production designer
- Herb Douglas (* 1922), long jumper
- Alfred E. Driscoll (1902–1975), politician
- William Dunham (* 1947), mathematician and mathematician historian
- Benedict Duss (1910–2005), Benedictine woman and founder of the first Benedictine convent in the USA
E.
- Herman P. Eberharter (1892-1958), politician
- Charles R. Eckert (1868–1959), politician
- Billy Eckstine (1914–1993), jazz singer, musician and band leader
- Tom Ebert (1919–2013), jazz musician
- Wallace John Eckert (1902–1971), astronomer and pioneer of scientific computing with computers
- Brendan Eich (* 1961), programmer
- Joe Eldridge (1908–1952), alto saxophonist and swing violinist
- Elias (* 1987), wrestler and musician
- Roy Eldridge (1911-1989), jazz trumpeter
- Albert Ellis (1913–2007), psychologist and psychotherapist
- Lisa Emery (* 1952), theater, film and television actress
- Giuseppe Enrici (1894–1968), Italian racing cyclist
- Charles Esten (* 1965), actor, singer, songwriter and comedian
- Harry Allison Estep (1884–1968), politician
- James Ewing (1866-1943), pathologist
F.
- Patrick Fabian (* 1964), film, television and theater actor
- Justin Fairfax (* 1979), politician
- Barbara Feldon (born 1933), actress
- Rube Ferns (1873–1952), boxer
- William R. Fey (* 1942), Roman Catholic religious chaplain and Bishop of Kimbe
- Jerry Fielding (1922–1980), radio announcer, arranger, and film and television composer
- Bob Filner (* 1942), politician, Mayor of San Diego and member of the US House of Representatives for California
- Michael Fimognari (* 1974), cameraman
- Mike Fincke (* 1967), astronaut
- Howard Fineman (born 1948), journalist
- Bernard Fisher (1918–2019), doctor and scientist
- J. Richard Fisher (* 1943), astronomer
- Joe Flaherty (born 1941), comedian and film actor
- Peter F. Flaherty (1924–2005), politician and lawyer
- Gaelen Foley (* 20th century), author of historical novels
- William Alfred Fowler (1911–1995), astrophysicist and Nobel Prize winner
- Stephen Flaherty (* 1960), musical composer
- Robert Forsythe (* 1949), economist
- Bill Fralic (1962-2018), American football player
- Björn Fratangelo (* 1993), tennis player
- Helen Free (* 1923), chemist
- Ron Frenz (* 1960), comic artist
- Stephen Frick (* 1964), astronaut
- Nancy Friday (1933-2017), author
- Harvey Friedman (born 1959), actor
- Michael Friedman (* 1982), racing cyclist
- Antoine Fuqua (* 1966), film director
G
- Bonnie Gadusek (born 1963), tennis player
- Barry Galbraith (1919–1983), jazz guitarist of swing and cool jazz
- Nancy Galbraith (* 1951), composer, organist and music teacher
- Rita Gam (1927-2016), actress
- Fred Gamble (* 1932), racing car driver and former Goodyear Race Director
- Chip Ganassi (* 1958), racing driver and racing team owner
- Billy Gardell (* 1969), actor and comedian
- Charles Garland (1898–1971), tennis player
- Mahlon Morris Garland (1856–1920), politician
- Erroll Garner (1921–1977), jazz pianist
- Norbert Felix Gaughan (1921–1999), Bishop of Gary
- Michael James Genovese (1919–2006), mobster of the American Cosa Nostra and boss of the LaRocca family
- John Gibson (born 1993), ice hockey player
- Bill Cormann Giessen (1932–2010), physicist, entrepreneur and university professor in Boston
- Felix Giobbe (1914–1985), jazz bassist
- Scott Glenn (born 1941), actor
- Jeff Goldblum (born 1952), actor
- Lester Goran (1928-2014), writer
- Eve Gordon (born 1960), actress
- Frank Gorshin (1933–2005), actor
- Bruce Gradkowski (born 1983), American football player
- Charles Graner (* 1968), soldier in the Iraq war
- Corey Graves (* 1984), WWE commentator, former wrestler
- Harry Greb (1894-1926), middleweight boxer
- Bill Green (1961-2012), Sprinter
- John Greene (1928–2007), theoretical physicist and applied mathematician
- Jimmy Grier (1902–1959), jazz musician, songwriter and band leader
- Benjamin Grierson (1826–1911), Brigadier General in the US Army
- Martha Grimes (* 1931), writer
- Charles Grodin (* 1935), actor, comedian, writer, radio presenter and theater director
- Joe Grushecky (* 1948 or 1949), musician
H
- Kevin Peter Hall (1955–1991), actor
- Jerome Daniel Hannan (1896–1965), Bishop of Scranton
- Karl Hardman (1927–2007), American horror film producer and actor
- Robert Hardt (* 1945), mathematician
- Beaver Harris (1936-1991), jazz drummer
- Joe Harris (1926–2016), modern jazz drummer
- Melissa Hart (* 1962), politician
- Terry Hart (* 1946), NASA astronaut
- Orrin Hatch (* 1934), Utah politician and representative in the US Senate
- Ernie Hawkins (born 1947), blues musician
- Michael V. Hayden (* 1945), General in the US Air Force
- Jonathan Haze (born 1929), actor
- John William Heard (* 1938), jazz musician and visual artist
- Bernard Hebda (born 1959), Catholic clergyman and Archbishop of Saint Paul and Minneapolis
- David Goodwin Heckel (* 1953), entomologist
- Henry John Heinz (1844–1919), inventor of Heinz Ketchup
- Henry John Heinz III (1938–1991), Senator
- Daniel Helminiak (* 1942), professor, author and Roman Catholic priest
- Philip Showalter Hench (1896-1965), physician
- Jake Herbert (* 1985), wrestler
- Francis J. Herron (1837–1902), General of the Northern States in the Civil War
- Philip Hershkovitz (1909–1997), mammalogue and curator
- Grant Heslov (* 1963), actor, director, screenwriter, producer and Oscar winner
- Treyvon Hester (born 1992), American football player
- John Heuser (* 1942), cell biologist, biophysicist and university professor
- Cameron Heyward (born 1989), American football player
- Ernest Hill (1900-1964), jazz bassist
- Henry Hillman (1918–2017), entrepreneur and philanthropist
- Samuel Dutton Hinman (1839–1890), pastor and missionary, Episcopal Church of the United States
- Jessica Ho (born 1997), tennis player
- John Hodiak (1914–1955), actor
- Gaby Hoffmann (* 1982), actress
- Arthur Hohl (1889–1964), theater and film actor
- JR Holden (* 1976), Russian-American basketball player
- Elmer J. Holland (1894–1968), politician
- David Hollander (* 1968), screenwriter, television director and producer
- Ken Hudson (1939–2012), basketball referee and official
- Ed Hugus (1923–2006), racing car driver
- Roger Humphries (* 1944), jazz drummer and music teacher
- Tommy Hunt (born 1933), rhythm and blues singer
- Charles Hutchison (1879–1949), actor and film director
I.
- James Benson Irwin (1930–1991), astronaut and lunar module pilot on the Apollo 15 mission
- William Wallace Irwin (1803-1856), politician
- Richard Isay (1934–2012), psychiatrist, university professor and author
- David Izenzon (1932–1979), jazz bassist
J
- Chevalier Jackson (1865-1958), medical doctor and laryngologist
- Jimmy Jackson (* 20th century), pianist and organist
- Gillian Jacobs (* 1982), actress and director
- Ahmad Jamal (* 1930), jazz pianist
- Peter Jannetta (1932-2016), neurosurgeon
- Eddie Jefferson (1918–1979), jazz singer and songwriter
- Jero (* 1981), enka singer
- Anick Jesdanun (1969-2020), journalist
- Leander Jordan (born 1977), American football player
K
- Karl W. Kamper (1941–1998), astronomer and asteroid discoverer
- DeAndre Kane (born 1989), basketball player
- George Simon Kaufman (1889–1961), author
- Edgar J. Kaufmann (1885–1955), entrepreneur and patron
- Gene Kelly (1912–1996), actor and dancer
- Mike Kelly (* 1948), politician
- Adrienne Kennedy (* 1931), author and playwright
- DJ Kennedy (* 1989), basketball player
- Joe Kennedy, Jr. (1923-2004), jazz musician and university professor
- V. Everett Kinsey (1909-1978), biologist and eye researcher
- Mark-Lee Kirk (1895-1969), film architect
- Meghan Klingenberg (* 1988), national soccer player
- Russell Knipp (1942-2006), weightlifter
- Catherine Baker Knoll (1930-2008), Pennsylvania politician and Lieutenant Governor
- John Kostecki (* 1964), professional sailor
- Zak Kovalcik (* 1983), track cyclist
- Robert W. Krepps (1919–1980), writer
- Harold F. Kress (1913-1999), film editor
- Cole Krueger (* 1991), Hungarian, formerly American short tracker
- John-Henry Krueger (* 1995), Hungarian, formerly American short tracker
- Cassidy Krug (* 1985), water diver
- Alma Kruger (1868 or 1871-1960), actress
L.
- Thomas Edward Lacher junior (* 1949), ecologist and mammaloge
- Jeffrey Lagarias (* 1949), mathematician
- Alois Langer (* 1945), electrical engineer
- James S. Langer (* 1934), theoretical solid-state physicist
- Susan Latshaw (born 1961), triathlete
- David Leo Lawrence (1889–1966), politician and governor of Pennsylvania
- Charles Leavitt (born 1970), screenwriter
- David Leavitt (* 1961), writer and university professor
- Chris Lee (1980–2019), Canadian-American ice hockey coach
- Sean Lee (born 1986), American football player
- Saul Leiter (1923–2013), photographer and painter
- Richard LeParmentier (1946–2013), actor and screenwriter
- Leonard Lerman (1925–2012), molecular biologist and geneticist
- John Lesher (* 1966), film producer
- John Leslie (1945-2010), porn actor and director
- Grant Lewis (born 1985), ice hockey player
- David Lewis (1916-2000), actor
- Herschell Gordon Lewis (1929–2016), filmmaker and advertising professional
- James Lightbody (1882–1953), track and field athlete and Olympic champion
- Buzzy Linhart (1943–2020), singer, songwriter, guitarist and vibraphonist
- Stephen Lippard (* 1940), chemist
- Donald Lippert (* 1957), Roman Catholic Bishop of Mendi
- Stephen Lippard (* 1940), chemist
- Tony Liscio (1940-2017), American football player
- Richard Lloyd (* 1951), guitarist and songwriter
- Warren Low (1905-1989), film editor
- Bill Lowe (* 1946), jazz musician, composer and university professor
- Mary Lowenthal Felstiner (* 1941), historian
- Lou R. Lowery (1916–1987), soldier and war photographer
- Maurice Lucas (1952-2010), basketball player
- Robert W. Lucky (* 1936), electrical engineer
- Martha L. Ludwig (1931–2006), biochemist and crystallographer
- Ray Luzier (* 1970), drummer
M.
- Carl Macek (1951–2010), screenwriter and film producer
- James McDevitt Magee (1877-1949), politician
- Ryan Malone (born 1979), ice hockey player
- Joe Manganiello (born 1976), film actor
- Dan Marino (born 1961), NFL quarterback for the Miami Dolphins
- Ernest Marland (1874–1941), politician and governor of Oklahoma
- Dodo Marmarosa (1925-2002), jazz pianist
- Adoni Maropis (born 1963), actor
- Brandon Marshall (born 1984), American football player
- Curtis Martin (born 1973), football player
- Robert F. Marx (1936–2019), pioneer of the "American Scuba divers"
- Sophie Masloff (1917–2014), Mayor of Pittsburgh
- Peter Matz (1928–2002), composer, arranger and orchestra leader
- Billy May (1916–2004), musician, composer, arranger and band leader
- Heather Mazur (born 1976), actress
- Myrtle McAteer (1878-1952), tennis player
- Dominick McCaffrey (1863-1926), boxer
- Mike McCarthy (born 1963), American football coach
- Betsy McCaughey (* 1948), politician and lieutenant governor of the state of New York
- Trevor McClurg (1816–1893), painter of the Düsseldorf School
- Judith McConnell (born 1944), actress
- TJ McConnell (born 1992), basketball player
- Suzie McConnell-Serio (born 1966), basketball player and coach
- Mack McCormick (1930–2015), folklore and music researcher
- David McCullough (* 1933), historian, biographer, narrator and lecturer
- Scott McDaniel (* 1965), comic artist
- Albert McIntire (1853–1935), politician and governor of Colorado
- Marshall McDonald (* 1959), jazz musician
- William C. McGann (1893–1977), film director, special effects designer, and cameraman
- Brett H. McGurk (* 1973), lawyer and diplomat
- Delsey McKay (1924-2004), musician and songwriter
- Judith McKenzie (* 1942), geologist
- Stewart McKinney (1931–1987), politician
- Robert McKnight (1820-1885), politician
- James McLane (born 1930), swimmer
- Robert S. McMillan (* 1950), astronomer and asteroid discoverer
- Paul McNulty (* 1958), lawyer and Deputy US Attorney General
- Andrew W. Mellon (1855–1937), banker, politician, and philanthropist
- Paul Mellon (1907–1999), entrepreneur, philanthropist, art collector, art patron, breeder and owner of racehorses
- Mel-Man (* 20th century), hip-hop producer
- Adolphe Menjou (1890–1963), actor
- Abby Lee Miller (* 1966), dance teacher, choreographer and director
- Dennis Miller (* 1953), actor, comedian, screenwriter and film producer
- Mac Miller (1992-2018), rapper
- Allan Mitchell (1933–2016), historian and university professor
- Joseph SB Mitchell (* 1959), computer scientist and mathematician
- Viola Mitchell (1911-2002), violinist
- Peter Molnar (* 1943), geologist
- Elliott Montroll (1916–1983), theoretical physicist and mathematician
- Olive Moorefield (born 1932), singer and actress
- Natalie Moorhead (1901-1992), actress
- William S. Moorhead (1923–1987), politician
- Lois Moran (1909–1990), stage and film actress
- Burton Morris (* 1964), Pop Art artist and painter
- JC Moses (1936–1977), jazz drummer
- William Motzing (1937–2014), composer, conductor and arranger
- Kermit Murdock (1908-1981), actor
N
- Christopher Nelson (* 20th century), makeup artist and Oscar winner
- Steve Nelson (* 1954), vibraphonist
- Sammy Nestico (* 1924), jazz musician
- Celeste Ng (* 1980), writer
- Gregory Nicotero (* 1963), makeup artist, film director and producer, screenwriter, stuntman, actor and expert in film effects
- Bill Nunn (1953-2016), actor
O
- William Scott O'Connor (1864-1939), fencer
- Bob O'Connor (1944–2006), politician and Mayor of Pittsburgh
- Judith O'Dea (born 1945), actress
- Paul O'Dette (* 1954), lutenist, theorbist, guitarist and musicologist
- Madalyn Murray O'Hair (1919–1995), civil rights activist
- Jennifer O'Loughlin (* 1978), soprano
- Bert O'Malley (* 1936), molecular and cell biologist
- Stewart O'Nan (born 1961), writer
- Jack Otterson (1905-1991), art director
P
- Andrea Parkins (* 20th century), sound artist and improvisation musician
- Horace Parlan (1931-2017), jazz pianist
- Benjamin Patterson (1934–2016), artist, musician and co-founder of the Fluxus movement
- Rand Paul (* 1963), doctor and politician
- Philip Pearlstein (* 1924), painter, graphic artist and draftsman
- Leo Pellegrino (* 1991), baritone saxophonist
- Alan J. Perlis (1922–1990), computer scientist and Turing Prize winner
- Corey Peters (born 1988), American football player
- Irving Pichel (1891–1954), actor and film director
- Roy Pike (* 1938), racing car driver and entrepreneur
- Sidney W. Pink (1916–2002), film producer, film director and screenwriter
- Jason Pinkston (born 1987), American football player
- Milton Plesset (1908–1991), physicist and engineer
- George Plumer (1762–1843), politician
- Amanda Polk (* 1986), rower, Olympic champion and world champion in figure eight
- Jimmy Ponder (1946–2013), jazz guitarist
- Billy Porter (* 1969), actor, singer, composer, playwright and director
- William Powell (1892-1984), actor
- Joe Pytka (born 1938), director
Q
- Zachary Quinto (born 1977), actor
R.
- Gerome Ragni (1942–1991), actor and painter
- Steven Rales (born 1951), entrepreneur
- Frederic Ramsey (1915–1995), jazz and blues writer, photographer and record producer
- Richard Rappaport (* 1944), painter
- Luke Ravenstahl (* 1980), politician
- Mona Ray (1905–1986), actress
- Eric Red (* 1961), director and screenwriter
- David A. Reed (1880–1953), Pennsylvania politician and Senate representative
- Dylan Reese (* 1984), ice hockey player
- Tom Regan (1938–2017), philosopher and activist in the animal rights movement
- Ed Earl Repp (1901–1979), science fiction, western and screenwriter
- Ron Rich (born 1938), actor
- Tom Ridge (* 1945), politician and first minister of the Ministry of Homeland Security
- Alison Riske (* 1990), tennis player
- Anita B. Roberts (1942-2006), biochemist and molecular biologist
- Leo Robin (1900–1984), musician, composer and songwriter
- Mary Roberts Rinehart (1876–1958), writer and journalist
- Jermaine Robinson (* 1989), arena football, American football and Canadian football player
- Rick Rockwell (born 1956), actor and screenwriter
- John McCarthy Roll (1947-2011), federal judge
- Dan Rooney (1932–2017), diplomat and entrepreneur
- Scott Ross (1951-1989), harpsichordist
- Zelda Rubinstein (1933-2010), actress
- Gretchen Rush (born 1964), tennis player
- Charles Taze Russell (1852–1916), founder of the Bible Students' Movement
- Babe Russian (1911–1984), jazz saxophonist
- Wyatt Ruther (1923–1999), modern jazz bassist
S.
- Brandon Saad (born 1992), ice hockey player
- Eddie Safranski (1918–1974), jazz bassist
- Avi Sagild (1933–1995), actress and socialist
- Henrik Samuelsson (* 1994), ice hockey player
- Miles Sanders (born 1997), American football player
- Robert Saudek (1911–1997), film and television producer
- Tom Savini (* 1946), make-up and special effects artist, stuntman, actor and director
- Matt Schaub (born 1981), football player
- Lou Scheimer (1928–2013), producer of cartoon series
- Kyra Schon (* 1957), actress and book author
- David O. Selznick (1902–1965), film producer
- Richard Mellon Scaife (1932-2014), billionaire
- Thomas E. Scanlon (1896–1955), politician
- Don Scharfetter (1934-2000), electrical engineer
- Joe Schmidt (* 1932), football player and coach
- Allison Schmitt (* 1990), swimmer and Olympic champion
- Edward Scull (1818–1900), politician
- Michael Seibert (* 1960), figure skater
- Peter Sellars (* 1957), theater director
- Shanice (* 1973), R&B singer
- George Shiras Junior (1832–1924), lawyer and judge at the US Supreme Court
- Jim Shooter (born 1951), comic book author
- Clifford Shull (1915-2001), physicist, Nobel Prize winner 1994
- Ronald Shusett (* 20th century), screenwriter and film producer
- Jim Simon (born 1940), football player
- James Sinegal (* 1936), entrepreneur and co-founder of the retail chain Costco Wholesale
- Johnny Sins (* 1978), porn actor and web video producer
- William Henry Singer (1868–1943), art collector and painter
- Rich Skrenta (* 1967), computer scientist, entrepreneur and inventor
- David Slepian (1923-2007), mathematician
- Ethel Smith (1902-1996), organist
- Sergio Somma (* 1987), ice hockey player
- Arnie Sowell (born 1935), middle-distance runner
- Paul Spadafora (* 1975), professional boxer and lightweight world champion
- RC Sproul (1939–2017), Reformed pastor, professor of theology and evangelical author
- Dakota Staton (1930-2007), jazz singer
- Aurelius Stehle (1877–1930), Benedictine, Archabbot
- Gertrude Stein (1874–1946), writer, publisher and art collector
- Robert J. Steinmiller junior (* 1978), actor
- Gerald Stern (* 1925), poet
- Ariana Stewart (* 1989), R&B singer and songwriter
- James J. Stoker (1905-1992), mathematician
- Russell Streiner (* 1940), film producer and actor
- Patrick Joseph Sullivan (1877–1946), politician
- Lynn R. Sykes (* 1937), geologist and geophysicist
- Syreeta (1946–2004), soul singer and songwriter
T
- Lyle Talbot (1902-1996), actor
- Phillips Talbot (1915-2010), journalist, diplomat, and Assistant Secretary of State
- Henry Ossawa Tanner (1859–1937), painter
- Joe E. Tata (born 1936), actor
- Ben Tatar (1930–2012), actor
- Jimmy Thackery (* 1953), blues singer, guitarist and composer
- Bill Thomas (* 1983), ice hockey player
- Carei Thomas (1938-2020), jazz musician
- Elliot Griffin Thomas (1926-2019), Roman Catholic Bishop of Saint Thomas
- Lamar Thomas (* 1975), rapper
- John N. Thompson (* 1951), evolutionary biologist
- Dick Thornburgh (born 1932), lawyer, politician, Governor of Pennsylvania and US attorney general
- Thomas Joseph Tobin (* 1948), Roman Catholic clergyman and Bishop of Providence
- Regis Toomey (1898–1991), actor
- Joshua Topolsky (* 1977), journalist
- Charles Champlain Townsend (1841-1910), politician
- William Tracy (1917–1967), film actor
- Vincent Trocheck (born 1993), ice hockey player
- Turbo B (born 1967), rapper
- Stanley Turrentine (1934-2000), jazz saxophonist
- Tommy Turrentine (1928–1997), modern jazz and hard bop trumpeter
- Jack Twyman (1934–2012), basketball player
U
- Ed Ulinski (1919-2006), football player and coach
- RJ Umberger (* 1982), ice hockey player
- Johnny Unitas (1933-2002), football player
- Denny Urban (* 1988), ice hockey player
V
- Frank J. Valenti (1911–2008), mobster of the American Cosa Nostra and head of the Rochester family
- Johnny Valiant (1946-2018), wrestler and wrestling manager
- Ross Ventrone (born 1986), football player
- Tom Vilsack (* 1950), politician
- Cyril John Vogel (1905–1979), Bishop of Salina
W.
- Adam Wade (* 1935), pop music singer and actor
- John Walker (1906–1995), art historian, curator and museum director
- Neil Walker (born 1985), baseball player
- Robert Walker (1909–1992), mathematician
- Bobby Wallace (1873-1960), baseball player
- Wendy Waller (* 20th century), opera and lied singer with a coloratura soprano / soprano voice
- Tom Wallisch (* 1987), freeskier
- Andy Warhol (1928–1987), pop artist
- Jeff Tain Watts (* 1960), jazz drummer
- Fritz Weaver (1926–2016), film and theater actor
- Mike Weber (* 1987), ice hockey player
- Beveridge Webster (1908–1999), pianist and music teacher
- Robert Allan Weinberg (* 1942), molecular biologist and university professor
- David Wellington (* 1971), author and blogger
- Charles West (1885–1943), actor
- Albert Gallatin Wetherby (1833–1902), malacologist, mineralogist and fossil collector
- John Wetzel (born 1991), football player
- Patrick Wey (* 1991), ice hockey player
- Randy White (born 1953), football player
- Robert V. Whitman (1928–2012), civil engineer
- George W. Wickersham (1858–1936), lawyer, politician and US Attorney General
- Earl Wild (1915-2010), pianist and composer
- Lauryn Williams (* 1983), sprinter and bobsledder
- Lawrence G. Williams (1913–1975), politician
- Lori Williams (born 1946), film actress
- August Wilson (1945–2005), playwright and playwright
- Lois Wilson (1894–1988), actress
- William Joseph Winter (* 1930), Roman Catholic auxiliary bishop in Pittsburgh
- Lauren Wood (* 20th century), pop singer and songwriter
- Euphemia R. Worthington (1881–1969), mathematician and university professor
- Jack Wright (* 1942), free jazz and improvisation musician
- Donald Wuerl (* 1940), Roman Catholic Archbishop of Washington
- Marvell Wynne (born 1986), soccer player
Y
- Karen Yasinsky (* 1965), artist and lecturer
- Peter Young (* 1940), painter
- Samuel Baldwin Marks Young (1840–1924), Lieutenant General in the US Army
Z
- Daniel Zampini (1901–1971), football player and official
- Jamie Zawinski (* 1968), programmer
- Chelsea Zhang (born 1996), actress
- Mackenzie Ziegler (* 2004), dancer, singer, actress and model
- Maddie Ziegler (* 2002), dancer, actress and model
- Fritzie Zivic (1913-1984), boxer
- Ramon Zupko (* 1932), professor of music composition