List of name reactions

Name reactions are reactions and reaction mechanisms in organic chemistry that are known enough or used frequently enough to be named. The reactions are named either after their discoverer or after a chemical. There are books that deal solely with name reactions.

Contents A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

A.

Surname	Explorer	Brief description	variants
Achmatowicz reaction	Osman Achmatowicz	Conversion of furans into dihydropyran
Acyloin condensation		Synthesis of α-hydroxy ketones from esters	Rühlmann variant
Albright-Goldman oxidation	J. Donald Albright and Leon Goldman	Selective oxidation of alcohols to aldehydes
Alder-Rickert reaction	Kurt Alder and Hans Rickert	Extension of the Diels-Alder reaction
Algar-Flynn-Oyamada reaction	Joseph Algar and John P. Flynn , T. Omayada	Synthesis of flavonols from chalcones
Alder-ene reaction	Kurt Alder	pericyclic reaction for the synthesis of alkenes	Schenck-en reaction
Aldol reaction	Charles Adolphe Wurtz and Alexander Porfirjewitsch Borodin	Addition reactions between aldehydes and / or ketones with acid / base catalysis
Alkene metathesis	Yves Chauvin	Olefin rearrangement
Allan-Robinson condensation	James Allan and Robert Robinson	Preparation of flavones or isoflavones by condensation of o -hydroxyaryl ketones with anhydrides of aromatic carboxylic acids
Amadori rearrangement	Mario Amadori	second step of the so-called Maillard reaction , a non-enzymatic browning
Andrussow method	Leonid Andrussow	Industrial synthesis of hydrogen cyanide from methane and ammonia
Angeli Rimini reaction	Angelo Angeli and Enrico Rimini	Color reaction for the detection of aldehydes
Anschütz anthracene synthesis	Richard Anschütz	Reaction of benzene with bromoethene
Appel reaction	Rolf Appel	Conversion of alcohols into alkyl halides
Arbusov reaction	Alexander Yerminingeldowitsch Arbusow	Production of alkylated phosphoric acid esters (also: Michaelis-Arbusow reaction)
Arens-van-Dorp reaction	JF Arens and DA van Dorp	Synthesis of α, β-unsaturated aldehydes	Isler modification
Arndt-Eistert homologation	Fritz Arndt and Bernd Eistert	Chain extension of carboxylic acids or ketones with diazomethane
Asinger reaction	Friedrich Asinger	Synthesis of 3-thiazolines (multi-component reaction)	Synthesis of 3-oxazolines
Aston Greenburg rearrangement	JG Aston and RB Greenburg	Synthesis of esters with a tertiary α-carbon atom
Atherton-Todd reaction	FR Atherton, HT Openshaw, and Alexander Robertus Todd	Conversion of dialkyl phosphites into dialkyl chlorophosphates
Aza-Claisen rearrangement	Ludwig Claisen
Auwers synthesis	Karl von Auwers	Synthesis of flavonols from coumarones
Aza-Cope rearrangement	Arthur C. Cope
Aza-Wittig reaction	Georg Wittig
Azo coupling		Reaction of diazonium salts with activated aromatics to form azo compounds

B.

Surname	Explorer	Brief description	variants
Baddeley isomerization	George Baddeley	Rearrangement of an alkyl group in polyalkylbenzenes
Baekeland-Manasse-Lederer reaction	Adolf von Baeyer	Synthesis of phenolic resins from phenol and aldehydes
Baeyer diarylmethane synthesis	Adolf von Baeyer	Electrophilic aromatic substitution for the production of diarylmethanes
Baeyer indole synthesis	Adolf von Baeyer and Adolph Emmerling	Synthesis of indoles
Baeyer oxindole synthesis	Adolf von Baeyer	Synthesis of oxindoles
Baeyer pyridine synthesis	Adolf von Baeyer	Synthesis of pyridine derivatives
Baeyer-Villiger oxidation	Adolf von Baeyer and Victor Villiger	Oxidation of ketones to esters with peroxycarboxylic acids
Balsohn alkylation	M. Bahlson	Alkylation of aromatics using alkenes
Bailey peptide synthesis	JL Bailey	Implementation of Leuchs' anhydrides with amino acids or peptide esters
Baker-Ollis sydnone synthesis	John Campbell Earl and Alan W. Mackney	Synthesis of Syndrons
Baker-Venkataraman rearrangement	Wilson Baker and K. Venkataraman	Synthesis of 1,3-diketone substituted phenol derivatives
Baljet reaction		Reaction for the detection and colorimetric determination of cardenolides
Balz-Schiemann reaction (Schiemann reaction)	Günther Balz and Günther Schiemann	Synthesis of fluoro-aryls from aryldiazonium salt
Bamberger rearrangement	Eugen Bamberger	Rearrangement of aromatic hydroxylamines to p-hydroxyaromatics
Bamford-Stevens reaction	William Randall Bamford and Thomas Stevens Stevens	base-induced conversion of tosylhydrazones into alkenes
Barber reaction	Philippe Barbier	Synthesis of secondary and tertiary alcohols
Bardhan-Sengupta synthesis	Jogendra Chandra Bardhan and Suresh Chandra Sengupta	Synthesis of phenanthrene
Bargellini reaction	Guido Bargellini	Synthesis of β-heteroatom-substituted 2-methylpropanoic acid derivatives
Beard reaction	Heinrich Bart	Synthesis of arylarsonic acids from diazonium salts
Bartoli indole synthesis	Giuseppe Bartoli	Synthesis of 7-substituted indoles from ortho -substituted nitrobenzenes
Barton arylation	Derek HR Barton	Arylation of phenols , enols , azoles and amines using organobismuth compounds
Barton decarboxylation	Derek HR Barton	radical decarboxylation of a carboxylic acid
Barton-McCombie deoxygenation	Derek HR Barton and Stuart W. McCombie	radical reaction to remove terminal organic groups, for example from carboxylic acid halides
Barton reaction	Derek HR Barton	δ-nitroso alcohols from nitrous acid esters
Barton-Zard reaction	Derek HR Barton and Samir Zard	Preparation of pyrrole derivatives from isonitriles and nitroalkenes
Batcho-Leimgruber indole synthesis	Andrew D. Batcho and Willy Leimgruber	Synthesis of indole from ortho -nitrotoluene
Baylis-Hillman reaction	Anthony B. Baylis and Melville ED Hillman	Synthesis of α-hydroxyvinyl carbonyls from vinyl ketone or ester, aldehyde and base
Béchamp reduction	Antoine Béchamp	Reduction of aromatic nitro compounds with iron in hydrochloric acid
Beckmann rearrangement	Ernst Beckmann	Rearrangement at the nitrogen atom: conversion of ketones via oximes to carboxamides
Beirut reaction	Makhluf J. Haddadin and Costas H. Issidorides	Synthesis of quinoxaline N, N'-dioxides
Belousov-Zhabotinsky reaction	Boris Pavlovich Belousov and Anatoli Markowitsch Schabotinsky	complex multi-component reaction with oscillating behavior
Benary reaction	Erich Bénary	Synthesis of α, β-unsaturated ketones from dialkylamino vinyl ketones
Benedict reaction	Stanley Benedict	Detection reaction for reducing sugars, flavonoids and coumarins
Benzidine rearrangement	Nikolai Nikolayevich Sinin	Conversion of N, N'-diphenylhydrazines (hydrazobenzene) to p-bisanilines (1-amino-4- (4-aminophenyl) benzene, benzidine)
Benzilic acid rearrangement	Justus von Liebig	Conversion of 1,2-diketones to α-hydroxycarboxylic acids
Benzoin addition	Arthur Lapworth	Synthesis of α-hydroxy ketones from aromatic aldehydes
Bergman cyclization	Robert G. Bergman	Thermal rearrangement of enediynes into benzene diradicals
Miner dismantling	Max Bergmann	Cleavage of peptides
Bergmann azlactone synthesis	Max Bergmann	Synthesis of peptides
Bernthsen reaction	August Bernthsen	Synthesis of acridines from diarylamines and carboxylic acids
Betti reaction	Mario Betti	Conversion of aldehydes, primary and secondary amines and aromatic compounds with a hydroxyl group
Biginelli reaction	Pietro Biginelli	Synthesis of tetrahydropyrimidones
Birch reduction	Arthur Birch	Reduction of aromatics to 1,4-dienes
Bischler-Möhlau indole synthesis	August Bischler and Richard Möhlau	Indole synthesis from anilines and α-bromo ketones	α-Hydroxyketones can be used
Bischler-Napieralski reaction	August Bischler and Bernard Napieralski	Cyclization of amides with POCl 3
Blaise ketone synthesis	Edmond Blaise	Synthesis of ketones by reacting an organozinc compound with an acyl halide
Blaise reaction	Edmond Blaise	an α-bromo ester reacts with a nitrile to form a β-keto ester
Blanc reaction	Gustave Louis Blanc	Chloromethylation of aromatics
Bodroux amide synthesis	Fernand Bodroux	Preparation of substituted amides from aromatic or aliphatic esters and an aminomagnesium halide
Bodroux-Tschitschibabin aldehyde synthesis	Alexei Jewgenjewitsch Tschitschibabin and Fernand Bodroux	Implementation of orthoformic acid esters with Grignard reagents
Boekelheide reaction	Virgil Boekelheide	Conversion of 2-methylpyridine- N -oxide and related compounds to 2-hydroxymethylpyridine and related compounds
Boekelheide rearrangement	Virgil Boekelheide
Bohn-Schmidt reaction	René Bohn and Robert Emanuel Schmidt	Reaction to produce polyhydroxyanthraquinones
Bönnemann synthesis	Helmut Bönnemann	Preparation of pyridines from a nitrile and an alkyne
Boord Olefin Synthesis	Cecil E. Boord	Production of alkenes
Borsche-Berkhout reaction	Walther Borsche and AD Berkhout	Preparation of 1,3-benzodioxane from phenols and aldehydes
Borsche-Drechsel cyclization	Walther Borsche and Edmund Drechsel	Synthesis of nitrogen-containing heterocycles from phenylhydrazones
Bosch reaction	Carl Bosch	Reaction of carbon dioxide with hydrogen to form elemental carbon (graphite), water and heat
Boulton-Katritzky rearrangement	A. John Boulton and Alan Katritzky	cyclic rearrangement of heterocycles
Bourguel alkyne synthesis	M. Bourguel	Synthesis of alkynes from 2,3-dibromo-1-propene
Bouveault aldehyde synthesis	Louis Bouveault	Implementation of formamides with Grignard reagents
Bouveault-Blanc reaction	Louis Bouveault and Gustave Louis Blanc	Reduction of esters with sodium to alcohols
Boyland Sims Oxidation	Eric Boyland and Peter Sims	Oxidation of anilines to ortho-aminophenols
Bradsher cyclization (Bradsher reaction)	Charles K. Bradsher	Synthesis of various polycyclic, aromatic compounds by acid-catalyzed cyclization
Bray-Liebhafsky reaction	William C. Bray and Herman A. Liebhafsky	complex multi-component reaction with oscillating behavior
Brellochs reaction	Bernd Brellochs	Synthesis of carboranes from aldehydes and boranates
Briggs-Rauscher reaction	Thomas S. Briggs and Warren C. Rauscher	complex multi-component reaction with oscillating behavior
Brook rearrangement	Adrian Gibbs Brook	Intramolecular migration of a silyl group to an oxygen atom
Brown hydroboration	Herbert Charles Brown	Functioning of alkenes
Bucherer reaction	Hans Theodor Bucherer	Reaction of naphthols to naphthylamines in the presence of ammonia and sodium hydrogen sulfite
Bucherer-Bergs synthesis	Hans Theodor Bucherer and Hermann Bergs	Conversion of carbonyl groups into hydantoins
Buchner reaction	Eduard Buchner	Synthesis of esters of cycloheptatriene
Büchner-Curtius-Schlotterbeck reaction	Eduard Buchner , Theodor Curtius and Fritz Schlotterbeck	Reaction of a carbonyl compound (aldehyde or ketone) with a diazoalkane
Buchwald-Hartwig coupling	Stephen L. Buchwald and John F. Hartwig	Palladium-catalyzed coupling reaction of an aryl halide or triflate with a primary or secondary amine
Burgess elimination (Burgess dehydration)	Edward M. Burgess

C.

Surname	Explorer	Brief description	variants
Cadiot-Chodkiewicz coupling	Władysław Chodkiewicz and Paul Cadiot	Copper-catalyzed coupling of terminal alkynes to diynes
Camps quinoline synthesis	Icilio Guareschi and later Rudolf Camps	Synthesis of hydroxy quinolines from N -acyl- ortho- acylanilines
Cannizzaro reaction	Stanislao Cannizzaro	Disproportionation of aldehydes in alcohols and carboxylic acids	crossed Cannizzaro reaction
Carboni-Lindsey reaction	RA Carboni and RV Lindsey junior	Synthesis of a pyridazine from a tetrazine and an alkene
Carroll Rearrangement (Kimel-Cope Rearrangement)	Michael Francis Carroll , Walter Kimel, and Arthur C. Cope	Rearrangement of β-ketoesters to γ, δ-unsaturated ketones
Castro-Stephens coupling	Charles E. Castro and Robert D. Stephens	Synthesis of aromatic alkynes by forming a carbon – carbon bond
Chan rearrangement	Tak-hang chan	Rearrangement from an acyloxacetate to a 2-hydroxy-3-ketoester
Chapman rearrangement	AW Chapman	thermal rearrangement of aryl imino esters to carboxamides
Chromotropic acid reaction		Detection reaction for formaldehyde
Ciamician-Dennstedt rearrangement	Giacomo Luigi Ciamician and Max Dennstedt	Conversion of pyrrole into halogen-containing pyridines
Claisen condensation	Ludwig Claisen	Condensation of esters to form β-keto esters	Stobbe condensation
Claisen-Schmidt condensation	Ludwig Claisen and J. Gustav Schmidt	Special case of the crossed aldol reaction
Claisen-Tishchenko reaction	Ludwig Claisen and Vyacheslav Yevgenyevich Tishchenko	Addition reaction of two aldehydes with aluminum alcoholate as a catalyst to form carboxylic acid esters
Claisen rearrangement	Ludwig Claisen	[3,3] Sigmatropic rearrangement of allyl vinyl ethers to unsaturated carbonyl compounds
Clauson-Kaas reaction	Niels Clauson-Kaas	Synthesis of N-substituted pyrroles from dialkoxy-tetrahydrofurans
Clayton-Jensen reaction	JO Clayton and WL Jensen	Chlorophosphorization of aliphatic hydrocarbons
Clemmensen reduction	Erik Christian Clemmensen	Deoxygenation of aldehydes and ketones in an acidic environment
Combes quinoline synthesis	Alphonse Combes	Quinoline derivatives from aniline and β-diketones
Conrad-Limpach quinoline synthesis	Max Conrad and Leonhard Limpach	Synthesis of quinoline from aniline and beta-keto esters
Cope elimination	Arthur C. Cope	Elimination reaction with N-oxides of tertiary amines
Cope rearrangement	Arthur C. Cope	[3,3] -sigmatropic rearrangement in 1,5-dienes	Oxy-Cope rearrangement
Corey Bakshi Shibata Reduction	Elias James Corey , Saizo Shibata and Raman K. Bakshi	enantioselective reduction of unsymmetrical ketones
Corey-Fuchs reaction	Elias James Corey and Philip L. Fuchs	Synthesis of alkynes from aldehydes
Corey Gilman Ganem Oxidation	Elias James Corey , Norman W. Gilman and BE Ganem	Synthesis of α, β-unsaturated methyl esters
Corey House reaction	Elias James Corey , Herbert O. House , Gary H. Posner, and George Whitesides	Lithium cuprates react with halides under CC coupling
Corey-Kim oxidation	Elias James Corey and Choung Un Kim	Synthesis of aldehydes from primary alcohols and ketones from secondary alcohols
Corey-Nicolaou macrolactonization	Elias James Corey and Kyriacos Costa Nicolaou	Production of macrocyclic lactones (macrolides)
Corey-Schmidt oxidation	Elias James Corey and Greg Schmidt	Oxidation of an alcohol to an aldehyde or carboxylic acid ester
Corey-Seebach reaction	Elias James Corey and Dieter Seebach	Conversion of aldehydes into ketones via deprotonated dithioacetals
Corey-Suggs oxidation	Elias James Corey and John William Suggs	Oxidation of alcohols to carbonyl compounds with pyridinium chlorochromate (PCC)
Corey Winter Elimination	Elias James Corey and Roland AE Winter	Preparation of olefins from 1,2-diols
Cornforth rearrangement	John W. Cornforth	Rearrangement of carbonyl-substituted 1,3-oxazoles to isomeric 1,3-oxazoles
Criegee ozonolysis	Rudolf Criegee	1,3-cycloaddition of ozone to alkenes and subsequent reactions
Criegee rearrangement	Rudolf Criegee	Rearrangement of the peroxyester of a tertiary alcohol into ketones , esters and carbonates
Curtius reaction	Theodor Curtius	thermal decomposition of carboxylic acid azides to isocyanates and their subsequent reactions

D.

Surname	Explorer	Brief description	variants
Dakin reaction	Henry Drysdale Dakin	Synthesis of dihydric phenols
Dakin West reaction	Henry Drysdale Dakin and Randolph West	Conversion of α-amino acids into α-acetamidoketones using acetic anhydride and a base
Danheiser benzannelation	Rick L. Danheiser
Darzens glycidate condensation	Georges Darzens	Oxiranecarboxylic acid esters through chain extension of aldehydes or ketones with α-chlorocarboxylic acid esters
Darzens halogenation	Auguste Georges Darzens	Synthesis of halogenated hydrocarbons from alcohols
Davidson oxazole cyclization	David Davidson (chemist)	Synthesis of substituted oxazoles from an O- acylacyloin
Delépine aldehyde oxidation	Marcel Delépine	Oxidation of an aldehyde to a carboxylic acid using silver (I) oxide catalysis
Delépine reaction	Marcel Delépine	Conversion of primary alkyl halides with hexamethylenetetramine to amines
De Mayo reaction	Paul Jose de Mayo	1,5-diketo compounds from enolizable diketones and olefins, domino reaction from photoaddition and retro-aldol reaction ${\displaystyle \beta }$
Demyanov rearrangement	Nikolai Jakowlewitsch Demyanow	Substitution of an amino group by a hydroxyl group
Dess-Martin oxidation	Daniel Benjamin Dess and James Cullen Martin	Oxidation of primary and secondary alcohols to aldehydes or ketones
Diazotization		Generation of diazonium salts from amines
Dieckmann condensation	Walter Dieckmann	intramolecular Claisen condensation
Diels-Alder reaction	Otto Diels and Kurt Alder	[2 + 4] cycloaddition
Dienol-benzene rearrangement	Hans Plieninger and Rolf Müller	Synthesis of a substituted benzene from a substituted dienol
Dienone-phenol rearrangement	Karl von Auwers and Karl Ziegler	Synthesis of a substituted phenol from a substituted dienone
Dimroth rearrangement	Otto Dimroth	a rearrangement reaction of exo- and endo-cyclic heteroatoms in heterocyclic rings
Di-π-methane rearrangement	Gary L. Grunewald and Howard Zimmerman	photochemical rearrangement of 1,4-dienes to vinylcyclopropanes
Doebner-Miller reaction	Oskar Doebner and Wilhelm von Miller	Preparation of quinoline and its derivatives	Beyer method
Doebner reaction	Oskar Doebner	Synthesis of acid derivatives of quinoline
Doering-LaFlamme-Allen synthesis	William von Eggers Doering and Paul M. LaFlamme	Synthesis of allenes from olefins
Doetz reaction	Karl Heinz Dötz	Benzo annulation via chromium-carbene complexes
Duff reaction	James Cooper Duff	Formylation of electron-rich aromatics

E.

Surname	Explorer	Brief description	variants
Eastwood olefination	G. Crank and FW Eastwood	Stereo-specific representation of alkenes
Edman breakdown	Pehr Edman	Method for determining the amino acid sequence of proteins and peptides
Eglinton reaction	Geoffrey Eglinton	Synthesis of symmetrical diynes from terminal alkynes
Honest Sachs reaction	Paul Ehrlich and Franz Sachs	Condensation of a methylene with an acomatic nitroso compound
Unicorn acylation	Alfred Einhorn and Friedrich Hollandt	Acylation of alcohols using anhydrides or carboxylic acid halides in a tertiary amine such as pyridine
Unicorn-Brunner reaction	Alfred Einhorn and Karl Brunner	Synthesis of 1,2,4-triazoles from hydrazines and diacylamines
Eisleb alkylation	Otto Eisleb	Alkylation reaction with an alkali halide
Elbs reaction	Karl Elbs	Pyrolysis of aromatic acyls to polynuclear aromatic systems
Elbe oxidation	Karl Elbs	Oxidation of phenols with persulfate
Eltekoff hydrolysis	A. Eltekoff	Hydrolysis of vinyl halides in aqueous alkaline solution for the production of carbonyl compounds (aldehydes or ketones)
Emde dismantling (also Hofmann-Emde dismantling)	Hermann Emde	Cleavage of quaternary ammonium salts to tertiary amines and hydrocarbons
Emmert reaction	Bruno Emmert and Erich Asendorf	Production of 2-pyridinedialkylcarbinol
Enders reagent	Dieter Enders	Asymmetric Synthesis Reagents (SAMP and RAMP)
Erlenmeyer synthesis	Friedrich Gustav Karl Emil Erlenmeyer	Synthesis of α-amino acids and α-keto acids from unsaturated azlactones
Erlenmeyer-Plöchl synthesis	Friedrich Gustav Karl Emil Erlenmeyer and Josef Plöchl	Synthesis of azlactones and amino acids
Eschenmoser fragmentation	Albert Eschenmoser	Synthesis of alkynes from epoxy ketones
Eschenmoser coupling	Albert Fischli and Albert Eschenmoser	Formation of vinylogous amides and urethanes
Eschweiler-Clarke methylation	Wilhelm Eschweiler and Hans Thacher Clarke	reductive alkylation of primary and secondary amines to tertiary amines with formaldehyde and formic acid
Ester pyrolysis	William P. Ratchford	Preparation of olefins by pyrolysis of carboxylic acid esters
Etard reaction	Alexandre Léon Etard	Oxidation of an alkyl-substituted phenyl derivative to an aldehyde

F.

Surname	Explorer	Brief description	variants
Faworski reaction	Alexei Yevgrafovich Faworsky	Preparation of α-carbonylalkene from alkynes and carbonyls
Faworski rearrangement	Alexei Yevgrafovich Faworsky	Rearrangement of cyclopropanone derivatives or α-haloketones to carboxylic acids
Feist-Bénary reaction	Franz Feist and Erich Bénary	Conversion of β-dicarbonyl compounds with α-halogen carbonyl compounds
Fenton reaction	Henry John Horstman Fenton	Iron salt catalyzed oxidation of organic substrates
Ferrario-Ackermann reaction	ME Ferrario and Fritz Ackermann	Cyclization of diaryl ethers
Fetizon oxidation	Marcel Fétizon and Michel Golfier	mild oxidation of alcohols to carbonyl compounds
Finkelstein reaction	Hans Finkelstein	Replacement of a halogenyl substituent of an organic compound by a different halogen ion
Fischer-Helferich glycosylation	Emil Fischer and Burckhardt Helferich	Acid catalyzed synthesis of O - or S -Glykosiden
Fischer-Hepp rearrangement	Otto Fischer and Eduard Hepp	Synthesis of a nitroso compound from an isomeric aromatic nitrosamine
Fischer oxazole synthesis	Emil Fischer	Synthesis of 2,5-substituted oxazoles
Fischer phenylhydrazine synthesis	Emil Fischer	Synthesis of phenylhydrazine from aniline
Fischer-Tropsch synthesis	Franz Fischer and Hans Tropsch	Production of liquid hydrocarbons from synthesis gas
Fischer esterification	Emil Fischer	acid esterification with excess alcohol
Fischer's indole synthesis	Emil Fischer	Preparation of indoles by reacting aryl hydrazones with ketones in the presence of Lewis acids
Fleming-Tamao oxidation	Kohei Tamao and Ian Fleming	Synthesis of primary and secondary alcohols
Flood reaction	EA Flood	Synthesis of halotrialkylsilanes from hexaalkyldisiloxanes
Forster-Decker reaction	Martin Onslow Forster and Hermann Decker	Preparation of secondary amines from primary amines
Forster diazoketone synthesis	Martin Onslow Forster	Synthesis of diazoketones from α-ketooximes and chloramine
Franchimont condensation	Antoine Paul Nicolas Franchimont	Linking of two α-bromocarboxylic acid molecules to form a new carbon-carbon bond
Frankland Duppa Reaction	Edward Frankland	Production of 2-hydroxycarboxylic acid alkyl esters
Fráter-Seebach alkylation	Georg Fráter, Dieter Seebach	stereospecific alkylation of β-hydroxy ester in the α position
Friend reaction	August friend	Synthesis of cyclopropane	Gustavson reaction
Friedel-Crafts acylation	Charles Friedel and James Mason Crafts	Acylation by electrophilic aromatic substitution
Friedel-Crafts alkylation	Charles Friedel and James Mason Crafts	Alkylation by electrophilic aromatic substitution
Friedlaender quinoline synthesis	Paul Friedländer	Reaction to produce quinoline
Frieze rearrangement	Karl Theophil Fries	Lewis acid catalyzed rearrangement of phenyl esters to aryl ketones
Fritsch-Buttenberg-Wiechell rearrangement	Paul Fritsch , Wilhelm Paul Buttenberg , Heinrich G. Wiechell	Synthesis of an alkyne from a 1,1-disubstituted vinyl halide
Fukuyama amine synthesis	Tohru Fukuyama	Two-step synthesis of secondary amines from primary amines
Fukuyama indole synthesis	Tohru Fukuyama	Indoles via radical intermediates
Fukuyama reduction	Tohru Fukuyama	Synthesis of aldehydes from thiol esters with triethylsilane in the presence of a palladium catalyst
Fürstner indole synthesis	Alois Fürstner	Indoles from o-acylaniline amides according to the McMurry reaction mechanism

G

Surname	Explorer	Brief description	variants
Gabriel-Colman rearrangement	Siegmund Gabriel and James Colman	Synthesis of substituted isoquinolines
Gabriel synthesis	Siegmund Gabriel	Synthesis of primary amines from alkyl halides and phthalimide potassium
Gassman indole synthesis	Paul G. Gassman	Synthesis of substituted indoles from aromatic amines
Gassman oxindole synthesis	Paul G. Gassman	Synthesis of oxindoles
Gassman reaction	Paul G. Gassman	Synthesis of ortho- alkylated anilines
Gattermann reaction	Ludwig Gattermann	Production of aromatic halides or aromatic nitriles by decomposing corresponding diazonium salts in the presence of copper powder
Gattermann synthesis	Ludwig Gattermann	Formylation of aromatics with HCN, HCl and Lewis acids
Gattermann-Adams synthesis	Ludwig Gattermann and Roger Adams	Formylation of aromatics with ZnCN 2 , HCl and Lewis acids
Gattermann-Koch synthesis	Ludwig Gattermann and Julius Arnold Koch	Formylation of aromatics with CO, HCl and Lewis acids
Gewald reaction	Karl Gewald	Synthesis of substituted 2-amino thiophenes
Ghosez cyclization	Léon Ghosez	Synthesis of δ-lactones
Gibbs-Wohl-naphthalene oxidation	Harry D. Gibbs and Courtney Conover	Synthesis of phthalic anhydride from naphthalene
Gilman-Speeter condensation	Henry Gilman and Merrill E. Speeter	Synthesis of a β - lactam from a Reformatzki reagent and an imine
Gilman-Van-Ess synthesis	Henry Gilman and Paul R. van Ess	Synthesis of ketones from carboxylic acids and lithium- alkyl compounds
Glaser coupling	Carl Glaser	Copper-catalyzed coupling of terminal alkynes to diynes
Glycol splitting (Criegee glycol splitting)	Rudolf Criegee	oxidative cleavage of vicinal diols
Glyoxaline method (imidazole method)	Daan Van Leusen and Albert M. Van Leusen	Synthesis of imidazoles from amines, glyoxal, aldehydes and ammonia
Gomberg-Bachmann reaction	Moses Gomberg and Werner Emmanuel Bachmann	Synthesis of unsymmetrical biphenyls
Gomberg radical reaction	Moses Gomberg	Synthesis of the triphenylmethyl radical
Gould-Jacobs reaction	Gordon Gould and Walter Abraham Jacobs	Production of quinoline derivatives
Graebe-Ullmann synthesis	Carl Graebe and Fritz Ullmann	Synthesis of carbazoles
Gribble amination	Gordon W. Gribble	Synthesis of indolines
Grignard degradation	Wilhelm Steinkopf	Dehalogenation of polyhalogen compounds
Grignard reaction	Victor Grignard	Reactions of Grignard reagents with electrophiles	Organo-lithium reaction
Grignard reduction	Victor Grignard	Side reaction to the Grignard reaction in the reaction of sterically hindered Grignard reagents with ketones
Gross fragmentation	Cyril A. Grob	A compound is broken down into three fragments
Grosheintz-Fischer-Reissert aldehyde synthesis	Jean M. Grosheintz , Hermann Otto Laurenz Fischer and Arnold Reissert	Production of aldehydes from the corresponding acid chloride
Grundmann aldehyde synthesis	Christoph Grundmann	Synthesis of aldehydes from carboxylic acid chlorides
Guareschi reaction	Icilio Guareschi	Synthesis of pyridine derivatives
Guerbet condensation	Marcel Guerbet	Synthesis of longer-chain alcohols from primary or secondary alcohols
Gustavson reaction	Gawriil Gawriilowitsch Gustawson	Synthesis of cyclopropane	Extension of the friend reaction

H

Surname	Explorer	Brief description	variants
Haber-Weiss reaction	Fritz Haber and Joseph Joshua Weiss	Synthesis of hydroxyl radicals from hydrogen peroxide and dioxide (1–)
Hajos-Parrish-Eder-Sauer-Wiechert reaction (Eder-Sauer-Wiechert modification or Eder-Sauer-Wiechert reaction)	Zoltan Hajos , David R. Parrish , Ulrich Eder , Gerhard Sauer and Rudolf Wiechert	Combination of an ( S ) - (-) - proline-catalyzed enantioselective Michael addition and a subsequent intramolecular aldol reaction that proceeds with cyclization	Use of other mostly cyclic amino acids as a catalyst
Haller-Bauer reaction	Albin Haller and E. Bauer	Cleavage of non- enolizable ketones into alkanes and carboxamides
Haloform reaction (unicorn reaction)	Alfred Einhorn	oxidative cleavage of methyl ketones
Hammick reaction	Dalziel Hammick	Synthesis of 2-pyridine alcohols
Hansley-Prelog acyloin condensation	VL Hansley, expanded by Vladimir Prelog	intramolecular variant of acyloin condensation
Hantzsch synthesis of dihydropyridine	Arthur Hantzsch	Synthesis of 1,4-dihydropyridines by condensation of β-diketones with aldehydes and ammonia
Hantzsch pyrrole synthesis	Arthur Hantzsch	Synthesis of pyrrole derivatives by reaction of β-ketoesters, amines and α-haloketones
Hass-Bender Oxidation	Henry B. Hass and Myron L. Bender	Preparation of substituted benzaldehydes
Haworth synthesis	Robert Downs Haworth	Synthesis of phenanthrene
Hayashi rearrangement	Mosuke Hayashi	acidification with sulfuric acid causes a rearrangement reaction of o-benzoylbenzoic acid
Heck reaction	Richard F. Heck	Palladium-catalyzed alkyl / arylation of olefins
Hegedus indole synthesis	Louis S. Hegedus	Indoles from o-allylanilines under Pd (II) catalysis
Heine reaction	Harold W. Heine	Isomerization of N- acylaziridines to the corresponding oxazoles
Hell-Volhard-Zelinsky reaction	Carl Magnus von Hell , Jacob Volhard and Nikolay Dimitrievich Zelinsky	α-halogenation of carboxylic acids
Helmchen synthesis	Günter Helmchen	Synthesis of chiral alcohols or carboxylic acids with the help of the Helmchen auxiliary
Hemetsberger indole synthesis	Helfried Hemetsberger and Dierk Knittel	Thermal decomposition of a 2-azidocinnamic acid ester into an indole-2-carboxylic acid ester
Henkel reaction	Bernhard Raecke	Synthesis of symmetrical dicarboxylic acids from the alkali salts of aromatic carboxylic acids
Henry reaction	Louis Henry	Base-catalyzed addition of nitroalkanes to aldehydes or ketones	Aza-Henry reaction
Autumn angel transamination	Robert M. Herbst and LL Engel	the amino group of an amino acid is transferred to a keto acid, with a new amino acid and an aldehyde being formed
Heron rearrangement	Stephen A. Glover	Conversion of an amide with two substituents with heteroatoms on the nitrogen atom to an ester and a 1,1-diimine
Heart reaction	Richard Heart	Thiophenol derivative from aniline
Hetero-Diels-Alder reaction		Synthesis of six-membered heterocycles with carbon – carbon double bonds
Heyns rearrangement	Kurt Heyns	Initial phase of the Maillard reaction
Hinsberg separation	Oscar Hinsberg	Synthesis of sulfonamides to identify various amines
Hinsberg thiophene synthesis	Oscar Hinsberg	Synthesis reaction for substituted thiophenes
High Campbell Reaction	Joseph Hoch , expanded upon by Kenneth N. Campbell	Synthesis of aziridines from oximes
Hock's phenol synthesis	Heinrich Hock	Synthesis of phenol and acetone from cumene - peroxide
Hofmann-Martius rearrangement	August Wilhelm von Hofmann and Carl Alexander von Martius	Rearrangement of N -alkylated aniline derivatives to ortho- and para -alkylated aniline derivatives
Hofmann rearrangement	August Wilhelm von Hofmann	Conversion of carboxamides into primary amines
Hofmann elimination	August Wilhelm von Hofmann	Degradation of amines to alkenes
Hofmann-Löffler-Freytag reaction	August Wilhelm von Hofmann , K. Löffler and C. Freytag	cyclic amines from acyclic amines
Hooker's oxidation	Samuel Cox Hooker	Oxidation of a 2-hydroxy-3-alkyl (or alkenyl) -1,4-benzoquinone leads to the exchange of a hydroxy and alkyl (alkenyl) group (the latter is also shortened by a methylene group)
Horenstein-Pählicke reaction	Heinrich Horenstein and Herrmann Pählicke	Halogen derivatives of tertiary amines react with salts of aromatic carboxylic acids
Horner-Wadsworth-Emmons reaction	Leopold Horner , William S. Wadsworth Jr., and William D. Emmons	Wittig-related olefination of aldehydes or ketones with phosphonic acid diesters	Still-Gennari olefination
Hosomi Sakurai reaction	Akira Hosomi and Hideki Sakurai	Implementation of carbonyl compounds and other electrophiles with allyl - silane
Houben-Hoesch reaction	Josef Houben and Kurt Hoesch	Acylation of electron-rich aromatics with nitriles, HCl and a Lewis acid with subsequent hydrolysis yields aryl ketones	Houben-Fischer synthesis
Huisgen pyrrole synthesis	Rolf Huisgen	Synthesis of substituted pyrroles
Huisgen reaction	Rolf Huisgen	1,3-Dipolar cycloaddition of alkenes or alkynes with 1,3-dipolar molecules such as azides , nitrile oxides or diazoalkanes
Hunsdiecker condensation	Heinz Hunsdiecker	Synthesis of cyclopentenones
Hunsdiecker reaction	Heinz Hunsdiecker and Claire Hunsdiecker	Decarboxylation of primary silver or thallium (I) carboxylates by reaction with chlorine , bromine or iodine
Hurd-Mori reaction	Charles D. Hurd and Raymond I. Mori	Preparation of thiazoles
Hydroboration (Brown Hydroboration)	Herbert Charles Brown	Addition of boranes to olefins

I.

Surname	Explorer	Brief description	variants
Ivanov reaction	Dimitar Ivanov	Addition of a carboxylate enolate to an aldehyde
Ipatiev synthesis	Vladimir Nikolayevich Ipatiev	Addition of a carbenium ion to alkenes without polymerization
Irvine-Purdie methylation	James Irvine , Thomas Purdie	Methylation of carbohydrates with iodomethane and silver (I) oxide

J

Surname	Explorer	Brief description	variants
Jacobsen epoxidation	Eric N. Jacobsen	enantioselective epoxidation of alkenes
Jacobsen reaction	Josef Herzig , expanded by Oscar Jacobsen	Sulphonation of tetrasubstituted benzenes
Japp-Klingemann reaction	Francis Japp and Felix Klingemann	Synthesis of aryl hydrazones by reaction of β-dicarbonyl compounds with diazonium salts
Jensen reaction	Bror Skytte Jensen	C – C linkage reaction for the synthesis of 4-acylpyrazolones
Johnson-Claisen rearrangement	William Summer Johnson and Ludwig Claisen	Ester synthesis
Johnson-Corey-Chaykovsky reaction	A. William Johnson , expanded by Elias James Corey and Michael Chaykovsky	Synthesis of epoxides , aziridines and cyclopropanes using sulfur ylides
Johnson-Polyene Cyclization	William Summer Johnson	cationic process for ring formation from alkenes
Jones oxidation	Ewart Jones	Oxidation of alcohol and aldehydes with chromium (VI) oxide
Julia olefination	Marc Julia	Synthesis of stereoselective alkenes from phenyl sulfones and ketones or aldehydes

K

Surname	Explorer	Brief description	variants
Kabachnik Fields reaction	Martin Israilewitsch Kabachnik and Ellis K. Fields	Multi-component reaction for the synthesis of α-aminophosphonates
Kahne glycosidation	Daniel E. Kahne
Kauffmann olefination	Thomas Kauffmann	Converting a ketone or an aldehyde into a methylene group
Bold reaction	Gary E. Keck	Asymmetric allylation
Kemp decarboxylation	Daniel S. Kemp	Special case of the Kemp elimination
Kemp elimination	Daniel S. Kemp	Base-catalyzed ring opening of a benzisoxazole
Kiliani-Fischer synthesis	Heinrich Kiliani and Emil Fischer	Extension of the carbon chain of sugars
Kinugasa reaction	Manabu Kinugasa	Synthesis of β-lactams
Knoevenagel reaction	Emil Knoevenagel	Conversion of aldehydes or ketones with CH-acidic methylene compounds	Doebner variant
Knorr quinoline synthesis	Ludwig Knorr	Preparation of quinolines from aniline and β-ketoesters
Knorr pyrrole synthesis	Ludwig Knorr	Synthesis of pyrroles by condensation of ketones with α-aminoketones
Koch reaction	Herbert Koch	Carboxylic acid synthesis from olefins ( alkenes ), carbon monoxide and water (hydroformylation)
Kocheshkov rearrangement	Xenofont Alexandrovich Kocheshkov	Comproportioning of tin tetraorganyls with tin tetrahalides
Kochi reaction	Jay K. Kochi	Decarboxylation of secondary and tertiary carboxylic acids by reaction with lead tetraacetate and lithium chloride
Koenigs-Knorr method	Wilhelm Koenigs and Eduard Knorr	synthetic production of glycosides from monosaccharide derivatives
Kolbe electrolysis	Hermann Kolbe	CC bond formation through anodic oxidation of carboxylic acids
Kolbe nitrile synthesis	Hermann Kolbe	Production of nitriles from alkyl halides and cyanide
Kolbe-Schmitt reaction	Hermann Kolbe and Rudolf Schmitt	Synthesis of hydroxybenzoic acids by carboxylation of phenates	Salicylic Acid Synthesis
Kondakov acylation	Ivan Lavrentevich Kondakov	Synthesis of β-haloketones from alkenes and carboxylic acid halides	Darzens olefin acylation, extension by Georges Darzens
Kondrat'eva pyridine synthesis	GY Kondrat'eva	Synthesis of pyridine derivatives from oxazole and a substituted alkene
Cornflower Oxidation	Nathan Kornblum	Conversion of alkyl halides into aldehydes with dimethyl sulfoxide
Korte rearrangement	Friedhelm Korte	Rearrangement of α-acyl lactones
Kostanecki-Robinson reaction	Stanislaus von Kostanecki and Robert Robinson	Production of coumarin or chromones	Allan-Robinson condensation is part of it
Krapcho decarboxylation	Andrew Paul Krapcho	Decarboxylation of malonic acid esters, β-ketocarboxylic acid esters and similar compounds
Kröhnke pyridine synthesis	Fritz Kröhnke	Synthesis of substituted pyridines from pyridine or pyridine derivatives
Kulinkovich reaction	Oleg Grigoryevich Kulinkovich	Synthesis of cyclopropanol / cyclopropylamine derivatives by reaction of Grignard compounds in the presence of titanium (IV) isopropoxide
Kumada clutch	Makoto Kumada	Nickel-catalyzed cross-coupling
Kutscherov reaction	Mikhail Grigoryevich Kutscherow	Synthesis of aldehydes or ketones from alkynes

L.

Surname	Explorer	Brief description	variants
Lander rearrangement	Henry L. Wheeler, Treat B. Johnson, and David F. McFarland, expanded by George Druce Lander	Thermal conversion of an alkyl imidate into an N -alkyl amide
Landolt reaction	Hans Heinrich Landolt	As Ioduhr known actor trial
Larock indole synthesis	Richard C. Larock	Synthesis of indoles by palladium-catalyzed annulation
Laux process	Julius Laux	Synthesis of aniline
Letts nitrile synthesis	Edmund A. Letts	Preparation of aromatic nitriles from acids with potassium thiocyanate
Lehmstedt – Tănăsescu reaction	Ioan Tănăsescu and Kurt Lehmstedt	Acridones made from 2-nitrobenzaldehyde and aromatic components
Leuckart-Wallach reaction	Rudolf Leuckart and Otto Wallach	reductive alkylation of carbonyls with formic acid to give amines
Ley oxidation	Steven Ley	Oxidation of primary and secondary alcohols to aldehydes or ketones with tetrapropylammonium perruthenate (TPAP)
Love reaction	Justus von Liebig and Adolf Lieben	Monomethyl ketones are converted into carboxylic acids shortened by one carbon atom; the methyl group of the methyl ketone is split off as haloform (e.g. iodoform) at the same time
Liebermann-Burchard reaction	Carl Liebermann and Hans Burchard	Detection reaction to cholesterol with acetic anhydride and concentrated sulfuric acid
Lobry-de-Bruyn-Alberda-van-Ekenstein rearrangement	Cornelis Adriaan Lobry van Troostenburg de Bruyn and Willem Alberda van Ekenstein	Base-catalyzed aldose-ketose isomerization
Lossen dismantling	Wilhelm Lossen	Degradation of hydroxamic acid derivatives to isocyanates
Luche reduction	Jean-Louis Luche	Reduction of aldehydes and ketones with cerium (III) chloride and reducing agents such as sodium borohydride
Lüttringhaus rearrangement	Arthur Lüttringhaus	Diaryl ethers in o-arylphenols

M.

Surname	Explorer	Brief description	variants
Maillard reaction	Louis Camille Maillard	complex reaction system that is responsible for browning food during roasting
Madelung indole synthesis	Walter Madelung	Indole synthesis, starting from 2-alkylated anilides
Maitland-Japp reaction	Francis Japp and William Maitland	Preparation of tetrahydropyranone derivatives from ketones and aldehydes
Makosza reaction	Mieczysław Mąkosza	Introduction of alkyl residues with functional groups in electrophilic aromatics
Malonic ester synthesis	William Henry Perkin Jr.	Alkylation of malonic acid esters
Mannich reaction	Carl Mannich	Amino-methylation of C-acidic compounds with formaldehyde and an amine / ammonia	Mannich-Eschenmoser methylenation
Marshalk reaction	Charles H. Marschalk	Introduction of substituents on phenolic anthraquinones
Martinet reaction	Joseph Martinet and André Guyot	Synthesis of dioxindole
McCormack reaction	William B. McCormack	Synthesis of phospholene oxides
McFadyen-Stevens reaction	John S. McFayden and Thomas S. Stevens	Synthesis of aromatic or heteroaromatic aldehydes
McLafferty rearrangement	Fred McLafferty	Reaction in the mass spectrometer
McMurry reaction	John E. McMurry	Coupling of ketones to alkenes
Meerwein-Ponndorf-Verley reduction	Hans Meerwein , Wolfgang Ponndorf and Albert Verley	Reduction of aldehydes or ketones to primary and secondary alcohols in the presence of aluminum alcoholates
Sea wine reduction	Hans Meerwein	Dediazonation of aryldiazonium salts
Meisenheimer rearrangement	Jakob Meisenheimer	Synthesis of alkoxyamines from amine oxides
Menke nitriding	Jean Babtiste Menke	Nitration of aromatics
Menschutkin reaction	Nikolai Alexandrovich Menshutkin	Formation of quaternary ammonium salts
Meyer-Hartmann reaction	Christoph Hartmann Victor Meyer	Synthesis of diaryliodonium salts
Meyer-Schuster rearrangement	Kurt Heinrich Meyer and Kurt Schuster	Rearrangement of secondary and tertiary propargylic alcohols to α, β-unsaturated ketones
Meyers synthesis	Albert I. Meyers	Synthesis of aldehydes from oxazines
Michael addition	Arthur Michael	1,4-addition of nucleophiles to α-β-unsaturated carbonyl compounds
Michaelis-Arbusow reaction	August Michaelis , Alexander Jerminingeldowitsch Arbusow and Boris Alexandrowitsch Arbusow	Synthesis of phosphonic acid esters (also: Arbusow reaction)
Miescher mining , also Meystre-Miescher mining	Charles Meystre and Karl Miescher	Breakdown of the side chain of bile acids
Mignonac reaction	Gilbert Thomas Morgan and Leslie Percy Walls	Optimization of the Picetet-Hubert reaction . Used for the synthesis of phenanthridine and its derivatives
Minisci reaction	Francesco Minisci	radical substitution of alkyl and acyl radicals on aromatics
Mislow-Evans rearrangement	Kurt Mislow and David Evans	Preparation of alkenols from alpha-substituted allyl sulfoxides
Mitsunobu reaction	Oyo Mitsunobu	Synthesis of esters, phenol ethers and the like a. from primary and secondary alcohols with triphenylphosphine and diethylazodicarboxylate	Mitsunobu lactonization
Morgan Walls reaction	Georges Mignonac	Synthesis of primary amines
Moureau-Mignonac imine synthesis	C. Moureau and G. Mignonac	Production of imines from nitriles by Grignard compounds
Mukaiyama aldol reaction	Teruaki Mukaiyama	Crossed aldol reaction	Mukaiyama-Michael reaction
Mukaiyama-Michael reaction	Teruaki Mukaiyama	Addition of enol silanes to α, β-unsaturated carbonyl compounds
Müller-Rochow synthesis	Eugene G. Rochow and Richard Müller	Process for the large-scale production of chloro (methyl) silanes

N

Surname	Explorer	Brief description	variants
Nagata response	Wataru Nagata	Hydrocyanation
Nazarov cyclization	Ivan Nikolayevich Nazarow	Cyclization of divinyl ketones to give cyclopentenones
Neber rearrangement	Peter Neber	Synthesis of α-aminated ketones from ketones
Nef reaction	John Ulric Nef	Synthesis of carbonyl compounds from nitroalkanes
Negishi clutch	Ei-ichi Negishi	CC bond formation between allylic, aromatic or olefinic residues via zinc-organic compounds
Nenitzescu indole synthesis	Costin Nenitzescu	Synthesis of 5-hydroxy-indoles from p -benzoquinone
Newman-Kwart rearrangement	Alexander Schönberg , expanded by Melvin Spencer Newman and Harold Kwart	Rearrangement of alkyl-substituted thionourethanes to thiolourethanes
Nicholas reaction	Kenneth M. Nicholas	Preparation of alkylated alkynes from propargyl alcohols or ethers
Niementowski reaction	Stefan Niementowski	Synthesis of quinazolines
Kidney stone reaction	Maximilian kidney stone	Conversion of carboxylic acid chloride into chloromethyl ketones with diazomethanes
Norrish reaction	Ronald George Wreyford Norrish	photochemical radical reactions of carbonyl compounds
Noyori hydrogenation	Ryōji Noyori
Nozaki-Hiyama-Kishi reaction	Hitosi Nozaki , Tamejiro Hiyama and Yoshito Kishi	Nickel-catalyzed chromium-mediated coupling reaction

O

Surname	Explorer	Brief description	variants
Oppenauer oxidation	Rupert Viktor Oppenauer	Reverse reaction of the Meerwein-Ponndorf-Verley reduction; Oxidation of primary and secondary alcohols to the corresponding aldehydes or ketones in the presence of aluminum alcoholates
Ortoleva-King reaction	Giovanni Ortoleva , expanded by L. Carroll King	Synthesis of pyridinium iodide salts
Orton rearrangement	Kennedy Joseph Previté Orton , G. Bender, Henry Edward Armstrong	Chlorine rearrangement on anilides
Overman rearrangement	Larry E. Overman	Allyl alcohols react with trichloroacetonitrile under basic conditions, resulting in rearranged trichloroacetic acid amides
Oxymercuration , also Hofmann-Sand reaction	KA Hofmann, JW Sand	Markovnikov-selective anti-addition of OH and Hg (II) with subsequent reduction
Ozonolysis	Rudolf Criegee	Cleavage of alkenes to carbonyl compounds

P

Surname	Explorer	Brief description	variants
Paal-Knorr synthesis	Carl Paal and Ludwig Knorr	Synthesis of heterocycles from 1,4-diketones
Parikh-Doering oxidation	Jekishan R. Parikh and William von Eggers Doering	Oxidation of primary and secondary alcohols to aldehydes and ketones similar to the Swern oxidation with DMSO and sulfur trioxide - pyridine complex
Passerini reaction	Mario Passerini	Synthesis of α-hydroxycarboxamides from carboxylic acid, ketone and isocyanide	Ugi reaction
Paternò-Büchi reaction	Emanuele Paternò and George Büchi	photochemical [2 + 2] cycloaddition of carbonyl with olefin
Pauly reaction	Hermann Pauly	Detection reaction for the amino acids tyrosine and histidine
Pauson-Khand reaction	Peter Pauson and Ihsan U. Khand	Synthesis of substituted cyclopentenones from alkene, an alkyne and carbon monoxide with dicobalt octacarbonyl
Payne rearrangement	George B. Payne	enantiospecific rearrangement of epoxides
Pechmann pyrazole synthesis	Hans von Pechmann	Synthesis of pyrazoles
Pechmann reaction	Hans von Pechmann	Synthesis of coumarin derivatives
Pellizzari reaction	Guido Pellizzari	Synthesis of 1,2,4-triazoles
Perkin's reaction	William Henry Perkin	Ester condensation-analogous reaction
Perkow reaction	Werner Perkow	Synthesis of vinyl phosphates from ketones
Petasis-Ferrier rearrangement	Nicos A. Petasis and Robert J. Ferrier	Conversion of an enol acetal into a tetrahydropyranone under the action of a Lewis acid
Peterson olefination	Donald John Peterson	Alkene synthesis by syn elimination from β-hydroxysilanes
Petrenko-Krittschenko synthesis of piperidone	Pavel Ivanovich Petrenko-Krittschenko	Precursor to the Robinson-Schöpf reaction
Pfitzinger reaction (Pfitzinger-Borsche reaction)	Wilhelm Pfitzinger and Walther Borsche ; Josef Halberkann	Synthesis of quinoline derivatives from isatin and carbonyl compounds	Half-can variant
Phillips-Ladenburg Benzimidazole Synthesis	MA Phillips and Albert Ladenburg	Synthesis of benzimidazoles
Pictet-Spengler reaction	Amé Pictet and Theodor Spengler	Preparation of isoquinolines from imines and iminium salts
Piloty-Robinson pyrrole synthesis	Oskar Piloty , Robert Robinson and Gertrude Maud Robinson	Synthesis of pyrroles from azines
Pfitzner-Moffatt oxidation	Klaus E. Pfitzner and John G. Moffatt	mild method for the oxidation of primary and secondary alcohols with N, N'-dicyclohexylcarbodiimide (DCC) and dimethyl sulfoxide (DMSO) into the corresponding aldehydes or ketones
Pinacol coupling	Rudolph Fittig	reductive coupling of two ketones to form a 1,2-diol
Pinacol rearrangement	Alexander Mikhailovich Butlerov	Acid-catalyzed rearrangement of 1,2-diols
Pinner reaction	Adolf Pinner	Reaction of a nitrile with an alcohol with acid catalysis; the result is the salt of an imino ester
Pinnick oxidation	Harold W. Pinnick	Oxidation of α, β-unsaturated aldehydes to α, β-unsaturated carboxylic acids using sodium chlorite
Plancher rearrangement (Ciamician-Plancher rearrangement)	Giuseppe Plancher , Giacomo Luigi Ciamician	Rearrangement of an alkyl / aryl group in disubstituted indolin-3-ol
Polonovski reaction	Max Polonovski	Rearrangement of amine oxides
Pomeranz-Fritsch reaction	Cesar Pomeranz and Paul Fritsch	Synthesis of isoquinoline from benzaldehyde and aminoacetaldehyde diethylacetal
Ponzio reaction	Giacomo Ponzio	Synthesis of 3-nitro- (2-dinitromethyl) -benzene
Porter-Silver Reaction	Curt C. Porter and Robert H. Silber	Detection of dihydroxyacetone structures
Prévost hydroxylation	Charles Prévost	1,2-dihydroxy addition to CC double bonds	Prévost-Woodward hydroxylation
Prévost-Woodward hydroxylation	Charles Prévost and Robert B. Woodward	1,2-dihydroxy addition to CC double bonds	Prévost hydroxylation
Prileshayev reaction	Nikolai Alexandrovich Prileschajew	Synthesis of epoxides from alkenes and peroxycarboxylic acids
Prins reaction	Hendrik Jacobus Prins	electrophilic addition of an aldehyde or ketone to an alkene or alkyne
Prins pinacol rearrangement	Hendrik Jacobus Prins
Pschorr cyclization	Robert Pschorr	Intramolecular ring closure of aromatic amines
Pummerer rearrangement	Rudolf Pummerer	Conversion of sulfoxides with acid anhydrides to α-acyloxysulfides

Q

Surname	Explorer	Brief description	variants
Quasi-Favorski rearrangement	Alexei Yevgrafovich Faworsky
Quelet reaction (Blanc-Quelet reaction)	R. Quelet and Gustave Louis Blanc	an electron-rich aromatic (e.g. anisole) is substituted in the para position by an α-haloalkyl radical	Blanc reaction

R.

Surname	Explorer	Brief description	variants
Radziszewski synthesis	Bronisław Leonard Radziszewski	Preparation of imidazole and its derivatives from diketones, ammonia and aldehydes
Ramberg-Bäcklund reaction	Ludwig Ramberg and Birger Bäcklund	Rearrangement of α-halosulfones to olefins in the presence of bases
Raschig Hooker Trial	Fritz Raschig and Hooker	Large-scale process for the production of phenol
Raschig trial	Fritz Raschig	Large-scale process for the production of hydroxylamine
Raschig synthesis	Fritz Raschig	Large-scale process for the production of hydrazine
Reed reaction (sulfochlorination)	Cortes F. Reed	Sulfochlorination of alkanes
Reformatzki reaction	Sergei Nikolaevich Reformatsky	Synthesis of β-hydroxycarboxylic acid esters from α-halocarboxylic acid esters and aldehydes / ketones in the presence of metallic Zn
Regitz diazo transfer	Otto Dimroth and Manfred Regitz	Base-induced transfer of a diazo group to CH-acidic compounds
Reichstein synthesis	Tadeus Reichstein	chemical-microbiological process for the production of ascorbic acid from D-glucose
Reilly-Hickinbottom rearrangement	Joseph Reilly and Wilfred John Hickinbottom	Variant of the Hofmann-Martius rearrangement
Reimer-Tiemann reaction	Karl Reimer and Ferdinand Tiemann	Synthesis of aromatic aldehydes with chloroform via a dichlorocarbene
Reissert indole synthesis	Arnold Reissert	Synthesis of indoles
Reissert reaction	Arnold Reissert	Functionalization of six-membered nitrogen aromatics
Reverdin reaction	Frédéric Reverdin	Nitration of 4-iodanisole with rearrangement of the iodine group
Riemschneider reaction	Randolph Riemschneider	Representation of thiocarbamates
Riley oxidation	Harry Lister Riley	Production of 1,2-diketones from carbonyl compounds in the alpha methyl or methylene group using selenium dioxide
Knight reaction	John Joseph Ritter	Amide synthesis from nitriles and substrates that can form carbenium ions
Robinson annulation	Robert Robinson	Sequence of Michael addition and aldol condensation for the generation of six-ring systems
Robinson-Gabriel synthesis	Robert Robinson and Siegmund Gabriel	Synthesis of oxazoles
Robinson-Schöpf reaction	Robert Robinson and Clemens Schöpf	Multicomponent reaction with double Mannich reaction for the production of tropinone and other tropane alkaloids
Rosenmund reduction	Karl Wilhelm Rosenmund	Reduction of acid chlorides to aldehydes with H 2 over a poisoned Pd catalyst
Rosenmund-von-Braun reaction	Karl Wilhelm Rosenmund and Julius von Braun	Production of aryl nitriles from aryl bromides and copper (I) cyanide	Sandmeyer reaction
Rothemund reaction	Paul Rothemund	Synthesis of meso- substituted porphyrins
Roush reaction	William R. Roush	Asymmetric allylation
Rowe rearrangement	Frederick Maurice Rowe	Synthesis of phthalazinones
Rubottom Oxidation	George M. Rubottom	α-hydroxylation of aldehydes and ketones
Ruff dismantling	Otto Ruff	Oxidation of aldonic acids with hydrogen peroxide to the next lower aldose
Rühlmann condensation	Klaus Rühlmann	Condensation of two esters to form α-hydroxycarbonyl compounds in the presence of trimethylsilyl chloride
Ružička ring synthesis	Leopold Ružička	Synthesis of cyclic ketones from dicarboxylic acids

S.

Surname	Explorer	Brief description	variants
Sabatier trial	Paul Sabatier and Jean Baptiste Senderens	Conversion of carbon dioxide and hydrogen into methane and water
Saegusa-Ito oxidation	Takeo Saegusa and Yoshihiko Ito	Oxidation of silylated enol ethers to enones
Sakurai reaction (Hosomi Sakurai reaction)	Hideki Sakurai and Akira Hosomi	Implementation of carbonyl compounds and other electrophiles with allyl - silane
Sandmeyer reaction	Traugott Sandmeyer	Introduction of various substituents (e.g. -Br, -SH, -CN) in aromatics via aryldiazonium salts, mostly in the presence of Cu (I) ions
Sarett oxidation	Lewis Hastings Sarett	Gentle oxidation of a primary or secondary alcohol
Schiemann reaction (Balz-Schiemann reaction)	Günther Schiemann	Introduction of fluorine substituents in aromatics via aryldiazonium tetrafluoroborates
Schlenk balance	Wilhelm Schlenk	Solvent-dependent behavior of Grignard compounds
Schmidt reaction	Karl-Friedrich Schmidt	Rearrangement at the nitrogen atom: preparation of carboxamides from ketone and hydrazoic acid
Scholl reaction	Roland Scholl	Coupling of aromatics
Schöllkopf method	Ulrich Schöllkopf	stereoselective amino acid synthesis
Schotten-Baumann method	Carl Schotten and Eugen Baumann	Preparation of esters and amides via carboxylic acid chloride, alcohol / amine and aqueous base	Unicorn acylation
Semmler-Wolff reaction	Friedrich Wilhelm Semmler , expanded by Ludwig Wolff	Preparation of aromatic amines
Serini reaction	Karl Heinrich Slotta and Klaus Neisser , expanded by Arthur Serini	Zinc-catalyzed conversion of steroidal 17-hydroxy-20-acetic acid esters into ketones with unchanged steroid backbones
Seyferth-Gilbert chain extension	Dietmar Seyferth and John C. Gilbert	Reaction of aldehydes and ketones to form alkynes	Bestmann modification
Shapiro reaction	Robert H. Shapiro	Synthesis of alkenes or lithium alkenes from carbonyl compounds
Sharpless epoxidation	Barry Sharpless	enantioselective synthesis of epoxides from allylic alcohols
Shi epoxidation	Yian Shi
Simmons-Smith reaction	Howard E. Simmons and Ronald D. Smith	Cyclopropanation of alkenes by zinc carbenoids
Simonini reaction	Angelo Simonini	Production of aliphatic esters
Skattebøl rearrangement	Lars Skattebøl	Obtaining allenes from geminal dihalocyclopropanes using an organolithium base
Skraup synthesis	Zdenko Hans Skraup	Preparation of quinoline and its derivatives	Doebner-Miller reaction
Smiles rearrangement	Samuel Smiles	Intramolecular, nucleophilic aromatic substitution	Truce Smiles rearrangement
Soai reaction	Kenso Soai	Alkylation reaction on a pyrimidine aldehyde
Sommelet synthesis	Marcel Sommelet	Conversion of primary alkyl halides with hexamethylenetetramine to amines
Sommelet-Hauser rearrangement	Marcel Sommelet and Charles R. Hauser	Rearrangement of quaternary ammonium salts to tertiary amines
Sonn-Müller reaction	Adolf Sonn and Ernst Müller	Synthesis of aldehydes from aromatic anilides
Sonogashira coupling	Kenkichi Sonogashira	Cross-coupling of terminal alkynes with aryl halides catalyzed by palladium and copper
Staudinger ketene cycloaddition	Hermann Staudinger	Synthesis of β-lactams
Staudinger reaction	Hermann Staudinger	Synthesis of amines from azides
Steglich esterification	Wolfgang Steglich	Esterification with dicyclohexylcarbodiimide (DCC) as coupling reagent and 4- (dimethylamino) pyridine (DMAP) as catalyst
Stephen Aldehyde Synthesis	Henry Stephen	Synthesis of aldehydes from nitriles
Stephens-Castro coupling	Robert D. Stephens and Charles E. Castro	Preparation of arylalkynes from terminal alkynes by means of copper-catalyzed cross-coupling of an aryl iodide and a copper acetylide
Stetter reaction	Hermann Stetter	Umpolung of aldehydes with catalytic amounts of sodium cyanide in DMF , followed by a Michael addition
Stevens rearrangement	Thomas S. Stevens	Rearrangement of quaternary ammonium salts with an electron-withdrawing group in the α-position to give tertiary amines
Stickland reaction	Leonard Hubert Stickland	Coupled fermentation of two α-amino acids with simultaneous deamination
Silence coupling	John Kenneth silence	Palladium -catalyzed coupling of an organotin compound with an sp 2 -hybridized organic halide
Stille Kelly coupling	John Kenneth Stille and T. Ross Kelly
Stobbe condensation	Johann Stobbe	Variant of Claisen condensation with diethyl succinate as the CH-acidic component
Stollé synthesis	Robert Stollé	Indole preparation from aniline derivatives and 2-halocarboxylic acid chlorides
Stork reaction	Gilbert Stork	Synthesis of 1,5-dicarbonyls from enamines	Michael addition
Strecker reduction	Adolph Strecker	Irreversible, oxidative degradation of α-amino acids to aldehydes and ketones
Strecker synthesis	Adolph Strecker	Synthesis of α-aminocarboxylic acid nitriles or amino acids from aldehydes, ammonia and hydrocyanic acid
Suzuki clutch	Akira Suzuki	Palladium-catalyzed cross-coupling between organoboronic acids and aryl halides
Swarts reaction	Frédéric Swarts	Synthesis of fluorocarbons and fluorochlorohydrocarbons
Swern oxidation	Daniel Swern	Oxidation of primary and secondary alcohols to aldehydes and ketones with DMSO and oxalyl chloride	various electrophiles instead of oxalyl chloride

T

Surname	Explorer	Brief description	variants
Takai-Lombardo reaction	Kazuhiko Takai and Luciano Lombardo	Methylation of unreactive ketones
Takai olefination	Kazuhiko Takai	Reaction of an aldehyde with a diorganochromium compound and leads to the alkene
Tebbe methylenation	Frederick Nye Tebbe	Double bonds from carbonyl compounds with the Tebbe reagent	Lombardy , Petasis
Ter-sea reaction	Edmund ter Meer	Conversion of a geminal nitrohalogenoalkane into a geminal dinitroalkane
Thorpe-Ziegler reaction	Jocelyn Field Thorpe and Karl Ziegler	Preparation of heterocycles and macrocyclic ketones
Tiffeneau ring expansion (Tiffeneau-Demjanow reaction)	Nikolai Jakowlewitsch Demjanow and Marc Tiffeneau	Ring expansion in cyclic ketones, also named additionally or solely after Demjanow
Tishchenko reaction (Claisen-Tishchenko reaction)	Ludwig Claisen and Vyacheslav Yevgenyevich Tishchenko	Condensation of aldehydes to esters using aluminum alcoholate in an anhydrous reaction medium
Traubean synthesis	Wilhelm Traube	Synthesis of purine derivatives
Driving reaction	Wilhelm Treibs	Acetoxylation of an alkene in the allyl position
Trost's asymmetric allylic alkylation	Barry Trost	Palladium-catalyzed allylic substitution
Cherniak-unicorn reaction	Joseph Tscherniak , Alfred Einhorn	Condensation of N -hydroxymethylamides or N -hydroxymethylimides with various aromatic compounds
Chichibabin pyridine synthesis	Alexei Yevgenyevich Chichibabin	Synthesis of pyridine derivatives from aldehydes and ammonia
Chichibabin reaction	Alexei Yevgenyevich Chichibabin	Preparation of 2- or 4-aminopyridines or -quinolines from heteroaromatics
Chugayev reaction , also Chugaev reaction	Lev Alexandrovich Chugayev	terminal olefins (by pyrolysis of alkylated xanthates)
Tsuji consolation response	Jirō Tsuji and Barry Trost	Palladium-catalyzed allylic alkylation

U

Surname	Explorer	Brief description	variants
Ugi reaction	Ivar Karl Ugi	Synthesis of α-aminoacylamide derivatives from aldehydes, amines, carboxylic acids and isocyanides (4-component condensation)	Passerini reaction , 3-component Ugi reaction (synthesis of α-aminoacylamide derivatives from imines, carboxylic acids and isocyanides)
Ullmann reaction	Fritz Ullmann	Synthesis of biaryls from aryl halides with elemental copper
Urech hydantoin synthesis	Friedrich Urech	Synthesis of hydantoins from α-amino acids

V

Surname	Explorer	Brief description	variants
Van Leusen reaction	Albert Van Leusen	Synthesis of nitriles from ketones and tosylmethyl isocyanide
Varrentrapp reaction	Franz Varrentrapp	Degradation of unsaturated carboxylic acids to carboxylic acids with two fewer carbon atoms, acetic acid and hydrogen
Victor Meyer reaction	Victor Meyer	Substitution reaction
Vilsmeier-Haack reaction	Anton Vilsmeier and Albrecht Haack	Formylation reaction with N-alkylated formamides and phosphorus oxychloride (POCl 3 )
Voges-Proskauer reaction	Otto Voges and Bernhard Proskauer	Testing of bacterial cultures for the formation of 3-hydroxy-2-butanone
Voigt reaction	Karl Voigt	Condensation reaction that leads to the formation of secondary or tertiary α-amino-ketones
Von Braun dismantling	Julius von Braun	Synthesis of nitriles and halogenated hydrocarbons from a carboxamide
Von Braun reaction	Julius von Braun	Synthesis of substituted cyanamides from tertiary amines
Von Braun Rudolph synthesis (von Braun Rudolph tetrazole synthesis)	Julius von Braun and Walter Rudolph	Synthesis of tetrazole derivatives
Von Richter reaction	Victor von Richter	Synthesis of aromatic acids from nitrobenzene derivatives

W.

Surname	Explorer	Brief description	variants
Wacker process (Wacker-Hoechst process)	Walter Hafner and Jürgen Smidt u. a. ( Wacker Chemie )	Oxidation of alkenes to carbonyl compounds using palladium (II) chloride , copper and oxygen
Wagner-Jauregg reaction	Theodor Wagner-Jauregg	Construction of a naphthalene structure from diaryl ethers and maleic anhydride
Wagner-Meerwein rearrangement	Georg Wagner and Hans Meerwein	Framework rearrangement of carbocations
Walden reversal , Waldensche reversal	Paul Walden	Change of configuration at a stereochemical center (usually a C atom)
Gelding rearrangement	Otto Wallach	acid-catalytic rearrangement of azoxybenzenes to hydroxyazobenzenes
Weermann dismantling	Rudolf Adrian Weermann	Degradation of amides to aldehydes with one carbon atom less
Weinreb reaction	Steven M. Weinreb		Weinreb amide synthesis
Weinreb amide ketone synthesis	Steven M. Weinreb	Conversion of carboxylic acids to ketones or aldehydes	Ketone synthesis
Wenker synthesis	Henry Wenker	Preparation of aziridine from ethanolamine
Wharton fragmentation	Peter S. Wharton	Breakdown or fragmentation of carbon chains with heterogeneous nucleophiles and leaving groups
Wharton olefin synthesis	Peter S. Wharton	Reduction of α, β-epoxy ketones to allyl alcohols
Weiss reaction (Weiss-Cook condensation)	Ulrich Weiss and James M. Cook	Synthesis of bicyclo [3.3.0] octanes
Wender indole synthesis	Paul Wender	Synthesis of indole derivatives
Westphalen rearrangement	Theodor Westphalen	Rearrangement of a methyl group and the resulting formation of a double bond
Willgerodt-Kindler reaction	Conrad Willgerodt and Karl Kindler	Preparation of arylacetic acid from aryl methyl ketones
Williamson ether synthesis	Alexander William Williamson	Synthesis of ethers via alcoholate / phenolate and alkyl halide
Wittig-Horner reaction	Georg Wittig and Leopold Horner	Olefination of aldehydes using alkyldiphenylphosphine oxides
Wittig reaction	Georg Wittig	Olefination of aldehydes and ketones using phosphorylides	Locksmith variant or lithium-free variant
Wittig rearrangement	Georg Wittig	Rearrangement of ethers to alcohols	1,2-Wittig rearrangement and 2,3-Wittig rearrangement
Well-degradation	Alfred Wohl	Aldoses are shortened by one carbon atom
Well-Aue reaction	Alfred Wohl and Wilhelm Aue	Formation of a phenazine from an organic nitro compound and an aniline derivative
Wohl-Ziegler reaction	Alfred Wohl and Karl Ziegler	allylic bromination of olefins with N-bromosuccinimide
Wolff-Kishner reaction	Ludwig Wolff and Nikolai Matwejewitsch Kischner	Deoxygenation of aldehydes and ketones via hydrazone
Wolff rearrangement	Ludwig Wolff	Ketenes from alpha-diazoketones
Wolffenstein-Böters reaction	Richard Wolffenstein , Oscar Boeters	Synthesis of dinitrophenol and trinitrophenol (picric acid)
Wurtz synthesis	Charles Adolphe Wurtz	Coupling of two alkyl halides to form alkanes
Wurtz-Fittig synthesis	Charles Adolphe Wurtz and Rudolph Fittig	Conversion of alkyl and aryl halides with sodium to alkylated aromatics

X

Surname	Explorer	Brief description	variants

Y

Surname	Explorer	Brief description	variants
Yamada clutch	Shun-ichi Yamada	Condensation reaction of a carboxylic acid and an amine to form an amide
Yamaguchi method	Masaru Yamaguchi	Formation of macrolide lactones from hydroxycarboxylic acids

Z

Surname	Explorer	Brief description	variants
Zerewitinov's reaction	Fyodor Wassiljewitsch Zerewitinow	Determination of H-acidic hydrogen atoms by adding Grignard reagent
Ziegler-Hafner synthesis	Karl Ziegler and Klaus Hafner	Synthesis for azulenes
Ziegler-Natta process	Karl Ziegler and Giulio Natta	stereospecific polymerization of double bonds with Ziegler-Natta catalysts
Zincke reaction	Theodor Zincke	Synthesis of pyridinium compounds from pyridines
Zincke-Suhl reaction	Theodor Zincke and Rütger Suhl	Reaction of p-cresol with carbon tetrachloride
Zincke nitriding	Theodor Zincke	Synthesis of nitrophenols
Zinin Reduction	Nikolai Nikolayevich Sinin	Reduction of aromatic nitro compounds to the corresponding aniline derivatives
Zwikker reaction	Jan Jacobus Lijnst Zwikker	Color reaction for the detection of barbiturates

For a further list see also Category: Name Reaction .

Web links

• Namesreactions.de
• organic-chemie.ch
• Chemiestudent.de ( PDF file )
• chempensoftware (en) ( Memento from February 7, 2008 in the Internet Archive )
• MerckIndex (en) (PDF file; 3.7 MB)

literature

• Zerong Wang: Comprehensive Organic Name Reactions and Reagents . 1st edition. 3 volumes. John Wiley & Sons , Hoboken (New Jersey) 2009, ISBN 978-0-471-70450-8 , doi : 10.1002 / 9780470638859.conrr489 (over 850 name reactions).
• László Kürti , Barbara Czakó : Strategic Applications of Named Reactions in Organic Synthesis . Background and Detailed Mechanisms. 250 named reactions. 1st edition. Elsevier Academic Press, Amsterdam · Boston 2005, ISBN 978-0-12-369483-6 ( limited preview in Google Book Search - 250 name reactions).
• Thomas Laue, Andreas Plagens: Name and catchword reactions in organic chemistry . 5th edition. Vieweg + Teubner Verlag , Wiesbaden 2006, ISBN 978-3-8351-0091-6 (over 140 name reactions).
• Jie Jack Lie: Name reactions. Springer 2009

Individual evidence

1. ↑ T. Omayada by Li Named Reactions , even as Omayada