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Spic
- Spice (* 1982), Jamaican dancehall singer
- Spice 1 (* 1970), American rap musician
- Spice, Gordon (* 1940), British automobile racing driver and racing car designer
- Spice, Richie (* 1971), Jamaican reggae musician
- Spicer Simson, Geoffrey Basil (1876–1947), British seaman and Africa explorer, hydrograph
- Spicer Simson, Theodore (1871–1959), British-American painter and sculptor
- Spicer, Angelina (* 1981), American actress and stand-up comedian
- Spicer, Dorothy (1908–1946), British aviator and aeronautical engineer
- Spicer, Eddie (1922-2004), English football player
- Spicer, James (1925–2015), British Conservative Party politician, Member of the House of Commons
- Spicer, Michael, Baron Spicer (1943–2019), British politician, Member of the House of Commons, journalist and author
- Spicer, Sean (* 1971), American press officer
- Spicer, William A. (1865–1952), Seventh-day Adventist minister
- Spicer, William E. (1929-2004), American physicist and professor at Stanford University
- Spicher, Stephan (* 1950), Swiss artist
- Spicher, Wilhelm (1898–1987), German politician (KPD), MdR, MdL
- Spichtig, Alois (1927–2014), Swiss graphic artist and sculptor
- Spichtinger, Josef (1926–1996), German local politician
- Spicius Cerialis, Quintus , Roman Senator
- Spick, Lee (1980-2015), English snooker player
- Špička, Denis (* 1988), Czech track cyclist
- Spickenagel, Karl-Heinz (1932–2012), German soccer goalkeeper
- Spickenreuther, Werner (1930–2015), German teacher and local researcher
- Spicker, Friedemann (* 1946), German literary scholar and aphorist
- Spicker, Gideon (1840–1912), German religious philosopher
- Spicker, Heiner (* 1931), German viol player and university professor
- Spicker, Julia , Austrian fashion and portrait photographer
- Spicker-Beck, Monika (* 1959), German author and historian
- Spickermann, Ferdinand (1812–1880), Berlin doctor and landowner
- Spickermann, Josef (1870–1947), German politician (DVP) and member of the German minority in the Sejm in Poland
- Spickermann, Wolfgang (* 1959), German ancient historian
- Spickernagel, Ellen (* 1941), German art historian
- Spickernagel, Wilhelm (1890–1928), German journalist, writer and politician
- Spickhoff, Andreas (* 1962), German lawyer and university lecturer
- Spickhoff, Georg (1872–1959), German school principal and local researcher
- Spickschen, Erich (1897–1957), German politician (NSDAP), MdR
- Spickschen, Lisa (* 1983), German actress, director
- Spicq, Ceslas (1901–1992), French Roman Catholic clergyman and university professor
- Spiculus , member of the Germanic imperial bodyguard (Germani corporis custodes)
Spid
- Spidi (1966–2018), Swiss clown
- Špidla, Vladimír (* 1951), Czech politician, member of the House of Representatives and EU Commissioner
- Špidlík, Tomáš (1919–2010), Czech theologian, cardinal of the Catholic Church
Game
- Spiecker called Döhmann, Indra (* 1970), German law scholar and university professor
- Spiecker, Carl (1888–1953), German journalist and politician (center, CDU), MdL
- Spiecker, Friedrich Albert (1854–1936), German entrepreneur and Protestant association official
- Spiecker, Hans (1891–1968), German politician (CDU), MdL
- Spiecker, Heinrich (* 1947), German forest manager
- Spiecker, Johannes (1856–1920), German Protestant missionary
- Spiecker, Kyrilla (1916–2008), German Benedictine, artist and author
- Spiecker, Oliver (* 1951), German author, journalist, songwriter and program developer
- Spiecker, Rainer (* 1961), German politician (CDU), MdL
- Spiecker, Rochus (1921–1968), German religious, publicist and theologian
- Spieckermann, Hermann (* 1950), German Protestant theologian
- Spieckermann, Ingrid (* 1951), German Protestant theologian
- Spiegel von und zu Peckelsheim, Carl (1808–1886), German administrative officer, manor owner and member of parliament
- Spiegel von und zu Peckelsheim, Edgar von (1885–1965), German submarine commander in World War I, Consul General of New Orleans and Marseille in World War II and writer
- Spiegel von und zu Peckelsheim, Raban (1841–1906), Westphalian manor owner, administrative officer and member of parliament
- Spiegel zu Peckelsheim, Adolf von (1809–1872), German landowner and Prussian district administrator
- Spiegel zu Peckelsheim, Joseph von (1878–1949), German district administrator of the Warburg district (1933–1943)
- Spiegel zum Desenberg and Canstein, Goswin Anton von (1712–1793), subdeacon and canon in various dioceses
- Spiegel zum Desenberg, Carl Ludwig von (1689–1742), Lieutenant General
- Spiegel zum Desenberg, Friedrich Wilhelm von (1775–1807), mining captain in the Duchy of Westphalia
- Spiegel zum Desenberg, Ludolf von , son of Gerhard II. Von Spiegel zum Desenberg and Agnes von Schönenberg
- Spiegel, Adolf (1856–1938), German chemist
- Spiegel, Adriaan van de (1578–1625), Flemish anatomist, surgeon and botanist
- Spiegel, Alfons (1928–2004), German journalist and head of sports at ZDF
- Spiegel, Anne (* 1980), German politician (Bündnis 90 / Die Grünen), MdL
- Spiegel, Bernhard (1826–1895), German Protestant theologian, superintendent and church historian
- Spiegel, Bernt (* 1926), German psychologist and market researcher and specialist in motorcycling
- Spiegel, Carmen (* 1956), German linguist
- Spiegel, Dennis , American film music writer
- Spiegel, Egon (* 1952), German Roman Catholic theologian
- Spiegel, Erasmus († 1551), court marshal of the Electorate of Saxony
- Spiegel, Erich (1919–1984), German politician, mayor of Stettin
- Spiegel, Erika (1925–2017), German social scientist and urban sociologist
- Spiegel, Ernest Adolf (1895–1985), American neurologist
- Spiegel, Ernst Ludwig Christoph von (1711–1785), German manor owner and Canon of Halberstadt
- Spiegel, Evan (* 1990), American Internet entrepreneur
- Spiegel, Fedor von , German manor owner and politician, MdR
- Spiegel, Ferdinand (1879–1950), German painter, graphic artist and illustrator
- Spiegel, Ferdinand August von (1764–1835), Archbishop of the Archdiocese of Cologne
- Spiegel, Franz Wilhelm von (1752–1815), Westphalian nobleman
- Spiegel, Friedrich (1820–1905), German orientalist, Iranist and expert on the Zendavesta
- Spiegel, Friedrich Ernst von (1770–1817), Knight of the Teutonic Order
- Spiegel, Gabrielle (* 1943), American mediaevalist
- Spiegel, Georg (1895–1960), German politician (SPD / SED), resistance fighter
- Spiegel, Hans (1894–1966), German painter
- Spiegel, Harry (1910–2000), Austrian member of the International Brigades and the Resistance
- Spiegel, Helmut (1932–2014), German author and editor
- Spiegel, Hendrik Laurenszoon (1549–1612), Dutch poet and humanist
- Spiegel, Hieronymus (1699–1779), German organ builder
- Spiegel, Hubert (* 1962), German journalist and literary scholar
- Spiegel, Hugo (1905–1987), German cattle dealer, father of Paul Spiegel, who later became President of the Central Council of Jews in Germany
- Spiegel, Jakob , imperial secretary, humanist and legal scholar
- Spiegel, Jeremias (1589–1637), German Lutheran theologian and rhetorician
- Spiegel, Joachim (1911–1989), German Egyptologist
- Spiegel, Josef F. (1927–2007), German theologian, deacon and author
- Spiegel, Julius Hans (1891–1974), German dancer and painter
- Spiegel, Jürgen , German drummer and music producer
- Spiegel, Karl (1863–1920), German teacher and fairy tale collector
- Spiegel, Karl (1868–1932), German trade unionist and politician (SPD), MdR
- Spiegel, Käthe , Austrian-Czechoslovak historian
- Spiegel, Laurie (* 1945), American composer
- Spiegel, Leopold († 1730), German organ builder in Prague
- Spiegel, Ludwig (1864–1926), lawyer and university professor
- Spiegel, Magda , German opera singer
- Spiegel, Marga (1912–2014), German Holocaust survivor
- Spiegel, Maria Anna Benedicta von (1874–1950), Abbess of the Benedictine Abbey of St. Walburg in Eichstätt
- Spiegel, Maria Aurora , foster daughter of Countess Aurora von Königsmarck
- Spiegel, Mark (* 1960), American economist
- Spiegel, Markus (* 1952), Austrian music producer
- Spiegel, Murray R. (1923-1991), American mathematician
- Spiegel, Paul (1937–2006), German journalist, entrepreneur and President of the Central Council of Jews in Germany
- Spiegel, Peter (* 1953), German non-fiction author and company founder
- Spiegel, Pirmin (* 1957), German clergyman, development worker, general manager and CEO of Misereor
- Spiegel, Raphael (* 1992), Swiss football player
- Spiegel, Renia (1924–1942), Polish-Jewish girl, diary author, victim of the Holocaust
- Spiegel, Roland (* 1960), German journalist, book author and editor
- Spiegel, Russ (* 1962), American jazz guitarist
- Spiegel, Sam (1901–1985), American film producer
- Spiegel, Scott (* 1957), American screenwriter, director, producer and actor
- Spiegel, Theodor Hermann von (1712–1779), Landdrost of the Duchy of Westphalia
- Spiegel, Tilly (1906–1988), Austrian author, resistance fighter against National Socialism and Nazi researcher
- Spiegel, Werner Friedrich Julius Stephan von (1802–1877), manor owner and canon of Halberstadt
- Spiegel, Wilhelm (1876–1933), German lawyer and politician (SPD)
- Spiegel, Yorick (1935–2010), German Protestant theologian
- Spiegel-Adolf, Mona (1893–1983), Austrian-American pathologist and chemist
- Spiegel-Behnke, Cornelia (* 1971), German geoscientist
- Spiegel-Borlinghausen, Adolph von (1792-1852), Westphalian and Prussian officer and civil servant
- Spiegel-Hage, Bella van der (* 1948), Dutch cyclist
- Spiegelberg, Erwin (1901–1938), German chemist
- Spiegelberg, Georg (1848–1913), German banker, art collector and namesake of the Foundation Kommerzienrat Georg Spiegelberg
- Spiegelberg, Herbert (1904–1990), American philosopher
- Spiegelberg, Johann Christian (1682–1732), German theater actor and director
- Spiegelberg, Julius (1833–1897), German entrepreneur and industrialist
- Spiegelberg, Marcus (* 1992), German politician (AfD), MdL
- Spiegelberg, Martin (1955–2020), German author (crime fiction) and jazz musician
- Spiegelberg, Moritz von († 1483), German clergyman
- Spiegelberg, Nikolaus von (1790–1866), Austrian cavalry general
- Spiegelberg, Otto (1830–1881), German gynecologist and university professor
- Spiegelberg, Ulrich (1956–2018), German pediatrician and local researcher
- Spiegelberg, Wilhelm (1870–1930), German Egyptologist
- Spiegelburg, Richard (* 1977), German athlete
- Spiegelburg, Silke (* 1986), German pole vaulter
- Spiegelfeld, Franz von (1802–1885), Austrian civil servant and governor
- Spiegelfeld, Giorgio (* 1981), Austrian actor
- Spiegelfeld, Markus von (1858–1943), governor of Tyrol and Vorarlberg
- Spiegelfeld-Schneeburg, Georg (* 1957), Austrian politician (ÖVP), member of the Federal Council
- Spiegelhalder, Oskar (1864–1925), watch manufacturer and collector, local researcher
- Spiegelhalter, Franz (1899–1988), German wood sculptor
- Spiegelhauer, Elfriede (1934–2013), German cross-country skier
- Spiegelman, Art (born 1948), American cartoonist, comic book author and writer
- Spiegelman, Bruce M. (* 1952), American cell biologist at Harvard Medical School
- Spiegelman, Joel (* 1933), American composer
- Spiegelman, Nadja (* 1987), American writer
- Spiegelman, Sol (1914-1983), American molecular biologist
- Spiegl, Fritz (1926–2003), British composer, writer and journalist
- Spiegl, Walter (* 1934), German author, translator and editor of crime and science fiction literature
- Spiegler, Eduard (1860–1908), Austrian dermatologist
- Spiegler, Eugen (* 1883), Austrian walker
- Spiegler, Franz Joseph (1691–1757), South German Baroque painter
- Spiegler, Hans Jacob , painter from Württemberg
- Spiegler, Mark , American film agent
- Spiegler, Mordechai (* 1944), Israeli soccer player and coach
- Spiegler, Ralph (* 1961), German lawyer and local politician (SPD)
- Spiehler, Anton (1795–1867), German Catholic priest, episcopal secretary, cathedral chapter
- Spiehler, Anton (1848–1891), German alpinist
- Spiehs, David (* 1974), Austrian film producer
- Spiehs, Karl (* 1931), Austrian film producer
- Spiekenheuer, Hubert (* 1928), German politician (CSU)
- Spieker, Anton (* 1989), German actor
- Spieker, Arkadius Maria Wilhelm (1910–1945), German Catholic friar
- Spieker, Christian Wilhelm (1780–1858), German writer
- Spieker, Christoph (* 1956), German historian and director of the historical site Villa ten Hompel
- Spieker, Franz-Josef (1933–1978), German filmmaker
- Spieker, Jan , German wandering dealer (Kiepenkerl), whose body was rediscovered as a bog body in 1978
- Spieker, Johann (1756–1825), German pastor and Reformed theologian
- Spieker, Johannes (1860–1914), German Roman Catholic priest and high school professor; first director of the Mariengymnasium Werl
- Spieker, Manfred (* 1943), German social scientist and university professor
- Spieker, Maria (* 1951), German painter and politician (Greens), Member of the Bundestag
- Spieker, Markus (* 1970), German author, journalist, doctor of history and ARD correspondent in Berlin
- Spieker, Paul Emmanuel (1826–1896), German architect and construction officer
- Spieker, Theodor (1823–1913), German mathematician
- Spiekerkötter, Bernd (* 1942), German football player
- Spiekermann, Anna († 1706), German witch trial victim
- Spiekermann, Erik (* 1947), German typographic and type designer
- Spiekermann, Gerd (* 1952), German author who writes in the Low German language
- Spiekermann, Hubertus (1942–2009), German doctor, dentist and university professor
- Spiekermann, Nicole Adele (* 1963), German actress
- Spiekermann, Sarah (* 1973), German business informatics
- Spiekermann, Uwe (* 1963), German historian
- Spiel, Christiane (* 1951), Austrian psychologist and professor at the University of Vienna
- Spiel, Georg Heinrich Gerhard (1786–1822), German lawyer, civil servant, historian, author and editor
- Spiel, Hilde (1911–1990), Austrian journalist and writer
- Spiel, Oskar (1892–1961), Austrian educator and psychologist
- Spielbauer, Adrian (* 1984), German actor
- Spielberg, Anne (* 1949), American screenwriter and film producer
- Spielberg, Arnold (1917-2020), American electrical engineer
- Spielberg, August Hermann (1827–1886), German architect and university professor
- Spielberg, Bernhard (* 1976), German Roman Catholic theologian
- Spielberg, Christine (* 1941), German athlete
- Spielberg, David (1939-2016), American actor
- Spielberg, Steven (* 1946), American director, film producer and screenwriter
- Spielberg, Wilhelm (1826–1890), German lawyer and politician (DFP), MdR
- Spielberger, Charles (1927-2013), American psychologist
- Spielberger, Kerstin (* 1995), German ice hockey player
- Spielberger, Leo (* 1961), German soccer player
- Spielbüchler, Karl (1911–1992), Austrian forest worker and politician (SPÖ), member of the National Council, member of the Federal Council
- Spielbüchler, Karl (1939–2012), Austrian legal scholar and constitutional judge
- Spielbuehler, Gary (* 1950), American football coach
- Player, Hugo (1854–1922), German sculptor
- Player, Johann Jakob (1741–1793), church painter
- Player, Josef (1900–1987), German psychologist, educator and curative educator
- Player, Marie (1845–1913), German painter
- Player, Martin (* 1964), Swiss business journalist and television presenter
- Player, Reinhard (* 1964), German art historian and museum director
- Player, Sieglind (* 1934), German writer and poet
- Player, Sonja (* 1978), Austrian soccer player
- Player, Willy (1937–2016), Swiss social-ethical journalist, editor and politician (SP)
- Spielhagen, Enno (1918–1974), German broadcaster, broadcaster, disc jockey, speaking teacher
- Spielhagen, Friedrich (1829–1911), German writer
- Spielhagen, Wolfgang (1891–1945), German municipal civil servant, deputy mayor of Breslau
- Spielhaus, Riem (* 1974), German scholar of Islam and Africa
- Spielhoff, Alfons (1912–1987), German politician (SPD); Dortmund Head of Culture
- Spielkamp, Matthias (* 1970), German journalist, entrepreneur and civil rights activist
- Spielman, Dan (born 1979), Australian actor
- Spielman, Daniel (* 1970), American mathematician and computer scientist
- Spielman, Rick (born 1962), American football official
- Spielman, Ron (* 1964), German singer, guitarist and composer
- Spielmann, Anna (* 1998), Austrian mountain biker
- Spielmann, Anton (* 1989), German musician, singer and guitarist
- Spielmann, Christian (1861–1917), German historian, archivist and writer
- Spielmann, Dean (* 1962), Luxembourg law scholar; Judge at the European Court of Human Rights
- Spielmann, Emmerich (1873–1952), Austrian architect
- Spielmann, Francisc (1916–1974), Romanian and Hungarian football player
- Spielmann, Fritz (1906–1997), Austrian composer, cabaret artist, pianist and singer
- Spielmann, Georg (1908–1985), German political concentration camp prisoner, resistance fighter against the Nazi regime and VVN functionary
- Spielmann, Götz (* 1961), Austrian film director and screenwriter
- Spielmann, Heinz (* 1930), German art historian and curator
- Spielmann, Hermann (* 1923), German soccer player
- Spielmann, Jacob Reinbold (1722–1783), French pharmacist, chemist and doctor
- Spielmann, Johann (1820–1882), Bohemian psychiatrist
- Spielmann, Johannes († 1532), abbot in the monastery of St. Blasien
- Spielmann, Josef (1885–1950), German politician (economic party), MdL
- Spielmann, Julius (1872–1925), Austrian politician; Member of the House of Representatives
- Spielmann, Karlheinz (1908–1980), German lawyer
- Spielmann, Leopold (1881–1941), Austrian pianist and conductor
- Spielmann, Margrit (* 1943), German politician (SPD), Member of the Bundestag
- Spielmann, Marvin (* 1996), Swiss-Congolese soccer player
- Spielmann, Max (1881–1970), German-speaking architect
- Spielmann, Max (1906–1984), Austrian painter, glass painter and sculptor
- Spielmann, Michael (* 1970), German speed skater
- Spielmann, Rudolf (1883–1942), Austrian chess player
- Spielmann, Siegfried (1921–1999), German carom player
- Spielmeyer, Günter (* 1925), German lawyer and judge at the Federal Social Court
- Spielmeyer, Walther (1879–1935), German psychiatrist and neurologist
- Spielrain, Ewald Emiljewitsch (1926–2009), Russian physicist and university professor
- Spielrein, Jan Nikolajewitsch (1887–1938), Russian mathematician and university professor
- Spielrein, Sabina (1885–1942), Russian-Jewish psychoanalyst
- Spielter, Carl Johann (1851–1922), German history and genre painter
- Spielvogel, Gunther (* 1944), German athlete
- Spielvogel, Jörg (* 1961), German ancient historian
- Spielvogel, Kathrin (* 1974), German actress and speaker
- Spielvogel, Robert (1911–2013), American avant-garde cameraman, film director and documentary filmmaker
- Spielvogel, Wolfgang (* 1945), German theater director and playwright
- Spier, Arthur (1898–1985), German educator and school director
- Spier, Bernd (1944–2017), German pop singer
- Spier, Bettina (1960–2008), German actress and voice actress
- Spier, Hilde (1901–1942), German doctorate in German and journalist
- Spier, Jeffrey , American Classical Archaeologist
- Spier, Julius (1887–1942), German psychoanalyst and founder of psycho-chirology
- Spier, Nana (* 1971), German actress and voice actress
- Spier, Robby (1918–1996), German composer and conductor
- Spier, Rosa (1891–1967), Dutch harpist
- Spier, Samuel (1838–1903), fighter for democracy and social justice
- Spier, Tim (1975–2017), German political scientist
- Spier, Uwe (1946–2013), German pop singer
- Spier, Wolfgang (1920–2011), German director, actor, voice actor and presenter
- Spiera, Francesco (1502–1548), Protestant Italian legal scholar and notary
- Spierer, Carlos (* 1963), German conductor
- Spierer, Simon (1926–2005), Swiss art collector and art patron
- Spierig, Michael (* 1976), German-Australian filmmaker
- Spierig, Peter (* 1976), German-Australian filmmaker
- Spierinck, Nicolas , Flemish illuminator
- Spiering, Christian (* 1948), German elementary particle physicist
- Spiering, Erich (* 1906), German DBD functionary, MdV
- Spiering, Joachim (* 1940), German general in the army of the Bundeswehr
- Spiering, Katharina (* 1974), German actress and voice actress
- Spiering, Rainer (* 1956), German politician (SPD), Member of the Bundestag
- Spiering, Walter , German soccer player
- Spierings, Stijn (* 1996), Dutch football player
- Spierling, Esperanza (* 1971), German artist
- Spierling, Hubert (1925–2018), German painter and glass artist
- Spierling, Volker (* 1947), German philosopher
- Spiero, Heinrich (1876–1947), German Germanist and literary historian
- Spiers, Reg (* 1941), Australian javelin thrower
- Spiers, Richard (1838–1916) British architect and watercolor painter
- Spiers, Ronald I. (* 1925), American diplomat
- Spiertz, Hans († 1968), German architect
- Spies von Büllesheim, Adolf Freiherr (1929–2011), German lawyer, farmer and politician (CDU), Member of the Bundestag
- Spies, Alexander (* 1955), German politician (Pirate Party), MdA
- Spies, August (1855-1887), American labor leader
- Spies, August (1893–1972), German politician (CDU), Member of the Bundestag, Member of the Bundestag
- Spies, Axel (* 1952), German politician (CDU)
- Spies, Ben (* 1984), American motorcycle racer
- Spies, Christoph (* 1985), German politician (SPD)
- Spies, Claudia (* 1961), German anesthetist
- Spies, Corinna (* 1950), German journalist and presenter
- Spies, Daisy (1905–2000), German dancer and choreographer
- Spies, David (* 1994), German soccer player
- Spies, Erdmann (1862–1938), Austrian politician (DnP), member of the National Council
- Spies, Fritz (1884–1965), German-Argentine civil engineer
- Spies, Gerd , German historian and museum director
- Spies, Gerlinde , German fencer
- Spies, Gerty (1897–1997), German writer
- Spies, Gottlieb (* 1927), German politician (SPD), MdL Rhineland-Palatinate
- Spies, Hannelore (1918–1986), German and politician (CDU), Member of the Bundestag
- Spies, Heike (* 1960), doctorate in German studies and deputy director of the Goethe Museum (Düsseldorf)
- Spies, Heinrich (1890–1961), German politician and Lord Mayor, honorary citizen of Düren
- Spies, Hermann (1865–1950), German composer, music researcher and priest
- Spies, Hermine (1857-1893), German oratorio and concert singer (alto)
- Spies, Ignaz (1831–1899), Franco-German mayor and politician, MdR
- Spies, Jean (* 1989), South African cyclist
- Spies, Joachim (1930–1994), German artist and art educator
- Spies, Joachim (* 1960), German journalist and author of detective novels
- Spies, Johann , German printer and publisher
- Spies, Johann Carl (1663–1729), German physician
- Spies, Josef (1906–1985), German politician (CSU), Member of the Bundestag
- Spies, Konstantin (1922–2005), German physician and virologist
- Spies, Leo (1899–1965), German composer and conductor
- Spies, Liesbeth (* 1966), Dutch politician (CDA)
- Spies, Louis von (1813–1889), Prussian district administrator
- Spies, Louisa von (* 1983), German actress
- Spies, Manfred (* 1938), German actor
- Spies, Manfred (* 1941), German political graphic artist
- Spies, Michael (* 1965), German soccer player
- Spies, Moriz von (1805–1862), Bavarian major general and war minister
- Spies, Otto (1901–1981), German orientalist and Islamic scholar
- Spies, Patrick (* 1979), German chef
- Spies, Paul (* 1960), Dutch art historian and museum director
- Spies, Pierre (born 1985), South African rugby player
- Spies, René (* 1973), German bobsleigh pilot and trainer
- Spies, Robert (1886–1914), German painter, printmaker and sculptor
- Spies, Thomas (* 1962), German politician (SPD), MdL
- Spies, Ulrik (1950–2013), German composer, music producer and drummer
- Spies, Uwe (* 1967), German soccer player
- Spies, Walter (1895–1942), German painter and musician
- Spies, Werner (* 1937), German art historian, journalist and museum director
- Spies, Wilhelm (1830–1901), Brunswick Minister of Justice and Education and German Imperial Judge
- Spies, Wilhelm (1907–1994), German lawyer and Nazi war judge
- Spies-Büllesheim, Ludwig Josef von (1785–1860), Prussian district administrator
- Spies-Neufert, Alice (1896–1990), German painter and author of books for young people
- Spiesberger, Karl (1904–1992), Austrian writer and magician
- Spieser, Chuck (1929-1996), American boxer
- Spieser, Friedrich (1902–1987), Franco-German autonomist Alsatian politician (NSDAP) and publisher
- Spieser, Jean-Michel (* 1942), French Christian archaeologist
- Spit from Frechen, Hermann († 1618), Canon in Münster
- Spieß, Adolf (1810–1858), German educator
- Spiess, Alexander (1833–1904), German physician and city doctor for the city of Frankfurt am Main
- Spieß, Alfred (1919–2001), German lawyer and senior public prosecutor
- Spieß, Annelotte (1912–2013), German painter and teacher
- Spieß, August (1815-1893), German homeland researcher
- Spieß, August , German history painter, illustrator, wood cutter and fresco artist
- Spieß, Carolin (* 1970), German theater and film actress
- Spieß, Christa Katharina (* 1966), German economist, education economist and professor for family and educational economics at the Free University of Berlin
- Spieß, Christian (* 1970), German Catholic theologian, social ethicist and university professor
- Spieß, Christian Heinrich (1755–1799), German actor, playwright and author of trivial literature
- Spieß, Christoph (1558–1610), 13th abbot of the Imperial Abbey of Ochsenhausen
- Spiess, Dieter (1924–2017), German entrepreneur
- Spieß, Eberhard (1902–1990), German Benedictine, Abbot Bishop of Peramiho
- Spiess, Eberhard (1925–2007), German film historian
- Spieß, Eduard (1849–1912), engineer and director of arts and crafts schools
- Spiess, Emil (1895–1985), Swiss Roman Catholic clergyman and educator
- Spiess, Emil (1938–2009), German painter and visual artist
- Spieß, Ernst (1927–2011), Austrian ski racer, trainer and functionary
- Spiess, Fabian (* 1994), German soccer goalkeeper
- Spieß, Felix (* 1972), German actor and voice actor
- Spieß, Fritz (1881–1959), German rear admiral
- Spiess, Gerry (1940–2019), American single-handed sailor
- Spiess, Gertrud (1914–1995), Swiss politician (CVP)
- Spieß, Gertrude (* 1947), Austrian politician (SPÖ), member of the state parliament in Burgenland
- Spieß, Gesine (1945–2016), German educationalist and gender researcher
- Spieß, Günter , German wheelchair fencer
- Spieß, Gunter (* 1964), German chess player
- Spiess, Hans († 1503), Swiss mercenary, executed as a murderer according to “God's judgment”
- Spiess, Hans Wolfgang (* 1942), German chemist
- Spieß, Hans-Arthur (1910–1979), German teacher, painter, graphic artist and engraver
- Spieß, Helga (* 1940), German graphic artist and children's book illustrator
- Spieß, Helmut , German skeleton athlete
- Spieß, Helmut (1902–1962), German film director and dramaturge
- Spieß, Hermann , General Commissioner of the Mainz Noble Association
- Spiess, Hubert (* 1964), Austrian actor, director and theater producer
- Spieß, Iris (* 1963), German politician (SPD), Member of the Bundestag
- Spiess, Irmgard (1898–1999), German entrepreneur
- Spiess, Josef (1933–2012), Austrian politician (ÖVP), member of the state parliament
- Spiess, Joseph (1838–1917), French engineer and pilot
- Spieß, Jürgen (* 1949), German ancient historian, speaker and author
- Spieß, Jürgen (* 1984), German weightlifter
- Spieß, Karl (1891–1945), German photographer
- Spieß, Karl von (1880–1957), Austrian teacher and folklorist
- Spieß, Karl-Heinz (* 1948), German historian
- Spieß, Lars (* 1994), German handball player
- Spiess, Ludovic (1938–2006), Romanian opera singer (tenor) and politician
- Spiess, Ludwig Heinrich (1820–1896), Polish entrepreneur in the pharmaceutical industry
- Spieß, Manfred (* 1940), German politician (CDU)
- Spiess, Martin (* 1955), Swiss biochemist and professor at the Biozentrum of the University of Basel, Switzerland
- Spieß, Martin (* 1981), German author
- Spieß, Meinrad (1683–1761), German composer
- Spiess, Monika (* 1942), German sculptor
- Spieß, Moritz Julius (1820–1897), German teacher and local researcher in the Ore Mountains
- Spieß, Nicola (* 1958), Austrian ski racer
- Spiess, Otto (1878–1966), Swiss mathematician
- Spiess, Paul (1924–2001), Swiss women's handball coach and pioneer of women's handball in Switzerland
- Spieß, Philipp Ernst (1734–1794), German historian, archivist, officer and publicist
- Spieß, Robert (1891–1982), German tennis player
- Spieß, Theodor (1890–1962), German lieutenant general in World War II
- Spieß, Tom (* 1961), German film producer
- Spieß, Tom (* 1994), German handball player
- Spieß, Uli (* 1955), Austrian ski racer
- Spieß, Werner (1891–1972), German historian and archivist
- Spiess, Willi (1909–1997), German visual artist and painter
- Spieß, Willi (* 1915), German soccer player
- Spiess-Hegglin, Jolanda (* 1980), Swiss politician
- Spießbach, Erich (1901–1956), German painter, draftsman, sculptor, restorer and author
- Spiessen, Max von (1852–1921), Prussian officer, poet, genealogist and heraldist
- Spiesser, Fritz (1909–1971), German writer
- Spiesser, Jacques (* 1947), French actor
- Spiesser, Judith (* 1982), German opera and oratorio singer
- Spießhofer, Johann Gottfried (1854–1917), German entrepreneur
- Spiesshofer, Ulrich (* 1964), German-Swiss manager
- Spiessl, Bernd (1921–2002), German maxillofacial surgeon and university professor
- Spießl, Wolfgang (1938–1998), German politician (Free Voters, CSU)
- Spieth, Arndt (* 1962), German geographer and book author
- Spieth, Frank (* 1947), German politician (Die Linke), Member of the Bundestag
- Spieth, Jakob (1856–1914), German missionary and Africanist
- Spieth, Jordan (* 1993), American golfer
- Spiethoff, Arthur (1873–1957), German economist
- Spiethoff, Bodo (1875–1948), German dermatologist and university professor
- Spiethoff, Bodo (1918–2000), German economist and writer
- Spiewak, Claudia (* 1954), German journalist
- Spiewak, Martin (* 1964), German journalist and essayist
- Śpiewak, Wiesław (* 1963), Polish religious, Roman Catholic Bishop of Hamilton in Bermuda
- Spiewok, Karl (1892–1951), German politician (NSDAP), MdR, MdL
Spig
- Spiga, Davide (* 1991), German television presenter
- Spigarelli, Sante (* 1943), Italian archer
- Spigath, Hans (1925–1989), German politician (SED), economic functionary (GDR)
- Spigelgass, Leonard (1908–1985), American screenwriter and film producer
- Spight, Thomas (1841-1924), American politician
Spij
- Spijker, Antonius MJM Herman van de (* 1936), Dutch theologian
- Spijkers, Ben (* 1961), Dutch judoka
- Spijkers, Daan (* 1987), Dutch beach volleyball player
Spik
- Špik, Luka (* 1979), Slovenian rower
- Spike * D (* 1990), German DJ and music producer
- Spike, John (* 1951), American art historian, critic and advisor
- Spiker, Olivia (* 1981), Polish-German amateur boxer
- Spiker, Samuel Heinrich (1786–1858), German journalist, travel writer and librarian
- Spikes, Dolores (1936–2015), American mathematician and university director
- Spikings, Barry (* 1939), British film producer
- Spikofski, Karl-Heinz (* 1927), German football player and coach
- Spiksley, Fred (1870-1948) English football player and coach
Game
- Špiláček, Radek (* 1980), Czech football player
- Špilak, Simon (* 1986), Slovenian racing cyclist
- Spilar, Gabriel (* 1980), Slovak ice hockey player
- Špilár, Marek (1975–2013), Slovak football player
- Spilberg, Adriana , Dutch Baroque painter
- Spilberg, Johannes (1619–1690), German-Dutch court painter
- Spilbergen, Joris van (1568–1620), Dutch navigator
- Spilcker, Burchard Christian von (1770–1838), judge, politician of the DDP and Hamburg senator
- Špiler, David (* 1983), Slovenian handball player
- Spilhaus, Arnold Wilhelm (1845–1946), South African businessman and bryologist of German origin
- Spilhaus, Athelstan Frederick (1911–1998), South African-American engineer, oceanographer, meteorologist, and inventor
- Spilimbergo, Lino Enea (1896–1964), Argentine draftsman and artist
- Špiljak, Mika (1916–2007), Yugoslav politician
- Spilker, Adolf (1863–1954), German chemist and technician
- Spilker, Anton (1903–1973), German furniture entrepreneur, furniture designer, interior designer and sculptor
- Spilker, Bettina (* 1978), Austrian university professor
- Spilker, Frank (* 1966), German singer, musician, songwriter and novelist
- Spilker, Heinz (* 1927), German sculptor of classical modernism
- Spilker, Heinz-Jochen (* 1948), German lawyer, former athletics trainer and functionary
- Spilker, James (1933-2019), American engineer
- Spilker, Karl-Heinz (1921–2011), German politician (CSU), Member of the Bundestag
- Spill, Friedrich (1872–1945), German politician (SPD); President of the People's Day in the Free City of Danzig (1928–1930)
- Spill, Sylabil (* 1983), German-Congolese rapper
- Spillane, Davy (born 1959), Irish folk musician and composer
- Spillane, Johnny (* 1980), American Nordic combined athlete
- Spillane, Mickey (1918–2006), American crime novelist
- Spillane, Robert (1964-2010), American actor
- Špillar, Jaroslav (1869–1917), Czech painter
- Špillar, Karel (1871–1939), Czech painter
- Spillecke, Hermann (1924–1977), German educator and politician (SPD), MdL, MdB, MdEP
- Spillecke, Horst (* 1921), German football player
- Spillenberger, Johann (1628–1679), German painter
- Spiller, Andrés (* 1946), Argentine oboist, conductor and music teacher
- Spiller, Andri (* 1995), Swiss ice hockey player
- Spiller, Bill (1913-1988) American golfer
- Spiller, CJ (b.1987) American football player
- Spiller, Cristiano (* 1975), Italian DJ
- Spiller, Hans (1923–2014), German legal scholar
- Spiller, Jörg-Otto (* 1942), German politician (SPD), MdA, MdB
- Spiller, Ljerko (1908–2008), Argentine violinist, conductor and music teacher
- Spiller, Marjorie (1897–1942) British actress and pilot
- Spiller, William Gibson (1863-1940), American neurologist and neuropathologist
- Spilles, Bert (* 1958), German local politician
- Spillett, Simon (* 1974), British jazz musician
- Spilliaert, Leon (1881–1946), Belgian painter
- Spilling, Willy (1909–1965), German composer and doctorate in musicology
- Spilling-Nöker, Christa (* 1950), German Protestant pastor
- Spillmann, Andreas (* 1959), Swiss cultural manager, head of the Swiss National Museum
- Spillmann, Franz (1901–1988), Austrian paleontologist
- Spillmann, Gerda (* 1920), Swiss entrepreneur
- Spillmann, Hans Rudolf (* 1932), Swiss sports marksman
- Spillmann, Jörg (* 1962), German soccer player
- Spillmann, Joseph (1842–1905), Swiss writer and religious
- Spillmann, Kurt R. (* 1937), Swiss historian, conflict researcher and university professor
- Spillmann, Lothar (* 1938), German perceptual psychologist and neuroscientist
- Spillmann, Markus (* 1967), Swiss journalist
- Spillmann, Matthias (* 1975), Swiss jazz trumpeter
- Spillner, Adolf von (1790–1871), Prussian major general
- Spillner, Bernd (* 1941), German linguist
- Spillner, Wolf (* 1936), German nature photographer and writer
- Spilman, John († 1626), German-English entrepreneur, paper manufacturer and jeweler
- Spilmann, Anton , Bernese statesman
- Spilotro, Anthony (1938–1986), Italian-American mobster of the Chicago outfit
- Spilotro, Michael Peter (1944–1986), American mobster and associate of the Chicago Outfit
- Spils, May (* 1941), German director
- Spilsbury, Bernard (1877-1947) British pathologist and forensic scientist
- Spilsbury, John (1739–1769) British cartographer and engraver
- Spiluttini, Margherita (* 1947), Austrian architectural photographer
Spin
- Spina, Angelo (* 1954), Italian clergyman, Roman Catholic Archbishop of Ancona-Osimo
- Spina, Bartolomeo de , Dominican, inquisitor, court theologian
- Spina, Dave (* 1983), Italian-American ice hockey player
- Spina, Franz (1868–1938), German bohemist and politician in Czechoslovakia
- Spina, Giuseppe (1756–1828), cardinal of the Roman Catholic Church
- Spina, Johannes de (1642–1689), German jurist and rector of Heidelberg University
- Spina, Lane (* 1962), American freestyle skier
- Spina, Maria Grazia (* 1936), Italian actress
- Spina, Peter de (1526–1569), physician and city physician from Aachen
- Spina, Peter de II (1563–1622), medic
- Spina, Peter de III. (1592-1655), medical practitioner
- Spina, Segismundo (1921–2012), Brazilian Romanist and Lusitanist
- Spinache (* 1979), Polish rapper and music producer
- Spinacino, Francesco , Italian composer and lutenist
- Spinadel, Erico (1929–2020), Austrian-Argentine engineer
- Spinadel, Laura P. (* 1958), Austrian architect
- Spinadel, Vera W. de (1929–2017), Argentine mathematician
- Špinar, Zdeněk Vlastimil (1916–1995), Czech paleontologist
- Spinat, Paul (1904–1989), German entrepreneur
- Spinath, Frank M. (* 1969), German psychologist and musician
- Spinazzola, Leonardo (* 1993), Italian football player
- Spinazzola, Vittorio (1863–1943), Italian classical archaeologist
- Spincke, Detlef (* 1954), German soccer player
- Spincke, Reinhard (* 1964), German Protestant theologian and Evangelical church official
- Spindel, Ferdinand (1913–1980), German painter, sculptor and object artist
- Spindelberger, Erwin (* 1956), Austrian trade unionist and politician (SPÖ), member of the National Council
- Spindelböck, Josef (* 1964), Austrian Roman Catholic priest, moral theologian and ethicist
- Spindelegger, Erich (1919–2014), Austrian politician (ÖVP), member of the National Council, member of the Federal Council
- Spindelegger, Michael (* 1959), Austrian politician (ÖVP), MEP
- Spindler, Alfred (1888–1948), German lawyer
- Spindler, Alfred (1906–1975), German politician (KPD), MdL
- Spindler, Arno (1880–1967), German naval officer, most recently rear admiral in World War II, naval writer
- Spindler, Benjamin (* 1985), German poker player
- Spindler, Carl (1841–1902), German entrepreneur
- Spindler, Charles (1865–1938), Alsatian artist
- Spindler, Christine (* 1960), German writer
- Spindler, Dieter (* 1950), German politician (CDU), Mayor of Meerbusch
- Spindler, Emil (1885–1957), German businessman and politician (USPD, SPD), Member of the Bundestag
- Spindler, Erica (* 1957), American writer
- Spindler, Ernst (1854–1916), German architect
- Spindler, Erwin (1860–1926), German artist, late romantic-realistic landscape painter and graphic artist
- Spindler, Fritz (1816–1905), German pianist and composer
- Spindler, Gabriele (* 1972), Austrian art historian and cultural manager
- Spindler, Georg Friedrich (1842–1909), German sculptor
- Spindler, Gerald (* 1960), German business lawyer
- Spindler, Gert P. (1914–1997), German textile manufacturer and social politician
- Spindler, Gottlob (1812–1876), German architect and construction officer from Württemberg
- Spindler, Günter (* 1949), German wrestler
- Spindler, Gustav (1859–1928), German forester
- Spindler, Harry (1931–1992), German diplomat, ambassador of the GDR
- Spindler, Heinrich Wilhelm , German cabinet maker
- Spindler, Herbert (* 1954), Austrian cyclist
- Spindler, Jan (* 1971), German politician (PDS, Die Linke), MdA
- Spindler, Joachim von (1899–1987), German ministerial official
- Spindler, Johann Friedrich , German cabinet maker
- Spindler, Joseph (* 1974), German duathlete and triathlete
- Spindler, Karl (1796–1855), German writer
- Spindler, Karl (1887–1951), German naval officer and author
- Spindler, Konrad (1939–2005), German prehistorian and researcher of the Ötzi mummy
- Spindler, Manfred (* 1934), German soccer player
- Spindler, Marlen (1931–2003), Russian artist
- Spindler, Matthias (* 1954), German journalist and historian
- Spindler, Max (1894–1986), German historian
- Spindler, Michael (1942–2017), German manager
- Spindler, Sid (1932-2008), Australian politician
- Spindler, Walter (* 1954), German general
- Spindler, Wilhelm (1810–1873), German laundry and dyeing entrepreneur and founder of the W. Spindler company
- Spindler, Wilhelm (1861–1927), German politician (center), MdR
- Spindler, Wilhelm (1893–1937), German politician (BVP), MdL
- Spindler, Wilhelm (1923–2013), German Sinto and civil rights activist
- Spindler, Wolfgang (* 1938), German music historian and university professor
- Spindler, Wolfgang (* 1946), German lawyer, judge and President of the Federal Fiscal Court
- Spindler, Wolfgang (* 1968), Roman Catholic theologian and university professor
- Spineanu, Ulm (1943–2006), Romanian politician, economist and manager
- Spinell, Joe (1936–1989), American actor and illustrator
- Spinell, Natalie (* 1982), German actress
- Spinella, Stephen (born 1956), American actor
- Spinelli, Altiero (1907–1986), Italian politician, member of the Camera dei deputati, MEP
- Spinelli, Anthony (1927-2000), American director
- Spinelli, Antonio (1630–1706), Theatine priest and privy councilor at the Bavarian court
- Spinelli, Domenico (1788–1863), Italian collector and archaeologist
- Spinelli, Filippo (1566–1616), nuncio and cardinal
- Spinelli, Giovanni Battista (1613–1658), Italian painter
- Spinelli, Giuseppe (1694–1763), Italian cardinal and prefect of the Propaganda Congregation
- Spinelli, Jerry (* 1941), American author for young people
- Spinelli, Justin (* 1979), American cyclocross and road cyclist
- Spinelli, Luca , Swiss investigative journalist
- Spinelli, Nicola (1325–1406), lawyer and politician in the service of Queen Joan I of Naples and Popes Urban V and Gregory XI.
- Spinelli, Nicola (1865–1909), Italian composer, pianist and conductor
- Spinelli, Salvatore (1746–1805), Italian Roman Catholic clergyman, Bishop of Lecce and Archbishop of Salerno
- Spinelli, Santino (* 1964), Italian musician and composer
- Spinellis, Loudovikos († 1904), Greek composer
- Spinello Aretino († 1410), Italian painter
- Spiner, Brent (born 1949), American actor and singer
- Spinesi, Gionatha (* 1978), Italian football player
- Spinetta, Jean-Cyril (* 1943), top French civil servant and manager
- Spinetta, Luis Alberto (1950–2012), Argentine rock musician and composer
- Spinetti, Giovanni , Italian piano maker
- Spinetti, Henry (born 1951), British drummer and session musician
- Spinetti, Massimo (* 1943), Italian diplomat
- Spinetti, Victor (1929–2012), British singer and actor
- Spingler, Andrea (* 1949), German translator of French literature
- Spingler, Renate , German opera singer (mezzo-soprano)
- Spingler, Tobias , painter
- Spingler, Wenzel S. (* 1964), German 3D designer
- Spinillo, Angelo (* 1951), Italian clergyman, Bishop of Aversa
- Spinjow, Nikolai Nikolajewitsch (* 1974), Russian Olympic champion in rowing
- Spink, Cyrus (1793-1859) American politician
- Spink, JC (1972-2017), American film producer
- Spink, John Stephenson (1909–1985), British Romanist and French scholar
- Spink, Nigel (* 1958), English football goalkeeper
- Spink, Solomon L. (1831-1881) American politician
- Spink, Tylor (* 1992), Canadian ice hockey player
- Spink, Tyson (* 1992), Canadian ice hockey player
- Spinka, Klaus (* 1960), Austrian grass skier
- Spinks, Charlton Watson (1877–1959), British general and the last Sirdar of Egypt
- Spinks, Cory (* 1978), American boxer
- Spinks, Leon (* 1953), American boxer
- Spinks, Michael (* 1956), American light heavyweight and heavyweight boxer
- Spinks, Terry (1938–2012) British boxer and trainer
- Spinler, Stefan (* 1970), German logistics scientist
- Spinnangr, Martin (* 1987), Norwegian beach volleyball player
- Spinnen, Burkhard (* 1956), German writer
- Spinner, Esther (* 1948), Swiss writer
- Spinner, Francis E. (1802-1890), American politician
- Spinner, Günter (* 1972), German lawyer
- Spinner, Helmut F. (* 1937), German philosopher, scientific theorist, sociologist and university professor
- Spinner, Kaspar H. (* 1941), Swiss Germanist and didactic specialist
- Spinner, Leopold (1906–1980), Austrian composer
- Spinner, Tony (born 1963), American guitarist and singer
- Spinner, Werner (* 1948), German manager and football official
- Spinner, Wilfried (1854–1918), Swiss missionary
- Spinney, Caroll (1933-2019), American puppeteer
- Spinney, Laura (* 1971), British writer and science journalist
- Spinning 9 (* 1990), German rapper
- Spinnler, Adolf (1879–1951), Swiss gymnast
- Spinnler, Erwin (* 1947), German soccer player
- Spinnler, Karl (1875–1936), Swiss politician (FDP)
- Spinnler, Lisette (* 1976), Swiss jazz singer
- Spinnrad, Jürgen , German sculptor and builder
- Spinoglio, Ángel (1931–2012), Uruguayan entrepreneur and politician
- Spínola Basadone, Agustín (1597–1649), Spanish cardinal of the Roman Catholic Church
- Spínola y Maestre, Marcelo (1835–1906), Spanish cardinal of the Roman Catholic Church and Archbishop of Seviila
- Spinola, Ambrosio (1569–1630), Spanish military leader in the Eighty Years War
- Spínola, Ambrosio Ignacio (1632–1684), Spanish bishop
- Spínola, António de (1910–1996), Portuguese general and politician
- Spinola, Bernhard (1836–1900), German lawyer and longstanding administrative director of the Charité
- Spinola, Christoph de Royas y († 1695), Flemish-Austrian Franciscan, cameralist, politician and bishop of Wiener Neustadt
- Spinola, Francis B. (1821-1891), American officer and politician
- Spinola, Giambattista († 1704), Cardinal of the Roman Church
- Spinola, Giandomenico (1580–1646), Italian bishop and cardinal
- Spinola, Giorgio (1667–1739), Italian clergyman, papal diplomat and cardinal
- Spinola, Giovanni (* 1935), Italian rower
- Spinola, Giovanni Battista (1681–1752), Italian clergyman and cardinal of the Roman Catholic Church
- Spínola, Hélder (* 1973), Portuguese biologist and ecologist
- Spinola, Massimiliano (1780-1857), Italian entomologist
- Spínola, Pedro (* 1983), Portuguese handball player
- Spinola, Ugo Pietro (1791-1858), Italian cardinal
- Spínola, Vanessa (* 1990), Brazilian heptathlete
- Spinosi, Jean-Christophe (* 1964), French conductor, violinist and founder of the Ensemble Matheus
- Spinosi, Laurent (* 1969), French football goalkeeper and goalkeeper coach
- Spinosi, Luciano (* 1950), Italian football player and coach
- Spinosi, Mathieu (* 1990), French film actor and violinist
- Spinotti, Dante (* 1943), American cameraman
- Spinoy, Antoon (1906–1967), Belgian politician
- Spinoza, Baruch de (1632–1677), Dutch philosopher of rationalism
- Spinrad, Hyron (1934-2015), American astronomer
- Spinrad, Norman (born 1940), American science fiction author
- Spinrads, Rolf (1942–1987), German television editor, director and author
- Spinrath, Norbert (* 1957), German policeman, trade unionist and politician (SPD), Member of the Bundestag
- Spintec , German music producer
- Spintzyk, Alexander (* 1999), German volleyball player
- Spinucci, Domenico (1739–1823), Italian clergyman, archbishop and cardinal of Benevento
- Spinzig, Otto (1873–1957), German mining official, mining industrialist and parliamentarian
Spy
- Spio-Garbrah, Ekwow (* 1953), Ghanaian politician, Director General of the Commonwealth Telecommunications Organization (CTO)
- Spies, James , American film producer and film director
- Spiotta, Dana (* 1966), American writer
Spir
- Spir, Afrikan (1837–1890), Russian philosopher and logician
- Spir, Juan-Carlos (* 1990), Colombian tennis player
- Spira, Andreas (1929-2004), German classical philologist
- Spira, Camilla (1906–1997), German actress
- Spira, Elizabeth T. (1942–2019), Austrian television journalist
- Spira, Françoise (1928–1965), French film and stage actress
- Spira, Fred (1924–2007), American photographer
- Spira, Fritz (1877–1943), Austrian actor
- Spira, Henry (1927–1998), Belgian-American animal rights activist
- Spira, Johannes de , printer in Venice
- Spira, Leopold (1913–1997), Austrian publicist and political author
- Spira, Lotte (1883–1943), German actress
- Spira, Mela (1893–1967), Austrian actress and writer
- Spira, Steffie (1908–1995), German actress
- Spira, Theodor (1885–1961), German Anglicist
- Spira, Wendelinus de († 1477), printer in Venice
- Spira-Wedeles, Aaron Simeon († 1679), Jewish scholar and rabbi
- Spirandelli, Zoltan (* 1957), German director and actor
- Spiranovic, Laura (* 1991), Australian soccer player
- Spiranovic, Matthew (* 1988), Australian soccer player
- Spîrcu, Doina (* 1970), Romanian rower
- Spirescu, Maria (* 1980), Romanian bobsleigh athlete and track and field athlete
- Spirgatis, Hermann (1822–1899), German pharmacist, chemist and university professor
- Špirić, Nikola (* 1956), Bosnian-Herzegovinian politician (SNSD)
- Spiridakos, Tracy (* 1988), Greek-Canadian actress
- Spiridon, Simona (* 1980), Austrian handball player and trainer
- Spiridonov, Eugen (* 1982), German gymnast of Russian descent
- Spiridonović, Srđan (* 1993), Austrian football player
- Spiridonow, Alexei Sergejewitsch (1951–1998), Soviet athlete
- Spiridonow, Andrei Wladimirowitsch (* 1982), Kazakh ice hockey player
- Spiridonow, Maxim Wladimirowitsch (* 1978), Russian ice hockey player
- Spiridonow, Nikola (* 1938), Bulgarian chess player
- Spiridonow, Vadim Semjonowitsch (1944–1989), Soviet film actor and voice actor
- Spiridonowa, Kristina Sergejewna (* 1998), Russian freestyle skier
- Spiridonowa, Marija Alexandrovna (1884–1941), Russian social revolutionary
- Spirig, Jolanda (* 1953), Swiss author
- Spirig, Rebecca , Swiss nurse and university professor
- Spirig-Hug, Nicola (* 1982), Swiss triathlete
- Spirin, Alexander Sergejewitsch (* 1931), Russian biochemist and molecular biologist
- Spirin, Gennadi Konstantinowitsch (* 1948), Russian illustrator
- Spirin, Ivan Timofejewitsch (1898–1960), Russian pilot and university professor
- Spirin, Leonid Wassiljewitsch (1932–1982), Soviet walker and Olympic champion
- Spirit, Majk (* 1984), Slovak rapper and member of the group H16
- Spirit Cave man , mummy, found in Nevada
- Spirito, François (1900–1967), Mafia godfather
- Spiritus, Wilhelm (1854–1931), Lord Mayor of Bonn
- Spirk, Ernst , Austrian harmonica maker
- Spirk, Ralph (* 1986), Austrian soccer player
- Špirko, Rastislav (* 1984), Slovak ice hockey player
- Spîrlea, Irina (* 1974), Romanian tennis player
- Spirli, Alfred (* 1957), French jazz musician
- Spiro, Annette (* 1957), Swiss architect
- Spiro, David (1901–1970), Polish-German rabbi in the Warsaw rabbinate and co-founder of the Israelite religious community in Fürth after the Second World War
- Spiro, Ernst (1873–1950), German railway engineer
- Spiro, Eugene (1874–1972), German-American painter and graphic artist
- Spiro, Friedrich (1863–1940), German classical philologist and musicologist
- Spiro, Georges (1909–1994), Polish-French painter who is assigned to Surrealism
- Spiro, Herbert (1924-2010), American political scientist, diplomat, and politician (Republican)
- Spiro, Ignaz (1817-1894), industrialist
- Spiro, Jordana (* 1977), American actress
- Spiro, Karl (1867–1932), German biochemist and physical chemist
- Spiro, Melford E. (1920-2014), American cultural anthropologist
- Spiro, Samantha (* 1968), British actress
- Spiro, Stanley Grove (1900-1948), South African pilot and banker
- Spiropoulos, Jean (1896–1972), Greek lawyer and judge at the International Court of Justice
- Spirovski, Aleksandar (* 1978), Serbian volleyball player
- Spirovski, Hristijan (* 1987), Macedonian-Australian musician and pianist
- Spiru, Nako (1918–1947), Albanian communist politician
Spis
- Spisak, Kati Jo (* 1983), American soccer goalkeeper
- Spisak, Michał (1914–1965), Polish composer
- Spisak, Neil (* 1956), American film and costume designer
- Spiske, Robert (1821–1888), German clergyman, founder of the Hedwig Sisters
- Spiß, Cassian (1866–1905), Benedictine monk and Catholic bishop
- Spiß, Kornelia (* 1965), Austrian politician (FPÖ), member of the state parliament
- Spiss, Toni (1930–1993), Austrian ski racer
- Spissak, Johann (1889–1942), Austrian working-class poet
- Spisso, Vicencio Scarano (* 1963), Venezuelan politician and entrepreneur
Spit
- Spit, Lize (* 1988), Belgian writer
- Spit, Nicolaus (1853–1929), Dutch Old Catholic clergyman and Bishop of Deventer
- Spitaels, Guy (1931–2012), Belgian politician and minister
- Spital, Hermann Josef (1925–2007), German clergyman, Bishop of Trier
- Spitaler, Anton (1910–2003), German orientalist, Semitic and Arabic philologist
- Spitaler, Armin (1898–1963), German lawyer and political scientist
- Spitaler, Ludwig (* 1913), German production and manufacturing manager
- Spitaler, Rudolf (1859–1946), Austrian meteorologist, astronomer and physicist
- Spitali, Giuseppe (* 1979), Italian football player
- Spitalny, Phil (1890–1970), American clarinetist and band leader
- Spitalsky, Anton (1831–1909), Austrian arms contractor, technical director of the Austrian Arms Factory
- Spitamas († 550 BC), husband of Amytis (Astyages)
- Spitamenes († 328 BC), general in Bactria and Sogdia
- Spiteller, Gerhard (1931–2017), Austrian natural product chemist
- Spiteller, Michael (* 1954), Austrian environmental chemist
- Spiteri Debono, Myriam (* 1952), Maltese politician
- Spiteri, Carm Lino (1932–2008), Maltese politician
- Spiteri, Dalila (* 1997), Italian tennis player
- Spiteri, Joseph (* 1959), Maltese clergyman, archbishop and diplomat of the Holy See
- Spiteri, Lino (1938–2014), Maltese politician
- Spiteri, Mary (* 1947), Maltese singer
- Spiteri, Mike (* 1955), Maltese pop rock singer
- Spiteri, Sharleen (* 1967), British musician
- Spiteri, Stephen C. (* 1963), Maltese historian, author and publicist
- Spiteris, Ioannis (* 1940), Greek clergyman, Roman Catholic bishop of Corfu (Greece)
- Spithill, James (* 1979), Australian sailor
- Spithöver, Josef (1813–1892), German founder of the St. Josef-Stift rheumatism clinic
- Spithridates († 334 BC), satrap of Lydia and Ionia
- Spitignev of Brno († 1199), Duke of Brno
- Spitko, Roman (* 1978), German badminton player
- Špitková, Jela (* 1947), Slovak-Austrian violin soloist and university teacher
- Spitra, Emil (1851–1924), Carinthian major importer
- Spitse, Sherida (* 1990), Dutch soccer player
- Spitt, Carl Heinrich (1732–1793), German mayor
- Spitta, Friedrich (1852–1924), Protestant theologian
- Spitta, Gertrud (1881–1967), German painter and graphic artist
- Spitta, Heinrich (1799–1860), German physician, poet and translator
- Spitta, Heinrich (1902–1972), German music teacher, composer and musicologist
- Spitta, Max (1842–1902), German architect and Prussian construction officer
- Spitta, Melanie (1946–2005), German filmmaker and Sinti civil rights activist
- Spitta, Philipp (1801-1859), German Protestant theologian and poet
- Spitta, Philipp (1841–1894), German musicologist and Bach biographer
- Spitta, Theodor (1873–1969), German politician (DDP, BDV, FDP), Member of the Bundestag
- Spitta, Walter (1903–1945), German Protestant pastor and member of the Confessing Church
- Spittal, Blair (* 1995), Scottish soccer player
- Spittel, Olaf R. (* 1953), German editor, writer, translator, media scientist and publisher
- Spittel-Wilson, Christine (1912-2010), English writer
- Spitteler, Adolf (1846–1940), Swiss chemist and entrepreneur
- Spitteler, Carl (1845–1924), Swiss poet and writer
- Spitteler, Werner (1940–2019), Swiss politician
- Spittelmaier, Johannes , Anabaptist theologian and preacher of the Anabaptist Church in the Moravian Nikolsburg
- Spittelmayr, Ambrosius (1497–1528), representative of the Austro-South German Anabaptist movement
- Spittka, Marko (* 1971), German judoka
- Spittler, Christian Friedrich (1782–1867), German secretary of the Basel Christianity Society
- Spittler, Gerd (* 1939), German ethnologist
- Spittler, Kerstin (* 1963), German rower
- Spittler, Ludwig Timotheus (1752–1810), German historian of church history, political history
- Spittler, Torsten (* 1961), German football coach
- Spitz, Alban (1906–1996), German painter, draftsman, woodcutter, glass painter, author of art-philosophical writings and Alemannic dialect texts
- Spitz, Alexander von (1832–1910), Prussian general of the infantry
- Spitz, Arno (1920–2014), German publisher
- Spitz, Barbara (* 1954), Austrian actress, singer and author
- Spitz, Dan (* 1963), American guitarist
- Spitz, Elisa (* 1963), American figure skater
- Spitz, Elisabetta (* 1953), Italian architect and administration manager
- Spitz, Ellen Handler (* 1939), American art scholar
- Spitz, Ernst (1902–1940), Austrian journalist and publicist
- Spitz, Georg Spencer (1892–1960), German banker
- Spitz, Harry Hermann (1899–1961), Austrian musician, radio editor and orchestra director
- Spitz, Malte (* 1984), German politician
- Spitz, Marc (1969–2017), American writer and music journalist
- Spitz, Mark (* 1950), American swimmer
- Spitz, Michael (1937–2008), German religious priest and religious educator
- Spitz, René (* 1968), German design critic and brand consultant
- Spitz, René A. (1887–1974), Austrian-American psychoanalyst
- Spitz, Robert (* 1955), German actor and director
- Spitz, Sabine (* 1971), German cyclist
- Spitz, Selina (* 1984), Austrian biathlete
- Spitz, Werner (* 1926), German-American forensic pathologist
- Spitz, Wilhelm von (1836–1910), Prussian lieutenant general
- Spitz master , medieval illuminator
- Spitzar, Marco (* 1964), German-Austrian artist and author
- Spitzauer, Leonhard (* 1985), German independent managing director and local politician (CSU)
- Spitzbart, Heinz (1930–2008), German gynecologist and obstetrician
- Spitzbart, Michael (* 1957), German physician
- Spitzck, Heiko (* 1974), German non-fiction author
- Spitzeder, Adele (1832–1895), German actress and cheater
- Spitzeder, Henriette (1800–1828), German opera singer (soprano)
- Spitzeder, Johann Baptist (1764–1842), German actor and singer (bass)
- Spitzeder, Josef (1796–1832), German theater actor and opera singer (bass)
- Spitzemberg, Franz Xaver von (1781–1864), Württemberg Chamberlain, Lieutenant General and Hof-Jägermeister
- Spitzemberg, Hildegard von (1843–1914), German salonnière
- Spitzenberg, Karl (1860–1944), German forester, master steward and inventor
- Spitzenberger, Herbert (1927–2019), German pianist and university professor
- Spitzpfeil, Lorenz Reinhard (1874–1945), German graphic artist, type artist, building researcher
- Spitzer, André (1945–1972), Israeli fencer and trainer, murder victim of Palestinian terrorists
- Spitzer, Bernd (* 1943), Austrian actor on stage and television
- Spitzer, Daniel (1835–1893), Austrian writer, satirist and feature writer, lawyer
- Spitzer, Dominik (* 1967), German doctor and politician (FDP), MdL
- Spitzer, Eliot (* 1959), American politician
- Spitzer, Emanuel (1844–1919), Austrian painter and graphic artist
- Spitzer, Frank (1926–1992), Austrian-American mathematician
- Spitzer, Gerhard (* 1964), Austrian politician (SPÖ), member of the state parliament and councilor
- Spitzer, Giselher (* 1952), German sports historian
- Spitzer, Hugo (1854–1936), Austrian philosopher and sociologist
- Spitzer, Humbert (1923-2004), long-time chairman of WITAF (Vienna Deaf-Mute Welfare Association)
- Spitzer, Jan (* 1947), German actor and voice actor
- Spitzer, Johann (* 1959), Austrian diplomat and ambassador to Lithuania
- Spitzer, Johann Georg , German patrician and mayor of the imperial city of Heilbronn (1655–1682)
- Spitzer, Josef (1907–1933), German communist and murder victim of the Köpenick Blood Week
- Spitzer, Juschka (* 1969), German theater actress and director
- Spitzer, Karsten (* 1961), German actor
- Spitzer, Leo (1887–1960), Austrian Romance philologist and literary theorist
- Spitzer, Leonhard (* 1950), German local politician (CDU), mayor of Voerde
- Spitzer, Leonie Adele (1891–1940), Austrian writer and teacher
- Spitzer, Leopold (1918–2012), Austrian politician and mayor (WPÖ)
- Spitzer, Leopold (* 1942), Austrian university professor for singing
- Spitzer, Lyman (1914–1997), American astronomer and physicist
- Spitzer, Manfred (* 1958), German neuroscientist and psychiatrist
- Spitzer, Martin (* 1965), Austrian musician
- Spitzer, Martin (* 1979), Austrian legal scholar
- Spitzer, Martin (* 1985), Austrian swimmer
- Spitzer, Martina (* 1962), Austrian film and theater actress
- Spitzer, Moritz (1900–1982), Israeli Indologist, publisher and Zionist activist
- Spitzer, Paul (1906–1933), German communist and murder victim of the Köpenick Blood Week
- Spitzer, Robert L. (1932–2015), American psychiatrist, university professor, and author
- Spitzer, Sarah (* 1984), German violinist
- Spitzer, Serge (1951–2012), Romanian-Israeli installation artist
- Spitzer, Thomas (* 1953), Austrian pop singer
- Spitzer, Thomas (* 1988), German author, poetry lamb and organizer
- Spitzer, Volkhard (* 1943), German pastor of the Christian Center
- Spitzer, Wolf (* 1940), German sculptor
- Spitzer-Marlyn, Eric (* 1952), Austrian musician
- Spitzing, Günter (* 1931), German writer
- Spitzing, Tamara (* 1957), German documentary filmmaker and archaeologist
- Spitzky, Marco (* 1992), German pool player
- Spitzl, Bruno (1887–1962), Austrian Benedictine, military chaplain in World War I, pastor in Vienna and pilgrimage priest in Maria Plain
- Spitzl, Christian Oskar (* 1959), German actor
- Spitzl, Daniel (* 1983), Austrian athlete
- Spitzlberger, Georg (* 1931), German historian
- Spitzmüller, Alexander (1862–1953), Austrian business leader and politician
- Spitzmüller, Alexander (1894–1962), Austrian composer
- Spitzmüller, Kurt (1921–2014), German politician (FDP / DVP), Member of the Bundestag
- Spitzmüller, Romy (* 1981), German marathon runner
- Spitzmüller, Wolfgang (* 1969), Austrian politician (Greens), member of the Burgenland Landtag
- Spitznagel, Petrus († 1465), Carmelite Father, Titular Bishop of Myra and Auxiliary Bishop in the Principality of Speyer
- Spitznas, Hans Adolf von (1699–1758), Württemberg Lieutenant General
- Spitznas, Manfred (* 1939), German ophthalmologist and professor emeritus for ophthalmology
- Spitzner, Adam Benedict (1717–1793), German Hebraist and Evangelical Lutheran theologian
- Spitzner, Alfred (1921–1992), German architect and politician (CSU)
- Spitzner, Anne (* 1988), German author
- Spitzner, Annemarie (1899–1934), German welfare worker and special needs teacher
- Spitzner, Balthasar Andreas (1679–1755), German Evangelical Lutheran theologian
- Spitzner, Carl (1831–1899), German doctor and porcelain collector
- Spitzner, Franz (1787–1841), German classical philologist and educator
- Spitzner, Georg Friedrich (1688–1764), Electoral Saxon civil servant
- Spitzner, Gerald (* 1972), Austrian composer
- Spitzner, Gustav (1803-1870), royal Saxon civil servant
- Spitzner, Hans (* 1943), German politician (CSU), MdL
- Spitzner, Heinz (1916–1992), German actor
- Spitzner, Johann Ernst (1731–1805), German Protestant theologian, economist and beekeeper
- Spitzner, Karl (1876–1951), German mining official
- Spitzner, Osmar (1924–1969), German lawyer
- Spitzner, Reinhard (1863–1922), German judge and writer
- Spitzner, Renate (* 1943), Austrian composer, musician, music teacher and music therapist
- Spitzner, Siegmund Wilhelm (1764-1825), German Protestant theologian and lawyer
- Spitzweg, Carl (1808–1885), Biedermeier painter
- Spitzweg, Simon (1776–1828), Munich merchant
- Spitzy, Hans (1872–1956), Austrian orthopedist
- Spitzy, Karl Hermann (1915–2013), Austrian physician
- Spitzy, Reinhard (1912–2010), Austrian and German diplomat and Secretary Ribbentrops
Spiv
- Spivack, Murray (1903-1994), American sound engineer
- Spivak, Charlie (1907–1982), American big band leader and jazz trumpeter
- Spivak, Daniel (* 1988), Israeli-Canadian ice hockey player
- Spivak, Elie (1902–1960), Canadian violinist and music teacher
- Spivak, Michael (* 1940), American mathematician
- Spivakovsky, Mark (* 1960), mathematician
- Spivakovsky, Michael (1919–1983), British violinist, conductor and composer
- Spivey, Jim (* 1960), American middle-distance runner
- Spivey, Nigel (* 1958), British classical archaeologist
- Spivey, Taylor (* 1991), American triathlete
- Spivey, Victoria (1906–1976), American blues singer, piano player, and composer
Spiw
- Spiwak, Pyotr Efimowitsch (1911–1992), Russian physicist
- Spiwakow, Wladimir Teodorowitsch (* 1944), Russian violinist and conductor
- Spiwakowski, Adolf (1891–1958), Russian-German-Australian singer (bass baritone) and music teacher
- Spiwakowski, Jascha (1896–1970), Russian pianist
- Spiwakowski, Tossi (1907–1998), Russian violinist
Spix
- Spix, Hermann (* 1946), German writer
- Spix, Johann Baptist von (1781–1826), German natural scientist
- Spix, Walter (1894–1942), German religious, victim of National Socialism
Spiz
- Spiżak, Mirosław (* 1979), Polish football player
- Spizow, Denis Sergejewitsch (* 1996), Russian cross-country skier
- Spizyn, Valeri Anatoljewitsch (* 1965), Russian walker
- Spizyn, Viktor Ivanovich (1902–1988), Russian chemist